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Blood and brain scans may predict stroke deterioration

NCT ID NCT07422636

Knowledge-focused Sponsor: University of Florence Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 213 people with acute ischemic stroke to see if combining brain scans with blood tests could better predict complications like brain swelling or bleeding. Researchers also used a mouse model to study how brain cells change after stroke. The goal is to find new ways to prevent further brain damage after a stroke.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could lead to better ways to predict and prevent brain swelling or bleeding after a stroke, improving patient outcomes.
What could go wrong
This is an observational study, not a treatment trial. The findings may not directly translate into new therapies, and the animal model may not fully mimic human stroke.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

213 people

The number who actually took part.

Started

Apr 2021

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients with acute ischemic stroke, admitted directly to the Emergency Department of the Careggi University Hospital in the period between 04/24/2021 and 06/30/2023, who met the following inclusion criteria.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Acute ischemic stroke; * Anterior Circulation stroke (TACS, PACS, LACS according Bamford classification); * Age ≥ 18 years; * Onset of symptoms within 12 hours; * Providing informed consent to data processing; Exclusion Criteria: * Diagnosis of haemorrhagic stroke; * Baseline and follow-up clinical and radiological parameters consistent with posterior circulation stroke; * Admission beyond 12 hours from symptoms onset; * Patients transferred from other hospitals or with in-hospital onset; * Patients denying or withdrawing their consent to data processing; * Pregnancy;

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Conditions

The condition(s) this trial relates to.

brain edema cerebrovascular disorder Disease Models, Animal ischemia reperfusion injury ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute ischemic stroke Animal model Cerebral edema Hemorrhagic transformation due to acute stroke Reperfusion injury

Contacts and locations

Locations

  • University of Florence, NEUROFARBA Department, Careggi Hospital

    Florence, Florence, 50134, Italy

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