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New arm therapy could help stroke survivors reach further

NCT ID NCT04118998

Symptom relief Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This study tests a new exercise therapy called Progressive Abduction Loading Therapy for people who recently had a stroke. The goal is to reduce a common arm problem called 'flexion synergy' that makes it hard to reach outward. 86 participants will receive either the new therapy or standard supported reaching exercises, and be tracked for one year to see if arm function improves.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Progressive Abduction Loading Therapy (a behavioral exercise therapy)
What this could lead to
If it works, this could lead to a better rehabilitation method that helps stroke survivors regain arm movement and reduce long-term disability.
What could go wrong
This is a mid-stage trial with only 86 participants, so results may not apply to all stroke survivors. The therapy is behavioral, so benefits may be modest and depend on individual effort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 86 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2021

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Hemiparesis confined to one side, (CMSA Stage 2 or 3 out of 7) 2. Stroke impacting parenchyma of the middle cerebral artery distribution 3. Within 90 days post-stroke 4. 18 to 85 years old 5. No or Mild-to-moderate Aphasia (NIHSS #9 Best Language. = 0 or 1- Describe picture; No or Mild-to-moderate Aphasia) 6. No or Mild extinction and inattention (NIHSS 11 Extinction and Inattention. = 0 or 1- No abnormality or Inattention to one modality.) 7. Ability to perform a 3-step motor command with the unaffected arm 8. Capacity to provide informed consent Exclusion Criteria: 1. Premorbid and persistent disability or motor impairment of the upper extremities 2. Brainstem and/or cerebellar lesion 3. Comorbidity medically contraindicating motor assessments 4. Any other chronic neurological condition 5. Pain or hypersensitivity limiting motor assessments 6. Limb edema limiting study motor assessments

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Conditions

The condition(s) this trial relates to.

middle cerebral artery infarction stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke, acute

Contacts and locations

Locations

  • Department of Physical Therapy and Human Movement Sciences

    Chicago, Illinois, 60611, United States

  • Northwestern Medicine Marianjoy Rehabilitation Hospital

    Wheaton, Illinois, 60187, United States

  • Shirley Ryan AbilityLab

    Chicago, Illinois, 60611, United States

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