One shot to save sight? gene therapy trial takes on diabetic retinopathy
NCT ID NCT04567550
First seen Sep 30, 2025 · Last updated May 20, 2026 · Updated 29 times
Summary
This study tests a one-time gene therapy called RGX-314 for people with diabetic retinopathy, a leading cause of vision loss. The treatment is given as a single injection behind the eye and aims to reduce the need for frequent eye injections over a lifetime. About 139 adults aged 25-89 with diabetic retinopathy (with or without swelling in the center of the retina) are participating. The goal is to see if this gene therapy can safely improve or stabilize vision and eye health.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Austin Clinical Research, LLC
Austin, Texas, 78750, United States
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Barnet Dulaney Perkins Eye Center
Phoenix, Arizona, 85016, United States
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California Eye Specialists Medical Group, Inc
Pasadena, California, 91107, United States
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California Retina Consultants
Bakersfield, California, 93309, United States
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California Retina Consultants
Santa Barbara, California, 93103, United States
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Charles Retina Institute, P.C.
Germantown, Tennessee, 38138, United States
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Cumberland Valley Retina Consultants
Hagerstown, Maryland, 21740, United States
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Duke University Eye Center
Durham, North Carolina, 27705, United States
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Mid Atlantic Retina
Philadelphia, Pennsylvania, 19107, United States
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NJ Retina
Teaneck, New Jersey, 07666, United States
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Northern California Retina Vitreous Associates Medical Group, Inc.
Mountain View, California, 94040, United States
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Ophthalmic Consultants of Boston
Boston, Massachusetts, 02114, United States
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Retina Research Institute of Texas, LLC
Abilene, Texas, 79606, United States
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Retina-Vitreous Associates Medical Group
Beverly Hills, California, 90017, United States
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Retinal Consultants San Diego
Poway, California, 92064, United States
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Retinal Consultants of Texas
The Woodlands, Texas, 77384, United States
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Retinal Diagnostic Center
Campbell, California, 95008, United States
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Retinal Research Institute, LLC
Phoenix, Arizona, 85014, United States
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Sierra Eye Associates
Reno, Nevada, 89502, United States
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Southeast Retina Center, PC
Augusta, Georgia, 30909, United States
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Springfield Clinic
Springfield, Illinois, 62702, United States
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Star Retina
Burleson, Texas, 76028, United States
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University Retina and Macula Associates, PC
Oak Forest, Illinois, 60452, United States
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Vision Research Center Eye Associates of New Mexico
Albuquerque, New Mexico, 87109, United States
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Wilmer Eye Institute/Johns Hopkins University School of Medicine
Baltimore, Maryland, 21287, United States
Conditions
Explore the condition pages connected to this study.