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Which exercise works best for stroke survivors with knee hyperextension?

NCT ID NCT07670728

Symptom relief Sponsor: Dow University of Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study compares two types of exercise—open kinetic chain (like leg raises) and closed kinetic chain (like squats)—to see which better reduces knee hyperextension in stroke survivors. Sixty adults who have had a stroke and can walk with some help will be randomly assigned to one of the two exercise programs for 4 weeks. The goal is to find which approach improves knee control, strength, balance, and daily function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise therapy (open and closed kinetic chain exercises)
What this could lead to
If it works, this could point toward a more effective exercise approach for reducing knee hyperextension and improving walking after a stroke.
What could go wrong
This is a small, early-stage trial with only 60 participants and a short 4-week treatment period. Results may not apply to all stroke survivors, and the exercises may not produce lasting improvements.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 65 weeks

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and female participants * Age between 30 and 65 years * Referred by a neurologist * Diagnosed case of stroke with one-sided hemiparesis * Functional ambulatory capacity (Functional Ambulation Category ≥ 2) * Muscle strength of at least grade 3+ on the Manual Muscle Testing (MMT) scale in the affected lower limb * No participation in other rehabilitation programs during the study period Exclusion Criteria: * Participants with any musculoskeletal condition such as osteoarthritis or ligament laxity * Significant cognitive, communicative, perceptual, or sensory problems that hinder understanding and/or following verbal commands * Pregnant individuals

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Conditions

The condition(s) this trial relates to.

congenital genu recurvatum stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebrovascular accident (stroke) Genu recurvatum Knee hyperextension

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dow University of Health Sciences Ojha Campus

    Karachi, Sindh, 75280, Pakistan

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