Sleep apnea treatment after stroke may save lives

NCT ID NCT03812653

Disease control Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using a CPAP machine to treat sleep apnea shortly after an ischemic stroke can reduce the risk of another stroke, heart attack, or death within 6 months. It also looks at whether CPAP improves overall recovery and brain function. Over 3,000 participants are involved, and they use a home sleep test and a CPAP device provided by the study.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: CPAP device (continuous positive airway pressure)
What this could lead to: If it works, this could show that treating sleep apnea soon after a stroke lowers the chance of another stroke or heart attack and improves recovery.
What could go wrong: This is a large trial, but it's still testing a theory. CPAP can be uncomfortable, and not everyone may use it enough to see benefits. Results may not apply to all stroke survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 3,062 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2019

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Current Inclusion Criteria, as of 6/28/2024: 1. Ischemic stroke within the prior 7 days. 2. NIH Stroke Scale Score ≥1 at the time of enrollment Previous Inclusion Criteria, prior to 6/28/2024: 1\. Ischemic stroke or TIA with ABCD ≥4, within prior 14 days. Exclusion Criteria (for entire time period): 1. pre-event inability to perform all of own basic ADLs 2. unable to obtain informed consent from subject or legally authorized representative 3. incarcerated 4. known pregnancy 5. current mechanical ventilation (can enroll later if this resolves) or tracheostomy 6. current use of positive airway pressure, or use within one month prior to stroke 7. anatomical or dermatologic anomaly that makes use of CPAP interface unfeasible 8. severe bullous lung disease 9. history of prior spontaneous pneumothorax or current pneumothorax 10. hypotension requiring current treatment with pressors (can enroll later if this resolves) 11. other specific medical circumstances that conceivably, in the opinion of the site PI, could render the patient at risk of harm from use of CPAP 12. massive epistaxis or previous history of massive epistaxis 13. cranial surgery or head trauma within the past 6 months, with known or possible CSF leak or pneumocephalus 14. recent hemicraniectomy or suboccipital craniectomy (i.e. those whose bone has not yet been replaced), or any other recent bone removal procedure for relief of intracranial pressure 15. current receipt of oxygen supplementation \>4 liters per minute 16. current contact, droplet, respiratory/airborne precautions

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Conditions

The condition(s) this trial relates to.

ischemic stroke obstructive sleep apnea syndrome sleep apnea syndrome acute coronary syndrome prevention target stroke disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CPAP Home sleep apnea test Ischemic stroke Multicenter trial Randomized clinical trial Sleep apnea Sleep apnea, obstructive Stroke Telemedicine

Contacts and locations

Locations

Avera Research Institute

Sioux Falls, South Dakota, 57108, United States
Banner University Medical Center Phoenix

Phoenix, Arizona, 85006, United States
Banner- University Medical Center Tucson

Tucson, Arizona, 85719, United States
Baptist Hospital of Miami

Miami, Florida, 33176, United States
Barnes-Jewish Hospital

St Louis, Missouri, 63110, United States
Baylor Scott & White Institute of Rehabilitation

Dallas, Texas, 75246, United States
Bellevue Hospital

New York, New York, 10016, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Bronson Methodist Hospital

Kalamazoo, Michigan, 49008, United States
Brooks Rehabilitation Hospital

Jacksonville, Florida, 32216, United States
Broward Health

Fort Lauderdale, Florida, 33305, United States
Buffalo General Medical Center

Buffalo, New York, 14203, United States
Carolinas Medical Center Atrium Health

Charlotte, North Carolina, 28203, United States
Carolinas Rehab Northeast

Concord, North Carolina, 28025, United States
Casa Colina

Pomona, California, 91767, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Chandler Regional Medical Center

Chandler, Arizona, 85224, United States
Christ Hospital

Cincinnati, Ohio, 45219, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Cooperman Barnabas Medical Center

Livingston, New Jersey, 07039, United States
Cox Medical Center

Springfield, Missouri, 65807, United States
Dignity Health - St. Joseph's Hospital and Medical Center

Phoenix, Arizona, 85013, United States
Doctors Medical Center of Modesto

Modesto, California, 95355, United States
Fort Sanders Regional Medical Center

Knoxville, Tennessee, 37916, United States
Geisinger Clinic

Danville, Pennsylvania, 17822, United States
George Washington University Hospital

Washington D.C., District of Columbia, 20037, United States
Grady Memorial Hospital

Atlanta, Georgia, 30303, United States
Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States
Guilford Neurologic Associates, Inc

Greensboro, North Carolina, 27401, United States
Gundersen Lutheran Medical Foundation

La Crosse, Wisconsin, 54601, United States
Hackensack Meridian Jersey Shore University Medical Center

Neptune City, New Jersey, 07753, United States
Harborview Medical Center

Seattle, Washington, 98195, United States
Hartford Hospital

Hartford, Connecticut, 06102, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Inova Fairfax

Falls Church, Virginia, 22042, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
Iowa Methodist

Des Moines, Iowa, 50309, United States
JFK Neuroscience Institute

Edison, New Jersey, 08820, United States
Jackson Memorial Hospital

Miami, Florida, 33136, United States
John Muir Medical Center- Walnut Creek Campus

Walnut Creek, California, 94598, United States
Kaiser Permanente Los Angeles

Los Angeles, California, 94612, United States
Kaiser Redwood

Redwood City, California, 94063, United States
Maimonides Medical Center

Brooklyn, New York, 11219, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic Saint Marys Campus

Rochester, Minnesota, 55905, United States
McLaren Flint

Flint, Michigan, 48532, United States
Memorial Hermann Texas Medical Center

Houston, Texas, 77030, United States
Memorial Medical Center

Springfield, Illinois, 62702, United States
Mercy San Juan Medical Center

Carmichael, California, 95608, United States
Methodist University

Memphis, Tennessee, 38105, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
Morton Plant Hospital

Clearwater, Florida, 33756, United States
NYP Columbia University Medical Center

New York, New York, 10032, United States
NYU Langone -Tish Hospital Medical Center

New York, New York, 10016, United States
NYU Langone Brooklyn

Brooklyn, New York, 11220, United States
North Shore University Hospital

Manhasset, New York, 11030, United States
Norton HealthCare

Louisville, Kentucky, 40218, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61603, United States
OSU Wexner Medical Center

Columbus, Ohio, 43210, United States
Ochsner Medical Center - Main Campus

New Orleans, Louisiana, 70121, United States
Olive View- UCLA Medical Center

Sylmar, California, 91342, United States
Orange County Global Medical Center

Santa Ana, California, 92705, United States
Palmetto Health Richland

Columbia, South Carolina, 29203, United States
Penn State Milton S. Hershey Center

Hershey, Pennsylvania, 17033, United States
Providence St. Vincent Medical Center

Portland, Oregon, 97225, United States
Rancho Los Amigos National Rehabilitation Center

Downey, California, 90242, United States
Ronald Reagan UCLA Medical Center

Los Angeles, California, 90095, United States
Ruby Memorial Hospital

Morgantown, West Virginia, 26506, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
Saint Cloud/Centracare Health

Saint Cloud, Minnesota, 56303, United States
Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Sarasota Memorial Hospital

Sarasota, Florida, 34239, United States
Scripps Memorial

La Jolla, California, 92037, United States
St. John Health System

Tulsa, Oklahoma, 74104, United States
St. Joseph's Hospital

Tampa, Florida, 33607, United States
St. Luke's University Hospital Bethlehem Campus

Bethlehem, Pennsylvania, 18015, United States
St. Mary's Hospital and Medical Center

Grand Junction, Colorado, 81501, United States
Staten Island University Hospital

Staten Island, New York, 10305, United States
Strong Memorial Hospital

Rochester, New York, 14642, United States
Suny Upstate Medical University

Syracuse, New York, 13210, United States
TMC Healthcare

Tucson, Arizona, 85712, United States
Tampa General Hospital

Tampa, Florida, 33606, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19122, United States
The University of Vermont Medical Center Main Campus

Burlington, Vermont, 05401, United States
Trinity Health Saint Mary's

Grand Rapids, Michigan, 49503, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
UC Davis Medical Center

Sacramento, California, 95817, United States
UC Irvine

Orange, California, 92868, United States
UCLA Kaiser Fontana

Ontario, California, 91761, United States
UCSD Health La Jolla

La Jolla, California, 92103, United States
UCSD Medical Center - Hillcrest Hospital

San Diego, California, 92103, United States
UCSF Helen Diller Medical Center at Parnassus Heights

San Francisco, California, 94143, United States
UF Health Shands Hospital

Gainesville, Florida, 32611, United States
UF Jacksonville

Jacksonville, Florida, 32209, United States
UH Cleveland Medical Center

Cleveland, Ohio, 11100, United States
UMass Memorial Medical Center,

Worcester, Massachusetts, 01655, United States
UPMC Presbyterian Hospital

Pittsburgh, Pennsylvania, 15213, United States
UVA Medical Center

Charlottesville, Virginia, 22908, United States
University Health Shreveport

Shreveport, Louisiana, 71103, United States
University of Alabama Hospital

Birmingham, Alabama, 35294, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
University of Illinois Hospital and Health Sciences System

Chicago, Illinois, 60612, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Maryland

Baltimore, Maryland, 21201, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of New Mexico Hospital

Albuquerque, New Mexico, 87106, United States
University of Utah Healthcare

Salt Lake City, Utah, 84132, United States
University of Wisconsin University Hospital

Madison, Wisconsin, 53715, United States
Virginia Commonwealth University

Richmond, Virginia, 23219, United States
Virginia Mason Medical Center

Seattle, Washington, 98101, United States
Wake Forest University Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States
West Chester Hospital

West Chester, Ohio, 45069, United States
Yale-New Haven Hospital

New Haven, Connecticut, 06510, United States

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