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Brain artery test may spot hidden stroke risk

NCT ID NCT07309705

Knowledge-focused Sponsor: Xuanwu Hospital, Beijing Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study is testing whether a new digital imaging analysis can more accurately predict stroke risk in 400 adults with narrowed brain arteries (50-99% blockage). Participants undergo standard angiography, and researchers use a computer method to measure blood flow impairment. They will be followed for one year to see who has a stroke or related death, comparing the new method to traditional measurements.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a more accurate way to identify which patients with brain artery narrowing are at highest risk of stroke, helping doctors tailor treatments.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly improve outcomes. The new method may not prove more accurate than current approaches.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 18 to 80 years with symptomatic intracranial atherosclerotic stenosis (50%-99%) of a major anterior-circulation artery, who experienced a target-artery-related ischemic event (ischemic stroke involving \<50% MCA territory or TIA) within the past 12 months and are eligible for medical therapy and DPR evaluation.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with intracranial atherosclerotic stenosis (ICAS) of the anterior circulation. 2. History of an ischemic cerebrovascular event related to the target artery within the past 12 months, including ischemic stroke involving less than one-half of the middle cerebral artery territory or transient ischemic attack. 3. Age between 18 and 80 years. 4. Stenosis severity of 50% to 99% identified by transcranial Doppler ultrasound, CT angiography, or MR angiography, and confirmed as 50% to 99% stenosis on digital subtraction angiography. 5. Good compliance, willingness to sign written informed consent, and ability to complete follow-up. Exclusion Criteria: 1. Non-atherosclerotic intracranial stenosis such as moyamoya disease, vasculitis, or arterial dissection. 2. Coexisting ipsilateral arterial stenosis greater than 50% other than the target lesion. 3. Large territorial infarction on MRI DWI involving at least one-half of the MCA territory with a modified Rankin Scale score greater than 3. 4. Contraindications to the use of antiplatelet agents or statins. 5. Inability to undergo DSA because of severe iodinated contrast allergy, severe hyperthyroidism, severe coagulation abnormalities with high bleeding risk, or severe cardiac, hepatic, or renal insufficiency. 6. Pregnant or breastfeeding women.

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Conditions

The condition(s) this trial relates to.

intracranial arteriosclerosis stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemodynamic Intracranial atherosclerosis icas Stroke

Contacts and locations

Locations

  • Department of Neurosurgery, Xuanwu hospital

    Beijing, Xicheng District, 100053, China

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Other studies related to the condition(s) this trial covers.