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Brain imaging may reveal who benefits most from carotid surgery

NCT ID NCT03068442

Knowledge-focused Sponsor: Scott Mcnally Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 45 people having carotid artery surgery to see if special brain scans can predict improvements in thinking and memory. Researchers will use PET/CT scans to measure inflammation in the brain and MRI to examine plaque in the carotid artery. The goal is to find imaging features that link inflamed plaque to brain inflammation and cognitive benefit after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
flutemetamol F 18 PET/CT imaging
What this could lead to
If successful, this could help doctors identify which patients are most likely to experience cognitive improvement after carotid surgery, leading to better surgical decisions.
What could go wrong
This is a small, early-phase study focused on imaging markers, not a treatment. The findings may not apply to all patients or lead to direct clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2017

Expected to finish

Sep 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: • Patients ≥18 years old and plans for carotid endarterectomy. Exclusion Criteria: * Patients with carotid occlusion will be excluded, due to one carotid contributing to both right and left brain blood supply. * Other known sources of cardioembolism, including atrial fibrillation, mechanical heart valve, left atrial or ventricular thrombus or intracardiac mass, endocarditis, EF \<30% * Known stroke mimics including multiple sclerosis or brain tumor * MRI contraindications per ACR guidelines, including patients with pacemakers, renal failure with eGFR\<30 ml/min/1.73m2, and contrast allergy * \[18F\]Flutemetamol contraindications per manufacturer guidelines, including patients with prior reactions * Known stage IV malignancy * Pregnancy

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Conditions

The condition(s) this trial relates to.

carotid stenosis Cognitive Dysfunction Inflammation inflammatory disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid artery plaque Cognitive impairment Inflammation

Contacts and locations

Locations

  • George E. Wahlen Department of Veterans Affairs Medical Center

    Salt Lake City, Utah, 84148, United States

  • University of Utah

    Salt Lake City, Utah, 84132, United States

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