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Tongue zaps may boost arm recovery after stroke

NCT ID NCT06386510

Symptom relief Sponsor: Université de Sherbrooke Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether stimulating the tongue with a non-invasive device can improve arm movement and brain plasticity in people who had a stroke at least six months ago. Participants will do a 4-week strength training program for their affected arm, combined with either real or sham tongue stimulation. Researchers will measure changes in arm function and brain activity to see if the tongue stimulation adds benefit.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cranial nerve non-invasive neuromodulation (CN-NINM) via tongue stimulation
What this could lead to
If it works, this could offer a new, non-invasive way to boost arm recovery after stroke by combining tongue stimulation with strength training.
What could go wrong
This is an early-stage trial with only 74 participants, and the tongue stimulation is experimental for stroke. It may not improve function more than training alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 74 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * be ≥18 years of age; * have had a unilateral supratentorial stroke; * be in a chronic stage of recovery (\>6 months); * present some UL motor recovery (Fugl-Meyer Stroke Assessment \[FMA-UE\] score ≥25/66); * are not involved in rehabilitation treatments. Exclusion Criteria: * significant spasticity at UL (score \>3 on the modified Ashworth scale); * major sensory deficit at UL (a score \<25/34 on the Nottingham sensory assessment and a score \<6 on the vibration threshold assessment); * hemineglect (\> 70% of unshaded lines on the same side as the motor deficit on the Line Cancellation test); * apraxia (score \>2.5 on the Alexander test); * a neurological disorder other than stroke-related; * orthopedic problems at UL; * cognitive impairment (score \<2/5 on the Mini-Cog); * significant pain intensity at UL (a score ≥ 6/10 on the Visual Analog Pain Scale); * absence of MEP (peak-to-peak MEP amplitude \<20μV); * contraindications to CN-NINM and TMS.

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CIRRIS

    RECRUITING

    Québec, Quebec, G1M2S8, Canada

  • CRIR/Feil/Oberfeld Research Center; Centre intégré de santé et de services sociaux de Laval; Jewish Rehabilitation Hospital

    RECRUITING

    Laval, Quebec, H7V 1R2, Canada

  • Centre de recherche sur le vieillissement

    RECRUITING

    Sherbrooke, Quebec, J1H 4C4, Canada

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