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Shock and flex: new combo therapy aims to restore ankle movement after stroke

NCT ID NCT07458750

Symptom relief Sponsor: University of Lahore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 16, 2026 · Updated 3 times

Summary

This study tests whether combining neuromuscular electrical stimulation (NEMS) with voluntary muscle contraction can improve ankle function in people with chronic stroke. Twenty-five participants will either receive conventional physiotherapy or NEMS plus active dorsiflexion exercises. Researchers will measure spasticity, range of motion, and muscle strength over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
neuromuscular electrical stimulation (NEMS) combined with voluntary muscle contraction
What this could lead to
If it works, this could point toward a simple, non-drug therapy to improve ankle movement and reduce stiffness in people who have had a stroke.
What could go wrong
This is a small, early-stage trial with only 25 participants, so results may not apply to everyone. The improvements measured are small-scale (range of motion, spasticity) and may not translate to major functional gains.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

43 to 83 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age of between 43 to 83 years of age * Diagnosed with chronic stroke (≥6 months in duration) with motor deficits resulting in hemiplegia * Mild ankle dorsiflexion possible * MAS score of ≤3 for dorsiflexors to the ankle joint * Be self-mobility either with or without aids . Exclusion Criteria: * Parkinson's or multiple sclerosis affecting the nervous systems of the body * Skeletal disorders that hinder the ability of the limb * Pacemaker or any condition which may lead to a contraindication with NMES * Spasticity (MAS ≥ 3) * Current botulinum toxin injections in the lower limb that developed the spasticity * Patients with any cognitive impairment (MMSE \< 24)

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Conditions

The condition(s) this trial relates to.

hemiplegia stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

Contacts and locations

Locations

  • University of lahore teaching hospital

    Lahore, Punjab Province, 54000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.