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Brain under pressure: new study reveals how low oxygen affects exercise

NCT ID NCT01614119

Knowledge-focused Sponsor: University Hospital, Grenoble Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at how the brain responds when people exercise while breathing low-oxygen air (like at high altitude). Thirty healthy men did exercise tests while researchers measured brain and muscle activity using special scans and stimulation. The goal was to understand why performance drops in low oxygen, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hypoxic gas mixture (12% oxygen)
What this could lead to
If successful, this could help scientists understand why exercise is harder at high altitude or in low oxygen.
What could go wrong
This is a small, early-stage study in healthy men, not patients. It measures brain activity, not a treatment, so it may not lead to any direct medical benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Start date

Jun 2010

Finished

Jul 2011

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male * 18-50 yrs * No cardiovascular, respiratory or neuromuscular disorders Exclusion Criteria: * Cardiovascular, respiratory or neuromuscular diseases * Contraindication for TMS and MRI

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia Hypoxia Hypoxia, Brain Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain hypoxia Hypoxia

Contacts and locations

Locations

  • Grenoble University Hospital

    Grenoble, 38042, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.