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New clinic program aims to tackle multiple chronic diseases in south africa

NCT ID NCT06248190

Disease control Sponsor: University of KwaZulu Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health education materials, and home visits from community health workers. The goal was to see if this approach could improve detection of new conditions, treatment changes, and control of existing conditions compared to usual care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
health system intervention (clinical decision support tool, health education, training, and community health worker visits)
What this could lead to
If successful, this approach could help primary care clinics better manage patients with multiple chronic conditions like HIV, high blood pressure, and diabetes, leading to improved health outcomes.
What could go wrong
This is a completed implementation study, not a drug trial. The results may not apply to other settings or countries, and the intervention requires significant training and resources to maintain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,837 people

The number who actually took part.

Started

Sep 2023

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 40 years or older * Receiving care for at least two of the following conditions, with at least one of the first five listed conditions being uncontrolled or patients indicated as struggling with the management of their condition: i. HIV (Self-reported current treatment). ii. hypertension (Self-reported current treatment. iii. diabetes (Self-reported current treatment). iv. asthma (Self-reported current treatment). vi. depression (Self-reported current treatment). vii. previous myocardial infarction (self-reported). viii. previous stroke (self-reported history). Exclusion Criteria: * Participants planning to relocate from either uMgungundlovu, KwaZulu-Natal, and Cape Metro in Western Cape, or changing their facilities during the period of the study. * Participants who are unable to give informed consent due to loss of capacity. * Participants self-reporting pregnancy * Participants who cannot communicate in English, isiXhosa, isiZulu, or Afrikaans. * Participants who are not willing to receive care for chronic conditions in their homes.

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Conditions

The condition(s) this trial relates to.

asthma Depression depressive disorder diabetes mellitus HIV infectious disease hypertensive disorder Multiple Chronic Conditions myocardial infarction stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma Depression Diabetes mellitus HIV infections Hypertension Myocardial infarction Stroke

Contacts and locations

Locations

  • Caluza Clinic

    Pietermaritzburg, South Africa

  • Delft CHC

    Cape Town, Western Cape, 7700, South Africa

  • Dr Abdurahman CHC

    Cape Town, Western Cape, 7700, South Africa

  • DuNoon CHC

    Cape Town, Western Cape, 7700, South Africa

  • Durbanville CHC

    Cape Town, Western Cape, 7700, South Africa

  • Eastwood Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Elsies CHC

    Cape Town, Western Cape, 7700, South Africa

  • Esigodini Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Gcumisa Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Gomane Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Gugulethu CHC

    Cape Town, Western Cape, 7700, South Africa

  • Gustrouw CDC

    Cape Town, Western Cape, 7700, South Africa

  • Hanover Park CHC

    Cape Town, Western Cape, 7700, South Africa

  • Heideveld CHC

    Cape Town, Western Cape, 7700, South Africa

  • Howick Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Impilwenhle Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Injabulo Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Kleinvlei CHC

    Cape Town, Western Cape, 7700, South Africa

  • Kraaifontein CHC

    Cape Town, Western Cape, 7700, South Africa

  • Macassar CDC

    Cape Town, Western Cape, 7700, South Africa

  • Mafatini Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Michael M

    Cape Town, Western Cape, 7700, South Africa

  • Mitchells Plain CHC

    Cape Town, Western Cape, 7700, South Africa

  • Mphophomeni Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Ndaleni Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Northdale Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Pata Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Retreat CHC

    Cape Town, Western Cape, 7700, South Africa

  • Richmond Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Songonzima Clinic

    Pietermaritzburg, KwaZulu-Natal, South Africa

  • Vanguard CHC

    Cape Town, Western Cape, 7700, South Africa

  • Willowfontein CHC

    Pietermaritzburg, KwaZulu-Natal, South Africa

More trials for these conditions

Other studies related to the condition(s) this trial covers.