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Stepping up stroke recovery: could intensive walking practice boost rehabilitation?

NCT ID NCT05393661

Disease control Sponsor: Indiana University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study tests whether a focused, intensive stepping training program, called FIRST, can improve walking ability in people recovering from a recent stroke. Participants in inpatient rehabilitation receive physical therapy that prioritizes walking practice at higher cardiovascular intensities. The study measures changes in walking speed, endurance, and balance from admission to discharge.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Focused intensive repeated stepping training (FIRST) during inpatient physical therapy
What this could lead to
If effective, this approach could help stroke survivors regain walking ability faster and more fully during inpatient rehabilitation.
What could go wrong
This is a quality improvement project, not a randomized controlled trial, so results may be influenced by other factors. The intervention's success depends on therapist adherence and patient tolerance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2017

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals admitted to the Rehabilitation Hospital of Indiana for acute inpatient rehabilitation poststroke

Ages

18 to 89 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \< 2 months poststroke Exclusion Criteria: * restrictions in lower extremity weightbearing (e.g., amputation or lower limb fracture) * unable to ambulate \> 50 m prior to their most recent stroke * discharged to home from inpatient rehabilitation after \< 1 week

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Conditions

The condition(s) this trial relates to.

Gait Disorders, Neurologic stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gait, hemiplegic Stroke, acute

Contacts and locations

Locations

  • Rehabilitation Hospital of Indiana

    Indianapolis, Indiana, 46254, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.