Can training the brain to think about words boost recovery from stroke-related aphasia?
NCT ID NCT06930131
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial tests whether adding metacognitive training—exercises that help people think about their own thinking—to standard word-finding rehabilitation can improve language skills in people with chronic aphasia after a stroke. The study involves 18 participants who will receive either the combined therapy or standard care. Researchers will measure changes in naming ability and brain connectivity to see if the approach helps.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Semantic rehabilitation combined with metacognitive training
- What this could lead to
- If effective, this combined therapy could improve word-finding and communication in people with chronic aphasia, potentially enhancing quality of life.
- What could go wrong
- This is a small early-stage trial with only 18 participants, so results may not apply broadly. The intervention is behavioral and may not produce lasting changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 18 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2025
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * First cerebral infarction * Chronic phase (\> 3 months) * Patient affiliated to a health insurance scheme * Usual french language * Severity score measures using the Boston Diagnostic Aphasia Examination battery scale corresponding to the mild or moderate level (score greater than or equal to 2) Exclusion Criteria: * Contraindication to undergoing brain MRI * Cognitive impairment pre-existing stroke (CQI code \> 3.4) (Law et al., 1995) * Chronic alcohol or drug abuse * Unstabilised psychiatric illness * Uncorrected sensory deficits * Diagnosed as having a progressive general pathology
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University Hospital of Toulouse
RECRUITINGToulouse, France
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