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Massive stroke study aims to unlock best treatment for double blockages

NCT ID NCT06965036

Knowledge-focused Sponsor: Azienda Unità Sanitaria Locale della Romagna Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at tandem stroke, a severe type of stroke caused by two blockages in series (one in a neck artery and one in a brain artery). Researchers will analyze data from about 2880 patients treated between 2018 and 2024 to identify risk factors and compare outcomes of different treatments like clot removal, stenting, and medications. The goal is to find which therapies lead to the best recovery and lowest risk of complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study succeeds, it could clarify which treatments (clot removal, stenting, medications) work best for tandem stroke, leading to better recovery guidelines.
What could go wrong
This is an observational study pooling existing data, not a controlled trial. Results may show associations but not prove cause and effect. Differences in care across hospitals could affect outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,880 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2018

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with stroke due to tandem occlusion in the anterior or posterior circulation, and patients with stroke due to isolated cervical artery occlusion, independently from previous thrombolysis, antiplatelet or anticoagulant use

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * acute ischemic stroke * tandem or isolated cervical artery occlusion (exploratory group) * emergent extracranial vessel stenting or no stenting (treatment grouping variable) Exclusion Criteria: * hemorrhagic stroke * no tandem occlusion and no isolated extracranial cervical vessel occlusion

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Conditions

The condition(s) this trial relates to.

ischemic stroke large artery stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute ischemic stroke due to isolated cervical artery occlusion Acute ischemic stroke related to tandem occlusion

Contacts and locations

Locations

  • Boston Medical Center

    Boston, Massachusetts, 02118, United States

  • Bufalini Hospital Comprehensive Stroke Center

    Cesena, 47521, Italy

  • Vall d'Hebron Institut de Recerca

    Barcelona, Spain