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Vitamin K2 supplement shows promise for stroke recovery in new trial

NCT ID NCT06817512

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 2 times

Summary

This study tests whether taking vitamin K2 supplements for one year can improve muscle strength and brain function in people who recently had an ischemic stroke. 190 participants will receive either vitamin K2 or a placebo daily. Researchers will measure handgrip strength and other outcomes over 12 months, with an additional year of follow-up.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin K2 (MK-7) supplement
What this could lead to
If it works, this could point toward a simple, safe supplement to help people regain muscle and brain function after a stroke.
What could go wrong
This is a small, early-stage trial with no phase designation. The supplement may show no benefit over placebo, and results may not apply to all stroke patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

190 people

The number who actually took part.

Started

Mar 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participants who meet all the following conditions will be included in the trial: 1. Men or women aged ≥ 18 years. 2. Patients with recent ischemic stroke(first or recurrent stroke no more than 7 days before admission)without significant residual limb paralysis, NIHSS score between 2-15, and muscle strength graded 2-4. 3. The patient and their legal guardian (or legally acceptable representative) voluntarily sign the informed consent form. Exclusion Criteria: Participants who meet any of the following conditions will be excluded from the trial: 1. Presence of consciousness disorders, aphasia, or swallowing disorders. 2. The diagnosis or suspicion of cerebral hemorrhage, atrial fibrillation, or other factors leading to cardiogenic cerebral infarction. 3. Coagulation dysfunction or use of vitamin K antagonists. 4. Suffering from chronic gastrointestinal malabsorption (such as celiac disease, short bowel syndrome), severe congestive heart failure, malignant hypertension, severe liver and kidney dysfunction, persistent malignant tumors (continuous treatment, or diagnosis of malignant tumors\<5 years), or other related diseases considered by researchers that seriously affect the patient's survival. 5. Having musculoskeletal diseases or cognitive impairment before the stroke. 6. Currently using or planning to use non research approved dietary supplements during the study period. 7. Currently using or planning to use drugs that affect cognitive or neurological function during the research period. 8. Restricted normal eating or currently receiving enteral or parenteral nutrition support. 9. Contraindications for MRI and other examinations. 10. Currently pregnant or planning pregnancy, currently breastfeeding. 11. Participated in a clinical trial using experimental drugs or devices within the past 3 months.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hongqi Hospital Affiliated to Mudanjiang Medical University

    Mudanjiang, Heilongjiang, 157000, China

  • The First Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, 150001, China

  • The Second Affiliated Hospital of Qiqihar Medical University

    Qiqihar, Heilongjiang, 161006, China

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