New stroke rehab study targets muscle coordination to restore arm movement

NCT ID NCT06523335

Knowledge-focused Sponsor: University of Houston Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a new type of exercise that retrains how muscles work together can improve arm function in people who have had a stroke. Researchers will compare this approach to standard strength training in 74 participants. The goal is to see if changing muscle coordination patterns leads to better movement and recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: neuromuscular coordination-guided rehabilitative training
What this could lead to: If successful, this could point toward a more effective rehabilitation technique for improving arm movement after stroke.
What could go wrong: This is an early-stage study with only 74 participants, so results may not apply to all stroke survivors. The intervention is non-invasive but may not lead to significant functional gains.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 74 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2024

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria for aged matched healthy group * Male or female whose age range between 40 and 75 * no known neurological injuries Exclusion criteria for aged matched healthy group * have an orthopedic disorder involving upper limbs; * have a history of any neurologic disease; * have any history of epilepsy of the potential participants and/or their family members; * are unable to consent; * are pregnant. Inclusion criteria for stroke group * male or female hemiparetic chronic stroke survivors; * age ranging between 40-75 year; * with single unilateral ischemic or hemorrhagic middle cerebral artery stroke; * neurologically stable for \>6 months; * have an expectation that current medication will be maintained without changes for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted; * without severe spasticity (Modified Ashworth (MA) \<4); * have not received botulinum toxin on the impaired arm within 3 months. Exclusion criteria for stroke group * have an orthopedic disorder involving upper limbs; * cognitive impairment sufficient to interfere with informed consent or successful completion of the protocol (Montreal Cognitive Assessment (MoCA) score \< 26); * a history of another neurologic disease; * anesthesia of joint position sense in upper limbs; * are pregnant or have a chance that they might be (self-reported);

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

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New stroke rehab study targets muscle coordination to restore arm movement

What the study statuses mean