Could a simple steroid boost stroke survival? major trial underway

NCT ID NCT06360458

Disease control Sponsor: Wan-Jin Chen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving the steroid methylprednisolone along with standard clot-removal treatment can lower the risk of death or severe disability in people who have had a major stroke. About 928 adults with a large blockage in a main brain artery will receive either the steroid or a placebo within 12 hours of their stroke. The main goal is to see if the drug helps more people survive and recover better at 90 days.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

928 people

The number who actually took part.

Started

Aug 2024

Expected to finish

Jun 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years. * The time from onset to randomization was within 12 hours. * Anterior circulation ischemic stroke was preliminarily determined according to clinical symptoms or imaging examination. * Occlusion of the intracranial internal carotid artery, the M1- or M2-segment of the middle cerebral artery by confirmed by CT angiography (CTA), MR angiography (MRA), or digital subtraction angiography (DSA). * Baseline National Institutes of Health Stroke Scale (NIHSS) ≥ 6. * Baseline Alberta Stroke Program Early CT Score (ASPECTS) \< 6 (based on non-contrast CT or MRI) and/or core infarct volume ≥ 50 ml (based on CTP with rCBF \< 30%). * Planned treatment with endovascular thrombectomy (EVT). * Informed consent obtained from patients or their legal representatives. Exclusion Criteria: * Intracranial hemorrhage confirmed by cranial CT or MRI. * mRS score \> 2 before onset. * Pregnant or lactating women. * Allergic to contrast agents or glucocorticoids. * Participating in other clinical trials. * The artery is tortuous so that the thrombectomy device cannot reach the target vessel. * Bleeding history (gastrointestinal and urinary tract bleeding) in recent 1 month. * Chronic hemodialysis and severe renal insufficiency (glomerular filtration rate \< 30 ml/min or serum creatinine \> 220 umol/L \[2.5 mg/ dL\]). * Life expectancy due to any advanced disease \< 6 months. * Follow-up is not expected to be completed. * Intracranial aneurysm and arteriovenous malformation. * Brain tumors with imaging mass effect. * Systemic infectious disease.

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Conditions

The condition(s) this trial relates to.

ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute ischemic stroke Large infarct core

Contacts and locations

Locations

900th Hospital of PLA Joint Logistic Support Force

Fuzhou, Fujian, 350025, China
909th Hospital of PLA Joint Logistic Support Force

Zhangzhou, Fujian, 363000, China
Affiliated Hospital of Guangdong Medical University

Zhanjiang, Guangdong, 524001, China
Affiliated Hospital of North Sichuan Medical College

Nanchong, Sichuan, 637000, China
Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Jinan, Shandong, 250011, China
Anxi County Hospital

Anxi, Fujian, 362400, China
Anxi Hospital of Traditional Chinese Medicine

Anxi, Fujian, 362400, China
Baotou Central Hospital

Baotou, Inner Mongolia, 14040, China
Biyan People's Hospital

Biyang, Henan, 463700, China
Bozhou People's Hospital

Bole, Xinjiang, 833400, China
Cardiovascular Hospital Affiliated to Shanxi Medical University

Taiyuan, Shanxi, 30001, China
Central people' s hospital of zhanjiang

Zhanjiang, Guangdong, 524037, China
Chongzhou People's Hospital

Chengdu, Sichuan, 611230, China
Department of Neurology, First Affiliated Hospital Fujian Medical University

Fuzhou, Fujian, 350005, China
Ezhou Central Hospital

Ezhou, Hubei, 436000, China
First Affiliated Hospital of Gannan Medical University

Ganzhou, Jiangxi, 341000, China
Fuqing City Hospital of Fujian

Fuqing, Fujian, 350300, China
Fuzhou University Affiliated Provincial Hospital

Fuzhou, Fujian, 350001, China
Gansu Province Central Hospital

Lanzhou, Gansu, 730050, China
Ganzhou People's Hospital, Ganzhou (G.Z.)

Ganzhou, Jiangxi, 341000, China
Guangzhou First People's Hospital

Guangzhou, Guangzhou, 510180, China
Gulin County People's Hospital

Gulin, Sichuan, 646500, China
Hefei First People's Hospital

Hefei, Anhui, 230061, China
Huanggang Central Hospital

Huanggang, Hubei, 438000, China
Huangshi Central Hospital

Huangshi, Hubei, 435000, China
Jiangxi Provincial People's Hospital

Nanchang, Jiangxi, 330006, China
Jinan Central Hospital Affiliated to Shandong First Medical University

Jinan, Shandong, 250013, China
Jingdezhen First People's Hospital

Jingdezhen, Jiangxi, 333000, China
Jingzhou Hospital Affiliated to Yangtze University

Jingzhou, Hubei, 434020, China
Jiujiang University Affiliated Hospital

Jiujiang, Jiangxi, 332000, China
Liaocheng People's Hospital

Liaocheng, Shandong, 252000, China
Liaocheng third people's hospital

Liaocheng, Shandong, 252000, China
Lichuan City Ethnic Traditional Chinese Medical Hospital

Lichuan, Hubei, 445400, China
Longyan First Affiliated Hospital of Fujian Medical University

Longyan, Fujian, 364000, China
Maoming Hospital of Traditional Chinese Medicine

Maoming, Guangdong, 525000, China
Maoming people's hospital

Maoming, Guangdong, 525000, China
Mianyang 404 Hospital

Mianyang, Sichuan, 621000, China
Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China

Mianyang, Sichuan, 621000, China
Mindong Hospital

Ningde, Fujian, 352100, China
Nanping First Hospital

Nanping, Fujian, 353000, China
Ningde Municipal Hospital, Ningde Normal University

Ningde, Fujian, 352100, China
Putian University Affiliated Hospital

Putian, Fujian, 351100, China
Qichun People's Hospital

Huanggang, Hubei, 435300, China
Quanzhou First Hospital Affiliated to Fujian Medical University

Quanzhou, Fujian, 362000, China
Qujing NO.1 Hospital

Qujing, Yunnan, 655000, China
Red Cross Hospital of Yulin City

Yulin, Guangxi, 537000, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai Municipality, 200025, China
Sanming First Hospital

Sanming, Fujian, 365000, China
Shantou Central Hospital

Shantou, Guangdong, 515031, China
Shanxi Provincial People's Hospital

Taiyuan, Shanxi, 30012, China
Shaowu Municiple Hospital

Shaowu, Fujian, 354000, China
Shiyan Hospital of Integrated Traditional and Western Medicine

Shiyan, Hubei, 442000, China
Shiyan Renmin Hospital

Shiyan, Hubei, 442000, China
Suining Central Hospital

Suining, Sichuan, 629000, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University

Guangzhou, Guangdong, 510120, China
Taihe County People's Hospital

Taihe Chengguanzhen, Anhui, 236600, China
Taihe Hospital Affiliated to Hubei University of Medicine

Shiyan, Hubei, 442000, China
The 910th Hospital of the Joint Logistics Support Force of the Chinese PLA

Quanzhou, Fujian, 362000, China
The Affiliated Hospital of Qingdao Univercity

Qingdao, Shandong, 266003, China
The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221002, China
The Central Hospital of Enshi Tujia And Miao Automomous Prefecture

Enshi, Hubei, 445000, China
The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430014, China
The First Affiliated Hospital of Hainan Medical University

Haikou, Hainan, 570102, China
The First Affiliated Hospital of USTC

Hefei, Anhui, 230001, China
The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, 361003, China
The First Affiliated Hospital, Jiangxi Medical College, Nanchang University

Nanchang, Jiangxi, 330006, China
The First Hospital of Putian City

Putian, Fujian, 351100, China
The First People's Hospital of Jiujiang

Jiujiang, Jiangxi, 332000, China
The First People's Hospital of Qingzhen

Qingzhen, Guizhou, 551400, China
The First People's Hospital of Tianmen in Hubei Province

Tianmen, Hubei, 431700, China
The First People's Hospital of Xianyang

Xianyang, Shaanxi, 712000, China
The First people's Hospital of Jiangxia District

Wuhan, Hubei, 430200, China
The Second Affiliated Hospital of Fujian Medical University

Quanzhou, Fujian, 362000, China
The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine

Fuzhou, Fujian, 350003, China
The Second Affiliated Hospital of Hainan Medical University

Haikou, Hainan, 570311, China
The Second Affiliated Hospital of Shandong First Medical University

Tai’an, Shandong, 271000, China
The Second People's Hospital of Yichang

Yichang, Hubei, 443000, China
The Third People's Hospital of Hubei Province

Wuhan, Hubei, 430033, China
Tianjin Huanhu Hospital

Tianjin, Tian, 300350, China
Tongji hospital, Tongji medical college, Huazhong university of science and technology

Wuhan, Hubei, 430030, China
Union Hospital Affiliated to Fujian Medical University

Fuzhou, Fujian, 350001, China
Wuhan Hankou Hospital

Wuhan, Hubei, 430012, China
Wuhan NO.1 Hospital

Wuhan, Hubei, 430022, China
Wuhan University Renmin Hospital

Wuhan, Hubei, 430060, China
Xiangyang Hospital of Traditional Chinese Medicine

Xiangyang, Hubei, 441000, China
Xiangyang No.1 People's Hospital, Hubei University of Medicine.

Xiangyang, Hubei, 441000, China
Xianning Central Hospital

Xianning, Hubei, 437100, China
Xihua People's Hospital

Wacheng Neighborhood, Henan, 466600, China
Yangtze University Affiliated Hospital

Jingzhou, Hubei, 434000, China
Yijishan Hospital of Wannan Medical College

Wuhu, Anhui, 241001, China
Yingtan people's hospital

Yingtan, Jiangxi, 335000, China
Zhangzhou Municipal Hospital of Fujian Province

Zhangzhou, Fujian, 363000, China
Zhongnan Hospital of Wuhan University

Wuhan, Hubei, 430071, China
Zhongshan Hosipital Xiamen University

Xiamen, Fujian, 361004, China
Zhoukou Centeral Hospital

Zhoukou, Henan, 466000, China
ZhuMaDian Centeral Hospital

Zhumadian, Henan, 463000, China
Zhumadian First People's Hospital

Zhumadian, Henan, 463000, China
Zigong Third People's Hospital

Zigong, Sichuan, 643020, China
Zoucheng People's Hospital, Shandong Province

Zoucheng, Shandong, 273500, China

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