Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Brain zaps and electric gloves: new hope for stroke survivors with severe hand paralysis?

NCT ID NCT03870672

Disease control Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 27, 2026 · Updated 2 times

Summary

This study tests whether combining two non-invasive therapies can improve hand function in people who had a stroke at least six months ago and have severe arm weakness. The therapies are a brain stimulation technique called rTMS and a device that uses electrical stimulation to open the weak hand, controlled by a glove on the strong hand. Researchers will compare three treatment combinations to see which works best and for whom.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS) and contralaterally controlled functional electrical stimulation (CCFES)
What this could lead to
If successful, this could lead to a new rehabilitation therapy that helps people with severe hand weakness after a stroke regain more use of their affected arm.
What could go wrong
This is an early-stage trial with only 72 participants, so results may not apply to everyone. The improvements may be small or not last long, and brain stimulation can cause discomfort or headache.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2019

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age 18 to 90 years old at time of randomization * greater than 6 months since a first clinical cortical or subcortical, ischemic or hemorrhagic stroke * severe upper limb hemiparesis defined as less than 10° active wrist extension or less than 10° active thumb abduction/extension or less than 10° active extension in at least two additional digits (i.e., will not meet minimum CIMT criteria) * ability to follow 3-stage commands and can remember 2 items from a list of 3 items after 3 minutes * adequate active movement of shoulder and elbow to position the paretic hand on one's lap for performance of functional task practice and CCFES-assisted hand opening exercises * skin intact on hemiparetic arm * surface electrical stimulation of the paretic finger and thumb extensors produces functional hand opening without pain * able to hear and respond to cues from stimulator * completed occupational therapy at least 2 months prior to enrollment (no concomitant OT) * full volitional hand opening/closing of the non-paretic hand * ability to follow instructions for putting on and operating the CCFES stimulator or a caregiver available to provide assistance Exclusion Criteria: * metal implant in the head * history of seizures as an adult * history of alcohol or substance abuse less than 10yrs prior to enrollment * intake of anticonvulsants or anti-depressants contraindicated with TMS * cardiac pacemaker or other programmable implant

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Cerebrovascular accident (CVA) are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

hemiplegia Paresis stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebrovascular accident (CVA) Hemiparesis Hemiplegia Stroke

Contacts and locations

Locations

  • Lerner Research Institute; Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.