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Blood pressure tweak during stroke procedure could save brains

NCT ID NCT05645861

Disease control Sponsor: Auckland City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether carefully managing blood pressure during a clot-removal procedure for stroke can improve patient recovery. About 550 people having emergency clot retrieval will have their systolic blood pressure kept within a specific target range. Researchers will then check their level of disability 90 days later to see if this approach leads to better outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
blood pressure management procedure
What this could lead to
If it works, this could point toward a standard way to manage blood pressure during clot retrieval, potentially improving recovery for stroke patients.
What could go wrong
This is a single trial with 550 participants, and the best blood pressure target is still unknown. Results may not apply to all stroke types or hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 550 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2019

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with anterior circulation stroke (ICA or proximal M1 or M2 segment of MCA) treated with ECR within 6 hrs of stroke onset and ECR patients presenting within 6-24 hours and favourable penumbra on perfusion scanning (see criteria 1-3). Additional criteria in the 6 to 24-hour window. 1. 'wake up' stroke; CT with no (or at most minimal) acute infarction or 2. patient 80 years or older (NIHSS of 10 and infarct volume less than 21 ml on DWI or CT perfusion-CBF) 3. patient less than 80 years (NIHSS of 10 and infarct volume less than 31 ml on DWI or CT perfusion-CBF NIHSS of 20 and infarct volume less than 51 ml on DWI or CT perfusion-CBF). Exclusion Criteria: * Rescue"' procedures eg acute ischaemic stroke associated with major medical procedures such as coronary artery stenting and coronary artery bypass * pre-stroke mRS\>=3 * not having GA * terminal illness with expected survival \<1 year * pregnancy * cardiovascular conditions where BP targeting will be contra-indicated * unable to participate in 3-month follow up

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Conditions

The condition(s) this trial relates to.

hypertensive disorder intracranial embolism ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blood pressure Embolus cerebral Stroke

Contacts and locations

Locations

  • Auckland City Hopsital

    Auckland, Auckland, 1023, New Zealand

  • Christchurch Hospital

    Christchurch, Canterbury, 8140, New Zealand

  • Gold Coast University Hospital

    Southport, Queensland, 4215, Australia

  • Metro South Hospital and Health Service via the Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Royal North Shore Hospital

    Sydney, New South Wales, 2065, Australia

  • Wellington Regional Hospital

    Newton, Wellington Region, 6021, New Zealand

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