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Higher-Dose eye injection may cut treatment visits for Vein-Related vision loss

NCT ID NCT05850520

Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a higher dose (8 mg) of the drug aflibercept against the standard dose (2 mg) in 892 adults with macular edema from a blocked retinal vein. The goal was to see if the higher dose works as well or better while allowing fewer injections. Participants received injections into the eye every 4 weeks for up to 60 weeks, and vision changes were measured at 36 weeks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

892 people

The number who actually took part.

Started

May 2023

Finished

May 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult ≥18 years of age (or country's legal age of adulthood if the legal age is \>18 years) at the time of signing the informed consent. * Treatment-naïve macular edema involving the foveal center secondary to RVO (BRVO, HRVO, or CRVO) diagnosed within 16 weeks (112 days) before the screening visit in the study eye. * Early Treatment Diabetic Retinopathy Study BCVA letter score of 73 to 24 (20/40 to 20/320) at screening and baseline visits in the study eye. Decrease in BCVA determined to be primarily the result of RVO in the study eye. * Mean CST ≥300 μm on optical coherence tomography (OCT) if excluding Bruch's membrane (e.g., Cirrus or Topcon) or ≥320 μm if including Bruch's membrane (e.g., Heidelberg Spectralis), confirmed by the reading center at the screening visit and by the site at baseline visit in the study eye. * Capable of giving signed informed consent form (ICF) by study participant or legally acceptable representative, which includes compliance with the requirements and restrictions listed in the ICF and in this protocol. * US participants will be required to have a Health Insurance Portability and Accountability Act (HIPAA) authorization; in other countries, as applicable according to national laws. * Women of childbearing potential (WOCBP) or men who are sexually active with partners of childbearing potential must agree to use highly effective contraception prior to the initial dose/start of the first treatment, during the study, and for at least 4 months after the last administration of study intervention. Contraceptive use by men or women should be consistent with local regulations regarding the methods of contraception for participation in clinical studies and fulfil the conditions set on Section 10.4.2. Exclusion Criteria: * Concurrent disease that causes substantial decrease of BCVA, is expected to limit BCVA recovery or is likely to require medical or surgical intervention during the study in the study eye. * Presence or history of the following ocular conditions: 1. Advanced age-related macular degeneration (neovascular AMD or geographic atrophy) in the study eye. 2. Diabetic macular edema or diabetic retinopathy, defined in diabetic participants as diabetic retinopathy lesions outside the area of the vein occlusion in the study eye and anywhere in the retina in the fellow eye. 3. Anterior segment neovascularization, vitreous hemorrhage, retinal detachment in the study eye. 4. Vitreomacular traction, epiretinal membrane or structural damage to the macula that is considered by the Investigator to significantly affect central vision or preclude improvement in vision in the study eye. 5. Macular hole of stage 2 and above in the study eye. 6. Myopia of a spherical equivalent of at least 8 diopters prior to any refractive or cataract surgery in the study eye. 7. Corneal transplant or corneal dystrophy in the study eye. 8. Idiopathic or autoimmune uveitis in the study or in the fellow eye. * Presence of the following ocular conditions at screening or baseline visit: 1. Significant media opacities, including cataract, that interfere with BCVA, or imaging assessments (e.g., fundus photography \[FP\], OCT) in the study eye. 2. Aphakia, or pseudophakia with absence of posterior capsule (unless it occurred as a result of a yttrium-aluminum-garnet \[YAG\] posterior capsulotomy performed more than 30 days before the screening visit), in the study eye. 3. Uncontrolled glaucoma (defined as IOP \>25 mmHg despite treatment with anti-glaucoma medication); or history or likely future need of glaucoma surgery in the study eye. 4. Intraocular inflammation/infection (including trace, or above, cells in the anterior chamber and/or vitreous) within 12 weeks (84 days) of the screening visit in the study or in the fellow eye. 5. Extraocular or periocular infection or inflammation (including infectious blepharitis, keratitis, scleritis, or conjunctivitis) in the study or in the fellow eye. * Uncontrolled blood pressure (defined as systolic \>160 mmHg or diastolic \>95 mmHg) at the screening visit or baseline visit. * Uncontrolled diabetes mellitus, defined by hemoglobin A1c (HbA1c) \>12% at the screening visit. * History of cerebrovascular accident or myocardial infarction within 24 weeks (168 days) before the screening visit or between screening and baseline visits. * Renal failure requiring dialysis, or renal transplant at screening or potentially during the study. * Any prior or concomitant ocular or systemic treatment (with an investigational or approved, anti-VEGF or other agent) or surgery for RVO in the study eye. * Previous administration of systemic anti-angiogenic medications for any condition. * Prior treatment of the study eye with any of the following drugs (any route of ophthalmic administration) or procedures: 1. Anti-angiogenic drugs at any time including investigational therapy (e.g., with anti-angiopoietin/anti-VEGF bispecific monoclonal antibodies). 2. Previous use topical steroids within 4 weeks (28 days) from the screening visit, or intraocular or periocular steroids within 16 weeks (112 days) from the screening visit, or steroid implants at any time. 3. Previous treatment with intraocular or periocular implant, gene therapy, or cell therapy at any time. 4. Treatment with ocriplasmin at any time. 5. Vitreoretinal surgery (including scleral buckling) at any time. 6. Any intraocular surgery, including cataract surgery, within 12 weeks (84 days) before the screening visit. 7. Previous treatment with retinal laser photocoagulation. * Prior treatment of the fellow eye with any of the following: a. Gene therapy, or cell therapy in the fellow eye at any time. * Participation in other clinical studies requiring administration of investigational treatments (other than vitamins and minerals) at the time of screening visit, or within 30 days or 5 half-lives of administration of the previous study intervention, whichever is longer.

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Conditions

The condition(s) this trial relates to.

central retinal vein occlusion with macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Macular edema secondary to retinal vein occlusion

Contacts and locations

Locations

  • AIBILI

    Coimbra, Coimbra District, 3000-548, Portugal

  • AP-HP - Hopital Lariboisiere

    Paris, Île-de-France Region, 75475, France

  • AS Ida-Tallinna Keskhaigla - Oftalmoloogiakeskus

    Tallinn, Harju, 10138, Estonia

  • ASST Fatebenefratelli Sacco

    Milan, Lombardy, 20122, Italy

  • Adelaide Eye and Retina Centre

    Adelaide, South Australia, 5000, Australia

  • Adnan Menderes Universitesi Tip fakultesi

    Aydin, 9100, Turkey (Türkiye)

  • Aichi Medical University Hospital

    Nagakute, Aichi-ken, 480-1195, Japan

  • Aier Eye Hospital (Chengdu)

    Chengdu, Sichuan, 610093, China

  • Aier Eye Hospital (LIAONING)

    Shenyang, Liaoning, 110003, China

  • Akita University Hospital

    Akita, Akita, 010-8543, Japan

  • Ankara Bilkent Sehir Hastanesi

    Bilkent Ankara, 6800, Turkey (Türkiye)

  • Ankara Etlik City Hospital | Ophthalmology

    Ankara, 06170, Turkey (Türkiye)

  • Ankara Numune Egitim ve Arastirma Hastanesi

    Ankara, 6100, Turkey (Türkiye)

  • Ansan Hospital | Nephrology

    Gyeonggi-do, 425-707, South Korea

  • Asan Medical Center | Ophthalmology

    Seoul, Seoul Teugbyeolsi, 05505, South Korea

  • Assuta Medical Centers - HaShalom

    Tel Aviv, 6789140, Israel

  • Austin Retina Associates - Central

    Austin, Texas, 78705, United States

  • Axon Clinical, s.r.o.

    Prague, 150 00, Czechia

  • Azienda Ospedaliera Policlinico Universitario Tor Vergata - Patologie Retiniche

    Rome, Lazio, 00133, Italy

  • Azienda Ospedaliero Universitaria Delle Marche - Clinica Oculistica

    Torrette, Ancona, 60126, Italy

  • Azul Vision Pasadena

    Pasadena, California, 91107, United States

  • Beijing Aier Intech Eye Hospital

    Beijing, Beijing Municipality, 100000, China

  • Beijing Hospital

    Beijing, Beijing Municipality, 100730, China

  • Berner Augenklinik am Lindenhofspital

    Bern, Canton of Bern, 3007, Switzerland

  • Bradford Royal Infirmary

    Bradford, West Yorkshire, BD9 6RJ, United Kingdom

  • Budapest Retina Associates

    Budapest, 1133, Hungary

  • Budapesti Bajcsy-Zsilinszky Korhaz es Rendelointezet

    Budapest, 1106, Hungary

  • CHLC - Hospital dos Capuchos - Servico de Oftalmologia

    Lisbon, Lisbon District, 1169-050, Portugal

  • CHU Bordeaux - Hopital Pellegrin - Ophtalmologie

    Bordeaux, New Aquitaine, 33076, France

  • CHU Dijon - Hopital Francois Miterrand

    Dijon, Bourgogne-Franche-Comté, 21000, France

  • CM Wolff

    Strasbourg, Grand Est, 67000, France

  • Capital Medical University (CMU) - Beijing Tongren Hospital

    Beijing, Beijing Municipality, 100062, China

  • Center for Retina and Macular Disease - Winter Haven

    Winter Haven, Florida, 33880, United States

  • Centre Hospitalier National d'Ophthalmologie Quinze-Vingt

    Paris, Île-de-France Region, 75557, France

  • Centre Ophtalmologique Transparence - Tours

    Tours, Centre-Val de Loire, 37000, France

  • Centre Ophthalmologie d'Imagerie et de Laser

    Paris, Île-de-France Region, 75015, France

  • Centre d'Ophtalmologie - Paradis-Monticelli

    Marseille, Provence-Alpes-Côte d'Azur Region, 13008, France

  • Centre d'ophtalmologie de l'Odéon

    Paris, Île-de-France Region, 75006, France

  • Centre for Eye Research

    East Melbourne, Victoria, 3002, Australia

  • Centro Hospitalar Universitario do Porto

    Porto, Porto District, 4099-001, Portugal

  • Centro Hospitalar Vila Nova de Gaia e Espinho | Unit 1 - Clinical Research Center

    Porto, Porto District, 4434-502, Portugal

  • Centrum Diagnostyki i Mikrochirurgii Oka Lens

    Olsztyn, 10-424, Poland

  • Centrum Medyczne Dietla 19 Sp. z o.o.

    Krakow, 31-070, Poland

  • Centrum Medyczne PROMED

    Krakow, 31-411, Poland

  • Centrum Medyczne Piasta 47

    Wałbrzych, 58-304, Poland

  • Charles Retina Specialists - Germantown

    Memphis, Tennessee, 38119, United States

  • Chiangmai University

    Chiang Mai, 50200, Thailand

  • China-Japan Friendship Hospital

    Beijing, Beijing Municipality, 100029, China

  • Chofu Eye Clinic

    Chōfu, Tokyo, 182-0024, Japan

  • Chongqing Aier Ophthalmology Hospital

    Chongqing, Chongqing Municipality, 400020, China

  • Cincinnati Eye Institute - Blue Ash

    Blue Ash, Ohio, 45242, United States

  • Clalit Health | Soroka Medical Center- Nephrology Department

    Beersheba, 8410101, Israel

  • Clinica Universidad De Navarra | Pamplona | Oftalmologia

    Pamplona, Pamplona, 31008, Spain

  • Clinical Center of Serbia

    Belgrade, 11000, Serbia

  • Clinical hospital center Zvezdara

    Belgrade, 11000, Serbia

  • Clinique Jules Verne - Nantes

    Nantes, Pays de la Loire Region, 44000, France

  • Clinique Rétine Tourny

    Bordeaux, New Aquitaine, 33000, France

  • Cumberland Valley Retina Consultants | Hagerstown, MD

    Hagerstown, Maryland, 21740, United States

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032, Hungary

  • Department of Ophthalmology

    Riga, Riga City, LV-1002, Latvia

  • Desert Retina Consultants - Palm Springs Office

    Palm Springs, California, 92262, United States

  • Dongyang People's Hospital

    Jinhua, Zhejiang, 322199, China

  • Dr. Kai Noor Silmakabinet OÜ

    Tallinn, Harju, 11412, Estonia

  • East Florida Eye Institute

    Stuart, Florida, 34994, United States

  • Edith Wolfson Medical Center | Internal Medicine Department

    Holon, 5822012, Israel

  • Espaco Medico de Coimbra

    Coimbra, Coimbra District, 3000-548, Portugal

  • Eye Center of the second Bethune Hospital, jinlin University

    Changchun, Jilin, 130022, China

  • Eyeclinic Albury Wodonga

    Albury, New South Wales, 2640, Australia

  • Fakultna Nemocnica s poliklinikou F.D.Roosevelta

    Banská Bystrica, Banská Bystrica Region, 975 17, Slovakia

  • Fakultna nemocnica Nitra

    Nitra, Nitra Region, 950 01, Slovakia

  • Fakultna nemocnica Trencin

    Trenčín, Trencín, 911 71, Slovakia

  • Fakultní Nemocnice Hradec Kralové

    Hradec Králové, 500 05, Czechia

  • Fakultní nemocnice Královské Vinohrady - Urologická klinikay

    Prague, 10034, Czechia

  • Fakultní nemocnice Ostrava

    Ostrava, 708 52, Czechia

  • Florida Eye Associates - Melbourne Main Office

    Melbourne, Florida, 32901, United States

  • Florida Retina Institute - Orlando

    Orlando, Florida, 32806, United States

  • Fondazione G.B.Bietti Per Lo Studio E La Ricerca In Oftalmologia - UOS Retina Medica

    Rome, Lazio, 00184, Italy

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    Milan, Lombardy, 20122, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Oculistica

    Rome, Lazio, 00136, Italy

  • Fort Lauderdale Eye Institute

    Plantation, Florida, 33324, United States

  • Frimley Park Hospital NHS

    Frimley, Surrey, GU167UJ, United Kingdom

  • Fukushima Medical University Hospital

    Fukushima, Fukushima, 960-1295, Japan

  • Gabinet Okulistyczny Prof. Edward Wylegala

    Katowice, 40-594, Poland

  • Ganglion Medical Center

    Pécs, 7621, Hungary

  • Gangnam Severance Hospital, Yonsei University Health System

    Seoul, Seoul Teugbyeolsi, 06273, South Korea

  • Guangzhou Aier Eye Hospital

    Guangzhou, Guangdong, 634050, China

  • Gunma University Hospital

    Maebashi, Gunma, 371-8511, Japan

  • Hacettepe Universitesi Tip Fakultesi

    Ankara, 06230, Turkey (Türkiye)

  • Hadassah Hebrew University Hospital Ein Kerem

    Jerusalem, 9112001, Israel

  • Hanusch-Krankenhaus Wien

    Vienna, State of Vienna, 1140, Austria

  • Hayashi Eye Hospital

    Fukuoka, Fukuoka, 812-0011, Japan

  • Hebei eye hospital

    Hebei, Hebei, 050010, China

  • Henan Provincial Eye Hospital

    Henan, Henan, 450008, China

  • Hobart Eye Surgeons

    Hobart, Tasmania, 7000, Australia

  • Hospital Al-Sultan Abdullah, UiTM | Opthalmology

    Bandar Puncak Alam, Selangor, 42300, Malaysia

  • Hospital Clinic De Barcelona | Oftamologia

    Barcelona, Barcelona, 08028, Spain

  • Hospital De La Santa Creu I Sant Pau | Oftalmologia

    Barcelona, Barcelona, 8025, Spain

  • Hospital General Universitario De Valencia | Oftalmologia

    Valencia, 46014, Spain

  • Hospital Selayang

    Shah Alam, Selangor, 68100, Malaysia

  • Hospital Shah Alam | Ophthalmology

    Shah Alam, Selangor, 40000, Malaysia

  • Hospital Universitari General De Catalunya | Oftalmologia

    Sant Cugat del Vallès, Barcelona, 08195, Spain

  • Hospital Universitari Vall D Hebron | Oftalmologia

    Barcelona, Barcelona, 08035, Spain

  • Hospital Universitario Miguel Servet | Oftalmologia

    Zaragoza, Zaragoza, 50009, Spain

  • Hospital Universitario Puerta De Hierro De Majadahonda | Oftalmologia

    Majadahonda, Madrid, 28222, Spain

  • Hospital Universitario Rio Hortega | Oftalmologia

    Valladolid, Valladolid, 47012, Spain

  • Hospital of LT University of Health Sciences Kaunas Clinics

    Kaunas, LT-50161, Lithuania

  • Hull and East Yorkshire Eye Hospital Hull and East Yorkshire

    Hull, East Riding of Yorkshire, HU32JZ, United Kingdom

  • Hyogo Medical University Hospital

    Nishinomiya, Hyōgo, 663-8501, Japan

  • Hyogo Prefectural Amagasaki General Medical Center

    Amagasaki, Hyōgo, 660-8550, Japan

  • Hôpital Intercommunal - Créteil Cedex

    Créteil, Île-de-France Region, 94010, France

  • Hôpital de la Croix Rousse

    Lyon, Auvergne-Rhône-Alpes, 69004, France

  • Inselspital Universitätsspital Bern

    Bern, Canton of Bern, 3010, Switzerland

  • Instituto Oftalmologico Gomez-Ulla S.L. | Oftalmologia

    Santiago de Compostela, A Coruña, 15706, Spain

  • International University of Health and Welfare Narita Hospital

    Narita, Chiba, 286-8520, Japan

  • Japanese Red Cross Nagasaki Genbaku Hospital

    Nagasaki, Nagasaki, 852-8511, Japan

  • Japanese Red Cross Saitama Hospital

    Saitama, Saitama, 330-8553, Japan

  • Japanese Red Cross Wakayama Medical Center

    Wakayama, Wakayama, 640-8558, Japan

  • Kagawa University Hospital

    Kita-gun, Kagawa-ken, 761-0793, Japan

  • Kagoshima University Hospital

    Kagoshima, Kagoshima-ken, 890-8520, Japan

  • Kaplan Medical Center

    Rehovot, 7610001, Israel

  • Keio University Hospital

    Shinjuku-ku, Tokyo, 160-8582, Japan

  • Kim's Eye Hospital

    Seoul, 07301, South Korea

  • Klinicki centar Vojvodine

    Novi Sad, 21000, Serbia

  • Klinikum Klagenfurt am Wörthersee

    Linz, Upper Austria, 4010, Austria

  • Klinikum d. Stadt Ludwigshafen - Ophthalmology

    Ludwigshafen, 67063, Germany

  • Knappschaftskrankenhaus Sulzbach

    Sulzbach, Saarland, 66280, Germany

  • Kobe University Hospital

    Kobe, Hyōgo, 650-0017, Japan

  • Kocaeli Universitesi Tip Fakultesi

    Kocaeli, 41380, Turkey (Türkiye)

  • Konventhospital Barmherzige Brüder Linz

    Linz, Upper Austria, 4020, Austria

  • Kozawa Eye Hospital and Diabetes Center

    Mito, Ibaraki, 310-0845, Japan

  • Kurume University Hospital

    Kurume, Fukuoka, 830-0011, Japan

  • LTD "Chichua Medical Center MZERA"

    Tbilisi, K'alak'i T'bilisi, 114, Georgia

  • LTD "IQ Clinic"- Ophthalmology

    Tbilisi, K'alak'i T'bilisi, 162, Georgia

  • Lady Davis Carmel Medical Center

    Haifa, 3436212, Israel

  • Lanzhou University - The Second Hospital (The Second Clinical Medical College of Lanzhou University)

    Lanzhou, Gansu, 730030, China

  • Leeds Teaching Hospitals NHS Trust | St James's University Hospital - Oncology

    Leeds, West Yorkshire, LS9 7TF, United Kingdom

  • Leicester Royal Infirmary

    Leicester, Leicestershire, LE1 5WW, United Kingdom

  • Lexum a.s., Evropska ocni klinika

    Prague, 140 00, Czechia

  • Lion Eye Institute

    Nedlands, Western Australia, 6009, Australia

  • Magyar Honvedseg Egeszsegugyi Kozpont

    Budapest, 1062, Hungary

  • Marietta Eye Clinic

    Marietta, Georgia, 30060, United States

  • Marsden Eye Surgery Center

    Parramatta, New South Wales, 2150, Australia

  • Matsumoto Eye Clinic

    Toride, Ibaraki, 302-0014, Japan

  • Medical Center Ophthalmology Associates - Northwest

    San Antonio, Texas, 78240, United States

  • Medical corporation Eiwakai Dannoue Ophthalmology clinic

    Kawasaki, Kanagawa, 211-0053, Japan

  • Medizinische Universität Graz

    Graz, Styria, 8036, Austria

  • Meir Medical Center

    Kfar Saba, 4428164, Israel

  • Mid Atlantic Retina - Bethlehem

    Bethlehem, Pennsylvania, 18107, United States

  • Mid Atlantic Retina - Philadelphia / Wills Eye Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Mid Atlantic Retina Specialists - Hagerstown

    Hagerstown, Maryland, 21740, United States

  • Midwest Retina - Main Office

    Dublin, Ohio, 43016, United States

  • Mie University Hospital

    Tsu, Mie-ken, 514-8507, Japan

  • Moorfields Eye Hospital

    London, Greater London, EC1V2PD, United Kingdom

  • Murakami Karindoh Hospital

    Fukuoka, Fukuoka, 819-8585, Japan

  • NJ Retina - New Brunswick

    New Brunswick, New Jersey, 08901, United States

  • NJ Retina | Teaneck

    Teaneck, New Jersey, 07666, United States

  • Nagoya City University Hospital

    Nagoya, Aichi-ken, 467-8602, Japan

  • National Defense Medical College Hospital

    Tokorozawa, Saitama, 359-8513, Japan

  • National Hospital Organization Tokyo Medical Center

    Meguro-ku, Tokyo, 152-8902, Japan

  • National Ophthalmic Research Institute - Fort Myers

    Fort Myers, Florida, 33912, United States

  • Nemocnice Pardubickeho kraje, a.s., Pardubicka nemocnice

    Pardubice, 530 03, Czechia

  • New Cross Hospital

    Wolverhampton, West Midlands, WV100QP, United Kingdom

  • New England Retina Associates

    New London, Connecticut, 06320, United States

  • Nihon University Hospital

    Chiyoda-ku, Tkyo, 101-8309, Japan

  • Northern California Retina Vitreous Associates - Mountain View Office

    Mountain View, California, 94040, United States

  • OasisEye Specialists

    Kuala Lumpur, Kuala Lumpur, 59200, Malaysia

  • Okayama University Hospital

    Okayama, Okayama-ken, 700-8558, Japan

  • Ophthalmic Consultants of Long Island

    Lynbrook, New York, 11563, United States

  • Osaka Metropolitan University Hospital

    Osaka, Osaka, 545-8586, Japan

  • Ospedale San Raffaele s.r.l.

    Milan, Lombardy, 20132, Italy

  • Osrodek Chirurgii Oka prof. Zagorskiego Sp. z o.o.

    Rzeszów, 35-017, Poland

  • Palmetto Retina Center, LLC - Florence

    Florence, South Carolina, 29501, United States

  • Peking Union Medical College Hospital CAMS

    Beijing, Beijing Municipality, 100730, China

  • Peking University First Hospital - Oncology Department

    Beijing, Beijing Municipality, 100034, China

  • People's Hospital of Ningxia Hui Autonomous Region - Opthalmology

    Ningxia, Ningxia, 750002, China

  • Profesorskie Centrum Okulistyki

    Gdansk, 80-809, Poland

  • Prywatna Klinika Okulistyczna OFTALMIKA

    Bydgoszcz, 85-631, Poland

  • Pusan National University Hospital

    Busan, Busan, 49241, South Korea

  • Qilu Hosp., Shandong Univ.

    Jinan, Shandong, 250012, China

  • RCM - St. Louis Park Retina Clinic

    Saint Louis Park, Minnesota, 55416, United States

  • Rabin Medical Center | Beilinson Hospital - Nephrology and Hypertension Institute

    Petah Tikva, 4941492, Israel

  • Rambam Health Corporation

    Haifa, 3109601, Israel

  • Rand Eye Institute

    Deerfield Beach, Florida, 33064, United States

  • Retina Associates - Elmhurst

    Elmhurst, Illinois, 60126, United States

  • Retina Associates - Lenexa

    Lenexa, Kansas, 66215, United States

  • Retina Associates of Western New York

    Rochester, New York, 14620, United States

  • Retina Center of New Jersey

    Bloomfield, New Jersey, 07003, United States

  • Retina Consultants of Nevada - Summerlin

    Las Vegas, Nevada, 89144, United States

  • Retina Consultants of Orange County - Fullerton

    Fullerton, California, 92835, United States

  • Retina Consultants of South Carolina - Ladson

    Ladson, South Carolina, 29456, United States

  • Retina Consultants of Southern California

    Redlands, California, 92374, United States

  • Retina Consultants of Southern Colorado, PC

    Colorado Springs, Colorado, 80909, United States

  • Retina Consultants of Texas - Bellaire

    Bellaire, Texas, 77401, United States

  • Retina Consultants of Texas - San Antonio Medical Center

    San Antonio, Texas, 78240, United States

  • Retina Consultants, LLC

    Salem, Oregon, 97302, United States

  • Retina Specialty Institute - Pensacola

    Pensacola, Florida, 32503, United States

  • Retina Vitreous Associates of Florida - Saint Petersburg

    St. Petersburg, Florida, 33711, United States

  • Riga East Clinical University Hospital "Gailezers"

    Riga, Riga City, LV-1038, Latvia

  • Rocky Mountain Retina Consultants - Main Office

    Salt Lake City, Utah, 84107, United States

  • Royal Liverpool University Hospital

    Liverpool, Merseyside, L7 8XP, United Kingdom

  • RétinElysée

    Lausanne, Canton of Vaud, 1006, Switzerland

  • SBU Gulhane Egitim ve Arastirma Hastanesi

    Ankara, 6010, Turkey (Türkiye)

  • SEHAT Pentagram

    Sofia, Sofia City Province, 1309, Bulgaria

  • Samsung Medical Center - Oncology Department

    Seoul, 06351, South Korea

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, Seoul Teugbyeolsi, 03722, South Korea

  • Shamir Medical Center (Assaf Harofeh)

    Ẕerifin, 7030000, Israel

  • Shanxi Eye Hospital

    Shanxi, Shanxi, 030002, China

  • Shida Eye Clinic

    Fujieda-shi, Shizuoka, 426-0029, Japan

  • Shiga University of Medical Science Hospital

    Ōtsu, Shiga, 520-2192, Japan

  • Shijiazhuang General Hospital

    Shijiazhuang, Hebei, 050000, China

  • Shinshu University Hospital

    Matsumoto, Nagano, 390-8621, Japan

  • Sihtasutus Tartu Ülikooli Kliinikum - Silmakliinik

    Tartu, Tartu County, 50406, Estonia

  • South Coast Retina - Long Beach

    Long Beach, California, 90807, United States

  • Southern Tohoku Eye Clinic

    Kōriyama, Fukushima, 963-8052, Japan

  • Spec. Hosp. of Ophthalm. Disease for Active Treatment Varna

    Varna, Varna Province, 9000, Bulgaria

  • Specialized Hospital For Active Treatment of Eye Diseases Zora

    Sofia, Sofia City Province, 1784, Bulgaria

  • Specialized hospital for ophthalmology OPHTAL

    Zvolen, Banská Bystrica Region, 960 01, Slovakia

  • Specjalistyczny Osrodek Okulistyczny Oculomedica

    Bydgoszcz, 85-870, Poland

  • Spokane Eye Clinical Research - South Hill / Downtown

    Spokane, Washington, 99204, United States

  • Srinagarind Hospital

    Khon Kaen, 40002, Thailand

  • St. Franziskus-Hospital Münster - Eye Center

    Münster, 48145, Germany

  • St. Marianna University Hospital

    Kawasaki, Kanagawa, 216-8511, Japan

  • St. Mary Hospital

    Seoul, 06591, South Korea

  • Strathfield Retina Clinic

    Strathfield, New South Wales, 2135, Australia

  • Sunderland Eye Infirmary

    Sunderland, Tyne and Wear, SR29HP, United Kingdom

  • Sydney Eye Hospital

    Sydney, New South Wales, 2000, Australia

  • Sydney Retina Clinic

    Sydney, New South Wales, 2000, Australia

  • Sydney West Retina Pty Ltd

    Westmead, New South Wales, 2145, Australia

  • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ

    Szeged, 6720, Hungary

  • Tel- Aviv Sourasky Medical Center - Nephrology

    Tel Aviv, 6423906, Israel

  • Texas Retina Associates - Fort Worth

    Fort Worth, Texas, 76104, United States

  • The Eye Institute of West Florida - Largo

    Largo, Florida, 33770, United States

  • The Fourth People's Hospital of Shenyang

    Shenyang, Liaoning, 110082, China

  • The Retina Care Center - Baltimore

    Baltimore, Maryland, 21209, United States

  • The Retina Group of Washington - Fairfax

    Fairfax, Virginia, 22031, United States

  • The Second Affiliated Hospital of Anhui Medical University

    Hefei, Anhui, 230601, China

  • The University of Tokyo Hospital

    Bunkyo-ku, Tokyo, 113-8655, Japan

  • Tianjin Medical University Eye Hospital

    Tianjin, Tianjin Municipality, 300384, China

  • Toho University Sakura Medical Center

    Sakura, Chiba, 285-8741, Japan

  • Tokiwadai Muranaka Eye Clinic

    Itabashi-ku, Tokyo, 174-0071, Japan

  • Tokyo Medical University Hachioji Medical Center

    Hachiōji, Tokyo, 193-0998, Japan

  • Tokyo Metropolitan Institute for Geriatrics and Gerontology

    Itabashi-ku, Tokyo, 173-0015, Japan

  • Tokyo Women's Medical University Hospital

    Shinjuku-ku, Tokyo, 162-8666, Japan

  • Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech.

    Wuhan, Hubei, 430030, China

  • Toyama University Hospital

    Toyama, Toyama, 930-0194, Japan

  • UW Health Carbone Cancer Center

    Madison, Wisconsin, 53792, United States

  • Uni Heidelberg / Augenklinik

    Heidelberg, 0, Germany

  • Unidade Local de Saúde de São João E.P.E. - Hospital São João - Serviço de Oftalmologia

    Porto, Porto District, 4200-319, Portugal

  • Uniklinik Bonn / Eye Clinic

    Bonn, 53127, Germany

  • University Eye Hospital Jules Gonin

    Lausanne, Canton of Vaud, 1004, Switzerland

  • University Retina and Macula Associates - Oak Forest

    Oak Forest, Illinois, 60452, United States

  • University of Fukui Hospital

    Yoshida, Fukui, 910-1193, Japan

  • University of Miyazaki Hospital

    Miyazaki, Miyazaki, 889-1692, Japan

  • University of Semmelweis/ Semmelweis Egyetem

    Budapest, 1083, Hungary

  • University of Yamanashi Hospital

    Chūō, Yamanashi, 409-3898, Japan

  • Universitätsklinikum AKH Wien

    Vienna, State of Vienna, 1090, Austria

  • Univerzitna nemocnica Bratislava, Nem. Sv. Cyrila a Metoda

    Bratislava, Bratislava Region, 851 07, Slovakia

  • Univerzitna nemocnica Bratislava, Nemocnica Ruzinov

    Bratislava, Bratislava Region, 826 06, Slovakia

  • Vilnius University Hospital Santaros Klinikos

    Vilnius, LT-08661, Lithuania

  • Vision Research Center

    Albuquerque, New Mexico, 87109, United States

  • Vista Klinik

    Binningen, Basel-Landschaft, 4102, Switzerland

  • Vitreo-Retinal Associates - Worcester

    Grand Rapids, Michigan, 49525, United States

  • Vitreoretinal Consultants of NY - Great Neck

    Great Neck, New York, 11021, United States

  • Vitreoretinal Consultants of NY - Hauppauge

    Hauppauge, New York, 11788, United States

  • Všeobecná fakultní nemocnice v Praze

    Prague, 12808, Czechia

  • Yamagata University Hospital

    Yamagata, Yamagata, 990-9585, Japan

  • Yamaguchi University Hospital

    Ube, Yamaguchi, 755-8505, Japan

  • Yeungnam University Medical Center

    Daegu, Daegu, 42415, South Korea

  • Yokohama City University Medical Center

    Yokohama, Kanagawa, 232-0024, Japan

  • York Teaching Hospital

    York, North Yorkshire, YO611DW, United Kingdom

  • ZheJiang Provincial People's Hospital

    Hangzhou, Zhejiang, 310014, China

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