Heart drug tested as migraine shield in small trial

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Be able to give voluntary written informed consent to participate. * Have a diagnosis of episodic migraine without aura according to The International Classification of Headache Disorders 3rd Edition. * Be in good general health and without any cardio- or cerebrovascular diseases, psychiatric disorders or other severe comorbidities. * Be 18-60 years of age. * Have a weight between 50-100 kg. * Have a normal standard resting 12-lead ECG at the screening visit with heart rate (HR) ≥ 60 bpm (the inclusion criterium of HR ≥ 60 bpm at screening has previously been used in studies with dosages of ivabradine up to 20 mg as single and multiple doses with no significant adverse events). * Be without any chronic use of medicine. * Have a negative urine-human chorionic gonadotropin (hCG) test at the screening visit if they are female of childbearing potential. Exclusion Criteria: * Suffer from tension type headache, as defined by the The International Classification of Headache Disorders 3rd Edition, more than five days a month on average in the last year. * Are diagnosed with any primary headache disorder apart from migraine without aura as de-fined in The International Classification of Headache Disorders 3rd Edition (relating to tension type headache, see above). * Suffer from any headache 48 hours prior to the start of the experiment or any migraine 72 hours prior to the start of the experiment. * Are allergic to ivabradine or levcromakalim. * Are lactose intolerant (due to Ivabradine tablets containing lactose). * Have a daily intake of any medicine other than oral contraception or use of drugs or other ed-ibles/beverages with potential serious interactions with ivabradine * Have a history of personal/familial or clinical signs of: cardiovascular and cerebrovascular disease (Long QT Syndrome, Cardiac dysrhythmia, Bradycardia, i.e. a resting heart rate of \< 60 bpm at screening, Amnestic information or clinical signs of hyper- or hypotension (Hypertension (systolic blood pressure \> 150 mmHg and / or diastolic blood pressure \> 100 mmHg)/Hypotension (systolic blood pressure \< 90 mm Hg and / or diastolic blood pressure \< 50 mmHg)), Heart failure (NYHA II or higher)); Psychiatric conditions; Drug abuse of any kind; Smoking; Other comorbidities or clinical signs of diseases of any kind considered by the investigating physician to make the participant ineligible because of safety concerns). * Are pregnant, breastfeeding or not using appropriate contraception. * Do not want any information on significant pathological findings in the study.