Neurovascular disorder

This trial tests whether transplanting neural stem cells directly into the brain can help people who have had a chronic ischemic stroke. The study involves adults aged 18-75 who had a stroke 6 to 60 months prior. Participants receive a single dose of stem cells, and the trial eva…

This study tests an experimental drug called ALN-APP in 200 adults with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain. The drug is given via spinal injection and aims to slow disease progression and reduce new brain bleeds. Participants will be …

This study tests a higher dose of the drug aflibercept (8 mg) given as an eye injection every 4 weeks to people with wet age-related macular degeneration (nAMD) or diabetic macular edema (DME). The goal is to see if this dosing schedule is safe and works well for those who have a…

This early study tests a new device (LAmbre II) that closes a small pouch in the heart called the left atrial appendage in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners. Ten participants will be followed for abo…

This study tests an experimental drug called BI 764524, given as an eye injection, in 190 adults with moderate to severe diabetic retinopathy. Participants receive different numbers of injections over a year, and doctors compare eye damage improvements against a sham procedure or…

Retinal vein occlusion happens when a clot blocks a vein in the eye, leading to vision loss. Current treatments manage the fluid buildup but do not remove the clot. This trial tests whether a robot can safely guide a tiny needle into the blocked vein to inject tPA, a clot-dissolv…

Researchers are testing two doses of an experimental eye implant called EC-104 against the standard Ozurdex implant in adults with diabetic macular edema. The trial enrolls people whose swelling did not improve enough with anti-VEGF injections but who have tolerated steroid eye t…

This large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…

This early study tests whether QLS-111 eye drops can improve blood flow to the back of the eye in people with non-proliferative diabetic retinopathy or certain types of glaucoma. Fourteen participants will use the drops twice daily for two weeks. The main goal is to measure chang…

BP-REACH tests whether a team-based program can help people who have had a stroke or heart attack lower their blood pressure. Participants receive a home blood pressure monitor, self-management education, monthly coaching calls, and medication management from a pharmacist. Resear…

This study tests whether a structured exercise program done at home can improve walking ability and overall recovery in people who recently had a stroke. About 208 adults who had a stroke within the past two weeks will be assigned to either the home exercise program or usual care…

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This study looks at whether semaglutide, a medicine for type 2 diabetes, can slow or prevent diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo injection once a week, in addition to their usual diabetes medicatio…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This study tests a device called a motor neuroprosthesis, an implantable brain computer interface designed to help people with severe paralysis control digital devices like computers or tablets. The device aims to bypass damaged motor pathways and transmit brain signals directly …

This study tests whether adding spironolactone to standard blood pressure treatment helps lower blood pressure more effectively in people who have had a stroke. About 160 adults who had a bleeding or clot-caused stroke are taking spironolactone or continuing their usual care. Res…

This pilot trial tests whether training with a portable robotic ankle exoskeleton, called AMBLE, can improve ankle push-off and walking speed in adults with chronic stroke and ankle weakness. Participants will complete 30 walking training sessions over 8 to 9 weeks while wearing …

This study tests whether Dysport injections can prevent chronic migraines in adults. Chronic migraine means having at least 15 headache days per month, with 8 being migraines. Participants receive injections into head, neck, and shoulder muscles every 12 weeks for up to 60 weeks.…

This real-world study is following 7,000 Chinese adults with established heart disease to see if adding Repatha® (a cholesterol-lowering injection) to their usual care reduces major cardiovascular events like heart attacks, strokes, and heart-related death. Participants are eithe…

This study tests a new medicine, EYP-1901, given as an eye injection to people with diabetic macular edema (DME), a condition that causes blurry vision in people with diabetes. The goal is to see if EYP-1901 works as well as the standard treatment (aflibercept) but with fewer inj…

This phase 3 trial tests EYP-1901, a new eye injection, against the standard treatment aflibercept for diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The study will enroll 240 participants and compare how well each drug improves vision …

This trial tests two early interventions for people who have had an ischemic stroke: a computerized cognitive training program for the patient and a psychoeducational program for the main caregiver. Both start about 20 days after hospital admission, much earlier than most rehabil…

This early-stage study tests a new drug, RO7497372, given as an eye injection for people with diabetic macular edema (DME), a condition that causes vision loss. The trial involves 151 participants and aims to check the drug's safety, how long it stays in the eye and blood, and it…

This study tests a new device (Laminar) to close the left atrial appendage, a small pouch in the heart, in 1500 people with non-valvular atrial fibrillation. The goal is to see if it is safer and works better than existing devices to reduce the risk of stroke and blood clots. Par…

This phase II trial tests whether an experimental drug called LT3001, given as a single intravenous infusion, can safely improve outcomes for people with acute ischemic stroke who are undergoing endovascular thrombectomy, a procedure to remove the blood clot. The study enrolls ad…

This trial tests whether adding brain stimulation techniques to standard swallowing therapy helps people who have trouble swallowing after a stroke. Researchers will compare neuromuscular electrical stimulation (NMES) alone with NMES combined with either transcranial direct curre…

This study looks at a device called ENTERPRISE 2 that helps doctors treat brain aneurysms (a bulging blood vessel in the brain). The device is used during a procedure to block the aneurysm with coils. The study includes 164 people aged 18 to 80 with certain types of brain aneurys…

This large Phase 3 study tests whether milvexian, an experimental oral blood thinner, can prevent another stroke in people who recently had a mild stroke or a high-risk mini-stroke (TIA). Over 12,500 participants are randomly assigned to receive either milvexian or a placebo, alo…

This study tests whether combining two non-invasive therapies can improve hand function in people who had a stroke at least six months ago and have severe arm weakness. The therapies are a brain stimulation technique called rTMS and a device that uses electrical stimulation to op…

This early-stage trial is testing whether focused sound wave pulses applied to the head—called transcranial pulse stimulation—can help people recover from a recent ischemic stroke. The study includes adults aged 20 to 80 who had a stroke 1 to 6 months ago and still have motor or …

This study tests a drug called faricimab (VABYSMO) in 218 people with diabetic macular edema who have not been treated before. The participants are Black/African American, Hispanic/Latino American, Native American/Alaska Native/Native Hawaiian/Pacific Islander, or Asian Indian. T…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This early-stage study tests whether a drug called anisodine hydrobromide is safe for people having a stroke caused by a blocked large artery in the brain. About 92 adults aged 18 to 80 who are already scheduled for a clot-removal procedure will receive the drug. The main goal is…

This trial tests whether a procedure to remove blood clots from veins in the brain works better than standard blood-thinning medication for people with cerebral venous sinus thrombosis (CVST), a rare type of stroke. Participants will be randomly assigned to receive either the end…

This trial tests whether high-dose vitamin D supplements can improve cognitive function in people who have had a stroke and developed thinking or memory problems. Participants will receive either vitamin D or a placebo for six months, and researchers will measure changes in cogni…

This study tests a new drug called EYE103 (Restoret) against an existing treatment, ranibizumab (Lucentis), for people with diabetic macular edema, a common cause of vision loss in diabetes. About 1,054 participants receive injections into the eye every 4 weeks for a year, then l…

This study tests a new drug called EYE103 (Restoret) against an existing treatment, ranibizumab (Lucentis), for people with diabetic macular edema, a condition that causes vision loss in diabetes. About 984 participants will receive injections into the eye every 4 weeks for a yea…

This phase 2 trial tests RGX-314, a gene therapy given as a single injection into the eye, for people with diabetic retinopathy. The goal is to see if it can improve vision and reduce the need for frequent anti-VEGF injections. About 139 adults with diabetes-related eye damage ar…

This study tests a device called the Surpass Evolve Flow Diverter, a small mesh tube placed inside an artery to redirect blood flow away from a brain aneurysm. The goal is to safely close the aneurysm and prevent it from rupturing. About 248 adults with unruptured, wide-neck aneu…

This study tests whether adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency stroke treatment helps people recover better after a severe stroke caused by a large blood clot in the front part of the brain. About 692 adults who are el…

This study tests whether the drug ubrogepant can prevent menstrual migraines when taken daily for a week around each period. About 496 women with regular cycles and a history of menstrual migraines will receive either ubrogepant or a placebo for three cycles, then all may receive…

This Phase I trial tests whether infusing specially trained immune cells, called TAA-T, can safely target and attack high-risk brain tumors in children and adults. The cells are made from the patient's own blood and are designed to recognize multiple tumor-related proteins, poten…

This study tests whether infusing a cold magnesium sulfate solution directly into the brain during emergency clot removal can improve outcomes for people with acute ischemic stroke. About 42 adults aged 18-80 with severe strokes will be randomly assigned to receive either standar…

This study tests a new approach called 'pill-in-pocket' anticoagulation for people with atrial fibrillation (AF), a heart rhythm condition that raises stroke risk. Instead of taking blood thinners every day, participants would stop them after a 30-day AF-free period and only rest…

This phase 2 study tests two drugs, sunitinib and temsirolimus, in 137 people with advanced rare tumors that have no cure. The goal is to see if these drugs can shrink tumors or slow their growth. Participants take one of the two drugs, and researchers measure how long the cancer…

This trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…

This study is a long-term follow-up for people who previously received an injection of RGX-314, a gene therapy, for diabetic retinopathy (with or without diabetic macular edema). The purpose is to monitor the safety and effectiveness of the treatment over a total of five years af…

This study asks whether wearing a small heart monitor for two weeks at a time, twice, can better detect hidden irregular heartbeats (atrial fibrillation) in older adults who recently had a stroke or mini-stroke, compared to the usual 1-2 day monitoring. Atrial fibrillation is a m…

This study tests a new type of balance training for people who had a stroke within the past few weeks. The training uses controlled wobbles and shifts in the support surface to challenge patients' balance in a safe way, aiming to improve their ability to walk and perform daily ac…

This trial tests whether adding melatonin to the standard preventive drug propranolol can better reduce migraine attacks in children aged 5 to 15. Sixty children with moderate-to-severe migraine disability will receive either melatonin plus propranolol or propranolol alone for th…

This study tests whether a focused, intensive stepping training program, called FIRST, can improve walking ability in people recovering from a recent stroke. Participants in inpatient rehabilitation receive physical therapy that prioritizes walking practice at higher cardiovascul…

This trial tests whether starting physical therapy early—while infants are still in the NICU and continuing until 12 months corrected age—can improve motor function and reduce the severity of motor delays in babies at high risk due to premature birth, brain injury, or other condi…

This Phase 3 trial tests a new drug called belzupacap sarotalocan (AU-011) for people with small choroidal melanoma or suspicious spots in the eye. The drug is injected into the eye and activated by a laser to target cancer cells. The study compares it to a sham (fake) procedure …

This trial tests whether using optical coherence tomography (OCT) during a procedure to reopen a chronically blocked carotid artery is safe. The blockage can cause strokes, and doctors often need to see what's inside the artery after crossing the blockage. OCT provides high-resol…

This trial compares two common procedures—carotid endarterectomy (surgery to clean out the artery) and carotid stenting (placing a mesh tube to hold it open)—in people who have recently had an ischemic stroke caused by a blocked carotid artery. The goal is to see which approach l…

This trial tests whether a gentle electrical current applied to the brain — called transcranial direct current stimulation (tDCS) — can help older adults recover the ability to swallow after a stroke. Hospitalized patients aged 60 to 80 with swallowing difficulties will receive e…

This trial tests two rehabilitation techniques — synergy-based electrical stimulation and task-oriented training — to see which better improves leg movement and mobility in people who had a stroke 1 to 6 months ago. Participants, aged 40 to 60, will receive one of the two approac…

This study looks at people with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull can damage vision. Researchers will track which patients need a surgical shunt to relieve pressure versus those who improve with weight loss and medication…

This study tests an experimental drug, NPI-001 (AT-001), in people with hereditary cystatin C amyloid angiopathy (HCCAA), a rare genetic condition that causes repeated brain bleeding and stroke. The trial includes about 15 participants aged 12 and older who carry the specific L68…

This trial tests whether a dietary supplement called Tertinat, containing epigallocatechin-3-gallate, can reduce major heart problems in people with atherosclerosis who have recently had bypass or stent surgery. Over two years, participants take either the supplement or a placebo…

This study tests whether giving stroke patients real-time feedback on muscle activity—either through a visual display or sounds—can improve balance, walking, and daily independence when added to standard physical therapy. The trial enrolls adults aged 20-30 who have had a hemiple…

This study tests whether a procedure called spinal cord stimulation can reduce blood vessel spasms that often occur after a brain aneurysm rupture. Participants have already had standard treatment for their aneurysm and will receive either real or sham stimulation. The goal is to…

This trial investigates whether combining neuromuscular electrical stimulation (NMES) with therapeutic ultrasound can help stroke patients who also have sarcopenia—a condition of low muscle mass and strength. Participants receive four weeks of daily therapy, and researchers measu…

This phase 3 study tests whether erenumab (Aimovig), a monthly injection already approved for adults, can prevent migraines in children aged 6 to 17 with episodic migraine. About 457 participants receive either the drug or a placebo for 3 months. The main goal is to see if the dr…

This study compares standard high-intensity gait training and gait training with electrical stimulation against a new approach that uses real-time feedback on how muscles work together (muscle synergies). The goal is to see if this biofeedback method helps people with chronic str…

This study tests a new way to control leg exoskeletons by reading muscle signals in real time. Researchers use high-density electrodes to capture nerve activity and predict a person's intended movement, then have the exoskeleton assist accordingly. The trial includes both healthy…

This trial tests whether a quick procedure called umbilical cord milking—pushing blood from the cord into the baby before clamping—can improve brain development in newborns who are limp or not breathing well at birth. The study follows over 3,400 infants from the earlier CORDMILK…

This study tests a small, refillable implant placed in the eye that delivers medication every 24 weeks, compared to standard monthly eye injections. It includes about 634 adults with diabetic macular edema, a condition that causes vision loss. The goal is to see if the implant wo…

This study tests whether a gentle, targeted electrical stimulation to the brain (HD-tDCS) can safely improve how stroke survivors perceive vertical balance. Participants who have had a stroke affecting one side of the brain will receive either active or sham stimulation while per…

This study tests whether virtual group visits—where patients meet online for diabetes education, support, and goal setting—can improve blood sugar control in people with type 2 diabetes who also have heart-related conditions. About 720 adults from participating clinics will take …

This trial tests a long-acting injection of leuprolide acetate in children with central precocious puberty, a condition where puberty starts too early. The goal is to suppress puberty-related hormones, slowing or stopping early development. The study includes children aged 4 to 9…

This study tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS), combined with paired associative stimulation (PAS), can improve arm and hand movement in people who have had a stroke. The trial includes 40 adults who experi…

This study tests whether a drug called neflamapimod can improve recovery of movement and thinking after a moderate to severe ischemic stroke. About 90 adults aged 45 and older will receive either the drug or a placebo for 12 weeks. The goal is to see if the drug helps reduce disa…

This trial tests whether a special training that uses unexpected slips on a low-friction platform can help stroke survivors improve their balance and reduce falls. Participants will practice recovering from slips in a safe lab setting, and researchers will track whether these ski…

This trial investigates whether using a device to continuously measure pressure inside the brain's fluid-filled spaces can improve outcomes for people who have had a bleeding stroke from a ruptured aneurysm. About 372 adults with moderate to severe bleeding will be randomly assig…

This study tests a new non-invasive brain stimulation device called kTMP (kilohertz transcranial magnetic perturbation) to see if it can help improve arm and hand movement in people who have had a stroke. The trial involves 7 adults aged 18-80 who had a stroke at least 12 months …

This study tests whether giving a fructose (a type of sugar) injection soon after a stroke, along with standard clot-busting treatment, can improve brain recovery. About 46 adults who have a stroke within the last 4.5 hours will be randomly assigned to receive either fructose plu…

This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial …

This study planned to test whether giving a child their own stored umbilical cord blood is safe for treating perinatal arterial ischemic stroke. It was designed for children aged 6 weeks to 6 years with MRI-confirmed stroke. The trial was withdrawn before enrolling any participan…

This study tests a new coil device (Kaneka i-ED) in 50 people with wide-necked brain aneurysms. The coil is placed inside the aneurysm to block blood flow and prevent rupture. Researchers will check how well it works, how safe it is, and whether it saves money compared to standar…

This study tests a special balloon catheter coated with the drug paclitaxel to treat narrowed or re-narrowed brain arteries. The balloon is inflated inside the artery to open it and release the drug, which may help prevent the artery from closing again. The trial includes 281 adu…

This pilot study tests a new device called OsciPulse that rapidly compresses the calves to improve blood flow and reduce the risk of blood clots in people hospitalized after a stroke. About 40 adults with leg weakness will be randomly assigned to receive either OsciPulse or stand…

This study looks at how well the migraine prevention drug atogepant works in real-world settings. Over 1000 adults with migraine who are already prescribed atogepant will be followed for 2 years. Researchers will measure how much patients feel their migraines have improved since …

This study looks at 3,500 unconscious patients who survived a cardiac arrest to find the best combination of sedation, fever control, and blood pressure management in the ICU. Each patient gets one of two levels for each factor (e.g., deep vs. light sedation, tight vs. loose feve…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests whether the drug farcimab (Vabysmo), given as an injection before and after eye surgery, can reduce bleeding complications in people with diabetes who have bleeding inside the eye. About 100 adults will receive either farcimab or a sham injection. The goal is to …

This phase 2 trial tests whether giving the clot-busting drug tenecteplase directly into the brain artery after standard clot removal is safe and feasible for people with severe stroke. About 40 participants who had a large artery blockage will receive either the drug or a saltwa…

This study tests a new eye injection called IBI302 for people with diabetic macular edema, a condition that causes vision loss due to diabetes. About 150 adults aged 18-80 with type 1 or 2 diabetes and swelling in the center of the retina will receive either IBI302 or an active c…

This study tests a new device called the Occlutech Flex II PFO Occluder, which is used to close a small hole in the heart (PFO) that can cause strokes. The trial involves 450 people who have had a stroke with no clear cause and a PFO. Researchers want to see if the new device wor…

This study aimed to test a drug called BAC in people with Alzheimer's disease or vascular dementia. The goal was to see if it could improve thinking and memory, and to check for side effects. However, the trial was withdrawn before any participants were enrolled, so no results ar…

This study looks at whether adding targeted laser treatment to the standard ranibizumab injections can help people with macular edema (swelling) from a central retinal vein occlusion need fewer injections over time. About 88 adults with this condition will receive either injectio…

This phase 2 trial tests a procedure called transarterial chemoembolization (TACE) for people with uveal melanoma that has spread to the liver. Doctors inject a chemotherapy drug (carmustine) mixed with an oily contrast agent (Lipiodol) directly into the liver's blood supply, the…

This study looks at the best way to stop tocilizumab in people with giant cell arteritis, a type of blood vessel inflammation. About 120 participants will either stop the drug suddenly or taper it slowly over time. The goal is to see which approach leads to fewer relapses and all…

This study looks at whether a procedure called endovascular treatment (EVT) can help people who have had a mild stroke caused by a blocked large artery in the brain. About 300 participants will either receive EVT plus standard medical care or standard care alone. The goal is to s…

This study aimed to see if removing additional small clots after the main blockage is cleared could help stroke patients recover better. It planned to compare standard care with extra mechanical or drug-based treatments. However, the trial was withdrawn and enrolled zero particip…

This Phase 3 trial compares two drugs—methotrexate and tocilizumab—for treating giant cell arteritis, a condition that causes inflammation in large arteries. Both drugs are given alongside a tapering course of prednisone. The goal is to see if methotrexate, a cheaper and easier-t…

This study tests if stem cells from umbilical cords can help people recover brain function after a stroke. It includes 40 adults who had a stroke and are now in the recovery phase. The treatment is given as an infusion, and researchers check if it improves daily living skills and…

This study tests whether a pre-filled syringe is as safe as the traditional vial when giving the medicine bevacizumab for certain eye diseases. About 120 people with wet age-related macular degeneration, diabetic macular edema, or branch retinal vein occlusion will receive inject…

This early-stage trial tests whether stem cells from donated umbilical cords are safe for people who recently had a stroke. Forty participants will receive three monthly infusions of the cells along with standard aspirin therapy. The study is currently on hold, and its main goal …

This study tests a blood-filtering device called DELP in people who have had a hemorrhagic stroke (bleeding in the brain). The filter removes fats and other substances from the blood to reduce brain swelling and damage. About 356 adults aged 18-80 with mild to moderate stroke sym…

This study compares two ways of giving faricimab, a drug injected into the eye, to treat diabetic macular edema (DME). One group gets injections on a fixed monthly schedule, while the other uses a 'treat and extend' approach where the time between injections is gradually lengthen…

This study looks at whether genetic testing can help doctors pick the right antiplatelet medicine for people who have had a stroke or mini-stroke. About 350 patients will be randomly assigned to either standard care or a genetic test that checks if a common drug, clopidogrel, is …

This study compares two ways to help stroke survivors control their blood pressure using telehealth. About 86 participants will receive either enhanced remote monitoring or standard care. The goal is to see which approach better helps people reach a safe blood pressure target and…

This study tested a one-time intravenous infusion of donor stem cells in adults aged 18 to 80 who had a recent (within 9 days) ischemic stroke. The goal was to help the brain heal and improve recovery. While promising, this approach is not a cure and patients still need standard …

This pilot study tests whether a blend of in-person therapy and home-based digital rehab (video calls and apps) works as well as traditional full in-person rehab for people recovering from stroke, brain bleeding, or head injury. Thirty participants will each try both approaches i…

This was a very early (Phase 1) study that planned to give a mixture of cold saline, minocycline, and magnesium directly into the brain's arteries right after a stroke procedure to reopen blocked vessels. The goal was to see if this cocktail could safely protect brain tissue and …

This study tests whether levodopa, a drug used for Parkinson's, can slow blood vessel changes in the eyes of people with diabetes. Researchers will give the drug or a placebo to 244 patients with early diabetic retinopathy and measure retinal electrical activity and imaging over …

This study tests an experimental drug called MW189 in 120 adults who have had a brain bleed (intracerebral hemorrhage). The goal is to see if the drug is safe and can reduce brain swelling. Participants receive the drug within 24 hours of their stroke and are monitored for side e…

This study looked at 800 adults who had a stroke from a large blood clot in the brain. It compared a new device called the NeVa Stent Retriever to standard devices used to remove the clot. The goal was to see if the new device could restore blood flow better and with fewer side e…

This study tests a device called the Contour System to treat brain aneurysms (weak spots in blood vessels that can burst). The device is placed inside the aneurysm to block blood flow and prevent rupture. The trial involves 250 adults aged 18-75 with a specific type of aneurysm. …

This study tests whether repeatedly inflating a blood pressure cuff on the arm (called remote ischemic conditioning) can improve thinking and memory in people who have had a stroke or have small vessel brain disease. Eighty participants will receive the treatment twice daily for …

This study compares two approaches—short-term anticoagulation (stronger blood thinners) versus antiplatelet therapy (milder blood thinners)—to prevent clots on a device placed in the heart's left atrial appendage. The trial involves 510 adults who have had this procedure. The goa…

This study follows 195 adults who received the WEB device, a mesh implant used to block blood flow into wide-neck brain aneurysms. Researchers are checking how well the device works and its safety over one year. The goal is to confirm that the device remains a reliable option for…

This study tests whether giving stroke patients extra tests—like checking for hidden heart problems, artery stiffness, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people in Stockholm will get this expanded check-up and a personal…

This Phase 3 trial tests whether butylphthalide soft capsules can improve thinking, memory, and daily living skills in people with mild to moderate vascular dementia. About 707 participants are randomly assigned to receive either the drug or a placebo for 52 weeks. The study aims…

This study follows 25 people aged 2 to 65 with cerebral palsy or brain damage from lack of oxygen who have already received a new gene therapy given as a nose spray. The therapy delivers 15 genes meant to repair the brain, reduce inflammation, and improve movement and thinking. R…

This study tests a higher dose (8mg) of aflibercept in 40 adults with proliferative diabetic retinopathy (PDR) who do not have swelling in the center of the retina. The goal is to see if this treatment can improve the severity of the disease and maintain vision over 96 weeks. Par…

This trial tests a nasal spray called MIG-SPRAY for preventing migraines in 45 adults aged 18-55. The spray forms a protective film inside the nose to possibly stop migraine triggers. Participants use it three times daily for three months, and researchers track side effects and m…

This early study tests whether beta-sitosterol, a plant-based supplement, can safely help people recover from a severe type of stroke called subarachnoid hemorrhage. Forty adults who have had this stroke will take the supplement for six months. The study will check for side effec…

This study looks at a device called the AMPLATZER PFO Occluder, which is implanted to close a hole in the heart (PFO) in people who have had a stroke. Over 1,200 participants are being followed for up to 5 years to see if the device prevents another stroke and is safe. The goal i…

This study is testing a device called the Pipeline™ Flex Embolization Device with Shield Technology™ to treat wide-necked brain aneurysms. The device is a small mesh tube that is placed inside the artery to divert blood flow away from the aneurysm, helping it heal. The study will…

This study tests whether galcanezumab, a monthly injection, can prevent chronic migraine in 312 adolescents aged 12 to 17. Participants receive either the drug or a placebo for 3 months. The main goal is to see if the drug reduces the number of migraine days per month.

This early-phase trial tests a combination of umbilical cord stem cells (injected into the brain) and a liquid called conditioned medium (given as nose drops) in 15 people who recently had a stroke. The goal is to see if this approach is safe and can help the brain grow new cells…

This Phase 2 trial tests whether a sleep-deepening drug (lower-sodium oxybate) or a nerve-stimulating device (non-invasive vagus nerve stimulation), or both, can help clear amyloid-beta protein from the brain in people with cerebral amyloid angiopathy (CAA). Sixty participants wi…

This study tests whether a newer type of blood thinner (DOA) works better than the standard one (VKA) for dissolving dangerous blood clots inside the heart. About 340 adults with such clots will be randomly assigned to one of the two treatments. The goal is to see which drug redu…

This study tests whether lower doses of the drug bevacizumab (Avastin) can effectively treat a severe form of retinopathy of prematurity (ROP) in premature infants. The trial includes 77 babies with type 1 ROP in zone I, the most dangerous type. Each infant receives a single inje…

This study tests if a device that closes a small pouch in the heart (left atrial appendage) is safer and more effective than long-term blood thinners for preventing strokes in people with atrial fibrillation. About 2,650 participants with AFib and high stroke risk are randomly as…

This study tests whether using a CPAP machine to treat sleep apnea shortly after an ischemic stroke can reduce the risk of another stroke, heart attack, or death within 6 months. It also looks at whether CPAP improves overall recovery and brain function. Over 3,000 participants a…

This study tests whether galcanezumab, a monthly injection, can prevent migraines in children and teens aged 6 to 17 with episodic migraine. Over 500 participants received either the drug or a placebo for 3 months. The goal is to see if the drug reduces the number of migraine day…

This study looks at whether giving steroids early to children who had a stroke from a condition called focal cerebral arteriopathy (FCA) can help reduce damage to the brain's arteries. About 80 children aged 1 to 18 will be randomly assigned to get steroids right away or only if …

This study is tracking 500 Italian adults with migraine to see how well the daily pill atogepant works in everyday life. Researchers will measure changes in monthly migraine days over a year. The goal is to find out if atogepant is a safe and effective preventive treatment for pe…

This phase 3 trial tests whether a drug called recombinant factor VIIa (rFVIIa), given within 2 hours of a bleeding stroke, can limit brain damage and improve recovery. About 860 adults aged 18–80 with spontaneous intracerebral hemorrhage are enrolled. The study compares rFVIIa t…

This study tests whether regular exercise and cognitive training, alone or together, can improve physical and mental function in adults aged 60+ who have had a stroke and also have high blood pressure or diabetes. Over 400 participants from five Chinese cities will take part in 1…

This study tests whether fenofibrate, a drug typically used to lower blood fats, can slow the worsening of diabetic retinopathy (eye damage) in adults with type 1 diabetes. Over 400 participants take either fenofibrate or a placebo daily for three years. The goal is to see if the…

This study tests a new device called SEAL™ that is placed inside a brain aneurysm to block blood flow and prevent rupture. About 279 adults with unruptured or recently ruptured aneurysms are taking part. The goal is to see if the device safely and effectively seals the aneurysm w…

This study tests whether carefully managing blood pressure during a clot-removal procedure for stroke can improve patient recovery. About 550 people having emergency clot retrieval will have their systolic blood pressure kept within a specific target range. Researchers will then …

This study tests whether high-intensity interval training (HIIT) on a stationary bike can improve heart rate variability—a key sign of recovery—in people who recently had a stroke. Fifty patients within three months of their first stroke will either do HIIT or low-intensity group…

This large trial tests whether a program led by village doctors can help control high blood pressure in rural China. Over 33,000 participants will receive training, discounted medications, and a simple treatment protocol. The study aims to see if this approach improves blood pres…

This Phase 2 trial tests whether the oral drug tonabersat can reduce retinal swelling in people with diabetic macular edema who still have good vision. About 128 adults with type 1 or 2 diabetes will take either tonabersat or a placebo daily for several months. The main goal is t…

This study tests whether giving the steroid methylprednisolone along with standard clot-removal treatment can lower the risk of death or severe disability in people who have had a major stroke. About 928 adults with a large blockage in a main brain artery will receive either the …

This study is checking how well a device called the GORE® CARDIOFORM Septal Occluder works and how safe it is for people who have had a stroke caused by a hole in the heart (PFO). Researchers will follow 300 patients in Japan for 12 months after the device is implanted. The goal …

This phase 2 study compares abelacimab, a new biologic blood thinner, to the standard drug rivaroxaban in 1,287 people with atrial fibrillation who are at moderate-to-high risk of stroke. The goal is to see if abelacimab causes fewer major or clinically relevant bleeding events w…

This study was designed to test a device called LAmbre Plus, which is implanted to seal off a small pouch in the heart where clots can form in people with atrial fibrillation. The goal was to see if it could safely prevent strokes in patients with large or irregularly shaped hear…

This early-stage trial tests whether a stimulant drug (methylphenidate, also known as Ritalin) given through an IV can safely help people with severe brain injuries regain consciousness. Ten adults in a coma or minimally conscious state will receive increasing doses to check for …

This study looks at whether stroke survivors can get effective arm rehabilitation at home using a device that stimulates the vagus nerve during therapy. About 50 people who already have the Vivistim implant will receive up to 36 hours of in-home therapy paired with nerve stimulat…

This study tests a healthy lifestyle program designed for people who have had a stroke. The program focuses on weight loss and increasing physical activity. Researchers will track 65 participants for 12 months to see if the program helps them achieve and maintain a healthier weig…

This study tests whether giving evolocumab, a powerful cholesterol-lowering drug, very early during a heart attack hospital stay can reduce the chance of another heart attack, stroke, or death. About 6,000 adults hospitalized for a heart attack are randomly assigned to receive ev…

This study tests a procedure that uses tiny coils to block blood flow in brain aneurysms (bulging blood vessels). The goal is to seal the aneurysm and prevent rupture. About 164 people with aneurysms 4-14mm in size are being followed for one year after treatment.

This study is testing the safety and effectiveness of a device called Silk Vista, used to treat brain aneurysms (a bulging blood vessel that can burst). Researchers are following 234 patients who already received the device as part of their normal care. The goal is to see how wel…

This early-phase trial tests whether injecting the chemotherapy drug melphalan directly into the eye's blood vessels can shrink large uveal melanomas (eye cancers) enough to then treat them with radiation. Ten adults with tumors at least 8 mm thick will receive the chemo injectio…

This study tests whether a video-based telehealth program, including an iPad and remote blood pressure monitoring, can help stroke survivors better control their blood pressure after leaving the hospital. The program also aims to reduce racial disparities in post-stroke care. Abo…

This pilot study tests whether temporarily raising blood pressure with drugs like phenylephrine or norepinephrine can reduce brain damage in people having a major stroke. About 40 adults with large-vessel blockage strokes will receive the blood pressure boost during standard clot…

This trial was designed to test a device called the CEREGLIDE 92 catheter, which aims to remove large blood clots from the brain in people having a severe stroke. The study planned to enroll patients with acute ischemic stroke and high disability scores. However, the trial was wi…

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder that can cause dangerous blood clots. Researchers want to know how often PNH appears in people under 50 who have had a stroke, mini-stroke, or brain vein clot with no clear cause. The study will screen 200 partici…

Researchers are testing whether an implanted loop recorder can detect atrial fibrillation in people who have had a stroke. The device continuously monitors heart rhythm for up to a year or longer. The pilot trial enrolls 24 patients across three centers to see if a larger study o…

Researchers are testing a noninvasive ultrasound method called ARFI to see if it can detect features of carotid plaque that raise stroke risk. The study includes adults with narrowed carotid arteries, some with symptoms and some without. By measuring plaque characteristics, the t…

After a traumatic brain injury, pressure can build inside the skull and cause serious harm. Doctors usually rely on a CT scan to spot this, but moving a critically ill patient to the scanner carries risks. This study tests two non-invasive ultrasound methods, transcranial Doppler…

Researchers are testing whether artificial intelligence can combine ultrasound images with routine health data to track changes in a person's physiology over time. The study enrolls adults with heart, lung, kidney, or blood vessel conditions, as well as healthy volunteers. The go…

This study tests a new device called nOCT that acts like a tiny camera on a flexible wire. It slides into brain blood vessels during standard aneurysm treatment to take detailed pictures of the vessel wall and any implanted coils or stents. The goal is to see if these images help…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study uses special brain scans (PET imaging) to measure amyloid buildup—a protein linked to Alzheimer's—in healthy older adults, people with mild memory problems, and those with dementia. Participants receive scans every 2-3 years for up to 20 years to see how amyloid change…

This study evaluates RDX-Aneurysm, a computer-assisted detection software designed to help radiologists find saccular intracranial aneurysms (bulging blood vessels in the brain) on MRI scans. Researchers will analyze 550 past scans—half with confirmed aneurysms and half without—t…

This study tests a laser-based imaging method that shows blood flow in the brain in real time during surgery. It involves 20 adults having brain surgery for conditions like aneurysms. The goal is to see if this technique can give surgeons continuous feedback, unlike the current d…

This study looks at CT scans of the heart from 22,000 people who had chest pain. Researchers want to see if certain features of plaque (fatty deposits) in the heart arteries can help predict who will later have a heart attack, stroke, or die from heart disease. The goal is to imp…

This study looks at better ways to find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 337 participants will use either a wearable patch for 72 hours or a handheld device three times a day to monitor their heart rhythm. The goal is to s…

This study tests whether using artificial intelligence (AI) to screen for diabetic eye disease during regular primary care visits helps more people get timely eye exams and follow-up care. About 1,700 adults with diabetes who haven't had an eye exam in the past year will take par…

This study aimed to see if a handheld device called CPMX3 could safely estimate brain pressure in children by measuring pressure in a forehead vein. It planned to compare these readings with standard invasive measurements in children aged 8 to 21 who already had brain pressure mo…

This study tests whether a water-resistant, wireless ECG patch worn for 7 days can detect more cases of hidden atrial fibrillation (a heart rhythm problem that raises stroke risk) than the usual 24-hour Holter monitor. Researchers will enroll 320 adults who recently had a stroke …

This study is testing whether monthly 12-lead ECG screenings at family health centers can detect undiagnosed atrial fibrillation (AF) in adults aged 65 and older. Participants will have 12 monthly visits over a year, and if AF is found, they will be started on blood thinners to r…

This study is testing whether an artificial intelligence (AI) program can spot early signs of diabetic retinopathy—a condition that can lead to blindness—in people with prediabetes and diabetes. Researchers will take pictures of the retina and use the AI to analyze them. The goal…

This study tests whether an AI program can find unruptured brain aneurysms on standard CT scans that people already get for other reasons. Ten adults with risk factors (like high blood pressure or being over 40) will have their scans checked by AI and then by a radiologist. The g…

This study tests whether using artificial intelligence (AI) to screen for diabetic retinopathy is faster and more accessible than the usual method with an eye doctor. About 548 adults with diabetes will be randomly assigned to either standard screening or AI-based screening using…

This study is testing whether a new risk score can help find people who have atrial fibrillation (an irregular heartbeat) but don't know it yet. About 1,955 adults at higher risk will use a remote ECG monitor at home. The goal is to see if the risk score correctly identifies who …

Antiphospholipid syndrome (APS) raises the risk of blood clots and strokes, and doctors often prescribe warfarin to prevent another stroke. Warfarin requires frequent blood tests and carries bleeding risks, especially for younger patients. This trial compares clopidogrel-based an…

This study tests a new medication called IPN10200, given as injections into the head and neck muscles, to prevent migraines in adults. About 641 people with episodic or chronic migraine will receive either the drug or a placebo. The goal is to see if it safely reduces the number …

This phase 3 study tests whether Dysport (a botulinum toxin type A) injections can prevent episodic migraine in adults. About 751 participants receive either Dysport or placebo injections every 12 weeks for up to 36 weeks. The goal is to see if the treatment reduces the number of…

This study tests a new medicine called atogepant to prevent migraines that happen around a woman's period. About 430 adult women with regular cycles and a history of migraines will take either atogepant or a placebo daily for 3 menstrual cycles. The goal is to see if the drug red…

This large Phase 3 study tests whether inclisiran, a twice-yearly injection, can prevent major heart problems like heart attacks, strokes, and heart-related death in people at high risk who have not yet had such an event. Over 14,000 participants are receiving either inclisiran o…

This trial tests whether intensive heart rhythm monitoring after a stroke can prevent another stroke. People who have had a stroke may have atrial fibrillation, a heart rhythm problem that comes and goes and is easy to miss. Researchers compare standard care with extra monitoring…

This trial asks whether hydroxyurea, a daily oral medication, can reduce the risk of a first stroke in children with sickle cell anemia. Researchers will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brain, a key indicator of stroke risk, in children aged…

This trial is testing a device called the Vine™ Embolic Protection System, which is implanted in the carotid arteries to trap blood clots before they travel to the brain. It is designed for people with atrial fibrillation who are already taking blood thinners but still have a hig…

This study tests whether a music-inspired community campaign, called Music4Health, can help lower blood pressure and improve stroke awareness among 1,412 youth (ages 14-24) and their caregivers (ages 40+) in Nigeria. Participants will take part in listening sessions and activitie…

This study looks at whether clopidogrel, a blood thinner, can prevent new silent brain infarctions (small, unnoticed strokes) in people who recently had a stroke or mini-stroke. Researchers will track 134 participants over 24 months using MRI scans and cognitive tests. The goal i…

This trial tests whether a combination of lifestyle interventions—brain training, yoga, music therapy, and a special diet—can slow or reverse early signs of neurological disorders like dementia, stroke, epilepsy, and Parkinson's disease. Participants are healthy adults aged 50 an…

This study tests whether fenofibrate, a drug already used for high cholesterol, can prevent diabetic retinopathy from worsening in people with mild to moderate disease. About 560 adults with diabetes will take either fenofibrate or a placebo for up to 6 years. The goal is to see …

This study tests whether following the MIND diet for 2 to 3 years can slow cognitive decline and reduce dementia risk in people aged 55 and older who have had an ischemic stroke. The MIND diet combines elements of the Mediterranean and DASH diets, with extra emphasis on leafy gre…

This pilot study tests a personalized lifestyle program for young adults (18-65) who have had a stroke or high-risk mini-stroke. The program includes intensive counseling on diet, exercise, and smoking, plus a wearable device to track health. Researchers want to see if this appro…

This study tests whether closing a small pouch in the heart (the left atrial appendage) during heart surgery can prevent strokes and blood clots. About 6,500 adults at risk for atrial fibrillation and stroke are taking part. The goal is to see if this simple addition to surgery i…

This study tests whether collecting sexual health information electronically during routine gynecologic visits can increase the use of PrEP, a medication that prevents HIV. About 1,170 women aged 15-65 who are not living with HIV will participate. The goal is to see if this appro…

This study tests whether closing the left atrial appendage—a small sac in the heart where blood clots often form—during planned heart surgery can prevent strokes in people with atrial fibrillation. About 1500 patients having coronary bypass or valve surgery are included. The goal…

This phase 3 trial tests whether adding regular, personalized exercise to standard medical care can prevent new strokes in 1300 people with symptomatic intracranial arterial stenosis (narrowed arteries in the brain). Participants are randomly assigned to either standard care or s…

This study tests a small device called Cerogrin that gently stimulates a nerve in the ear, aiming to improve thinking and memory in people with vascular dementia or mild cognitive impairment. Twenty-four participants will use the device at home for 30 minutes daily over four week…

This study is testing a digital care program for adults with migraine. The program includes a wearable device that uses nerve stimulation, personalized exercises, and support from a care team. The goal is to see if it can reduce the number of migraine days per month. About 140 pe…

Researchers are testing whether manual vagus nerve stimulation, a hands-on technique that targets the vagus nerve without surgery or electrical devices, can improve movement, autonomic function and thinking skills in people who had a stroke at least six months earlier. Participan…

This study tests a new program called PA-ChatS that helps people increase physical activity in the first 6 weeks after a stroke. Participants wear a Fitbit to track steps and have weekly phone meetings with an occupational therapist for 6 weeks. The study includes 25 stroke survi…

Researchers are testing whether adding glenzocimab to standard endovascular therapy improves recovery in adults with acute ischemic stroke caused by a large blocked vessel and a large area of brain damage. Participants receive either glenzocimab or a placebo as an intravenous inf…

This study tests whether taking vitamin K2 supplements for one year can improve muscle strength and brain function in people who recently had an ischemic stroke. 190 participants will receive either vitamin K2 or a placebo daily. Researchers will measure handgrip strength and oth…

This pilot study is testing whether memantine, a drug already used for Alzheimer's, can improve arm and leg function after an ischemic stroke. Twenty participants with arm weakness will receive either memantine or a placebo for several weeks. The study measures motor skills and t…

This pilot study tests a freezing technique called cryoneurolysis to see if it can ease pain in adults with chronic migraine—a condition causing frequent, severe headaches. Participants will track their headaches in a diary for at least a month before treatment, then receive the …

This trial tests whether a high-intensity breathing exercise program, started within days of an acute stroke, can strengthen the muscles used for breathing and speech. Hospitalized stroke patients will be randomly assigned to either this new training or conventional diaphragmatic…

This trial investigates whether adding focused shock wave therapy to standard Botox injections can better ease foot stiffness and improve walking in people with post-stroke spastic equinovarus foot. Participants are randomly assigned to receive Botox alone, shock waves just befor…

This study tests a new exercise therapy called Progressive Abduction Loading Therapy for people who recently had a stroke. The goal is to reduce a common arm problem called 'flexion synergy' that makes it hard to reach outward. 86 participants will receive either the new therapy …

This trial explores whether an affordable robot can help people with HIV who have had a stroke improve their arm and leg function. Participants will use the robot for rehabilitation exercises, and researchers will measure changes in movement, balance, and quality of life. The goa…

This trial explores whether five daily sessions of a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce fatigue in people who have had a stroke. Participants will receive either real or sham stimulation, and their fatigue levels wi…

This study tests whether combining virtual reality games with physical therapy can reduce chronic pain in children aged 7 to 21. Twenty participants with pain in the head, neck, or upper limbs will attend six weekly sessions. They will play VR games designed to encourage movement…

This study tests whether a mindfulness-based program (MBCT) delivered by phone or video can help people with migraines and depressive symptoms. About 145 adults with 4-20 headache days per month and mild to moderate depression will be randomly assigned to phone, video, or usual c…

This study investigates whether keeping a headache diary helps adults with migraine feel better and manage their condition. Participants track their headaches in a virtual diary, and researchers measure changes in quality of life and disability. The goal is to see if this low-cos…

This study tests whether adding home-based telerehabilitation via WhatsApp video calls to standard outpatient therapy improves hand function in people who had a stroke 1-6 months ago. Forty-eight participants will be split into two groups: one gets standard therapy plus daily 30-…

This study tests whether combining neuromuscular electrical stimulation (NEMS) with voluntary muscle contraction can improve ankle function in people with chronic stroke. Twenty-five participants will either receive conventional physiotherapy or NEMS plus active dorsiflexion exer…

This study tests a device called GaitBetter that combines treadmill walking with cognitive training (like thinking tasks) to help stroke survivors improve their walking and balance. About 76 people who had a stroke (either within 8 weeks or more than 6 months ago) will use the de…

This early study tests a new device called PRIMUS that stimulates nerves in the head and face to treat chronic migraine. Only 7 people with hard-to-treat migraines are taking part. The main goal is to see if the device is safe, not yet if it works.

This study explores whether dry needling — a technique where thin needles are inserted into tight muscles to trigger a twitch — can reduce spasticity (stiffness) in people who have had a stroke. Researchers will measure changes in nerve pathways and movement over two visits. The …

This study compares two types of exercise—open kinetic chain (like leg raises) and closed kinetic chain (like squats)—to see which better reduces knee hyperextension in stroke survivors. Sixty adults who have had a stroke and can walk with some help will be randomly assigned to o…

This study explores whether joining a weekly reading group can improve reading comprehension and communication confidence in adults with aphasia, a language disorder often caused by stroke. Participants read a book at home and then discuss it in a 90-minute group session each wee…

This study tests a short, high-dose form of brain stimulation called repetitive transcranial magnetic stimulation (rTMS) in 20 people who had a stroke at least 6 months ago. The goal is to see if it is safe and acceptable, and whether it can improve cognitive problems like memory…

This study tests two different movement training methods—sprinter-style and skater-style—to see which better improves balance and coordination in people who had a stroke at least six months ago. Twenty-two participants will do 30-minute sessions three times a week for four weeks.…

This study looks at whether a 60-day nerve stimulation device placed near the back of the head can help people with stubborn headaches. Researchers will track pain levels, daily function, and how often participants need emergency care. About 300 adults with various headache types…

This study looks at whether an 8-week mindfulness course can help people who had a stroke at least 6 months ago. About 28 participants will take the course either right away or after a wait. The goal is to see if the course is practical and if it improves emotional well-being and…

This study compares two types of hand and arm therapy for people who had a stroke 3 to 6 months ago. One therapy involves restraining the good arm to force use of the affected arm, while the other focuses on using both arms together. Both groups also receive standard physical the…

This study compares two treatments—Functional Electrical Stimulation (FES) and Whole Body Vibration Training (WBVT)—to see which better improves leg control, balance, and daily activities in people who had a stroke 6 months to 1 year ago. Thirty-four adults aged 35 to 70 will rec…

This study compares two physical therapy approaches—Rood's techniques (using touch, stretch, and ice) and PNF patterns (diagonal movements)—to improve arm and hand function in people who recently had a stroke. 28 adults aged 40-60 with a first-time stroke will receive one of the …

This study compares two physical therapy techniques—PNF and NDT—to see which better helps stroke survivors improve trunk control and balance. It will involve 32 people aged 40-65 who have had a recent stroke. Participants will receive electrical stimulation plus one of the two th…

This study tests whether a special arm brace that reads muscle signals can help stroke survivors with severe arm weakness recover better during early rehabilitation. Three veterans who had a stroke within the past 6 months will use the device alongside standard therapy. The goal …

This study compares two rehabilitation methods—somatosensory stimulation (using touch) and task-based mirror therapy (using a mirror to trick the brain)—to see which better improves arm and hand function in stroke survivors. About 24 adults who had a stroke 1 to 6 months ago will…

This study tests whether combining gentle touch stimulation with nerve exercises can improve arm movement and feeling in people who had a stroke 6-12 months ago. 53 adults aged 45-65 with lasting arm weakness and sensory loss are participating. The goal is to see if this therapy …

This study compares two types of exercise programs to see which one better improves balance and leg movement in people who have had a stroke. The study includes 52 adults aged 45 to 65 who had a stroke 6 to 10 months ago and have mild to moderate leg weakness. Participants will d…

This study looks at whether a treatment called pulsed radiofrequency (PRF) on a nerve at the back of the head can help people with migraines. Researchers measured pain sensitivity and disability in 100 adults before and up to 3 months after the procedure. The goal is to see if th…

This study tests whether exercising both legs together (bilateral training) or just the affected leg (unilateral training) with visual feedback from mirrors and floor targets works better for improving balance, walking, and sensation in people who had a stroke. Fifty participants…

This small study tests whether a four-session program combining music and nature activities can improve wellbeing for people with acquired brain injuries and their care partners. Ten adult participants will complete surveys before and after the program. The goal is to see if this…

This study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can improve speech recovery in people with aphasia after stroke or brain injury. Twelve adults with apraxia of speech will receive either active or sham stimulation during 16 wee…

This study planned to test whether an augmented reality (AR) app called Reia could help stroke survivors with arm weakness do rehab exercises at home. Participants would have used an AR headset for daily 30-minute sessions over 8 weeks, with weekly video check-ins from a therapis…

This study is testing a new device that uses gentle vibrations on the belly, back, or temples to help people with chronic pain conditions like pelvic pain, abdominal pain, low back pain, or migraine. About 50 adults will try the real device or a placebo to see if it safely reduce…

This early study tests the safety of a new device called PRIMUS that uses mild electrical pulses on nerves in the forehead and back of the head to treat chronic cluster headache. Five people with frequent, hard-to-treat attacks will be enrolled. The goal is to see if the device i…

This study compares a new numbing gel (chloroprocaine HCl 3%) to standard eye drops plus a shot for pain relief during eye injections. About 236 adults with conditions like diabetic macular edema or age-related macular degeneration will take part. The goal is to see if the gel wo…

This study tests whether a program combining exercise, healthy eating advice, and education about migraine can reduce the number of attacks in people with frequent or chronic migraines. About 140 adults who are not very active will take part. The goal is to see if lifestyle chang…

This study tests an online program called Migraine Manager for teens aged 11 to 17 with frequent migraines (8 or more per month). The tool gives personalized tips on healthy habits like drinking water, eating regularly, exercising, and sleeping well. Researchers will compare 80 t…

This study was designed to see whether the drug amitriptyline or lifestyle changes work better for people with vestibular migraine, a condition that causes dizziness and headache. The plan was to randomly assign adults with definite vestibular migraine to one of the two treatment…

This study tests whether inhaling lavender, peppermint, or a mix of both can change how sensitive people with migraine are to pressure pain. Two hundred adults with migraine will inhale one of the oils or a control solution for 15 minutes. Researchers measure pain thresholds befo…

This study tests whether vibrating the tendons, combined with robotic arm training, can improve arm and hand movement in people who had a stroke at least 6 months ago. 40 participants will receive the therapy, and researchers will measure changes in motor function and body awaren…

This pilot study tested three different strengths of inhaled cannabis (2.5%, 5%, and 10% THC) against a placebo to see if they could quickly relieve migraine headaches. Twenty adults with migraine took part in a crossover design, meaning each person tried all options. The main go…

This study tests whether adding an interactive screen (MYRO) to standard therapy helps people who had a stroke and have trouble paying attention to one side of their world (left neglect). About 30 adults with a recent stroke will be split into two groups: one gets standard therap…

This study tests whether a mild electrical current applied to the brain (tDCS) during speech therapy can improve language recovery in people with aphasia after a stroke. Two hundred adults with language problems from left-brain damage will receive either real or fake stimulation …

This study planned to test whether a soft robotic exosuit worn on the ankle could help stroke survivors walk better. Participants would have done high-intensity gait training with or without the exosuit. The goal was to see if the suit could improve walking distance and speed. Ho…

This study tests a set of virtual reality exergames in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. 25 participants will try games like virtual cooking an…

This study was designed to compare a tiny steroid insert (Dextenza) placed in the tear duct against standard steroid eye drops (prednisolone) after cataract surgery in people with diabetes. The goal was to see which better controls eye inflammation and swelling. However, the stud…

This study tests whether adding a mild electrical stimulation to the neck muscles can help people who recently had a stroke and now have trouble swallowing. Forty participants will receive either standard swallowing therapy or therapy plus electrical stimulation. The goal is to s…

This study tests whether a virtual reality (VR) headset can help people who have had a stroke improve arm movement. Eighteen adults in Ethiopia will use the VR system for nine sessions over three weeks. Researchers will measure how usable and comfortable the system is, and also c…

This study tests whether combining a gentle brain-stimulation technique (transcranial direct current stimulation) with core stability exercises can improve trunk control, balance, and walking ability in people who have had a stroke. Sixty participants aged 55 and older who had a …

This study tests a remotely delivered 8-week program called ReStoreD for couples where one partner has had a stroke. The program teaches goal-setting, communication, and positive thinking skills to reduce anxiety and depression. Researchers will enroll 400 couples to see if the p…

This study tests whether using a robotic exoskeleton for arm exercises helps people who had a stroke recover arm function better than standard therapy. About 70 adults with moderate to severe arm weakness within 90 days of their first stroke will participate. The goal is to see i…

This study looks at whether acupuncture can reduce migraine pain and lower signs of inflammation and brain stress in the blood. Researchers will compare three types of gentle stimulation: laser, electro, and traditional acupuncture. 75 adults with migraines will receive treatment…

This study planned to test a combination of naltrexone and acetaminophen for treating migraine attacks. It was designed in two stages: first comparing the combo to each drug alone and placebo, then finding the best dose. However, the trial was withdrawn before any participants we…

This pilot study explores whether fine motor hand exercises can help improve swallowing problems in older adults who recently had a stroke. Researchers believe that activating the hand and mouth areas of the brain together may boost recovery. The study involves 30 participants an…

This study tests whether a high-dose, intensive therapy program can improve arm movement and quality of life in people who had a stroke at least 6 months ago. Nine participants will receive 6 hours of therapy per day, 5 days a week, for 3 weeks, including occupational and physica…

Researchers are running an international registry to follow adults who had an ischemic stroke or transient ischemic attack and also have a patent foramen ovale, a small opening between the upper chambers of the heart. The registry collects real-world information on how these pati…

Researchers are comparing two ways of finding atrial fibrillation in people who have had an ischemic stroke or a transient ischemic attack (TIA). One method uses a standard electrocardiogram (ECG) in the hospital, and the other uses a prolonged cardiac monitor worn for a longer p…

Researchers at Semmelweis University are studying whether bacteria that cause gum disease also show up in damaged blood vessels. They will compare samples from the mouth and from diseased artery sites in 100 people who need surgery for aortic aneurysm or carotid artery narrowing.…

This study tests a new computer-based visual training task for people who have lost part of their vision due to a stroke. Participants watch moving patterns on a screen and learn to detect motion direction, with the goal of improving visual abilities. The study first checks if th…

This long-term study follows over 3,700 adults in Baltimore to understand why some people age healthier than others. Researchers are looking at how race, income, and neighborhood affect risks for diseases like diabetes, heart disease, and memory loss. Participants visit mobile he…

This study looks at whether having physical therapy (PT) and occupational therapy (OT) together in one session works as well as having them separately for stroke patients in the hospital. About 567 adults admitted for acute stroke will be randomly assigned to either co-treatment …

Researchers at Chungnam National University Hospital are studying blood and cerebrospinal fluid from adults who had an out-of-hospital cardiac arrest and received post-resuscitation care. The goal is to map molecular changes over time and see how they relate to the severity of br…

Researchers in Finland are surveying about 2,000 adults who were treated for a stroke between 2020 and 2022 in two regions. The postal questionnaire asks about health, daily functioning, work and income, social inclusion, and experiences with social and health services. The goal …

This study looks at how common strokes and silent brain injuries are in young adults (ages 16-25) with sickle cell anemia, especially in Nigeria where the disease is widespread. Researchers will use brain scans and blood tests to check for damage and identify risk factors like hi…

This study looks at how often nurses should check on people in the ICU after they have had a brain aneurysm treated. The goal is to see if checking every hour versus every two hours affects how well patients sleep. Thirty adults who had a planned aneurysm coiling will take part, …

This study follows over 1,000 adults who had their first stroke to see how many develop spasticity—a condition where muscles become stiff or rigid—within the first year. Researchers will monitor participants and create a best-practice guide for doctors to spot and treat this comm…

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study looks at whether tiny RNA particles called exosomal microRNAs in the blood can act as a 'stroke clock' for people with a severe type of stroke caused by a blocked large artery in the front of the brain. Researchers will compare blood samples from stroke patients to hea…

This study tests whether artificial intelligence can accurately predict how patients recover after an ischemic stroke. Researchers will enroll 1000 adults from three European hospitals and use standard hospital data plus remote monitoring via a mobile app to train AI models. The …

This study follows 120 stroke survivors for six months, using brain scans and movement tests to understand why some people develop arm stiffness and weakness. Researchers hope to find early signs that predict recovery, which could guide future rehabilitation. Participants must ha…

This study is collecting long-term, real-world data from about 6,000 adults being treated with Roche eye medications (Faricimab or the Port Delivery System with Ranibizumab) for conditions like wet age-related macular degeneration and diabetic macular edema. The goal is to unders…

This study looks at over 3,400 newborns who are not vigorous at birth (between 35 and 42 weeks). Doctors want to see if milking the umbilical cord (pushing blood into the baby) before clamping it leads to fewer cases of brain injury or death compared to clamping the cord right aw…

This 5-year study follows 250 people with von Hippel-Lindau disease who have brain or spinal cord tumors. Researchers use regular MRI scans and blood tests to see how fast tumors grow and what factors like hormones might affect growth. The goal is to better understand which tumor…

This study will use artificial intelligence (AI) to analyze eye scans from 554 adults with diabetic macular edema (DME). The goal is to see if AI can predict when a person's eye treatment needs to change. Participants will not receive any new treatment; instead, researchers will …

This study aims to find biological markers (biosignatures) in people with ALS and FTD to make diagnosis more precise. Researchers will analyze samples like spinal fluid, skin, and tears from 230 participants using advanced techniques. The goal is to create a 'disease fingerprint'…

This pilot study tests whether automated, personalized coping messages can help stroke survivors increase their physical activity. Researchers will enroll 50 adults who had a stroke 3 months to 3 years ago and can walk without help. The main goal is to see if the program is pract…

This study is testing whether a device that gently stimulates a nerve in the ear is safe and tolerable for healthy children. Ten children will receive a single 30-minute session while their heart rate, oxygen levels, and brain waves are monitored. The goal is to learn how the sti…

This study looks at whether the migraine medication rimegepant is safe to take during pregnancy. Researchers will compare pregnancy outcomes in women who took rimegepant to those who did not. The study includes women aged 16 to 49 with migraine. However, only one person has been …

This study follows adults hospitalized with hemorrhagic stroke to see how procalcitonin, a blood marker, changes over the first few days. The goal is to determine if procalcitonin can help doctors tell whether a fever is due to a bacterial infection or another cause, potentially …

This study follows 5,000 people who recently had an ischemic stroke or a high-risk transient ischemic attack (TIA, often called a mini-stroke). The goal is to see how well standard post-stroke care works in the real world and to track patients' health and quality of life for up t…

This study is a long-term follow-up for 100 people who completed a previous trial of bel-sar, an experimental treatment for early choroidal melanoma (a type of eye cancer). Participants will not receive any new treatment but will be monitored for about 5 more years to check for s…

This study looks at children who had hypoxic-ischemic encephalopathy (HIE) at birth, a condition caused by lack of oxygen to the brain. Researchers want to see if combining MRI scans taken shortly after birth with scans taken at school age can better predict cognitive outcomes li…

This study follows 500 adults under 45 who have narrowing of a major brain artery, a condition that can raise stroke risk. Researchers will track participants over time to see how the narrowing progresses and who goes on to have a stroke. The goal is to better understand the natu…

This study follows 46 people with gyrate atrophy, a rare genetic condition that causes vision loss, over 4 years. Researchers measure ornithine levels in the blood and track changes in the retina using eye scans and photos. The goal is to learn how the disease progresses under st…

This study follows 800 adults who have had their first ischemic stroke in Central Norway for up to 10 years. Researchers will track how physical activity, medication use, and control of blood pressure and cholesterol affect the risk of death, another stroke, or severe disability.…

This trial tests whether a treadmill that automatically adjusts its speed to the walker can help people with weakness on one side of the body take more even steps. Participants with hemiparesis from a stroke or traumatic brain injury will walk on both a self-pacing and a fixed-pa…

This study looks at whether data from wearable devices like smartwatches can track and even predict migraine headaches. Twenty adults with chronic migraine will use a phone app and a smart device to record heart rate and movement. The goal is to see if this information can help f…

This study investigates whether people with neurodegenerative diseases—like Alzheimer's, Parkinson's, or ALS—show changes in behavior, social circumstances, or health before and after their diagnosis. Researchers will compare the records of over 61,000 patients with those of matc…

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study tested a new MRI method to better predict stroke risk in people with intracranial atherosclerosis, a condition where arteries in the brain become narrowed. Researchers measured how well different parts of the brain responded to changes in blood flow. The goal was to fi…

This study looks at whether stroke patients who do high-intensity rehab at home recover just as well as those who go to a rehab facility. Researchers will follow 500 patients who choose home rehab and compare their progress to patients who went to inpatient rehab. The goal is to …

This study tests whether everyday rehabilitation therapy sessions can be recorded and measured more objectively using wrist-worn sensors, a video camera, and an audio recorder. Adults with neurological conditions like stroke, Parkinson's disease, or spinal cord injury will wear t…

This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fa…

This study tests whether a new scoring system, called PRO-ICH, can accurately predict how well people will recover after a spontaneous brain hemorrhage. Researchers will also check if adding certain blood markers improves the score's accuracy. The goal is to give doctors a reliab…

This study tests whether pairing vagus nerve stimulation (VNS) with language training can improve memory and learning in people who have already used VNS for movement recovery after a stroke. Participants, who already have a VNS implant, will try learning a new language while the…

This long-term study follows over 121,000 female nurses to explore how hormones, diet, lifestyle, and genetics affect the risk of heart disease and stroke. Researchers are analyzing blood samples to create a 'metabolomic risk score' that could help predict coronary heart disease.…

This study looks at how short bursts of aerobic exercise affect brain function in older adults and stroke survivors. Researchers will compare three groups: one doing moderate cycling to raise lactate levels, one doing light cycling, and one receiving health education only. Partic…

This observational study looks at how inserting a central venous catheter into the neck affects pressure inside the skull in patients with acute brain injury. Researchers will monitor brain pressure, blood flow, and oxygen levels during and after the procedure in about 120 ICU pa…

This study uses a non-invasive eye scan called OCTA to examine tiny blood vessels in the retina of adults with type 1 diabetes. The goal is to detect early signs of diabetic retinopathy, a leading cause of vision loss, before symptoms appear. Researchers will measure vessel densi…

This study investigates how people physically interact with each other during tasks like collaboration, competition, and cooperation. The goal is to design robot controllers that mimic these human behaviors, which could then be used in devices like exoskeletons to improve motor l…

This study investigates how the brain coordinates muscle activity during walking rehabilitation in people recovering from a stroke. Researchers use high-density electromyography (HD-EMG) to track neural synergies—groups of muscles that receive common signals from the brain—over t…

This study examines how ankle impairments affect walking ability in people who had a stroke at least six months ago. Researchers use a robotic device to measure ankle control and sensation, comparing results with standard walking tests and clinical scales. The goal is to develop …

This study explores how sex hormones (like testosterone and estrogen) during puberty relate to migraine pain and sensitivity in adolescents aged 11-15. Researchers will test pain responses and track migraine disability in 100 teens with and without migraines. The goal is to bette…

This study looks at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. Participants have mild memory concerns or are at risk for cognitive decline.…

This study uses a new, child-friendly brain imaging technique called OPM-MEG to understand how immune-related brain diseases (like autoimmune encephalitis and multiple sclerosis) and other brain conditions affect children aged 2 to 25. Standard scans often miss problems with memo…

This study follows 250 people who had a type of stroke called intracerebral hemorrhage (ICH) to understand why some experience progressive cognitive decline. Participants undergo advanced brain scans and tests of thinking and movement at 12–24 months after their stroke, with foll…

This trial investigates whether measuring high-sensitive troponin, a protein released during heart injury, can predict heart complications in people undergoing surgery to open a narrowed carotid artery. About 527 participants will have their troponin levels checked before and aft…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study tests whether a newer, less invasive heart-lung machine (MiECC) reduces brain swelling and stroke risk compared to the standard machine used during open heart surgery. Researchers will measure optic nerve sheath diameter (a marker of brain pressure) and track strokes o…

This observational study tracks 5,000 people taking common blood thinners (like rivaroxaban or apixaban) or antiplatelet drugs (like aspirin). Researchers regularly measure drug levels in the blood to see how they relate to clots or bleeding events. The goal is to find the best d…

This study follows 214 men treated for prostate cancer to see how many develop lower limb lymphedema (leg swelling) and who is most at risk. Participants attend check-ups every three months for 18 months. The goal is to better understand this side effect and its impact on quality…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This study follows 350 people who survived a brain bleed (intracerebral hemorrhage) and were part of earlier trials. Researchers will test memory, thinking, and movement skills over time, and collect blood samples to look for signs of ongoing inflammation. The goal is to see if s…

This study looks at 1,000 patients on blood thinners who had a minor head injury and a normal first CT scan. Researchers want to see if a second CT scan 24 hours later finds any delayed brain bleeding. The goal is to understand whether the extra scan is needed and how often it le…

This study looks for tiny plastic particles in brain tissue removed during surgery for spontaneous bleeding. Researchers will test if these plastics are linked to more inflammation and worse recovery in 150 patients. No new treatment is given; the goal is to understand if environ…

This study aims to help adults aged 40 and older in Upper Manhattan get better eye care. It will offer free eye screenings at local health centers and senior centers, and provide support like scheduling appointments and transportation. The goal is to see if this extra help leads …

This study follows up with people who took part in the CREST-2 trial to see how well treatments for carotid artery narrowing work over the long term. It includes about 2,480 participants who had either surgery, stenting, or intensive medical management. The main goal is to track …

This study looks at whether having a rehabilitation doctor see stroke patients early in their hospital stay can shorten how long they stay and reduce the chance of coming back. Researchers are tracking 3,000 stroke patients to see if this coordinated care approach improves recove…

This study looks at why people with antiphospholipid syndrome (APS) — a condition that raises blood clot risk — may have narrowed brain arteries. Researchers will use advanced MRI scans on 60 APS patients to check for artery narrowing and plaque buildup. The goal is to better und…

This registry follows 63 patients with choroidal melanoma or early eye lesions who were treated with the experimental drug bel-sar in earlier studies. The goal is to monitor long-term safety, side effects, and any spread of the disease over time. Participants are not receiving ne…

This study looks at how newer diabetes medications (SGLT2 inhibitors and GLP-1 receptor agonists) affect the eyes of people with type 2 diabetes. Researchers will monitor 40 adults who take metformin and are starting these newer drugs. The goal is to see if these drugs cause any …

This study looks at whether brain scans can help predict which people with migraine will respond to a class of drugs called CGRP antibodies. Researchers used MRI to measure brain structure, activity, and blood flow in 219 adults with frequent migraine before and after 12 weeks of…

This study uses brain scans to see how the brainstem and other brain areas respond to mild electrical pulses on the face and arm in 40 healthy volunteers. The goal is to better understand the brain circuits involved in facial pain and touch, which could help future research on mi…

This study looks at whether a program called I-SITE can help rural health clinics use teleophthalmology (remote eye exams) to screen more diabetic patients for eye problems. Up to 10 health systems and 10,000 patients will take part. The goal is to see if screening rates improve …

This study looks at 45 people having carotid artery surgery to see if special brain scans can predict improvements in thinking and memory. Researchers will use PET/CT scans to measure inflammation in the brain and MRI to examine plaque in the carotid artery. The goal is to find i…

This study collects movement data from 250 people with stroke, Parkinson's disease, or leg amputations using wearable sensors and video. The goal is to build an online database that researchers can use to study how people move and recover. No treatments are being tested—this is p…

This study looks at whether blood flow restriction training (using tight bands on the legs during exercise) can improve walking in people who had a stroke at least 6 months ago. 40 participants, aged 40-65 with mild leg stiffness, will do resistance exercises with or without bloo…

This study follows 250 adults in the UK who already use rimegepant for migraine attacks. Over 12 weeks, they report how quickly the drug eases pain and other symptoms. The goal is to see how consistently rimegepant works in everyday life.

Most stroke survivors struggle to stay physically active after rehab, raising their risk of another stroke. This study works with survivors, carers, and staff to design a program that supports long-term activity. 34 participants will help shape and test the program.

This study looks at whether MRI or CT should be the first scan for people with suspected acute ischemic stroke. Researchers will track how often doctors follow the assigned scan type and compare outcomes. The goal is to see if a larger study comparing these imaging methods is pos…

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study follows over 2,400 adults in Korea who have had their first stroke. Researchers will track their recovery, daily activities, and quality of life for 10 years. The goal is to learn what factors help or hinder long-term recovery after a stroke.

This study looks at two different blood pressure goals for adults who just had brain tumor surgery. Half the patients will have a target of less than 160 mmHg, the other half less than 140 mmHg. Researchers want to see which group leaves the hospital sooner, without more bleeding…

This study reviewed the medical records of 2500 people who received hyperbaric oxygen therapy (HBOT) for conditions like traumatic brain injury, stroke, fibromyalgia, or age-related decline. Researchers compared computerized thinking and memory tests taken before and after treatm…

This study is creating a simple test to check if people with Alzheimer's or similar conditions can understand and agree to medical decisions. Researchers will work with 100-150 participants to compare the new test with existing methods and look at brain scans and blood markers. T…

This study was designed to see how changing the head position affects pressure inside the skull in people who had a brain bleed from a burst aneurysm. It planned to monitor adults with a pressure monitor already in place. However, the study was withdrawn before enrolling anyone, …

This study looks at how activating muscles changes the way people who have had a stroke perceive touch. Researchers will measure the smallest electrical pulse that can be felt on the fingertips while muscles are at rest and while they are active. The goal is to better understand …

This study tests whether watching storytelling videos can help African American and Black patients with atrial fibrillation (an irregular heartbeat) start and continue taking blood thinners to prevent strokes. About 80 adults who are not currently on blood thinners but have a hig…

This study looks at 20 adults who had a stroke within the past week. Each person will get both a CT scan and a PET scan of the brain to see which method better shows blood flow and metabolism. The goal is to find the best way to image stroke damage, not to test a new treatment.

This study looks at how social factors like income, education, and lifestyle might influence the risk of a brain aneurysm bursting. Researchers will analyze data from 1,800 patients using artificial intelligence to find patterns. The goal is to improve risk prediction and help pr…

This study looks at whether stopping overnight neurological checks in stroke patients can help prevent delirium, a common and serious complication. Researchers will compare patients who continue standard overnight checks with those who have them stopped, measuring rates of deliri…

This study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal to protect the brain. About 728 adults on ventil…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study was designed to track hidden symptoms like memory or concentration problems in people recovering from a brain bleed (subarachnoid hemorrhage). Researchers planned to follow patients for one year using questionnaires to see how these symptoms affected daily life and ret…

This study compares 120 adults with primary headaches (migraine or tension-type) to healthy individuals. Researchers will measure tenderness in head and neck muscles and general pain sensitivity elsewhere in the body. The goal is to understand how these factors relate to headache…

This study follows 1,000 stroke survivors and their caregivers to understand how social factors and discrimination affect recovery. Researchers will survey participants over time to measure outcomes like quality of life and caregiver strain. The goal is to identify why some group…

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study looks at spinal fluid and blood from 150 adults who had bleeding from a brain aneurysm. Researchers use a special laser technique to find proteins and genes that might predict when dangerous blood vessel spasms will happen. The goal is to better understand these marker…

This study follows about 100 premature babies who were treated for retinopathy of prematurity (ROP) in an earlier study. Researchers will check their eyesight and overall development over time to see how they are doing. No new treatment is given in this study.

This study tests whether a small device placed under the skin can detect hidden atrial fibrillation (an irregular heartbeat) in people with heart failure who are at high risk for stroke. About 477 participants either received the implant or standard care. The goal is to see if th…

This study tests a new handheld tool that measures muscle stiffness (spasticity) in people who have had a stroke. Researchers want to see if the device gives the same or better results than standard clinical tests. The study involves 40 adults aged 18-75 with a history of stroke …

This study brings together stroke survivors, families, staff, and researchers to co-design a toolkit that helps everyone follow trial protocols in inpatient stroke rehabilitation. The goal is to reduce missed sessions and errors, making trial results more trustworthy. About 38 pe…

This study looks at whether short bursts of breathing air with less oxygen (like at high altitude) can improve arm and hand function in people who had a stroke at least six months ago. Twenty participants will undergo 15 cycles of one-minute low-oxygen breathing followed by norma…

This study compares two methods to detect reduced blood flow to the brain during carotid artery surgery: asking awake patients to move their hand versus using a near-infrared spectroscopy (NIRS) headband. The trial involves 160 people with narrowed carotid arteries. The goal is t…

This study is building a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genetic and other markers to find better ways to predict serious complications like kidney failure, heart disease, and stroke. Th…

This study measures how much force leg muscles can produce and how they use oxygen in people with stroke or sarcopenia (age-related muscle loss). Researchers will test hip, knee, and ankle strength at different angles and speeds. The goal is to gather data that could help design …

This study follows over 50,000 Chinese adults who were first surveyed between 2011 and 2014. Researchers will check how chronic lung, heart, metabolic diseases, and cancers have developed or changed over more than a decade. The goal is to understand how multiple health problems o…

This study looks at whether a blood test can help doctors figure out when a stroke began. This is important because some people wake up with stroke symptoms and don't know the exact start time, which can prevent them from getting clot-busting drugs. Researchers will take blood fr…

This long-term study uses yearly brain scans, genetic tests, and thinking/memory assessments to track changes in nearly 1,800 people with various dementias (like Alzheimer's and vascular dementia) and over 140 healthy older adults. The goal is to better diagnose, monitor, and eve…

This study looks at whether artificial intelligence can improve predictions of serious heart events in people with chest pain. Researchers will analyze stress echocardiogram results and routine medical data from about 2,281 adults. No extra visits or tests are needed for particip…

This study follows 1000 adults who have had a stroke to better understand how the brain recovers. Researchers use brain scans, electrical signals, and physical tests to find patterns linked to recovery. The goal is to improve predictions and treatments for stroke survivors.

This study looks at how headaches work by using capsaicin (the spicy part of chili peppers) and ice water to trigger mild, temporary pain in people with and without headache disorders. Researchers measure changes in pain signals and tear production to better understand conditions…

This study follows 102 adults with sickle cell disease to track how often silent and overt strokes occur. Participants undergo regular MRI scans and neurological exams over 3.5 years. The goal is to gather data that could lead to the first stroke prevention trials specifically fo…

This study is creating a database of medical information and biological samples (blood, urine, and cheek swabs) from 1,000 newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. The goal is to measure biomarkers in the blood that cou…

This study followed 602 people who had a stroke to see how many later had seizures. Researchers looked at blood tests, brain scans, and EEG recordings to find clues that might predict who is at risk. The goal is to better understand why some stroke survivors develop epilepsy.

This study follows about 300 children who had seizures shortly after birth to see if their genes influence whether they develop epilepsy later in childhood. Researchers will combine genetic information with brain scans and EEG results to create a risk score. No new treatments are…

This study looks at how focused ultrasound (sound waves) aimed at the cerebellum changes brain activity and thinking in 20 healthy adults aged 18 to 40. Participants do thinking tasks after real or fake ultrasound. The goal is to learn how the cerebellum affects brain function, n…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study uses MRI scans to check for hidden brain aneurysms in close relatives (parents, siblings, or children) of people who have had a bleeding aneurysm. It aims to find who is at higher risk and how lifestyle factors like smoking or high blood pressure affect that risk. Abou…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…

This study looks at whether platelet activation in the blood is higher in people whose brain aneurysm has already burst compared to those with an unruptured aneurysm. Researchers will collect blood samples from 230 patients during treatment. The goal is to see if platelet activit…

This study follows 400 people who had a brain aneurysm rupture and were treated with a procedure called embolization. The goal is to learn about their long-term recovery and whether the aneurysm can come back. Researchers will track neurological outcomes using a standard scale. T…

This study uses advanced MRI scans to measure blood flow in the brains of 100 adults with moyamoya disease, a condition that narrows major brain arteries and raises stroke risk. Participants will have scans and cognitive tests before and after their clinically needed surgery. The…

The Brain Health Registry is an online project that collects information about memory, mood, sleep, diet, and exercise from adults over 18. Participants also take simple cognitive tests online. The goal is to build a large database to speed up research into brain diseases like Al…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study tests different ways to reach and enroll women and Black/Latino adults in heart disease research. Participants receive educational text messages about heart health and research opportunities. The goal is to see if these methods increase diversity and trust in clinical …

This study follows 10,000 people with both obstructive sleep apnea and high blood pressure over many years. Researchers will track how well patients use CPAP machines and blood pressure medications, and whether this reduces the chance of heart attacks, strokes, heart failure, or …

This observational study is testing whether a new digital imaging analysis can more accurately predict stroke risk in 400 adults with narrowed brain arteries (50-99% blockage). Participants undergo standard angiography, and researchers use a computer method to measure blood flow …

This study looks at how safe and effective newer blood thinners (NOACs) are for Korean adults with atrial fibrillation, a heart rhythm problem that raises stroke risk. Researchers will track about 1,000 patients for strokes, bleeding, and heart events. The goal is to better under…

This study looks at blood stem cells (called EPCs) in people with and without diabetes to see if they work differently. Researchers want to know if these cells can predict diabetic retinopathy, an eye disease that can cause vision loss. The study involves 78 adults, including 39 …

This study aims to make it easier and more accurate to detect tiny blood clots (microemboli) in the brain, which are strong predictors of future strokes. Researchers will have experts analyze 850 recordings of brain blood flow signals to develop a standard way to identify these c…

This study is testing whether rehabilitation that combines physical and mental exercises (called dual-task training) can help people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will design and try out different dual-task strategies in small gr…

This study looks at 250 stroke patients to understand why some arrive late at the hospital. Researchers use a questionnaire, mapping tools, and brain scans to find social, transport, and knowledge barriers. A machine learning model will try to predict who is at risk for delay, wi…

This study collects blood and urine samples from 500 people with rare brain vessel diseases, such as CADASIL and moya-moya. Researchers aim to find biomarkers that could improve care or identify new treatment targets. Participants are already part of an existing rare disease coho…

This study looks at how often a common heart side effect (first-degree atrioventricular block) occurs when verapamil is used at high doses to prevent cluster headaches. Researchers will monitor 60 patients starting or already on verapamil, using ECGs and blood tests. The goal is …

This study tested a new device that measures blood flow, pressure, and temperature inside the brain, while also draining fluid. It was designed for patients with serious brain injuries who already need standard monitoring. Only one person took part, and the goal was to see if the…

This observational study is tracking 1,000 patients with stable atrial tachycardia to see how well different rhythm control treatments work over the long term. Researchers are focusing on serious outcomes like death, stroke, and heart-related hospital stays. The goal is to gather…

This study follows 600 people with and without chronic kidney disease (CKD) for up to four years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that make thinking and memory worse in CKD patients. Partic…

This study gathers information from 8,000 stroke patients worldwide to learn more about seizures that happen after a stroke. Researchers will analyze the data to see how well patients recover and to create a tool that can predict who might develop epilepsy. The goal is to improve…

This study looks at whether modern medicines (like statins and newer blood thinners) can keep the one-year stroke rate below 5% in people with narrowed neck arteries who have already had a minor stroke or warning signs. About 114 participants are being followed to see how well th…

This study looks at tandem stroke, a severe type of stroke caused by two blockages in series (one in a neck artery and one in a brain artery). Researchers will analyze data from about 2880 patients treated between 2018 and 2024 to identify risk factors and compare outcomes of dif…

This study is a registry that will collect real-world data from 750 people with brain aneurysms treated with MicroVention devices. The goal is to see how well these devices work and how safe they are in everyday medical practice. Participants will be followed for at least one yea…

This study looks at whether alexithymia—trouble recognizing or describing emotions—is linked to how often women get migraines. Researchers will track 350 female migraine patients aged 12-65 using questionnaires. The goal is to understand if emotional awareness affects migraine se…

This study follows 1,400 women who had a stroke with no known cause. Researchers use a small implantable heart monitor to check for hidden atrial fibrillation, an irregular heartbeat that can cause strokes. The goal is to see if detecting this condition and using blood thinners c…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. The study was withdrawn before enrolling …

This study tests whether artificial intelligence can improve how emergency call operators recognize strokes. Researchers will analyze 1,000 emergency calls to see if AI can detect signs of stroke more accurately than current methods. The goal is to help stroke patients get to the…

This study is testing a special eye test called microperimetry to see if it can detect early signs of dry age-related macular degeneration and diabetic retinopathy. Researchers will measure how sensitive the central retina is to light and compare it with standard scans. The goal …

This study uses monthly MRI scans to closely watch brain changes in 75 people with cerebral amyloid angiopathy (CAA), a condition common in older adults that can cause bleeding and strokes. Researchers aim to understand how small bleeds and silent strokes develop over time. Parti…

This study tests whether artificial intelligence can predict malignant brain edema, a life-threatening swelling, in patients who have had a major stroke. Researchers will analyze CT scans and clinical data from over 1,600 patients to see if the AI can identify early warning signs…