Neurovascular disorder

When babies lack oxygen around birth, they can suffer lasting brain damage. No treatment currently repairs that injury. Researchers are testing whether oral sildenafil, a drug already used safely in babies for lung blood pressure, can help. In this Phase 2 trial, 60 newborns with…

Researchers are testing a gene therapy called NXL-001 in people who have lasting movement problems from an ischemic stroke. The study enrolls 9 adults, 2 to 12 months after their stroke, who have moderate to severe arm or leg weakness despite rehabilitation. Each participant rece…

This study tests an experimental drug called THN391, given as an injection into the eye, for people with diabetic macular edema (DME) — a condition where fluid builds up in the retina due to diabetes, causing vision loss. The trial involves 21 adults aged 18 to 80 with DME and vi…

After cardiac arrest, the brain often suffers from low oxygen even when the heart is restarted. This pilot trial tests whether using a non-invasive forehead sensor to monitor brain oxygen and adjust ICU treatments can keep oxygen levels above a target. Adults who remain in a coma…

This study tests whether clot-busting drugs (alteplase or tenecteplase) are safe and effective for stroke patients who have taken a blood thinner (FXa inhibitor) in the last 48 hours. Current guidelines avoid this treatment due to bleeding concerns, but new evidence suggests it m…

This study tests a drug called JX10 in people who have had a stroke and arrive at the hospital 4.5 to 24 hours later. The goal is to see if JX10 can improve recovery and reduce disability compared to a placebo. About 740 participants will be randomly assigned to receive JX10 or a…

This study tests if a catheter-based device that closes a small pouch in the heart (left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4000 participants at high risk of stroke will be enrolled.…

This phase 3 trial tests whether an experimental drug called MK-8748 can treat diabetic macular edema (DME), a condition where fluid builds up in the retina and blurs vision. About 960 adults with DME will receive either MK-8748 or the standard treatment aflibercept via eye injec…

This study is testing whether placing stroke patients in a head-down position (Trendelenburg) before a clot-removal procedure can improve their recovery. Researchers will enroll 210 adults with a severe stroke caused by a large blocked artery. The goal is to see if this simple po…

Researchers at the University of South Carolina are testing a program that pairs nurses with community health workers to coach adults who have chronic conditions like diabetes, high blood pressure, heart disease, kidney disease, or a prior stroke. Each patient joins with a carepa…

This study tests two ways to treat proliferative diabetic retinopathy, a serious eye problem caused by diabetes. One group gets eye injections of faricimab plus laser treatment; the other gets vitrectomy surgery with laser. Researchers will track vision and how many extra treatme…

This study tests a drug called sovateltide in 160 people who have had an ischemic stroke (a stroke caused by a blood clot). The goal is to see if the drug helps patients recover better and is safe. Participants receive either the drug or a placebo within 24 hours of their stroke,…

Researchers are testing whether a home-use pulsed electromagnetic therapy device can slow cognitive decline in people with mild to moderate Alzheimer's disease, Lewy body dementia, or vascular dementia. About 48 participants will use the device three times a day for 15 minutes ov…

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This study tests a one-time gene therapy called surabgene lomparvovec (Sura-vec) for diabetic retinopathy, a common eye problem from diabetes that can lead to blindness. About 576 adults with moderate-to-severe non-proliferative diabetic retinopathy will receive either the gene t…

This study is testing whether a device that uses mild electrical pulses to stimulate arm muscles and the tongue can help stroke survivors regain arm movement. Researchers will enroll 288 participants, including stroke patients with arm weakness and healthy controls. The main goal…

This study tests whether combining a gentle brain stimulation technique (tDCS) with exercises that challenge both thinking and walking can improve how stroke survivors handle doing two things at once. Seventy-two participants who had a stroke at least six months ago will receive …

This study tests whether a simple, non-invasive treatment called remote ischemic conditioning (RIC) can help people recover better after a moderate stroke in the back part of the brain. RIC involves briefly inflating a blood pressure cuff on the arm to restrict blood flow, then r…

This study compares three oral medications used to prevent migraines: atogepant (a newer drug), topiramate, and propranolol (both older). About 1,335 adults with migraine will be randomly assigned to one of the three drugs for 12 weeks. Researchers will track headache frequency a…

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This phase 3 trial is testing atogepant, a daily pill already approved for adults, to prevent episodic migraines in children aged 6 to 17. About 450 participants will receive either a low or high dose of the drug or a placebo for 12 weeks. The goal is to see if it safely reduces …

Researchers in China are studying whether newer flow diverter stents can safely and effectively treat wide-neck brain aneurysms. About 280 patients will receive one of these stents, which is threaded through blood vessels to the brain and left in place to redirect blood flow away…

This trial tests whether adding endovascular treatment, a procedure to remove blood clots, to standard medical care improves recovery in people with a mild stroke caused by a blockage in the basilar artery. Participants receive either standard care alone or standard care plus the…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and then emergency treatment to remove a clot. Some patients develop bleeding in the brain after the procedure, and doctors want to know if starting blood thinners early …

This early-phase trial tests a nasal spray called NEO100 (a purified natural compound) in 12 children with certain aggressive brain tumors. The goal is to see if it's safe, find the best dose, and check if the drug reaches the tumor. Participants will receive increasing doses, an…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can lower brain pressure in people with idiopathic intracranial hypertension (IIH). IIH causes high pressure inside the skull, leading to headaches, ringing in the ears, and vision problems. The trial…

This study tests whether the clot-busting drug tenecteplase can help people who have a stroke more than 4.5 hours ago, including those who wake up with stroke symptoms. About 1,325 adults with brain imaging showing salvageable tissue will be randomly assigned to receive tenectepl…

This Phase 3 trial tests whether sovateltide, a drug that stimulates ETB receptors, can improve recovery after an acute ischemic stroke. About 514 adults aged 18-80 will receive either sovateltide or a placebo alongside standard care. The main goal is to see if more patients achi…

This trial tests whether removing a brain bleed with a minimally invasive scope within hours of symptoms improves recovery. 300 adults with a specific type of brain bleed will be randomly assigned to either get the surgery plus standard care, or standard care alone. The study wil…

This study tests a drug called DM199 in about 728 people who have had a moderate stroke and cannot get clot-removing treatments. The drug is given through a vein and then as shots under the skin for three weeks. Researchers want to see if it helps patients recover better than a p…

This early-stage trial tests an experimental drug called RO7663498, given as an injection into the eye, for people with diabetic retinopathy. The main goal is to check safety and how the drug moves through the body. About 30 participants will receive multiple doses to see if it i…

This trial tests whether adding robotic rehabilitation devices to standard physiotherapy can improve arm and leg function in adults with movement problems from stroke, spinal cord injury, traumatic brain injury, or orthopedic surgery. Participants will receive robotic-assisted se…

This early-stage trial tests an experimental drug called RO7823653, given as an eye injection alone or with an approved drug (faricimab), for people with diabetic macular edema—a condition where diabetes causes fluid buildup and vision loss in the center of the eye. The study wil…

This trial tests whether a powered leg exoskeleton called ZEPU AI9 can safely and effectively help people with walking difficulties caused by stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will be randomly assigned to receive either exoskeleton-assiste…

This trial tests whether adding a robotic leg-training device (ZEPU-AI5) to standard rehab can safely improve walking, strength, and balance in adults aged 18–60 with lower-limb problems from stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will receive …

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

This study tests whether a robotic device called ZEPU-AI3 can safely help people with lower limb weakness from stroke, spinal cord injury, or orthopedic surgery improve their walking. Participants receive either standard rehabilitation alone or standard rehab plus robot-assisted …

Researchers are testing whether an intravenous dose of the enzyme dornase alfa can reduce the body's inflammatory response after an acute ischemic stroke. The trial enrolls 36 adults who arrive at the hospital within 12 hours of symptom onset and have moderate to severe stroke sy…

This study follows 1,200 people who received special fabric tubes (grafts) to repair or replace damaged arteries in the neck, belly, or legs. Researchers want to see how well the grafts work over time and how often problems like blockages or infections happen. It is an observatio…

This study tests a robotic device called ZEPU-AI1 that helps people with leg weakness practice standing and walking. The trial includes adults aged 19 to 60 who have walking problems from stroke, spinal cord injury, or orthopedic surgery. Half of the participants will use the rob…

This trial tests whether robotic devices that guide arm and leg movements can safely improve strength, coordination, and daily function in adults with movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions. Participants will use the devices thre…

This pilot study tests whether giving tenecteplase directly into brain arteries after thrombectomy can restore blood flow in acute ischemic stroke patients whose vessels remain partly blocked. Thirty adults with a large vessel blockage in the front of the brain receive the drug t…

Researchers compare two imaging strategies for planning left atrial appendage closure in adults with nonvalvular atrial fibrillation. Participants are randomly assigned to have their heart anatomy assessed either by transesophageal echocardiography or by cardiac CT angiography be…

This pilot trial asks whether adding a robotic hand-training device to standard rehabilitation is safe, practical, and helpful for people with arm and hand motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions. Participan…

This study tests a special balloon coated with medicine to open narrowed arteries in the brain and prevent strokes. About 264 people with severe artery narrowing will be treated and followed for 12 months. The goal is to see if the balloon is safe and keeps arteries open better t…

Researchers are testing whether intravenous tenecteplase, a clot-dissolving drug, can improve recovery for people with acute ischemic stroke when given 4.5 to 6 hours after symptoms begin. The trial enrolls adults with confirmed stroke and moderate to severe symptoms. Participant…

This pilot study tests whether a virtual-reality system controlled by muscle activity can help improve arm and hand movement in people recovering from stroke or spinal cord injury. Participants use a wearable device that detects muscle signals through sensors on the skin and prov…

This study compares standard medical care to a new, less invasive surgery for people with a severe bleeding stroke. The surgery uses a small tube to drain the blood clot and delivers clot-busting medicine directly into the brain. Researchers want to see if this approach helps pat…

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking antico…

This trial tests whether adding tocilizumab, an anti-inflammatory drug, to standard blood thinners improves recovery in people with acute cerebral venous thrombosis, a type of stroke caused by a blood clot in the brain's veins. Researchers will give 80 adults either a single infu…

This study tests a new eye injection called KIO-104 for people with macular edema, a condition where fluid builds up in the eye and blurs vision. About 28 adults will receive multiple doses to see if the drug is safe and helps reduce swelling. The goal is to find a steroid-free o…

This phase 3 trial tests whether adding tocilizumab, an anti-inflammatory drug, to standard emergency stroke treatment improves outcomes for people with a severe stroke in the back of the brain. About 348 adults will receive either tocilizumab or a placebo by IV right before a pr…

This study looks at whether a cardiac rehabilitation program can improve recovery for people who have had a stroke. Researchers will enroll 150 stroke survivors and add cardiac rehab to their usual care. They will measure walking ability, daily function, and whether the program r…

Researchers in Belo Horizonte, Brazil, are testing iVIDAVC, a behavior-change program adapted from an Irish model, to help stroke survivors adopt healthier habits. The program combines an educational session, one-on-one coaching, and weekly group meetings led by a physiotherapist…

This study is testing a device called a flow modulator to treat wide-necked brain aneurysms. The device is placed inside the artery to redirect blood flow away from the aneurysm, helping it close off. Researchers will check if the device is safe and effective in 214 adults over 1…

This trial tests whether anisodine hydrobromide can reduce brain damage in people who have had a severe ischemic stroke and are undergoing a procedure to remove the blood clot. The study includes about 200 adults aged 18 to 80 with a blockage in a major artery in the front of the…

This study tests whether giving the protein albumin (given as an IV drip for four days) along with standard clot-removal treatment helps people recover better after a severe stroke caused by a large blockage. About 1,200 adults aged 18-80 with anterior circulation strokes will be…

This study tests whether eptinezumab, given through a vein, can safely reduce the number of migraine days in children and teens aged 6 to 17 with episodic migraine. Participants receive either the drug or a placebo, and researchers track monthly migraine days over 12 weeks. The g…

This phase 3 trial tests whether giving a clot-busting drug called rhPro-UK before a mechanical clot removal procedure improves recovery for people with severe stroke. About 820 participants who had a stroke 4.5 to 24 hours earlier will receive either the drug or a placebo, follo…

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

This study tests whether a laptop-based memory training program can help people who had a stroke more than a year ago improve their ability to learn and remember new information. Participants will complete memory exercises twice a week for five weeks. Researchers will measure cha…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This Phase 2 trial tests an experimental drug called EYE103 (Restoret) in 160 people with wet age-related macular degeneration or macular edema from a branch retinal vein occlusion. Participants receive three eye injections of either a low or high dose of EYE103, spaced four week…

This study looks at whether starting insulin to lower high blood sugar on day 4 after a severe stroke is better than starting on day 1. About 200 adults with severe stroke and high blood sugar will be randomly assigned to early or delayed treatment. The goal is to see if delaying…

This study tests whether giving patients electrical muscle stimulation and high-protein shakes soon after a type of stroke (aneurysmal subarachnoid hemorrhage) can prevent muscle loss and improve recovery. Thirty adults will receive the combo therapy or standard care. The main go…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study tests a 3-month home program for people aged 50+ who recently had a stroke and are returning home. The program combines guided stepping training with tips to reduce long periods of sitting. Researchers measure changes in daily steps, mobility, and disability over 12 mo…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This trial is investigating whether adding a clot-removal procedure, called endovascular treatment, to standard medical care can improve outcomes for people who have had a severe stroke caused by a blockage in the basilar artery, a major vessel at the back of the brain. The study…

This study tests whether taking stroke patients directly to a special imaging and treatment room (angio suite) speeds up care compared to the usual approach of getting a CT or MRI first. About 594 adults with severe stroke symptoms will be randomly assigned to one of the two path…

This study tests whether a procedure called hemoadsorption, which filters the blood, can help people with severe ischemic stroke. Researchers will compare standard care plus hemoadsorption to standard care alone in 116 adults. The goal is to see if the procedure reduces the chanc…

This trial tests whether task-specific drawing exercises can improve hand dexterity and motor function in people recovering from a stroke, compared with standard fine motor training. Adults aged 40 to 70 with subacute stroke will be randomly assigned to one of two four-week progr…

This study tests an oral medication called BI 1815368 in 300 adults with center-involved diabetic macular edema, a common cause of vision loss in diabetes. Participants take tablets twice daily for about 11 months, and doctors compare vision changes between those on the drug and …

This study tests whether raising carbon dioxide levels slightly during general anesthesia can improve blood flow to the brain before clot removal in stroke patients. Fifty adults with large-vessel stroke will be randomly assigned to either normal or moderately high carbon dioxide…

This trial tests whether the amount of therapist supervision during home-based telerehabilitation changes arm recovery in stroke survivors. Researchers will enroll 30 adults aged 40 to 70 with mild to moderate arm impairment and randomly assign them to either three videoconferenc…

This study tests whether the drug atogepant (Qulipta) can safely prevent chronic migraines in teenagers aged 12 to 17. About 420 teens with chronic migraine will take either atogepant or a placebo pill daily for 12 weeks. Researchers will track side effects and changes in monthly…

This study tests a new medicine called BI 3812465 for people with diabetic macular edema, a condition that causes swelling in the center of the eye and can lead to vision loss. The trial has two parts: first, a small group gets low to high doses to check safety, then a larger gro…

This trial compares two rescue procedures for people who have a stroke caused by a hardened, narrowed brain artery that still has significant blockage after initial endovascular treatment. About 486 participants will be randomly assigned to receive either balloon angioplasty or s…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This study tests whether giving a strong cholesterol-lowering drug (PCSK9 inhibitor) before emergency stroke treatment helps people recover better. About 652 adults with a major stroke will be randomly assigned to receive either the intensive drug or standard care. The main goal …

This study looks at whether removing a large blood clot from the brain (endovascular thrombectomy) is better than standard medical care for stroke patients who already had a moderate-to-severe disability before their stroke. About 1,060 adults with a recent stroke and a pre-exist…

This study compares two methods to protect the brain during a procedure to open a narrowed neck artery (carotid stenting). The standard method uses a small filter to catch debris, but some particles may still reach the brain. The new method adds a balloon that temporarily stops b…

This phase 3 trial tests whether Xeomin (a botulinum toxin type A injection) can reduce the number of migraine days in people with chronic migraine. About 780 participants will receive either Xeomin or a placebo injected into head and neck muscles every 12 weeks for up to 55 week…

This study tests whether giving stroke patients a personalized diet plan within two days can lower the risk of death within 30 days. About 3,084 adults with moderate to severe stroke will take part. Dietitians will track food intake and adjust nutrition, using supplements or tube…

This trial tests a digital tongue-pressure training device that gives real-time feedback to help stroke survivors with swallowing problems, a condition called dysphagia. The device measures tongue strength in different areas and guides users through exercises. Researchers will co…

This trial tests whether adding mirror therapy to standard rehabilitation improves walking and leg function in people who had a stroke. Participants are adults aged 40 to 70 who had their first stroke 3 to 6 months ago and can walk at least 10 meters. Half will receive convention…

This trial tests whether a 3-week rehabilitation program using an exoskeleton can help people who have had a stroke correct a condition called lateropulsion, where the body leans to one side due to a distorted sense of vertical. Participants will receive 15 sessions combining exo…

This trial tests whether a Mediterranean diet, enriched with extra virgin olive oil or walnuts, can lower the chance of stroke and slow cognitive decline in people with cerebral amyloid angiopathy (CAA) or CADASIL, two conditions that affect blood vessels in the brain. Participan…

This study tests whether a robot can help people who had a stroke 1 to 12 months ago improve movement and feeling in their arm and hand. Participants first receive gentle, robot-guided stretching, then practice active movements with the robot, which can assist or resist as needed…

This study looks at the best way to manage high blood pressure in people having a stroke who are eligible for clot-busting medication. Currently, doctors lower blood pressure first, then give the drug, which can delay treatment. The trial will compare this step-by-step approach t…

This study tests whether removing a blood clot from the brain up to 72 hours after a stroke can help patients recover better than standard care. About 336 adults with severe strokes due to a large vessel blockage will be randomly assigned to get the clot removal procedure or usua…

This study is testing whether the clot-busting drug tenecteplase is safe and effective for people aged 80 and older who have had a stroke. Researchers will track 392 patients to see how well they recover and if there are any serious side effects. The goal is to find out if this t…

This study tests an implanted device that stimulates nerves at the back of the head to prevent chronic cluster headaches. Ten adults with difficult-to-treat cluster headaches will receive the implant and use it daily for 48 weeks. Researchers will track side effects and whether t…

This study tests a 16-week home-based physiotherapy programme for people who have recently had a stroke. The programme combines in-person and remote sessions, an online exercise platform, and goal-setting to help participants do more rehabilitation. Researchers will see if this a…

This trial investigates whether giving a low dose of the clot-busting drug alteplase directly into the brain artery, right after successful mechanical clot removal, can improve recovery in people with a severe stroke caused by a large vessel blockage. About 416 adults who have ha…

This trial tests whether parecoxib, an anti-inflammatory drug, can improve recovery in people hospitalized after a spontaneous subarachnoid hemorrhage (SAH) — a type of bleeding stroke. The study includes 112 adults aged 18-85 with SAH, who will receive either parecoxib or a plac…

This phase 3 trial compares an experimental drug, tabirafusp tedromer, against the standard treatment aflibercept for people with diabetic macular edema (DME), a leading cause of vision loss in diabetes. About 910 adults with DME will receive injections into the eye and be follow…

This trial investigates whether daphnetin, a compound from certain plants, can improve cognitive function in people with vascular cognitive impairment—a condition where reduced blood flow to the brain affects memory and thinking, but not yet dementia. Participants aged 50-80 with…

This trial tests whether a computer-based rehabilitation system called NeuroTechR3 can help people improve arm and hand function after a stroke. Participants will play upper extremity rehabilitation games on a computer for 30 minutes, three times a week. The study measures change…

This trial tests whether placing a stent in a narrowed or blocked neck artery during emergency stroke treatment helps people recover better than just removing the clot in the brain. About 15-20% of severe strokes involve both a brain clot and a neck artery blockage. The study wil…

This study looks at whether successfully restoring blood flow in the brain using the Tigertriever device, a tool that removes clots during a stroke, may also help protect cognitive abilities like memory and attention. Researchers will follow 424 adults aged 18 to 75 who had a lar…

This trial tests whether a gentle electrical stimulation applied to the ear—called transcutaneous auricular vagus nerve stimulation—can help people recover consciousness after surgery for a spontaneous brain hemorrhage. The study will include 160 adults aged 18 to 75 who remain i…

This trial tests whether adding metacognitive training—exercises that help people think about their own thinking—to standard word-finding rehabilitation can improve language skills in people with chronic aphasia after a stroke. The study involves 18 participants who will receive …

This trial tests whether adding self-administered hand therapy at home, using a videogame controller called the Twirlstone, can improve hand dexterity and coordination in stroke survivors. Participants, who are within six weeks of a stroke and have arm or hand weakness, will eith…

This study compares two procedures used to treat unruptured wide-neck brain aneurysms: flow diverter stents and stent-assisted coiling. Researchers will follow 274 adults from three centers in China who receive one of these treatments as part of routine care. The main question is…

This study compares two approaches for people with mild-to-moderate carotid artery stenosis (narrowing of the neck arteries): a standard statin regimen versus a statin plus a PCSK9 inhibitor (evolocumab) given as biweekly injections. The main goal is to see whether the combinatio…

This study is a registry that will follow about 200 people with brain aneurysms who are treated with a flow diverter device (p64, p64 MW, or p48 MW). The goal is to see how safe and effective these devices are in real-world practice across France. Participants will be monitored f…

This trial investigates whether combining repetitive transcranial magnetic stimulation (rTMS) with aerobic exercise can treat depression and improve walking in people who have had a stroke. Participants will receive either real or sham rTMS along with exercise sessions over 12 we…

This trial investigates whether giving clot-busting drugs (tenecteplase or alteplase) to people who have an ischemic stroke while taking direct oral anticoagulants (blood thinners) is safe and effective. About 906 adults who had a stroke within 48 hours of taking a DOAC will be r…

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This trial compares two rehabilitation approaches—neurodevelopmental technique (NDT) and mirror therapy—to see which better improves coordination, leg function, and walking ability in people recovering from a sub-acute stroke. Forty adults aged 45 to 65 with hemiplegia (weakness …

This trial is testing whether vitamin D supplements can improve bone density, body composition, strength, walking speed, and physical performance in people hospitalized with neurological disorders like stroke, spinal cord injury, or traumatic brain injury. Participants will recei…

This trial investigates whether a procedure to remove blood clots from arteries in the back of the brain can improve recovery in people who had a stroke more than 24 hours ago but within the last 7 days. Participants will either receive standard medication alone or the clot-remov…

This study follows 3,000 ischemic stroke patients who also have cerebral microbleeds — tiny spots of old blood in the brain. Researchers are tracking how different antithrombotic drugs (blood thinners) affect the number of microbleeds and the risk of future strokes or brain bleed…

This trial tests whether flushing a stent-graft with carbon dioxide before implanting it in the aorta can reduce the number of tiny air bubbles that travel to the brain during the procedure. These bubbles are a major cause of stroke and silent brain damage in patients undergoing …

After a cardiac arrest, some patients develop seizures that do not respond to standard treatment. This trial tests whether putting the brain into a deeper state of electrical silence — called burst suppression — can stop those seizures better than the usual approach of only suppr…

This large trial compares robot-assisted rehabilitation to traditional one-on-one physiotherapy for people who have had a stroke. Researchers are measuring how well each approach helps patients regain independence in daily activities, as well as costs and patient satisfaction. Th…

This trial tests whether a structured arm therapy program delivered through video calls can improve upper limb function in people who had a stroke at least six months ago, compared with the same therapy given in a clinic. Sixty-eight participants will receive modified Constraint-…

This trial tests whether adding electrical muscle stimulation to a standard motor relearning program improves arm function more than the program alone in people recovering from a subacute stroke. Thirty-six participants will receive either the combined therapy or the program only…

This trial investigates an unapproved medical device designed to help control a specific disease. Participants receive the device to see if it can reduce symptoms or manage the condition. The study focuses on safety and effectiveness in people with the disease.

This trial tests whether apixaban, a newer blood thinner with fixed dosing, works as well as warfarin for dissolving dangerous blood clots in the heart's main pumping chamber. Adults with a confirmed left ventricular thrombus are randomly assigned to receive either apixaban or wa…

This trial compares two endovascular procedures for treating unruptured wide-neck brain aneurysms: a flow diverter device (Pipeline) versus traditional stent-assisted coiling. About 266 adults aged 18–75 with these aneurysms will be randomly assigned to one treatment and followed…

This trial compares two strategies to prevent another stroke in people with severe narrowing of a major brain artery. One group receives a drug-eluting stent (a mesh tube that releases medication to keep the artery open) along with aggressive blood-thinning medication. The other …

This study investigates whether a personalized, technology-based rehabilitation program can improve arm movement and function in people who have had a stroke. Participants will receive the technology-enhanced therapy three times a week for about a month, alongside standard care. …

This trial tests a new device called the P3 Occluder System designed to close a patent foramen ovale (PFO) — a small opening between the upper chambers of the heart. The study includes adults aged 18 to 65 who have had a stroke possibly linked to a PFO. Participants receive the i…

This study tests a surgically implanted device that uses mild electrical pulses to stimulate muscles in the legs and trunk. The goal is to help people with paralysis from spinal cord injury, stroke, or other conditions exercise, stand, step, and improve balance. Ten participants …

This trial investigates whether two medications—colchicine (an anti-inflammatory) and deferoxamine (an iron chelator)—can prevent further brain injury after a hemorrhagic stroke. Up to 2,000 adults aged 18–80 with a spontaneous brain bleed will receive one of four treatments: sta…

This phase 3 trial tests whether tegoprazan, a stomach acid blocker, can prevent gastrointestinal complications like bleeding and ulcers in people who have had an ischemic stroke and are taking antiplatelet drugs (blood thinners). About 1,500 adults in South Korea will receive ei…

This trial tests three different blood pressure management strategies in people who have had a stroke and received endovascular therapy (a procedure to remove a clot). The goal is to find the safest and most effective way to lower blood pressure after treatment to improve recover…

This study investigates whether adding neuromuscular electrical stimulation (NMES) to reactive balance training helps people who have had a stroke recover more effectively from slips and trips. Participants, who are at least six months post-stroke and able to walk on a treadmill,…

This early-stage trial tests a new drug called SNE-101 in people who have had an acute ischemic stroke within the past five days. The main goal is to see if SNE-101 is safe and tolerable, and to find the highest safe dose. The study also looks at whether SNE-101 can improve motor…

This trial investigates a 'maximal medical treatment' bundle for people with intracerebral hemorrhage (bleeding in the brain). The bundle includes rapid blood pressure control, reversal of blood thinners, and a drug to reduce bleeding, all delivered within the first 72 hours in a…

This trial compares two types of surface-modified flow diverters—special stents used to treat unruptured brain aneurysms. The goal is to see which device causes fewer small brain injuries (seen on MRI) and fewer stroke-like symptoms after the procedure. About 196 people with unru…

This study tests whether giving the drug milrinone directly into the brain's arteries, followed by a 72-hour IV drip, can prevent brain damage in people who develop artery spasms after a bleeding stroke from a burst aneurysm. The trial will enroll 306 adults across multiple hospi…

This pilot study explores whether taking high-dose cocoa extract supplements is feasible and acceptable for people with episodic migraine. Researchers will compare two doses of cocoa extract to a placebo, tracking how many participants stick with the daily pills for 12 weeks. The…

This phase 3 trial tests whether a shorter, lighter course of corticosteroids (28 weeks) works as well as the standard longer course (52 weeks) for giant cell arteritis, a condition that inflames blood vessels. The study aims to reduce side effects from long-term steroid use. 150…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study tests whether using a nicardipine infusion (a fast-acting blood pressure drug) can help more stroke patients with brain bleeding reach a safe blood pressure within one hour of arriving at the hospital. About 88 adults with acute intracerebral hemorrhage and high blood …

This study tests whether giving caffeine to newborns with hypoxic ischemic encephalopathy (HIE) can reduce death or long-term disability. HIE is a brain injury caused by lack of oxygen around birth. The trial will enroll 830 full-term infants and give them either caffeine or a pl…

This study compares a new 'virtual stroke unit' approach to standard stroke unit care for people with a stroke who are not eligible for a clot removal procedure. The virtual unit uses video calls and monitoring equipment to let a specialist team at a main hospital help guide care…

This study tests a drug called tenecteplase (TNK) for people who have had a stroke caused by a blood clot in the brain. The drug is given up to 24 hours after symptoms start, using only a simple CT scan to decide who can get it. The goal is to see if TNK helps people recover bett…

This study compares two blood thinner strategies after left atrial appendage closure (LAAC) in people with atrial fibrillation. Sixty participants will receive either aspirin alone or aspirin plus clopidogrel for three months. The goal is to see which approach better prevents sma…

This study tests whether the Luna EMG rehabilitation robot can help people who had a stroke more than a year ago improve arm movement. Five participants will use the robot for 30 minutes per session as part of their rehab. The goal is to see if the robot can make arm movements sm…

This study tests whether adding a PCSK9 inhibitor (Recaticimab) to standard statin therapy can reverse plaque buildup in brain arteries of people with asymptomatic intracranial atherosclerosis. About 300 participants will receive either the drug combo or statins alone for 24 week…

This study will follow 2,641 people with episodic or chronic migraine to see how well newer drugs—like monoclonal antibodies, gepants, ditans, and a sumatriptan-naproxen combo—work in everyday life. Researchers will track monthly migraine days, pain relief within 2 hours, and any…

This study looks at how well a device called WEB works for treating brain aneurysms (weak spots in blood vessels) in real-life medical practice. It will include 1,000 people of any age who have had this device placed. The main goals are to see if the aneurysm is sealed off at 12 …

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with chronic stroke move their arms and legs again. Only 3 participants will be implanted with electrodes on the brain and spine. The main goal is to check safety, but researche…

This trial investigates whether people with diabetic macular edema can safely monitor their vision and eye health at home instead of making frequent hospital visits. Participants use a home vision tester and a portable eye scanner every four weeks, with results sent to their doct…

This early-stage trial tests whether stem cells from the placenta, given through an IV, are safe and might help people recover from a recent stroke. About 24 participants will receive either the stem cells or a placebo. Researchers will track their recovery over two years, focusi…

This study tests a nurse-led program called BEST CARE ICTUS_HC for adults hospitalized with acute stroke in hospitals without specialized stroke units. The program includes staff training, swallowing tests, and environmental adaptations to help with attention and safety. Research…

This study looks at people over 65 who recently had a stroke with no clear cause. Doctors suspect they may have hidden atrial fibrillation (an irregular heartbeat) not caught in the hospital. The trial compares two treatments: a blood thinner (apixaban) or aspirin, to see which b…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study is tracking how well a device called NeVa VS works to open narrowed brain arteries in people who had a bleeding aneurysm. The device is already approved for this use, and researchers want to see how it performs in routine care. About 200 adults will be followed to meas…

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This study tests whether starting heart rhythm control therapy soon after a stroke can prevent future strokes, heart-related deaths, or hospital stays in people with atrial fibrillation. About 1,746 participants will receive either early comprehensive treatment or usual care. The…

This study looks at whether a 15-week lifestyle program combining weight management and exercise can improve walking and daily function in obese veterans who had a stroke at least six months ago. Researchers will measure changes in walking distance, daily steps, and overall recov…

This study is testing a non-invasive device that stimulates the vagus nerve (a major nerve in the neck) to see if it is safe and helpful for people who have had a severe bleeding stroke called aneurysmal subarachnoid hemorrhage. About 25 adults in the intensive care unit will rec…

This study tests whether a custom 3D-printed external skull cap can prevent Sunken Flap Syndrome, a condition where the brain sinks after part of the skull is removed. 72 patients who had decompressive craniectomy will either wear the cap or not, and researchers will compare brai…

This study looks at whether people with atrial fibrillation can safely stop taking long-term blood thinners after a procedure that closes off a part of the heart called the left atrial appendage. Participants will get a reduced dose of the blood thinner apixaban for just 3 months…

This study tests whether giving dornase alfa (a drug already used for cystic fibrosis) daily for up to 14 days after a brain bleed from a ruptured aneurysm can help people recover better. The goal is to see if more patients can live independently at 6 months. The trial will enrol…

This study tests whether tilting a stroke patient's head down 15 degrees for 30-90 minutes before a clot removal procedure can improve blood flow to the brain. About 118 adults with a specific type of stroke will be randomly assigned to either the head-down tilt or standard posit…

This trial is testing a drug called tenecteplase for people with a severe stroke caused by a blockage in the basilar artery at the back of the brain. About 688 participants will receive either tenecteplase or standard care within 24 hours of symptoms starting, followed by a clot-…

This study tests whether a balloon angioplasty procedure can prevent early neurological decline in people who have had a minor stroke due to a narrowed brain artery. The trial will enroll 100 adults who have already received standard medication but still show fluctuating or worse…

This study tests whether a handheld, ultra-widefield eye scanner (OCT) can accurately identify preterm infants with severe retinopathy of prematurity (ROP), a condition that can harm vision. The scanner takes detailed images of the retina without touching the eye, potentially red…

Researchers are testing a radioactive tracer called 18F/68Ga-GP1 that binds to a protein found on blood clots. Adults with suspected, newly diagnosed, or previously treated thrombi receive one intravenous injection and then undergo PET/CT or MRI imaging. The study measures how mu…

Researchers test whether a portable low-field MRI scanner in the emergency department can help diagnose ischemic stroke faster and guide treatment. The trial enrolls 60 adults who arrive within 6 hours of stroke symptoms and are eligible for clot-busting drugs or clot removal. By…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial features, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) to …

Researchers are testing whether a radioactive tracer called 18F-DPA714 can help PET/CT scans spot inflammation in the brain. The study includes adults with conditions linked to brain inflammation, such as stroke and neurodegenerative diseases. Each participant receives one inject…

This pilot study tests whether a special PET scan using a tracer called Florbetaben can detect inflamed plaque in arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method can identify unstable plaques that are likely to…

This study is testing whether a new ultrasound device called SYLVER can measure blood flow in the brain as accurately as the standard CT scan. It involves 50 ICU patients with brain injuries or bleeding. If it works, doctors could monitor brain health at the bedside without movin…

Brain arteriovenous malformations (bAVMs) are tangles of abnormal blood vessels that can rupture and cause bleeding in the brain. Researchers have found that these malformations often carry specific genetic mutations, but detecting them currently requires analyzing tissue removed…

This trial asks whether a home sleep apnea test can be a better first step than an overnight lab study for diagnosing obstructive sleep apnea in people with dementia or mild cognitive impairment. Sleep apnea is common in these conditions and can worsen thinking problems, but many…

This study tests whether a bedside monitoring device, placed on the head right after a mechanical thrombectomy for acute ischemic stroke, can predict which patients will have poor neurological outcomes. The device uses near-infrared spectroscopy to measure brain oxygen levels and…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study is testing a new, noninvasive imaging device called HH-SECTR to see inside the eyes of premature infants with retinopathy of prematurity (ROP), a condition that can affect vision. The goal is to see if this technology can provide clearer, more detailed images of the re…

This study evaluates a portable, low-field MRI device (Hyperfine Swoop) for diagnosing stroke in people arriving at the emergency department with symptoms lasting less than 12 hours. Participants receive the low-field scan in addition to standard CT imaging. The goal is to see if…

This study is developing and testing an artificial intelligence (AI) model to help diagnose a specific type of stroke called branch atheromatous disease (BAD)-related stroke. BAD strokes are hard to identify because symptoms are not specific, and diagnosis requires combining clin…

This study tests whether a quick, routine ultrasound measurement (called the resistance index) can accurately identify people with narrowed neck arteries who have normal brain blood flow response. If it works, many patients could avoid a time-consuming, specialized test. The stud…

This trial tests a wearable bracelet called Stroke Alarm that detects when a stroke causes arm weakness. People aged 50 and older with certain high-risk conditions (like recent mini-stroke, atrial fibrillation, or artery disease) wear the device for 3 months. The goal is to see i…

This study tests a simple 10-question scale designed to help neurologists quickly identify migraine patients who could benefit from physiotherapy. Many migraine patients have neck problems that make their headaches worse, but neurologists often lack time or training to assess thi…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This phase 3 trial tests whether taking rimegepant once daily can prevent migraine attacks in people with chronic migraine (15 or more headache days per month). About 400 adults will receive either rimegepant or a placebo for 12 weeks, then all participants may receive rimegepant…

Researchers are testing whether primary care clinics can prevent heart attacks and strokes by automatically calculating each patient's cardiovascular risk and sending monthly text messages with advice to those at high risk. The trial enrolls about 22,000 adults aged 40 to 79 in Y…

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half …

Researchers are comparing two LDL cholesterol targets in adults who have had a small vessel occlusion stroke, a type of stroke caused by blocked small arteries deep in the brain. Participants receive standard cholesterol-lowering drugs, with or without ezetimibe or PCSK9 inhibito…

The VISTA trial compares two approaches for people who have had a stroke or mini-stroke caused by severe narrowing of an artery in the neck that supplies the back of the brain. Participants are randomly assigned to receive either a drug-eluting stent plus blood thinners or blood …

The CEST trial compares two timings for carotid revascularization, a procedure that clears a narrowed neck artery to prevent another stroke. It enrolls adults who have had recent stroke symptoms and an MRI-confirmed small area of brain injury in the territory of that artery. Part…

This Phase 2 study tests whether a daily pill called EVO756 can prevent migraines in adults who have not had success with other preventive treatments. About 330 participants will receive either EVO756 or a placebo, and researchers will track how many migraine days they have each …

This phase 3 trial tests whether taking aspirin for five days around the time of brain aneurysm coiling can prevent strokes. About 440 adults with an unruptured brain aneurysm scheduled for coiling-only treatment will receive either aspirin or a placebo. Researchers will check fo…

This phase 3 trial tests whether injections of Xeomin (a botulinum toxin type A) into head and neck muscles can prevent episodic migraines. About 990 adults with episodic migraine will receive either Xeomin or a placebo every 12 weeks for up to 55 weeks. The main goal is to see i…

This study tests a program in the Dallas County Jail that identifies people at high risk for HIV and offers them testing and education about PrEP, a daily pill that prevents HIV. A patient navigator helps interested individuals connect with PrEP providers after they are released.…

This large study tests whether a smartphone app can help prevent strokes by detecting atrial fibrillation (an irregular heartbeat) early. Adults aged 65 and older in Austria are randomly assigned to use the 'Pulskontrolle' app for pulse checks or to receive usual care. If the app…

This trial tests whether a community-based screening program using advanced eye imaging (OCT, fundus photography, and pressure checks) can prevent vision loss from age-related macular degeneration, diabetic retinopathy, and glaucoma better than simple vision tests alone. About 60…

This study tests whether using a carotid ultrasound (a neck scan) to find hidden plaque in arteries can help prevent heart attacks and strokes in people with inflammatory rheumatic diseases like rheumatoid arthritis or lupus. About 1,944 participants aged 50 and older will be spl…

This study tests whether an oral blood pressure drug, propranolol, can prevent severe eye disease (retinopathy of prematurity) in extremely premature infants. About 276 babies born before 28 weeks and weighing under 1250 grams will receive either propranolol or a placebo. The goa…

This trial tests whether spinal cord stimulation (SCS) can reduce muscle spasticity in adults who have had a stroke. Participants will have a small device implanted that sends electrical pulses to the spinal cord. Half will receive active stimulation for six weeks, while the othe…

This study tests whether high-intensity interval training (HIIT) on a recumbent stepper can improve muscle power in people who have had a stroke. 66 chronic stroke survivors aged 50-80 will be randomly assigned to HIIT, moderate-intensity continuous training, or stretching for 12…

This study tests whether a personalized form of brain stimulation (tDCS) can help people who had a stroke more than 3 months ago regain arm movement. Researchers will use brain scans to tailor the stimulation to each person and measure changes in brain connectivity and motor func…

This study looks at whether adjusting deep brain stimulation (DBS) can improve movement, speech, and swallowing in people already implanted with DBS for conditions like tremor, stroke, or traumatic brain injury. Researchers will test hand dexterity, grip strength, facial movement…

This study looks at whether doing resistance exercises (like leg presses) can reduce swelling in the lower legs of people with lymphedema. It also checks if wearing compression garments during exercise makes a difference. Thirty-six adults with lower limb lymphedema will exercise…

Researchers are testing whether MLC901 (NeuroAiD II), a natural capsule, helps people recover after a mild to moderate ischemic stroke. The trial enrolls 80 adults aged 18 to 80 who are within 2 to 10 days of their stroke. Participants receive either MLC901 plus standard stroke c…

Researchers are testing whether transcranial direct current stimulation, a gentle electrical current applied to the scalp, combined with a cognitive behavioural programme can reduce fatigue in people who have had a stroke. The trial enrolls 75 adults who had a stroke at least six…

People who lose arm and hand function after stroke or injury often need more therapy than clinics can provide. Researchers are studying ReHandyBot, a robotic device that guides hand and forearm exercises using virtual reality and touch feedback. The trial checks whether patients …

After a stroke, some people develop unilateral spatial neglect, where they ignore one side of their body or surroundings. Researchers are testing whether an immersive virtual reality program that involves playing a virtual piano can improve this condition. Adults with stroke and …

This study tests zavegepant (Zavzpret), a nasal spray already approved for migraines, in 200 adults who also take CGRP-targeting preventive medications. Researchers want to see if it provides headache relief within 2 to 4 hours and improves daily function. The goal is to find a s…

This study tests whether adding a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to standard physical therapy can improve arm and hand function in people who have had a first ischemic stroke. Sixty-six adults aged 18 to 80 with…

This pilot study tests whether a device called IVS3 is tolerable and easy to use for arm recovery in people who had a stroke at least 6 months ago. The device uses mirrored video to create the illusion that the affected arm is moving. Researchers will track how many sessions part…

This study tests whether forced aerobic exercise (using a bike that helps move your legs) can improve arm and leg recovery after a stroke better than traditional therapy. About 66 people who had a stroke 3-9 months ago will take part. Researchers will also check if this approach …

This pilot trial tests whether a home-based, technology-supported hand training program can improve hand function in adults who had a stroke at least six months ago. Participants receive either remotely guided hand activities via video conferencing or a standard home exercise pam…

Care homes face shortages of trained staff, and more than half of residents have some form of dementia. Researchers are testing whether retired volunteers can lead a group music and discussion program called Making Connections Thru Music. The study enrolls 196 people: volunteers …

Researchers are testing a digital app called BRAIN that uses artificial intelligence to personalize cognitive stimulation for people with dementia. The app tailors activities to each person's interests and background, aiming to improve engagement, quality of life, and relationshi…

Researchers are testing whether combining transcranial random noise stimulation (tRNS) with neurofeedback can improve attention in adults who have sustained a brain injury from stroke, trauma, or lack of oxygen. Participants receive sessions that pair 10 minutes of tRNS with 20 m…

This study tests an oral medication called ubrogepant, already approved for adults, to see if it safely and effectively treats migraine attacks in children and adolescents aged 6 to 17. About 1,059 participants with a history of migraine will receive either a low or high dose of …

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for people who have had a stroke more than six months ago and still feel very tired. Fatigue is a common problem after a stroke that can make daily activities hard. The researchers will give r…

Researchers at the University of South Florida are testing whether stroke survivors with chronic aphasia can improve their spontaneous speech by listening to recordings of themselves and correcting mistakes. Participants complete language tasks and then use tablets and headphones…

Researchers at Georgetown University are testing whether a mild electrical brain stimulation called transcranial random noise stimulation (tRNS) can boost the effects of visual training in people who have lost part of their vision from brain damage. The study includes 30 adults w…

Researchers are testing whether electroacupuncture can prevent migraines that strike around a woman's period. The trial enrolls 40 women aged 18 to 45 who have regular cycles and at least three headache days during each menstrual window. Participants receive either real electroac…

Researchers are testing whether blocking blood vessels in the middle meningeal artery with a liquid material called SQUID can reduce the number of migraine days in people with chronic resistant migraine. The study enrolls 30 adults aged 21 to 70 who have had chronic migraine for …

This study tests a wearable sensor that tracks neck muscle activity during swallowing exercises, providing real-time feedback to patients. Researchers want to see if adding this device to standard therapy improves swallowing more than therapy alone. The study includes 120 adults …

Researchers are testing whether giving a neuroprotective drug called 3-n-butylphthalide directly into the brain's arteries is safe and practical for people having a stroke caused by a blocked vessel. Participants are adults who are already scheduled for endovascular therapy, a pr…

This study tests whether a small, wearable device that stimulates the ear with mild electricity can reduce long-term pain after a stroke. Researchers will enroll 24 adults who have had a stroke at least 6 months ago and still have pain in their upper arm. Participants will use th…

Researchers at the University of Rochester are testing a home-based computer program that trains people to detect visual stimuli in their blind field. The trial enrolls adults who have lost part of their vision because of damage to the brain's visual cortex, often from a stroke. …

Researchers are testing an experimental oral drug called BGE-102 in adults with diabetic macular edema, a condition where fluid leaks into the center of the retina and blurs vision. The trial enrolls about 180 people with type 1 or type 2 diabetes and center-involved DME. Partici…

Researchers are testing whether giving a neuroprotective drug called 3-n-butylphthalide directly into the brain's arteries is safe and practical for people who have had an ischemic stroke and cannot receive standard clot-removing therapy. The study enrolls 30 adults with moderate…

Researchers are testing whether Tai Chi training or acupuncture can reduce migraine attacks in Hong Kong Chinese women with episodic migraine. The trial assigns 132 participants to either 24 weeks of Tai Chi or a course of acupuncture. The team tracks migraine frequency and days,…

This study tests whether a home-based telerehabilitation program, using games, exercises, and video calls with therapists, can improve arm function and reduce disability in people who had a stroke 90-150 days ago. 202 participants will be randomly assigned to receive telerehabili…

This study tests a drug called N-acetyl-L-leucine for people aged 4 and older with CACNA1A gene disorders, which can cause coordination problems, dizziness, and migraines. About 60 participants will receive either the drug or a placebo, then switch, to see if it improves movement…

This study tests a new behavioral therapy called PICTURE IT, delivered via telemedicine, to help people with aphasia after a stroke. The therapy uses pictures and spoken words to stimulate the right side of the brain, aiming to improve language skills. Researchers will compare it…

This study tests a system called STRIVE, which turns a hospital room TV into a motion-tracking gaming console for stroke patients. Using a camera and laptop, it tracks arm and hand movements during games that involve reaching and grasping, without needing controllers or wearable …

This study tests whether a tongue endurance exercise program can improve swallowing in adults who have had a stroke. Seventy participants will be randomly assigned to either the tongue exercise group or a sham therapy group. They will do home-based exercises for 8 weeks and have …

This study tests whether combining a gentle brain stimulation technique (tDCS) with repetitive arm and hand exercises can help people who have neglect after a stroke. Neglect means they have trouble paying attention to one side of their body or space. The study also aims to combi…

This pilot study tests whether the Voiceitt app can help people with speech impairments caused by conditions like cerebral palsy, stroke, ALS, or Parkinson's disease communicate more effectively. Participants use the app to see if it improves speech clarity and daily communicatio…

This study tests if blocking the middle meningeal arteries in the brain is safe and feasible for people with hard-to-treat chronic migraines. About 13 participants will undergo the procedure and be followed for 6 months. The goal is to reduce migraine-causing substances in the br…

This study looks at whether yoga is a practical and helpful activity for adults who have had a stroke at least three months ago. Forty participants in Nova Scotia will try both virtual and in-person yoga classes twice a week for 90 minutes, plus one recorded session. Researchers …

This study tests whether escitalopram (Lexapro), a common antidepressant, combined with computer-based naming therapy can improve language recovery in people with aphasia after a stroke. About 88 participants who had a left-hemisphere stroke within the past 5 days will receive ei…

This study tests whether whole-body vibration therapy, given after a Botox injection, can reduce muscle tightness and improve balance in stroke survivors. Fifty participants with ankle spasticity will either receive vibration or a placebo for 4 weeks. Researchers will measure cha…

This early study tests a 14-day course of the oral drug zuranolone in 6 stroke survivors with moderate to severe depression. Researchers want to see if the drug is safe, well-tolerated, and improves mood. Participants take 50 mg daily and complete mood questionnaires and blood te…

This study tests an investigational inhaled medication called ASY202 (dihydroergotamine dry powder) for treating migraine attacks in adults. Participants use a handheld inhaler to take the drug or a placebo during separate migraine episodes, and neither they nor the study team kn…

This study tests whether mindfulness therapy, added to standard care, can reduce migraine attacks and improve quality of life in people with high-frequency episodic migraine. Researchers will use EEG, MEG, and wearable devices to measure brain activity before and after treatment,…

This clinical trial investigates whether photobiomodulation, a non-invasive light therapy, can reduce muscle spasticity in adults who have had a stroke. About 42 participants with spastic hemiparesis will receive either active light therapy or a placebo treatment on their calf mu…

This trial investigates whether an experimental, unapproved medical device can help relieve symptoms in people with a specific condition. Researchers are enrolling participants to test the device's effects and safety. The goal is to see if this new approach could offer a drug-fre…

This trial asks whether an intravenous dose of magnesium sulfate can relieve acute non-traumatic headaches—such as migraines, tension-type, or cluster headaches—more effectively than the standard painkiller paracetamol. Adults arriving at the emergency department with moderate to…

This study tests whether a smarter electrical stimulation device can help people recover arm and hand movement after a stroke. Participants with moderate arm weakness will be randomly assigned to receive either standard cyclic stimulation or a new EMG-triggered stimulation that r…

This trial tests whether Occupational Performance Coaching (OPC) can help adults who have had a stroke and finished rehabilitation get back to activities they value. Participants are randomly assigned to receive OPC or an attention control, both delivered virtually. The study mea…

This phase 2 trial tests whether an oral drug called BMS-986368 can reduce spasticity—muscle tightness and spasms—in adults who had a stroke 4 to 18 months ago. The drug works by boosting natural compounds in the body that calm overactive nerves. Researchers will measure changes …

This pilot study tests whether watching special videos can help people recover leg movement after a stroke. Twelve participants will use a video system that shows their good leg moving, while they try to copy the movement with their affected leg. They will do this 5 times a week …

This trial tests whether a 12-week online Hatha yoga program, done at home twice a week, can reduce migraine frequency and pain when added to usual medication. The study includes 60 adults aged 18–65 with high-frequency episodic migraine (at least 1 year of history) who are on st…

This study tests a wearable robotic knee device (AKO-R) to help people who have had a stroke walk more symmetrically. Twenty participants will do treadmill and overground walking with the device. Researchers will check safety and measure improvements in step length and stance tim…

This study tests whether adding immersive virtual reality (VR) to robotic walking rehabilitation is tolerable for people who cannot walk after a stroke. Thirty non-walking stroke patients will try both standard robotic rehab and VR-enhanced sessions. Researchers will measure moti…

This study looks at whether adding a modified form of cognitive behavioral therapy (a type of talk therapy) to standard occupational or speech therapy can improve emotional well-being and daily functioning in stroke survivors. The trial will enroll 80 adults who had a stroke at l…

This study looks at whether a regular exercise program can improve the benefits of botulinum toxin (Botox) injections for arm stiffness after a stroke. About 70 stroke survivors with arm spasticity will receive Botox and then be randomly assigned to either a prescribed exercise r…

This study looks at urinary problems in people recovering from a stroke. Researchers compare patients with and without bladder issues and test two simple behavioral approaches: for those with thinking difficulties, training to go to the toilet immediately when they feel the urge;…

This study tests whether adding telerehabilitation (home-based, supervised and independent arm exercises) to usual care improves arm function and reduces disability after a stroke. Twenty adults in Brazil who had a stroke about 4 months ago will participate. The goal is to see if…

This study tests a mixed-reality system called RehAtt to help people recover movement after a stroke. Ten participants with one-sided weakness will use the system for arm, walking, and balance exercises. Researchers will interview them to see if the system is easy, motivating, an…

This study tests if pairing a gentle, non-invasive brain stimulation (tDCS) with personalized physical therapy can help people with cerebellar damage (from stroke, tumor, or degeneration) improve movement and daily function. About 30 adults aged 18-75 will participate. The goal i…

This study tests whether adding a wearable vibratory device to standard physiotherapy helps improve arm function in people with hemiplegia (paralysis on one side) after a stroke. Thirty adults who had a stroke 3 to 6 months ago will be split into two groups: one gets usual therap…

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This study tests whether adding a gentle electrical current to the brain (tDCS) during intensive arm therapy helps women recover arm movement after a stroke. Twenty-four women will receive either real or fake stimulation over two weeks. The goal is to see if the combo improves ar…

This study tests a home grip assistance glove (SaeboGlove) to help stroke survivors use their weaker arm in everyday tasks. About 100 adults who had a stroke more than three months ago and have trouble opening their hand will try the glove at home. Researchers will compare how we…

This study tests a special hand device that helps people who had a stroke and cannot open their hand to grab things. The device is designed to let users control it themselves to pick up, move, and release objects like a glass or spoon. Researchers will compare how well 30 partici…

This study compares two physical therapy approaches—rhythmic guided movements and static muscle contractions—to see which better improves arm function, strength, and coordination in people who had a stroke 1 to 6 months ago. Forty participants aged 40 to 60 with arm weakness on o…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve word-finding in people who have trouble speaking after a stroke. Researchers will use MRI scans to guide the stimulation and see how the brain responds. The trial involves 45 participants …

This study is testing whether a device that sends small electrical pulses to leg muscles can help people with chronic stroke improve their balance and walking. Twenty participants will be exposed to slip- and trip-like disturbances on a treadmill, with and without the stimulation…

This study tests whether a gentle electrical current applied to the brain can make speech therapy more effective for people with chronic aphasia (trouble speaking or understanding language) after a stroke. About 50 adults who had a stroke at least six months ago will receive eith…

This study compares Swiss ball exercises versus kinesthetic training to see which better improves balance and mobility in people who had a stroke at least six months ago. Thirty-six participants aged 45-65 will do supervised exercises for 8 weeks. Balance and movement will be mea…

This study is testing whether combining two types of electrical stimulation can help people who have had a stroke lift their toes while walking. Participants will receive mild electrical currents on their scalp and leg while doing walking exercises. The goal is to see if this com…

This study tests whether a noninvasive brain stimulation technique, timed to the patient's own brain waves, can improve arm and hand movement after an ischemic stroke. Researchers will enroll 144 adults who had a stroke 1-14 days ago and have significant arm weakness. Participant…

This pilot study tests whether a hands-on therapy called Mobilization and Tactile Stimulation (MTS) can help stroke survivors who have unilateral neglect—a condition where they are unaware of one side of their body. Six adults who are at least 20 weeks post-stroke will receive MT…

This study tests a 12-week dance program designed for stroke survivors who have weakness on one side of the body. The program combines movement improvisation and adaptive dance to help improve balance, mobility, confidence, and participation in daily and social activities. Resear…

This study looks at whether the antidepressant vortioxetine can help people who suffer from both depression and migraine. Researchers will track 31 adults over 12 weeks to see if their mood and headache symptoms improve. The goal is to find a treatment that works for both conditi…

This pilot study tests whether a 4-week home-based cognitive strategy training program can help adults with chronic stroke become more independent in daily activities like dressing and cooking. Eighteen participants will work with an occupational therapist in their own homes. The…

This study tests whether stimulating the tongue with a non-invasive device can improve arm movement and brain plasticity in people who had a stroke at least six months ago. Participants will do a 4-week strength training program for their affected arm, combined with either real o…

This study tests a special mouth exercise program for people who still have trouble swallowing 12 weeks after a stroke. Researchers want to see if the device can improve swallowing function and quality of life. The trial involves 60 participants and uses a camera test to measure …

This study tests two treatments for muscle stiffness in the lower leg after a stroke: Botox injections (a single session) and dry needling (12 weekly sessions). Researchers will measure changes in muscle reflexes and thickness in 90 participants across Belgium, Spain, and Canada.…

This study tests whether using conversational hypnosis during a transoesophageal echocardiogram (a heart ultrasound done through the throat) can make the procedure more comfortable for patients. Researchers will enroll 150 adults and measure their comfort levels right after the e…

This study investigates how stroke affects arm swing during walking and whether real-time virtual reality feedback can help improve it. Researchers will measure muscle activity and movement in both stroke survivors and healthy adults to understand the differences. Participants wi…

This study looks at how stroke changes the way people move their arms when walking. Researchers will measure brain activity and muscle patterns in 84 people (some who had a stroke and some healthy) while they walk on a treadmill. The goal is to understand why arm swing is often a…

This study looks back at medical records of up to 5,000 adults who had a brain aneurysm treated with special mesh tubes called flow diverters. Researchers want to see how well these devices work and how safe they are by checking things like successful placement, complications, an…

Researchers are studying how testosterone therapy affects headaches and brain structure in transmasculine teens. About 100 participants aged 12 to 20 who plan to start testosterone will have brain MRI scans, blood tests, and headache diaries over one year. The goal is to learn wh…

Researchers at 24 hospitals in Japan are following 500 people who had an acute ischemic stroke while also living with active cancer. The study measures how often a second stroke occurs within three months and which clinical factors, such as cancer type, stroke features, and test …

This study looks at how heart rate variability (a measure of stress response) relates to emotional control and parent-teen relationships in 74 adolescents with depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to better unders…

This study is creating a large collection of health information and biological samples (like blood, saliva, and eye tissue) from people with and without retinal diseases. Researchers aim to use this database to better understand conditions like age-related macular degeneration an…

This study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …

Researchers are building a large database of cognitive, behavioral, lifestyle, and genetic information from people with neurodegenerative diseases such as Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. The goal is to find biomarkers that help do…

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

This study looks at whether lying flat (0 degrees) or with the head raised (30 degrees or more) after a stroke clot removal procedure helps people recover better. About 2240 adults who had a stroke from a large blood vessel blockage will be randomly assigned to one of the two hea…

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people scheduled for DBS surgery will have extra temporary electrodes placed on the brain to measure muscle activity during stimu…

This study follows 100 adults with diabetic eye disease who are already receiving standard anti-VEGF injections for swelling in the center of the retina. Researchers will use advanced vision tests and imaging to track changes over time. The goal is not to test a new drug, but to …

Researchers are studying whether an ischemic stroke in the middle cerebral artery territory triggers inflammation and scarring in the heart muscle. The trial enrolls 44 adults with acute stroke and 24 people with stroke-like symptoms but no brain infarct as a comparison group. Pa…

Researchers are studying how well people who have had a stroke learn a complex arm and hand skill when they train with one arm versus both arms. Participants include healthy volunteers, people in the early days after a stroke, and people more than six months past a stroke. They p…

Researchers at Xiangya Hospital are building a tool that uses several types of brain monitoring to predict whether patients with severe acute brain injury will be awake, comatose, or deceased 90 days after ICU admission. The study enrolls 200 adults aged 18 to 80 with conditions …

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

Researchers are building a global registry to collect patient-reported surveys, genetic test results, and medical records from people with Charcot-Marie-Tooth disease and related inherited neuropathies. The study is open to children and adults with a confirmed or suspected diagno…

Researchers are studying blood proteins in people who have a severe ischemic stroke caused by a blocked artery in the front of the brain. All 800 participants receive endovascular treatment, a procedure that threads a catheter through blood vessels to remove the clot. The team me…

This study will look at 54,000 adults having surgery with general anesthesia to see how different oxygen levels affect their recovery. Patients will receive lower, intermediate, or higher oxygen during their operation. The goal is to find which oxygen level reduces the risk of or…

Researchers want to know whether training one arm after a stroke can improve the other arm, and which brain regions make that possible. The study includes healthy adults, people in the early days after a stroke, and people with long-term stroke effects. Participants play serious …

This study will follow 450 people with diabetes (and some without) for several years to track how their eyes change. Researchers will use advanced eye tests like visual field analysis, contrast sensitivity, and retinal imaging to see which measurements best show disease progressi…

Researchers at the University of Miami are studying whether advanced eye imaging devices can reveal useful information about the eye in health and disease. The study has two parts: one observes the eyes of healthy people and people with conditions such as multiple sclerosis, dry …

This study looks at how brief mental stress affects heart function and brain health in 450 adults aged 40-60. Participants complete two sessions: one with stress tests and heart monitoring, another with brain scans and memory tests. The goal is to understand links between stress …

This registry is following 4,000 people who have been treated with Medtronic devices for brain aneurysms or ischemic stroke. Researchers are tracking how well the devices work in everyday medical practice, including how often aneurysms are fully closed and how many patients regai…

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and raises the risk of strokes and dementia, over nine years. Researchers will use brain scans, blood tests, and other exams to track how the disease changes blood vessels and thinkin…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This observational study will follow 2000 adults with type 2 diabetes to see how their eating habits, body composition, and grip strength change over time. Researchers hope to identify patterns that could help improve care. Participants must be 18 or older and able to complete ba…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…

This study follows 8,000 adults who have had a stroke to learn why some develop memory and thinking problems afterward. Researchers will track changes in cognition, brain scans, and blood samples over time. The goal is to help doctors identify who is at risk for dementia and pave…

Researchers are following 10,000 registered nurses in Xiamen, China, to see how genes, lifestyle, and environment relate to common chronic diseases like high blood pressure, heart disease, stroke, diabetes, kidney disease, and some cancers. The study collects health and lifestyle…

This study is testing a new PET scan tracer called 18F-GP1 that sticks to activated platelets in blood clots. Researchers will scan 120 adults who recently had an ischemic stroke to see if they can find where clots are coming from. The goal is to better understand different types…

Researchers are building a large database of high-resolution MRI scans from stroke patients in China to study the fatty plaques inside brain arteries. The study enrolls adults who recently had an ischemic stroke and have a specific plaque in a major brain artery. By tracking thes…

Researchers at six Italian headache centers are following about 800 adults with trigeminal autonomic cephalalgias, a group of rare headaches that includes cluster headache, paroxysmal hemicrania, SUNCT, SUNA, and hemicrania continua. The study observes routine care rather than as…

This study wants to improve how we measure children's recovery and experience after surgery and anesthesia. Researchers will translate and test a recovery scale for Danish children aged 4-12, and also develop a new questionnaire that lets children describe their own hospital expe…

This study is testing a new non-invasive device that uses laser speckle to measure blood flow and structure inside the eye. Researchers will compare these images with standard vision tests in 500 people with various retinal conditions. The goal is to see if this technology can be…

This study looks at whether unconscious patients with brain injuries who show brain activity in response to music and language on an EEG are more likely to wake up and recover. Researchers will monitor 300 adults in the ICU, along with healthy volunteers, to see if these brain si…

This study looks at whether damage to the blood-brain barrier right after a stroke can help predict who will have memory or thinking problems later. Researchers will follow 150 stroke survivors for three years, checking their thinking skills by phone. The goal is to better unders…

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study looks at 958 people having a severe stroke to find out if general anesthesia (being fully asleep) or procedural sedation (being drowsy but breathing on your own) leads to better recovery after a procedure to remove a blood clot from the brain. Participants will be rand…

This study follows over 2,500 teens aged 11 to 17 who come to the emergency room with a mild traumatic brain injury (mTBI). Researchers want to see if they develop new or worsening depression or anxiety in the months after injury. Teens and their parents fill out questionnaires a…

This study follows 45 people who have had their first ischemic stroke to see how their brains adjust to changes in sensory input, a process called sensory reweighting. Researchers will test balance and walking at several points over six months, and use brain scans to look for rel…

This study is creating a large collection of medical data and biological samples from 1,100 people with brain aneurysms. The goal is to find better ways to predict which aneurysms are at risk of rupturing, which could lead to more personalized monitoring and treatment. Participan…

This study uses a special robot called IntelliArm to measure how arm stiffness, spasticity, and movement change during recovery from a first stroke. Researchers will track 56 people who had a stroke less than a month ago, measuring their arm function with standard tests and robot…

This study aims to understand how the brain responds to magnetic stimulation when it is timed with natural brain waves. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to find ways to make brain stimulation more effective for im…

This study tests whether ultrasound scans and patient questionnaires can better track disease activity in people with giant cell arteritis, a condition that inflames arteries and can cause blindness. Researchers will follow 175 patients in remission for one year, using ultrasound…

This study follows 185 adults in the Netherlands who are hospitalized with serious trauma injuries. Researchers will ask them to fill out short questionnaires about their quality of life, pain, fatigue, and daily functioning at several points over a year. The goal is to see wheth…

This study is testing whether a simple vision screening program in general practice can help detect vision loss early in adults over 70 who have at least one chronic condition. Participants will have three vision tests done by their GP or nurse, then visit a collaborating opticia…

This study examines how hospital admissions and treatments for stroke and transient ischemic attack (TIA) changed during the COVID-19 pandemic across Europe. Researchers will collect data from about 40 stroke units, covering admissions, length of stay, and procedures like thrombo…

This study aims to develop and fine-tune a medical artificial intelligence (AI) model to assist with diagnosing and managing gastric, cardiovascular, and cerebrovascular diseases. Researchers will use a large dataset of patient records, medical images, and doctor-patient dialogue…

This trial tests whether one session of high-frequency repetitive transcranial magnetic stimulation (rTMS) can increase brain activity in the motor cortex of stroke patients with severe arm weakness. Participants, who have had a stroke more than six months ago and cannot voluntar…

This observational study will follow 2,500 people who had a brain hemorrhage and received minimally invasive surgery. Researchers want to see how well patients recover in real-world settings. The study does not test a new drug or procedure, but gathers data to improve future care…

This study looks at whether specific proteins released into the blood after a traumatic brain injury or cardiac arrest can help doctors assess damage and predict recovery. Researchers will collect blood samples from patients starting in the ambulance or emergency department and c…

This trial tests a brain-computer interface called CortiCom, which is surgically placed on the brain's surface to record signals related to speech and arm movement. The goal is to see if these signals can be decoded to control software and devices, potentially helping people with…

This study is testing whether a light-based cap (HD-DOT) can measure how well the brain responds to changes in carbon dioxide, a key indicator of stroke risk. Researchers will compare this cap to standard MRI in people with and without sickle cell disease, aged 6 to 70. Participa…

This study is a long-running registry that collects detailed health information from all stroke and dementia patients in Erlangen, Germany. It aims to understand how these diseases develop and affect people over time, regardless of age or severity. Participants are followed for l…

This study tests how Tizanidine, a drug used for muscle stiffness, changes arm movement in people who have had a stroke. Researchers will measure brain activity, muscle responses, and movement patterns in 64 participants. The goal is to understand what limits movement after strok…

This study investigates how a recent stroke affects the ability to learn new motor skills that require using both arms or hands together. Researchers will use robotic devices to measure learning and brain imaging to see which brain areas are involved. The goal is to understand wh…

This study is building a large online registry of US adults who experience sinus, ear, dizziness, and headache symptoms, with or without a migraine diagnosis. Participants answer questions about their symptoms, how these affect daily life, and which treatments they have tried. Th…

This study is testing whether a special MRI technique, called 4D Flow MRI, can better detect and predict the growth of unruptured brain aneurysms. Researchers will follow adults with these aneurysms, using the advanced imaging to measure changes in the aneurysm's shape over time.…

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study looks at how blood levels of common blood thinners (apixaban, dabigatran, edoxaban, and rivaroxaban) change over time in Chinese patients with atrial fibrillation. Researchers will take blood samples before and after stopping the medication for medical procedures. The …

This study investigates whether physical exam findings called somatic dysfunction — impaired function of the body's framework — can be linked to energy expenditure, heart rate variability, and quality of life in people who have had a stroke. Researchers will assess 100 chronic st…

This study investigates whether ultrasound measurements of thigh muscle thickness can help detect sarcopenia (muscle loss) and fear of movement in people who have had an ischemic stroke. Researchers will compare ultrasound results with standard tests like handgrip strength and a …

This study is a registry that will follow 1500 adults treated for acute ischemic stroke with Medtronic devices. Researchers will track safety, how well the devices restore blood flow, and whether patients regain independence after 90 days. The goal is to see how these devices wor…

This study follows 5,000 people with mild cognitive impairment or mild-to-moderate dementia living at home in Bavaria, along with their family caregivers. Researchers collect detailed information on health, daily function, care needs, and quality of life over several years. The g…

This study is testing whether a non-invasive eye scan called optical coherence tomography (OCT) can help track neurological diseases like multiple sclerosis, Alzheimer's, Parkinson's, and migraine. Over two years, researchers will measure the thickness of retinal layers in 840 pa…

This study aims to create a better way to predict stroke risk in people with atrial fibrillation (an irregular heartbeat) who are already taking direct oral anticoagulants (DOACs), a type of blood thinner. Even with these medications, some patients still have strokes. Researchers…

This study tracks how fast the 'halo sign' — a key ultrasound marker of inflamed arteries — disappears after starting steroid treatment in people with giant cell arteritis, a rare disease that can cause blindness. Researchers will scan the temporal arteries of 64 newly diagnosed …

This study looks at whether special MRI scans can help predict which people with severe narrowing of brain arteries (70-99% stenosis) are most likely to have another stroke. Participants have already had a minor stroke and are enrolled in a larger treatment trial. They will get a…

This study follows 100 stroke survivors over six months to understand how sitting balance, standing balance, and walking recover. Using wearable sensors and an interactive assessment game, researchers measure movement, coordination, and reaction time. The goal is to identify reco…

This study tests whether a video camera with artificial intelligence can track newborn brain health by analyzing their movements. About 200 babies in the NICU will be recorded continuously from admission to discharge. The AI's findings are kept from doctors for now, to see if the…

This study investigates why endometriosis and migraine often occur together. Researchers will measure pain sensitivity and sex hormone levels in four groups: people with endometriosis, people with migraine, people with both conditions, and healthy controls. Participants complete …

This study tests whether a 6-week program that combines a pedometer with phone or video coaching is practical for people who had a stroke at least 6 months ago. 24 participants will track their steps and set goals with an occupational therapist. The main goal is to see if people …

This study aims to learn how patients with severe stroke move during their hospital stay. Fifty adults will wear a small activity tracker (activPAL) that records lying, sitting, standing, and stepping. Researchers will compare this data with standard mobility goals to understand …

This observational study investigates why some people develop epilepsy after a stroke, while others do not. Researchers will compare first-time stroke patients with healthy volunteers using brain imaging (MRI), electrical brain recordings (EEG), and overnight sleep studies. The g…

This study investigates whether monitoring brain blood flow during heart surgery can help predict strokes afterward. Researchers will use non-invasive sensors to track how well the brain regulates its own blood supply during different phases of surgery. The goal is to develop a m…

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury.…

This study investigates the sequence of early warning signs, called premonitory symptoms, that occur before a migraine headache starts. Researchers will follow 500 adults with migraine who will record their symptoms using an electronic diary for up to five attacks. The goal is to…

This study follows 5000 people admitted to a neuro-intensive care unit with life-threatening brain conditions like bleeding in the brain or severe seizures. Researchers collect medical data and biological samples to better understand how brain injuries progress and what factors h…

This study aims to uncover genetic and environmental risk factors for hemorrhagic stroke, a type of stroke caused by bleeding in the brain. Researchers will analyze DNA, RNA, and blood samples from 1,000 adults who have had such a stroke, comparing them to healthy controls. By id…

This study explores whether migraine attacks can be predicted before the headache phase begins. Researchers will monitor people with episodic migraine (10–14 migraine days per month) using a wearable device that tracks heart rate and other body signals, along with a diary of earl…

This study looks at how well hospitals manage severe oxygen deprivation (asphyxia) in newborns at or near full term. Researchers will review care given during labor and after birth to find where improvements can be made. The goal is to help doctors and nurses provide better, fast…

This study looks at MRI scans of 128 people who have had a brain hemorrhage (bleeding in the brain). Researchers want to see if a specific contrast pattern called a 'spot sign' can help predict which bleeds might get worse. By understanding these patterns, doctors hope to identif…

This study investigates the specific cognitive strengths and weaknesses of children and adults with Sturge-Weber Syndrome (SWS), a rare condition affecting blood vessels in the brain, skin, and eyes. Participants complete a series of tests measuring memory, attention, language, a…

This study uses PET and MRI brain scans to compare the activity of two key brain chemicals—dopamine and acetylcholine—in 30 people who have had a stroke, half with apathy and half without. The goal is to better understand what causes apathy after a stroke, which could eventually …

This observational study is looking at 250 people who have had a stroke or mini-stroke due to narrowing of arteries in the brain. Researchers want to see if a specific platelet protein (FcγRIIa) and blood flow patterns on MRI can help predict who will have another stroke within a…

This study uses brain scans (fMRI) and sensory tests to explore how different types of chronic pain affect the brains of children and teens aged 10-17. Researchers hope to find shared and unique brain patterns across conditions like migraines, fibromyalgia, and abdominal pain. Th…

This study is following 3000 people in China who have cerebral venous thrombosis, a rare type of blood clot in the brain. Researchers will collect blood and spinal fluid samples to learn more about the disease and find markers that could help with diagnosis. The goal is to better…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study looks at why some people with chronic migraine don't get better with standard treatments. Researchers want to see if a person's level of suggestibility—how easily they respond to suggestions or expectations—might help predict who could benefit from placebo effects. The…

This study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after st…

This study looks at the best way to treat a fluid pocket (pseudomeningocele) that can form under the scalp after brain surgery. It compares doing nothing active (just watching and caring for the wound) with doing a procedure like draining the fluid or another surgery. The goal is…

This study follows 180 adults with cerebral small vessel disease to see how their condition changes over time after a stroke. Researchers will use MRI scans and blood tests to track disease progression and look for links to thinking skills, daily function, and stroke recurrence. …

This study tests whether adding immersive virtual reality (VR) to standard physical therapy helps people who recently had a stroke regain arm movement and improve quality of life. Researchers will also look at blood markers and genes that might predict recovery. About 120 adults …

This study looks at 50 adults who had a stroke caused by a blocked middle brain artery and were treated with a clot-removal procedure called thrombectomy. Researchers will use special MRI scans to measure brain activity and metabolism in the damaged area. The goal is to find earl…

This study is creating a large database of health information from 743 adults with HIV/AIDS across Brazil. Researchers will look at how common chronic diseases like heart disease, kidney disease, and cancer are in this group. The goal is to gather data to help improve health poli…

This study is testing three different doses of a non-invasive brain stimulation technique called rTMS in 26 chronic stroke survivors with arm weakness. The goal is to see which dose best boosts brain signals to the hand muscles and improves motor learning. Participants will recei…

This observational study at Yale University will follow 150 people who have had an ischemic stroke to see how changes in blood pressure affect their recovery. Researchers will use brain scans and thinking tests to understand the connection. The goal is to find better ways to mana…

This registry collects information from people with inherited retinal diseases, like retinitis pigmentosa and Stargardt disease. Participants share their symptoms, family history, and genetic test results online. The goal is to help researchers understand these rare diseases and …

This study tests a digital lifestyle platform designed to support patients after they leave inpatient rehabilitation. It includes people with COPD, heart problems, fractures, or minor stroke. Participants use the platform for six months, receiving personalized recommendations and…

This study tests a new set of procedures called the HI-SPEED Protocol, designed to help hospitals evaluate stroke patients faster and decide who needs to be transferred for advanced care. The goal is to reduce the time patients spend in the first hospital before being moved to a …

This study aims to find early warning signs for major chronic diseases like stroke, heart disease, and cancer by following 4,500 healthy adults aged 30-80 in Lishui. Participants will receive regular check-ups and long-term monitoring. The goal is to improve prevention and care a…

This study looks at how a newborn's brain and blood flow work together in the first minutes after birth. Researchers will place a small patch on the baby's scalp to measure brain activity and oxygen levels. The goal is to learn more about how babies adjust to life outside the wom…

This study looks at 150 patients who are unresponsive after a brain bleed (intracerebral hemorrhage). Researchers use EEG to detect hidden brain activity when patients are asked to imagine moving. The goal is to see if this activity can predict who will regain consciousness and h…

Cerebral palsy (CP) is a brain injury that affects movement, but diagnosing it can take up to 2 years. This study follows 600 high-risk infants (premature, brain-injured, or with abnormal exams) across Irish hospitals. Researchers will use EEG sleep tests, protein markers, and co…

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This study looks at sleep problems like sleep apnea and insomnia in 226 people who have had a stroke. Researchers want to see how these sleep issues affect recovery, daily activities, and quality of life. Participants will use a home sleep test and a smartwatch to track sleep and…

This study explores whether a special MRI technique can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from the MRI scanner. The goal is to retrain the brain's language areas to wor…

This study looks at how sleep problems and stress can trigger migraines in adults. Participants wear a WHOOP band to track sleep and body signals, and answer daily questions via a smartphone app. The goal is to find personal patterns and give tailored advice to reduce migraine at…

This study looks at how a stroke can disrupt the body's automatic functions, like heart rate and blood pressure control. Researchers will compare 100 people who had a stroke or a mini-stroke using brain scans, blood tests, and heart function tests. The goal is to understand why t…

This study follows 24 people who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers want to see how AF changes over two years by monitoring heart activity, blood markers, and heart structure. The goal is to better understan…

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel function in the brains of inactive adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers in 64 participants. Th…

This study compares how well stroke neurologists and a deep learning AI model predict recovery in 250 stroke patients. Researchers will track actual disability at 24 hours and 3 months, then compare those results to predictions made by doctors and the AI. The goal is to understan…

This study tests whether a new type of exercise that retrains how muscles work together can improve arm function in people who have had a stroke. Researchers will compare this approach to standard strength training in 74 participants. The goal is to see if changing muscle coordin…

This study follows 600 adults who have had their first stroke to see how their thinking and memory change over time. Researchers will look at factors like brain reserve and daily habits to understand why some people get worse while others stay stable. The goal is to better predic…

This study tests a fast genetic test done in the hospital to see if it helps doctors pick the best blood thinner for stroke patients. Some people have a gene variation that makes the common drug clopidogrel less effective. The test checks for 11 known gene variants and alerts the…

This study uses a special camera called an adaptive optics scanning laser ophthalmoscope to take incredibly detailed pictures of the retina, the light-sensitive layer at the back of the eye. Researchers will compare images from healthy people and those with eye diseases like Star…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study tests whether brain-computer interfaces (BCIs) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. Families receive a BCI kit and participate in 12 virtual coaching sessions over 3-6 months. The goal is t…

This study is tracking 5,000 people who had a brain bleed from a ruptured aneurysm. Researchers are collecting medical data to find factors that predict complications like delayed brain injury or long-term disability. The goal is to create a computer model that helps doctors fore…

This study from the University of Oxford looks at why women who had high blood pressure during pregnancy are more likely to develop heart and blood vessel disease later in life. Researchers will follow 200 women who gave birth 10 to 25 years ago, using heart scans, exercise tests…

This study tests whether a gentle electrical current applied to the brain (tACS) can improve hand movement in people who had a stroke more than 6 months ago. Researchers will use brain scans and EEG to see how the stimulation changes brain activity. 45 participants (including hea…