MIND diet may shield stroke survivors from dementia
NCT ID NCT04337255
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether following the MIND diet for 2 to 3 years can slow cognitive decline and reduce dementia risk in people aged 55 and older who have had an ischemic stroke. The MIND diet combines elements of the Mediterranean and DASH diets, with extra emphasis on leafy greens and berries. Researchers will compare changes in thinking skills and brain scans between those on the MIND diet and those receiving usual post-stroke care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- MIND diet (a hybrid of Mediterranean and DASH diets emphasizing green leafy vegetables and berries)
- What this could lead to
- If it works, this could show that a specific diet helps prevent dementia in people who have had a stroke.
- What could go wrong
- This is a behavioral intervention, not a drug, so results may be modest. The study is relatively small (250 people) and diet adherence can be challenging, which may weaken the findings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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250 people
The number who actually took part.
- Started
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Dec 2021
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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55 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* Inclusion Criteria * Men and women, 55 years of age - inclusive- or older * Acute stroke as defined by an acute focal neurological deficit in combination with one of the following: acute ischemic infarct (stroke) as documented by either a DWl positive lesion on MR imaging or a new lesion on a delayed CT scan * Written informed consent by patient prior to study participation * Willingness to complete all assessments and participate in follow-up * Willing to participate and give informed consent * Adequate Visual and auditory acuity to undergo neuropsychological testing * Exclusion criteria * CDR\>=0.5 * Nuts, berries, olive oil, or fish allergies * Use of medications to treat Alzheimer's disease or Parkinson's disease * Aphasia * Conditions of psychosis or bipolar disorder judged by study investigators to potentially interfere with study compliance over 3 years * Report of alcohol or substance abuse within six months, or heavy alcohol consumption (\>2 drinks/d women; \>3 drinks/d men) * Unstable or recent onset of cardiovascular disease, such as myocardial infarction within six months or presence of congestive heart failure (Stages II-IV) * Cancer treatment \<= 5 years except non-melanoma skin cancer , basal cell skin cancer (this criterion may be waived at the site PI's discretion) * Illness that might be associated with weight change, such as a history of stomach or gastrointestinal conditions (Inflammatory Bowel Disease, Crohn's Disease, malabsorption, colostomy, bowel resection, gastric bypass surgery, etc.) * History of liver disease, HIV or Hepatitis C * An intracerebral hemorrhage as documented on CT or MRI * Pre- hospitalization diagnosis of dementia or mild cognitive impairment * Patients presenting one of the following diseases: cerebral venous thrombosis, traumatic cerebral hemorrhage, intracerebral hemorrhage because of a known or image-guided assumed vascular malformation, pure meningeal or intraventricular hemorrhage * Patients presenting a malignant disease with life expectancy \< 3 years * Residence in a nursing home and thus going back to nursing home upon discharge * Participation in an ongoing investigational drug study * Exception to these guidelines will be rare but may be considered on a case by case basis at the discretion of the PI's
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Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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