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Simple blood test could unlock stroke treatment for thousands

NCT ID NCT07453277

Knowledge-focused Sponsor: Izmir Katip Celebi University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a blood test can help doctors figure out when a stroke began. This is important because some people wake up with stroke symptoms and don't know the exact start time, which can prevent them from getting clot-busting drugs. Researchers will take blood from 80 adults with stroke and measure certain proteins to see if they can tell if the stroke started less than 4.5 hours ago or longer. If successful, this blood test could make stroke treatment available to more people, even without advanced brain scans.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with acute ischemic stroke whose onset time is unknown or who present with a wake-up stroke. Serum/plasma samples obtained from venous blood samples taken during routine clinical practice in all patients will be analyzed for GFAP, UCH-L1, sNfL, PEBP1, and MMP-9 levels. Patients' demographic data, clinical characteristics, NIHSS scores, and magnetic resonance imaging (MRI) findings (particularly DWI-FLAIR mismatch status) will be recorded from the electronic patient record system. The performance of the multi-compartment molecular panel formed by the obtained biomarker levels in distinguishing the biological time window of acute ischemic stroke (≤4.5 hours vs. \>4.5 hours) will be evaluated by comparing it with the imaging-based reference method.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Be 18 years of age or older 2. Presence of acute focal neurological deficit 3. Presentation within ≤24 hours of the last time the patient was well Exclusion Criteria: 1. Intracranial hemorrhage 2. Active infection or sepsis 3. Major surgery/trauma within the last 14 days 4. Active autoimmune disease 5. Stroke within the last 3 months 6. Immunosuppressive therapy

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Emergency medicine Stroke, acute

Contacts and locations

Locations

  • Izmir Katip Çelebi University Ataturk Research and Training Hospital

    Izmir, 35220, Turkey (Türkiye)

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