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Scientists track platelet changes to unlock mysteries of delayed brain injury

NCT ID NCT06375889

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to better understand why some people develop delayed brain damage after a brain aneurysm rupture. Researchers measured platelet activation over time in 90 patients, comparing those with aneurysm bleeds to those with other types of brain bleeds. The goal was to clarify how platelets and blood vessel damage contribute to delayed complications, which could lead to better monitoring or treatments in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

90 people

The number who actually took part.

Started

Jun 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

We therefore chose to carry out an exhaustive recruitment of the active file of consecutive patients eligible for the study selection criteria. In the Medical ICA and Neurovascular ICU Department of the Pierre Wertheimer Hospital of the Hospices Civils de Lyon, treating patients with sub-aneurysmal meningeal haemorrhage or intraparenchymal haemorrhage. 40 patients in each group

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and Female Adults ≤18 years of age. * Hospitalised in the neurological intensive care unit of the Pierre Wertheimer Hospital of the Hospices Civils de Lyon following an aneurysmal meningeal haemorrhage of any modified Fischer score, previously diagnosed by cerebral CT scan. * Patients admitted to the neurological intensive care unit or the NICU of the Pierre Wertheimer Hospital of the Hospices Civils de Lyon for an intra-parenchymal haematoma. * Patient who has been informed and has formulated his/her non-opposition, or close relative of the patient who has been informed and has formulated his/her non-opposition. * Affiliated to a social security scheme. Exclusion Criteria: * Non-aneurysmal SAH * Ischaemic stroke * Patients with previously known platelet function disorders * Pregnant or breast-feeding women * Patients under legal protection (guardianship, curatorship, safeguard of justice) * Patients under compulsory psychiatric care * Patients taking part in a study which may interfere with the present study

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Conditions

The condition(s) this trial relates to.

acquired aneurysmal subarachnoid hemorrhage brain ischemia subarachnoid hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aneuvrysmal subarachnoid hemorrhage Delayed cerebral ischemia Endotheliopathy Platelets kinetic

Contacts and locations

Locations

  • Anaesthesiology and Intensive Care medicine department, Pierre Wertheimer hospital

    Bron, Auvergne-Rhône-Alpes, 69005, France

  • Neurovascular intensive care unit department, Pierre Wertheimer hospital

    Bron, Auvergnes-Rhones-Alpes, 69005, France

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