Simple ultrasound check may replace complex stroke risk test
NCT ID NCT05780619
First seen Jun 25, 2026 · Last updated Jul 09, 2026 · Updated 3 times
Summary
This study tests whether a quick, routine ultrasound measurement (called the resistance index) can accurately identify people with narrowed neck arteries who have normal brain blood flow response. If it works, many patients could avoid a time-consuming, specialized test. The study will involve 77 participants with significant carotid artery narrowing or blockage.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could provide a quick, simple test to identify which patients with carotid artery narrowing need further evaluation for stroke risk.
- What could go wrong
- This is a small, early-stage diagnostic study (77 participants) testing a new use for an existing measure. The results may not apply to all patients or settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 77 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2023
- Expected to finish
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Jun 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study will be carried out at the University Hospital of Nîmes in the department of explorations and vascular medicine (EMV), for patients referred for HRV measurement with a significant stenosis or occlusion.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * The patient must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan * Stenosis ≥ 70% in diameter reduction in NASCET equivalent or occlusion of atheromatous origin of the cervical internal carotid artery, asymptomatic or symptomatic. * Presence of a temporal window sufficient to record the homolateral and contralateral middle cerebral artery. * Patient of legal age with free and informed consent. * Patient who has signed the consent form. * Patient affiliated or beneficiary of a health insurance plan. Exclusion Criteria: * The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study * The subject refuses to sign the consent * It is impossible to give the subject informed information * The patient is under safeguard of justice or state guardianship * Contraindication to Acetazolamide Diamox® injection. * Absence of temporal acoustic window (non visualization of the cerebral parenchyma, no recordable intracranial vessel). * Insufficient temporal window (visualizable brain parenchyma, no recordable MCA) * Internal or common carotid artery stenosis ≥70% or occlusion, contralateral to the primary lesion. * Stenosis ≥50% of the middle cerebral artery homolateral or contralateral to the cervical lesion. * Patient in exclusion period determined by another study. * Patient under court protection, guardianship, or conservatorship. * Patient refusing to sign the consent form. * Patient unable to express his or her will (dementia, disturbed consciousness, etc.) * Patient for whom it is impossible to give informed information for health reasons or because of a language barrier. * Pregnant, parturient, or breastfeeding patient.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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CHU de Nîmes
RECRUITINGNîmes, France
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