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Can low blood flow predict stroke? new study investigates

NCT ID NCT00590980

Knowledge-focused Sponsor: University of Illinois at Chicago Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 82 people with blocked arteries supplying the back of the brain to see if low blood flow raises the risk of stroke or mini-stroke. Participants had already experienced a stroke or transient ischemic attack (TIA) and had at least 50% blockage in those arteries. Researchers used MRI to measure blood flow and tracked participants for future strokes. The goal was to determine if blood flow levels can help predict who is at highest risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors identify which patients with blocked brain arteries are at highest risk of stroke, leading to better prevention strategies.
What could go wrong
This is an observational study with only 82 participants, so results may not apply to everyone. It does not test a new treatment, so direct patient benefits are limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

82 people

The number who actually took part.

Started

Jul 2008

Finished

Dec 2014

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Neurology/Neurosurgery Clinic

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Stroke or TIA in the vertebrobasilar territory * Conventional or CT angiographic demonstration of ≥50% stenosis or occlusion of extracranial or intracranial vertebrobasilar artery * Symptoms within 60 days of enrollment * Age 18 and above * Able to provide informed consent Exclusion Criteria: Neurologic criteria: * Major disabling stroke prohibiting the ability to return for follow-up assessment * Any neurological disease which would confound follow-up assessment Medical criteria: * Any severe co-morbidity condition with less than 12 month life expectancy * Known cardiac disease associated with cardioembolic risk specifically atrial fibrillation, prosthetic valves, endocarditis, left atrial/ventricular thrombus, cardiomyopathy with EF\<25%, cardiac myxoma * Blood dyscrasias, specifically polycythemia vera, essential thrombocytosis, sickle cell disease Disease criteria: * Non-atherosclerotic disease vertebrobasilar disease including dissection, fibromuscular dysplasia, vasculitis, radiation induced vasculopathy * Unilateral vertebral stenosis or occlusion Patient criteria: * Unable or unwilling to undergo MRI or cerebral angiography or CTA * Pregnancy concurrent participation in an interventional trial for treatment of vertebrobasilar disease. * Renal dysfunction will be exclusionary if it precludes angiography. No subjects will be excluded based upon gender, race, ethnic group, religion or socioeconomic status. Children will not be recruited as atherosclerotic VBD is a condition that affects adults primarily in later life and is not a disease that occurs or is relevant in children.

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Conditions

The condition(s) this trial relates to.

brain ischemia cerebrovascular disorder stroke disorder transient ischemic attack vertebrobasilar insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain ischemia Cerebrovascular disorder Ischemic attack, transient Stroke Vertebrobasilar insufficiency

Contacts and locations

Locations

  • Columbia University

    New York, New York, 10032, United States

  • Jeffrey Kramer, MDSC at Mercy Hospital

    Chicago, Illinois, 60616, United States

  • UHN-Toronto Western Hospital

    Toronto, Ontario, M5T 2S8, Canada

  • University of California at Los Angeles - UCLA

    Los Angeles, California, 90095, United States

  • University of Illinois at Chicago

    Chicago, Illinois, 60612, United States

  • Washington University

    St Louis, Missouri, 63110, United States

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