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New study aims to sharpen detection of silent brain clots

NCT ID NCT07172165

Knowledge-focused Sponsor: Universidade do Porto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to make it easier and more accurate to detect tiny blood clots (microemboli) in the brain, which are strong predictors of future strokes. Researchers will have experts analyze 850 recordings of brain blood flow signals to develop a standard way to identify these clots. The goal is to create a reliable tool that can be used in future clinical trials and routine care to better prevent strokes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 850 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Clips of Transcranial Doppler monitoring either MES or non-MES high intensity transient signals (e.g. artifacts, speckle).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: MES of presumed solid form or non-MES high intensity transient signals Obtained from on a human subject with age equal to or more than 18years old Obtained from proximal middle cerebral artery (M1 segment) Clip with 20 seconds duration with clearly event of interest marked using TCDPlayer With an overall background spectrum of reasonable quality to be analyzed Exclusion Criteria: MES in gaseous form Use of ultrasound contrast agent or agitated saline in the previous 24 hours Obtained from patients with mechanical valve Obtained from patient during any cardiac surgery or endovascular procedure1 Obtained from patient with recent severe trauma Clips with multiples inseparable MES (e.g. curtain)

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Microemboli Stroke Transcranial doppler ultrasound

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Medicine University Porto

    Porto, 4200-319, Portugal

More trials for these conditions

Other studies related to the condition(s) this trial covers.