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Brain bleed survivors studied for clot Removal's Long-Term brain benefits

NCT ID NCT05611918

Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study follows 350 people who survived a brain bleed (intracerebral hemorrhage) and were part of earlier trials. Researchers will test memory, thinking, and movement skills over time, and collect blood samples to look for signs of ongoing inflammation. The goal is to see if surgically removing the clot helps prevent long-term cognitive decline.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could show that removing the clot after a brain bleed helps prevent memory and thinking problems later in life.
What could go wrong
This is an observational follow-up, not a new treatment trial. It cannot prove cause and effect, and results may not apply to all survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 350 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2023

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study populations includes all surviving cases identified and recruited through the 5-year durations of the MISTIE III and ENRICH trials and with follow-up periods extending from 2013-2017 and 2016-2022, respectively.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants in the study must be survivors enrolled in MISTIE III and ENRICH trials at end of each trial's final follow-up (day 365 in MISTIE III and day 180 in ENRICH). Relatives of known survivors that are found to be deceased since the end of each trial will be interviewed to capture relevant data. Exclusion Criteria: * None

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Hemorrhage hemorrhage, intracerebral, susceptibility to intracerebral hemorrhage intracranial thrombosis Memory Disorders Motor Activity stroke disorder thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Clot (blood); brain Clot blood Cognitive decline Cognitive impairment Hemorrhage ICH Ich - intracerebral hemorrhage Intra cerebral hemorrhage Memory impairment Motor activity Stroke Survivorship

Contacts and locations

Locations

  • Albert Einstein Montefiore

    The Bronx, New York, 10461, United States

  • CommonSpirit (formerly Mercy San Juan Medical Center; dignity health)

    Chicago, Illinois, 60606, United States

  • Dignity Health component - St. Joseph's Hospital and Medical Center

    Sacramento, California, 95819, United States

  • Hennepin Healthcare Research Institute

    Minneapolis, Minnesota, 55415, United States

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • Inova Health System Foundation

    Fairfax, Virginia, 22042, United States

  • Johns Hopkins Hospital

    Baltimore, Maryland, 21205, United States

  • Mayo Clinic, Jacksonville

    Jacksonville, Florida, 32224, United States

  • Rutgers - Robert Wood Johnson Medical School

    Piscataway, New Jersey, 08854, United States

  • Scripps Health

    La Jolla, California, 92037, United States

  • Stanford University

    Stanford, California, 94305, United States

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, 19107, United States

  • University of Alabama at Brimingham

    Birmingham, Alabama, 35294, United States

  • University of Cincinnati

    Cincinnati, Ohio, 45220, United States

  • University of Illinois at Chicago

    Chicago, Illinois, 60607, United States

  • University of Kansas Medical Center

    Fairway, Kansas, 66205, United States

  • University of Louisville

    Louisville, Kentucky, 40292, United States

  • University of Maryland Baltimore

    Baltimore, Maryland, 21201, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of New Mexico

    Albuquerque, New Mexico, 87131, United States

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas, 78229, United States

  • University of Texas, Houston Health Science Center

    Houston, Texas, 77030, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Washington University in St. Louis, School of Medicine

    St Louis, Missouri, 63130, United States

  • Yale University

    New Haven, Connecticut, 06511, United States

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