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Brain surgery breakthrough? scientists watch blood Pressure's role in bleeding

NCT ID NCT05874050

Knowledge-focused Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 160 adults having planned brain surgery to see if raising blood pressure during the operation makes it harder for surgeons to stop bleeding. Doctors increased blood pressure slightly with a medicine and noted if extra steps were needed to control bleeding. The goal was to understand the relationship between blood pressure and bleeding risk, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

160 people

The number who actually took part.

Started

Nov 2022

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All consecutive adult patients scheduled to undergo elective supratentorial neurosurgical surgery.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All consecutive adult patients scheduled to undergo elective supratentorial neurosurgical surgery. Exclusion criteria: * Urgent or emergent surgery * Neurovascular surgery * Subtentorial surgery * Trans nasal approaches * Back surgery * Acute or chronic kidney injury as defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines (Kellum \& Lameire, 2013; Stevens \& Levin, 2013) * Coagulation derangement (platelet count \< 100\*10\^9/L, international normalized ratio (INR) or activated partial thromboplastin time (aPTT) \> 1.5 times the normal laboratory range) or anticoagulant/antiplatelet treatment without appropriate withhold intervals, as per existing guidelines * Preoperative severe hemodynamic instability, according to the judgment of the attending physician * Age \< 18 years * Pregnancy or breastfeeding * Absence of informed consent

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Conditions

The condition(s) this trial relates to.

hypertensive disorder intracerebral hemorrhage Intracranial Hemorrhages supratentorial cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blood pressure Intracranial hemorrhages Neurosurgery Supratentorial brain tumor

Contacts and locations

Locations

  • Fondazione IRCCS Istituto Neurologico C. Besta

    Milan, Milano, 200133, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.