Can a magnetic helmet help stroke survivors heal faster?
NCT ID NCT06064747
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether low-frequency magnetic brain stimulation (rTMS) can improve recovery in 60 people who had a severe stroke and received emergency treatment to reopen blocked arteries. Participants received either real or sham stimulation for 3 days after their procedure. The goal was to see if the stimulation could reduce brain damage and disability. Results are not yet available.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- low-frequency repetitive transcranial magnetic stimulation (rTMS)
- What this could lead to
- If it works, this could point toward a new add-on therapy to help stroke patients recover better after emergency treatment.
- What could go wrong
- This is a small, early-phase pilot trial with only 60 participants, so results may not apply to all stroke patients. The treatment is also short-term (3 days) and may not produce lasting benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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60 people
The number who actually took part.
- Started
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May 2024
- Finished
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Jul 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. 18 - 80 years, male or female; 2. Clinically diagnosed as acute anterior ischemic stroke, artery occlusion occurred at the terminal of the intracranial carotid artery, T-shaped bifurcation or M1 segment of the middle cerebral artery; 3. Within 24 hours of stroke onset; 4. Eligible for other imaging indications for bridging therapy or direct mechanical thrombectomy: ASPECTS ≥6 certified by the latest brain CT imaging; Patients within 6-16 hours after stroke onset should meet the mismatch criteria, which was defined as infarction core volume \<70 ml, mismatch ratio ≥1.8 and the ischemic volume \> 15 ml (DEFUSE-3 Criteria); or NIHSS score ≥ 10 with infarction -core volume \< 31 cm3, or NIHSS score ≥ 20 with infarction core volume ≤ 51 cm3 (DAWN Criteria); Patients within 16-24 hours after stroke onset should meet the mismatch criteria, which was defined as NIHSS score ≥ 10 with infarction-core volume \< 31 cm3, or NIHSS score ≥ 20 with infarction-core volume ≤ 51 cm3 (DAWN Criteria); 5. Planned to receive bridging therapy (endovascular therapy after intravenous alteplase) or direct endovascular therapy; 6. Pre-morbid modified Rankin Scale ≤1; 7. 6 ≤ NIHSS ≤ 25 before endovascular therapy; 8. Signed informed consent from subjects or legally authorized representatives Exclusion Criteria: 1. TMS contraindications include metallic foreign bodies in the head, pacemaker, implantable drug pumps, cochlear implants, etc. 2. Epilepsy or history of epilepsy, intracranial hypertension, tumor and other serious neurological disorders; 3. Midline displacement and brain parenchymal mass effect seen in head CT and other images; 4. Head CT or MRI showed bilateral acute cerebral infarction; 5. CT or MRI showed a large area of infarction (\> 1/3 of the area supplied by middle cerebral artery); 6. Evidence of acute intracranial hemorrhage; 7. Before the bridging therapy, other thrombolytic drugs besides alteplase or tenecteplase were used; 8. A history of congenital or acquired hemorrhagic disease, coagulation factor deficiency, or thrombocytopenia disease; 9. After blood pressure control, the systolic blood pressure was still ≥180 mmHg or the diastolic blood pressure was ≥110 mmHg; 10. Known recent or current serum creatinine exceeding 1.5 times the upper limit of normal or estimated glomerular filtration rate (EGFR) \< 60 mL/min; 11. Patients during pregnancy or lactation and within 90 days of planned pregnancy; 12. Patients with severe mental disorders or dementia who can not cooperate with informed consent and follow-up; 13. Patients with malignancy or severe systemic disease and expected survival of less than 90 days; 14. Participants in other clinical intervention studies within 30 days before randomization or who were participating in other clinical intervention studies.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beijing Tian tan Hospital
Beijing, Beijing Municipality, 100070, China
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