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Could Mountain-Air breathing boost stroke recovery?

NCT ID NCT07113457

Knowledge-focused Sponsor: Shirley Ryan AbilityLab Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether short bursts of breathing air with less oxygen (like at high altitude) can improve arm and hand function in people who had a stroke at least six months ago. Twenty participants will undergo 15 cycles of one-minute low-oxygen breathing followed by normal air. The goal is to understand how this method affects the brain and muscles, not to test a new drug or device.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acute Intermittent Hypoxia (AIH) - brief sessions of breathing lowered oxygen levels
What this could lead to
If successful, this could point toward a simple, drug-free way to enhance motor recovery after stroke.
What could go wrong
This is a very small, early-stage study (20 people) focused on understanding how AIH works, not on proving it as a treatment. Results may not apply to all stroke survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * A first time, unilateral, ischemic, hemispheric stroke, confirmed by MRI * Chedoke stage of hand assessment \>= 3 * Ability to open and close affected hand * Able to understand and communicate in english * Able to independently consent * over 6 months post stroke * Must have a hemoglobin level above 10g/dl * Must have ability to leave research visit with a compainon/group trasportation * WOCBP must be comfortable confirming negative pregnancy prior to hypoxia * Must not be involved in any other research intervention study testing upper extremities Exclusion Criteria: * History of prior neurological disorders * Brain stem or cerebellar stroke; mean Fazekas score rated on initial fluid-attenuated inversion recovery MRI greater than equal to 3 * Severe Aphasisa * Pre-existing hypoxic pulmonary disease * Includes positive Covid-pneumonia diagnosis within 1 year of screening visit * Severe hypertension (\>160/100) * Any ischemic cardiac disease

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Conditions

The condition(s) this trial relates to.

Hypoxia ischemic stroke Muscle Spasticity stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

Contacts and locations

Locations

  • Shirley Ryan AbilityLab

    Chicago, Illinois, 60611, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.