Double drug combo offers hope for migraine sufferers
NCT ID NCT05653986
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested how well two approved migraine medications, ubrogepant (for acute attacks) and atogepant (for prevention), work together in real-world settings. 391 adults with migraine used both drugs as prescribed by their doctor for 30 days. The goal was to see if the combination helped people get meaningful pain relief and return to normal daily activities faster.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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391 people
The number who actually took part.
- Started
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Dec 2022
- Finished
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Aug 2024
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult participants with migraine using Migraine Buddy mobile application and prescribed Ubrogepant and Atogepant by their physician
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Reports meeting migraine diagnostic criteria consistent with International Classification of Headache Disorders (ICHD) (i.e., they report symptoms accompanying their headaches that meet migraine criteria22 at screening). * Currently using ubrogepant for acute treatment of migraine. * Experienced at least 3 migraine attacks in the last 30 days. * Currently taking atogepant for preventive treatment of migraine and has been taking atogepant, at the same dose, for at least 30 days. Exclusion Criteria: * Report currently taking Rimegepant (Nurtec®) for migraine treatment (acute or preventive). * Report currently taking any of the anti-CGRP mAbs for preventive treatment of migraine: * Erenumab (Aimovig®) * Galcanezumab (Emgality®) * Fremanezumab (Ajovy®) * Eptinezumab (Vyepti®)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Montefiore/Albert Einstein /ID# 252243
The Bronx, New York, 10461, United States
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Other studies related to the condition(s) this trial covers.
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