Could a common pill protect stroke survivors from another stroke?
NCT ID NCT04760717
First seen Apr 04, 2026 · Last updated Jun 22, 2026 · Updated 12 times
Summary
This study tests whether adding spironolactone to standard blood pressure treatment helps lower blood pressure more effectively in people who have had a stroke. About 160 adults who had a bleeding or clot-caused stroke are taking spironolactone or continuing their usual care. Researchers measure home blood pressure after 3 months to see if the drug makes a difference.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Temple University Hospital
Philadelphia, Pennsylvania, 19140, United States
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University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States
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Wake Forest Baptist Health
Winston-Salem, North Carolina, 27157, United States
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Yale New Haven Hospital
New Haven, Connecticut, 06512, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Spironolactone
What this could lead to
If it works, this could point toward a better way to manage blood pressure after a stroke, potentially reducing the risk of another stroke.
What could go wrong
This is a small, early-phase trial. Spironolactone may not lower blood pressure more than standard treatments, and it can cause side effects like high potassium levels.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.