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Spinal fluid test may spot brain damage early after hemorrhage

NCT ID NCT04998370

Knowledge-focused Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 366 people who had a brain bleed from a burst aneurysm. Researchers measured hemoglobin in the fluid around the brain and spine to see if it could predict secondary brain injury, like artery spasms or lack of blood flow. The goal is to find a better way to monitor patients and catch complications early.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple test to catch brain complications early after a brain bleed.
What could go wrong
This is an observational study, not a treatment trial. It only measures a marker, so it won't directly improve outcomes. Results may not change current care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

366 people

The number who actually took part.

Started

Aug 2021

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of patients admitted to an academic tertiary care center due to an aneurysmal subarachnoid hemorrhage. The primary objective of the study focuses on patients included with EVD, while secondary objectives consider patients with both, EVD and LD as well as patients without any drainage system.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age ≥ 18 years * hospital admission due to an aneurysmal subarachnoid hemorrhage (diagnosis radiologically confirmed) Exclusion Criteria: * non-aneurysmal subarachnoid hemorrhage (eg. trauma, perimesencephalic subarachnoid hemorrhage). * participation in another study with CSF sampling or an interventional medical product within the 30 days preceding and during the present study. * previous enrolment into the current study

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Conditions

The condition(s) this trial relates to.

acquired aneurysmal subarachnoid hemorrhage brain ischemia intracranial vasospasm subarachnoid hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Delayed cerebral ischemia Delayed ischemic neurological deficit Subarachnoid hemorrhage, aneurysmal Vasospasm

Contacts and locations

Locations

  • Johannes Kepler Universität Linz, Universitätsklinik für Neurochirurgie

    Linz, 4040, Austria

  • Kantonsspital Aarau

    Aarau, Canton of Aargau, CH-5001, Switzerland

  • Kantonsspital St. Gallen

    Sankt Gallen, Canton of St. Gallen, CH-9007, Switzerland

  • Klinikum rechts der Isar TUM

    München, Bavaria, 81675, Germany

  • Medizinische Universität Wien, Klinik für Neurochirurgie

    Vienna, 1090, Austria

  • University Hospital Zurich

    Zurich, Canton of Zurich, 8091, Switzerland

  • Universitätsklinikum Mannheim

    Mannheim, Baden-Wurttemberg, 68167, Germany

  • Universitätsklinikum Tübingen

    Tübingen, Tübingen, 72076, Germany

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