Vertebral column disorder

This trial studies a device called coflex, a small implant placed in the spine after decompression surgery for lumbar spinal stenosis (a narrowing of the spinal canal that causes back and leg pain). The study includes 40 adults with moderate to severe stenosis and low back pain. …

This study looks at people who received a total lumbar disc prosthesis (Baguera®L) for lower back pain or sciatica caused by disc degeneration or herniation. The goal is to see how many return to their original job five years after surgery. Unlike spinal fusion, which often limit…

This study tested an experimental drug called NVG-291 in people with spinal cord injuries to see if it could help improve movement and strength. The trial was stopped early and included 24 adults with cervical spinal cord injuries. Participants received either the drug or a place…

This study compared a new bone graft material (ABM/P-15) to the standard bone graft in 120 adults having surgery for spinal deformity. The goal was to see if the new graft leads to fewer additional surgeries and better bone healing. Patients were randomly assigned to receive eith…

This study tested whether a smartphone app could help people with incomplete spinal cord injury manage bladder issues. 88 adults were split into two groups: one received standard nursing, the other used a special app for 4 weeks that provided health education, bladder tracking, a…

This study tested a new way to set the breathing machine during back surgery. Instead of using standard settings, doctors adjusted the machine based on how stiff the patient's lungs were. The goal was to see if this approach could reduce lung problems after surgery. The study inv…

This completed early-phase trial tested whether the drug 4-AP (dalfampridine), combined with special nerve stimulation and leg exercises, could improve muscle strength and control in people with spinal cord injury. 26 adults with injuries at or above the lower back took part. The…

This pilot study tested a sleeve worn on the forearm that uses muscle signals to stimulate hand muscles, helping people with tetraplegia from spinal cord injury grasp and manipulate objects. Twelve adults with chronic cervical SCI completed a 12-week training program using the de…

This study looked at whether taking NSAIDs every day, instead of only when needed, can prevent spine damage in people with ankylosing spondylitis who are also receiving anti-TNF therapy. 188 adults participated in this Phase 3 trial. The goal was to see if continuous NSAID use re…

This study followed 77 adults who received spinal implants (PASS LP, PASS DEGEN, or PASS TULIP PRIME) to treat degenerative spine conditions like disc degeneration or spinal deformity. The main goal was to see if the bones fused properly after 24 months. Researchers also tracked …

This study tested whether using a patient's own bone marrow stem cells (BMAC) mixed with donor bone works as well as the standard bone graft taken from the hip for spinal fusion surgery. Seventeen adults with degenerative disc disease were randomly assigned to one of the two meth…

This small pilot study tested two ways to stimulate the spinal cord—one with a surgically implanted device and one with surface electrodes—combined with a robotic exoskeleton to help people with spinal cord injury walk. Four men with complete paralysis below the chest took part. …

This study tested a device called ExaStim that uses mild electrical stimulation on the skin over the spinal cord to help people with chronic cervical spinal cord injury improve arm and hand function. Thirty-three participants used the device at home for 4 weeks after a training p…

This study looked at whether adding methotrexate to adalimumab (a biologic drug) reduces the chance that the body makes antibodies against adalimumab in people with ankylosing spondylitis. About 110 adults with active disease who did not respond well to NSAIDs took part. The goal…

This study tested a special balance training program for people with incomplete spinal cord injury who are at high risk of falling. The training involved unexpected pushes or pulls to trigger a stepping response, with some participants also receiving electrical stimulation to hel…

This Phase 3 trial tested a new drug called XKH004 in 323 adults with moderate-to-severe active ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. The drug works by blocking two inflammatory proteins, IL-17A and IL-17F. Participants received either X…

This pilot study tested whether adding a special type of electrical stimulation to standard wound care helps heal chronic pressure injuries (bedsores) in people with spinal cord or brain injuries. Twenty adults with stage II-IV pressure sores that hadn't healed after four weeks o…

This study looked at how well upadacitinib, an anti-inflammatory pill, controls pain in people with axial spondylarthritis (axSpA), a condition causing chronic back pain. Over 700 adults from 19 countries took the drug as prescribed by their doctors and were followed for 12 month…

This study tested a new rehabilitation approach for people with spinal cord injury. Ten participants received a spinal cord stimulation implant and used a robotic exoskeleton to help them walk. The goal was to improve leg muscle strength and overall quality of life. The combinati…

This study tested a drug called AK111 in 510 adults with active ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. Participants received either AK111 or a placebo as a shot under the skin over 48 weeks. The main goal was to see if AK111 improves symp…

This study tested a new therapy that combines two types of electrical stimulation with balance training (like video games) to help people with incomplete spinal cord injury improve their standing balance. Seventeen participants completed 12 sessions over 4 weeks. The goal was to …

People with spinal cord injury (SCI) face higher risks of heart disease and diabetes, partly due to chronic inflammation and poor blood vessel function. Exercise helps but is often not possible. This small study tested whether repeated passive heating (using a water-perfused suit…

This study tested a daily pill called upadacitinib in 734 adults with axial spondyloarthritis, a type of arthritis that causes pain and stiffness in the spine. The drug was compared to a placebo to see if it could reduce symptoms and control the disease. Results showed that upada…

This study tested whether a person with chronic paralysis from a spinal cord injury could control hand movements using only their thoughts. The participant, who already had a brain implant from the BrainGate study, used a computer to decode their intended grasp patterns. Those si…

This study looked at how well ViviGen, a bone graft made from donated human bone cells, helps fuse neck bones in people having 2- or 3-level neck surgery. 100 patients were followed to see if their bones fused and how their pain and function improved. The goal was to gather real-…

This study tested the drug RINVOQ in 69 adults with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Participants took RINVOQ as prescribed by their doctor and were followed for up to a year. The goal was to see how safe and effective the drug is in real…

This study tested whether combining a mild brain stimulation technique (tDCS) with a new mental and physical rehab method (NEUROM) can help people with chronic spinal cord injury regain leg movement and feeling. Fifty-six participants with paralysis below the lower back were rand…

This study looked at how safe and effective upadacitinib is for Korean patients with rheumatoid arthritis, atopic dermatitis, ankylosing spondylitis, or psoriatic arthritis. Over 2,300 adults took the drug as prescribed by their doctor and were followed for about 28 weeks. Resear…

This study tested an experimental drug called elezanumab in people with a recent cervical spinal cord injury. The goal was to see if the drug could improve arm and hand movement and was safe. About 60 adults aged 18-75 with severe neck-level injuries received either the drug or a…

This study tested a new device called the HYDRAFIL system for people with long-term low back pain from worn-out spinal discs. 35 adults who had not gotten better with standard treatments received the implant. The main goal was to see if the device could be safely placed and help …

This study tested a special spinal implant (the Keos Lumbar Interbody Fusion Device) in 25 adults with degenerative disc disease or related spine conditions. The goal was to see how well the device helped bones fuse and how it affected pain and quality of life. Participants had s…

This pilot study tested whether combining neuromuscular electrical stimulation with daily vitamin D could improve bone health in veterans with chronic spinal cord injury. Six participants underwent 9 months of treatment, with bone changes measured by MRI and DXA scans. The goal w…

This study looked at using a surgical approach from the back (posterior) to treat bacterial infections of the spine. 47 patients underwent the procedure, which involved removing infected tissue and stabilizing the spine. The researchers found no major complications and reported s…

This study followed 361 adults with degenerative disc disease who had minimally invasive spinal fusion surgery. The goal was to see how well these procedures reduce disability and pain over 5 years. Researchers compared different surgical approaches to find which works best for p…

This study tested a new gel-like product that helps stop bleeding during spinal surgery. It was compared to an existing product in 130 patients with spinal stenosis, tumors, or injuries. The goal was to see if the new product works just as well and is safe to use.

This study tested a new artificial disc called Simplify® for people with severe neck and arm pain from cervical degenerative disc disease. The trial involved 150 adults who received the disc and were compared to a historical group that had spinal fusion surgery. The goal was to s…

This study followed 145 people who received the Simplify Cervical Artificial Disc to treat neck problems caused by worn-out discs. Researchers checked if the disc was still working safely after 5 years, looking for pain improvement, device failures, or need for more surgery. The …

This study tested a new artificial disc called the Simplify Disc for people with two-level cervical disc disease causing arm pain, neck pain, or nerve problems. The trial involved 182 participants and compared the disc to standard fusion surgery. The goal was to see if the disc i…

This study followed 291 patients for 5 years after receiving the Simplify Disc, an artificial disc for the neck. The goal was to see if the disc remains safe and effective over time. Researchers measured pain, nerve function, and whether any further surgeries were needed.

This study tested a drug called bimekizumab in 332 adults with active ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. Participants received either the drug or a placebo injection. The goal was to see if the drug could reduce symptoms like pain and…

This study tested a new type of spine surgery called ILIF for people with degenerative disc disease, a condition where spinal discs wear down causing pain and nerve issues. 77 adults over 40 who had not improved with other treatments received the surgery. Researchers measured cha…

This study looked at whether a special bone graft called Osteocel Plus, which contains stem cells, helps the spine bones fuse together after surgery. It included 51 adults with degenerative disc disease who had not improved with other treatments. The goal was to see if this graft…

This study compared two surgical techniques for treating lumbar degenerative disc disease: traditional open surgery (open PLIF) and a newer, less invasive version (MAS PLIF). Researchers tracked complications and pain relief in 67 adults who needed spinal fusion. The goal was to …

This study looked at a product called Osteocel Plus used during neck fusion surgery for people with degenerative disc disease. The goal was to see how well the bones fused together and how safe the product was. 182 adults were followed for 24 months after surgery. The results wer…

This study tested Osteocel Plus, a bone graft material that contains stem cells, in 28 adults with degenerative disc disease who needed spinal fusion surgery. The goal was to see if it helps the spine bones fuse together as well as standard bone grafts. Researchers measured fusio…

This study tested Osteocel Plus, a special bone graft that contains stem cells, in 19 people with degenerative disc disease who needed spinal fusion surgery. The goal was to see if the graft helps bones fuse together as well as the standard method using the patient's own bone. Th…

This study looked at using Osteocel Plus, a bone graft material, in a type of spine surgery called XLIF for people with degenerative disc disease and back pain. 104 adults aged 18-80 who needed fusion of one or two lower spine segments were enrolled. The main goal was to see how …

This study looked at the safety and performance of two types of expandable spine implants (MLX and XLX ACR) in 109 adults with degenerative disc disease, spondylolisthesis, or scoliosis. Researchers tracked complications, bone fusion, and improvement in nerve symptoms after surge…

This study tested a new plate system used during spine fusion surgery in 75 adults with conditions like degenerative disc disease or scoliosis. The goal was to see if the plate is safe and helps bones fuse together properly. Researchers measured pain relief and fusion success ove…

This study looked at how safe and well a new spinal implant (Modulus ALIF System) works in 123 adults having back surgery. The patients had conditions like worn-out discs or slipped vertebrae. The main goals were to check for complications and see if the bones fused properly afte…

This study tested whether a home exercise program using electrical stimulation to move the legs, combined with a personalized diet, could improve body composition and metabolism in adults with spinal cord injury. Twenty-six participants were assigned to either exercise plus diet …

This study tested whether a man-made bone graft putty (AttraX) works as well as using the patient's own bone for spinal fusion surgery. 45 adults with degenerative spine conditions were enrolled. The main goal was to see if the putty helped bones fuse together just as well as the…

This study tested a new 3D-printed titanium implant for spine fusion surgery in 36 adults with degenerative disc disease, spondylolisthesis, or scoliosis. The implant is designed to help bones in the spine grow together after surgery. Researchers looked at safety, how well the bo…

This study tested a new artificial disc called NeoDisc against standard fusion surgery (ACDF) in 488 people with a damaged disc in the neck. The goal was to see if NeoDisc is as safe and effective at relieving pain and improving function over two years. Participants were randomly…

This study tested a drug called MT-3921 (Unasnemab) in 72 people with recent severe neck spinal cord injuries. The goal was to see if it could improve arm and hand function better than a placebo. Participants received the drug or placebo by IV over 6 months, and their motor score…

This completed study tested two doses of the drug tranexamic acid (TXA) in 62 adults undergoing multilevel spinal surgery. The goal was to see which dose better reduces blood loss and the need for blood transfusions. Results could help surgeons choose the safest and most effectiv…

This study tested a new drug, netakimab, in 113 Chinese adults with active ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. The goal was to see if netakimab works better than a placebo (a dummy treatment) at reducing symptoms. Participants received…

This study tested whether adding functional electrical stimulation (FES) bicycle ergometry to robotic rehabilitation helps people with chronic incomplete spinal cord injury walk better. 38 participants completed 20 sessions over 4 weeks. The goal was to see if the combination imp…

This study tested whether a bone-building drug (teriparatide) and a vibrating platform, alone or together, could improve bone density in 60 adults with chronic spinal cord injury who had low bone mass. Participants received daily injections of teriparatide, used a vibration devic…

This early-stage trial tested an experimental treatment called IDCT (injectable disc cell therapy) in 38 people with chronic low back pain due to degenerative disc disease. Participants received either a low or high dose of the cell therapy or a sham procedure. The goal was to ch…

This early-stage trial tested a single dose of an experimental drug called ALMB-0166 in 24 people with acute spinal cord injury. The main goal was to check safety and how the drug moves through the body. Participants had moderate to severe injuries and were scheduled for surgery …

This Phase 3 trial tested golimumab, an anti-inflammatory biologic, given as an IV infusion to 208 people with active ankylosing spondylitis. Participants received either golimumab or a placebo. The main goal was to see if more people on golimumab had at least a 20% improvement i…

This small pilot study tested whether pairing vagus nerve stimulation with rehabilitation is safe and feasible for people with cervical spinal cord injury. Six participants received an implanted nerve stimulator and underwent rehab sessions. The study focused on safety and whethe…

This study tests whether a 12-week adaptive exercise program can reduce chronic inflammation in people with spinal cord injury (SCI). Chronic inflammation is linked to heart and lung disease, the top causes of death in SCI. Twenty-four adults with SCI will be randomly assigned to…

This study tested three different weight loss strategies in 110 adults with chronic spinal cord injury who were overweight. The strategies included portion-controlled meals, enhanced self-monitoring with technology, and a tailored lifestyle program called GLB-SCI. The goal was to…

This study looked at how well a bone graft material called Natural Matrix Protein (NMP™) works in 53 patients who had spinal fusion surgery for degenerative disc disease. The main goal was to see if the bones fused properly on CT scans and X-rays. Researchers also measured change…

This phase 2 trial tested whether combining testosterone therapy with a special type of electrical stimulation (long pulse width) could rebuild leg muscle in 12 people with spinal cord injury whose muscles no longer respond to standard electrical stimulation. Participants receive…

This study looked at different bone graft materials used during spinal fusion surgery for people with degenerative disc disease. About 119 patients were randomly assigned to receive either their own bone, a protein that stimulates bone growth, or one of three stem-cell-based graf…

This pilot study tested whether a year of monthly romosozumab injections, followed by a year of weekly alendronate pills, can improve bone health in women with chronic spinal cord injury and osteoporosis. Twelve non-ambulatory women participated. The goal was to see if this two-s…

This early-phase trial tested a device called SC0806, which is surgically implanted into the spine. It releases a growth factor to encourage nerve repair in people with complete spinal cord injury. Ten participants were randomly assigned to receive either the device plus rehabili…

This study tested whether using a special PET scan (FAZA) to find oxygen-starved (hypoxic) tumor cells can help guide proton therapy for chordomas of the skull base, spine, or sacrum. 64 adults who had surgery or were getting radiation received a higher radiation dose to the hypo…

This early study tested a wireless patch that uses a tiny electric current to push two drugs (neostigmine and glycopyrrolate) through the skin and into the blood. The goal is to help people with spinal cord injury have predictable bowel movements without needles. Only 2 healthy v…

This study tested whether a brain-computer interface (BCI) training program could improve hand and arm function in people with recent spinal cord injuries. Thirty participants used a system that reads brain signals during hand motor imagery exercises. The goal was to see if this …

This study tested whether a radiation-free ultrasound system can accurately screen for scoliosis in 442 Hong Kong schoolgirls aged around 10, who are at high risk for curve progression. The goal was to see if ultrasound could identify which girls truly need an X-ray, reducing unn…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study tested a simple, portable virtual reality balance test (called VETS) to see if it could help diagnose and track cervical spondylotic myelopathy (CSM), a spinal cord condition common in veterans. Eight participants with CSM and a control group performed balance tasks un…

This study tests whether a personalized nutrition plan can help people with a recent spinal cord injury avoid gaining unhealthy body fat and becoming obese. About 56 participants will receive tailored dietary advice for one year. The goal is to improve long-term health and preven…

This pilot study tested whether a one-day Acceptance and Commitment Therapy (ACT) workshop, plus a follow-up phone call, could help prevent chronic pain after back surgery. 45 adults scheduled for spinal surgery took part. The study focused on whether the workshop was acceptable …

This study tested whether a single dose of zoledronic acid, a drug already used for osteoporosis, can prevent the rapid bone loss that often follows a spinal cord injury. Researchers enrolled 60 adults who had recently lost the ability to walk due to injury. They measured changes…

This study tested a new gel called Collabarrier® to see if it can prevent scar tissue from forming after back surgery for herniated discs or spinal stenosis. Sixty-nine adults having their first back surgery were randomly given either the new gel or an existing one. Researchers c…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tests a new, long-lasting painkiller (liposomal bupivacaine) that works for up to 72 hours after spine surgery, compared to the standard 6-8 hour painkiller. About 204 adults having lower back surgery will be randomly assigned to receive one of the two painkillers. The…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This study tested a special exercise called blood flow-restricted resistance exercise (BFRE) in 10 people with incomplete spinal cord injury. Participants did arm exercises with a cuff that limits blood flow, plus electrical stimulation if needed, twice a week. The goal was to se…

This study tested whether applying low-frequency electromagnetic fields to the lower back could reduce sciatica pain and improve postural control in people with a lumbar disc herniation. Forty-four adults aged 30 to 45 with mild to moderate disc prolapse received either electroma…

This completed study compared two minimally invasive surgeries for herniated discs: full endoscopic lumbar discectomy (FELD) and microdiscectomy (MD). Researchers enrolled 200 adults aged 18-85 with single-level disc herniation and sciatica. The goal was to see which technique pr…

This study tested two treatments for chronic tailbone pain (coccygodynia) in 100 adults. One group received osteopathic manual therapy—gentle hands-on techniques to mobilize the tailbone and relax muscles—over 6 weeks. The other group got a nerve block injection guided by X-ray. …

This study tested a smart faucet that uses voice, motion, and remote controls to help people with spinal cord injury (SCI) get water for drinking, grooming, and washing without needing help. 40 participants with SCI and control subjects used the faucet in clinics and at home. The…

This completed study tested three different rehabilitation approaches—robotic rehabilitation, functional electrical stimulation (FES), and occupational therapy—to see which works best for improving hand and arm function in people with tetraplegia (paralysis of all four limbs) due…

This study looked at whether a lumbar epidural steroid injection can reduce restless legs syndrome symptoms in 45 adults with lumbar central spinal stenosis. Participants received a standard injection as part of routine care, and their restless legs severity, pain, disability, an…

This study tested whether adding core stability training to standard physical therapy improves trunk control and sitting balance in people with incomplete spinal cord injury. 46 participants aged 25-35 with injuries between T6 and T12 took part. The core training focused on exerc…

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This study tested a smart faucet that can be controlled by voice, eye gaze, or hand motion to help people with cervical spinal cord injury drink water and groom themselves. Twenty-eight participants tried the faucet to see if they could complete tasks like drinking, rinsing, and …

This study compares core stabilization exercises to a daily physical activity program in children aged 10-18 with juvenile spondyloarthropathy, a type of arthritis. The goal is to see if targeted core training can reduce pain, fatigue, and improve quality of life better than gene…

This small study tested whether a device that gently stimulates a nerve in the ear (called auricular vagus nerve stimulation) is safe for people with chronic spinal cord injuries. Sixteen participants received the stimulation over two visits. The main goal was to check for side e…

This study tested two physical therapy techniques—nerve flossing and deep neck flexor strengthening—in 62 adults with cervical spinal stenosis. The goal was to see which method better reduces pain, improves neck movement, and helps with daily activities. Participants did their as…

This completed Phase 2 trial tested a smart, hands-free faucet called Access-H2O for people with spinal cord injury. The faucet uses voice, motion, and remote controls to let users get water for drinking, grooming, and washing without help. Twenty-three participants with spinal c…

This study tested whether brief periods of breathing low-oxygen air (acute intermittent hypoxia) can improve arm, leg, and walking function in people with incomplete spinal cord injury. Sixty-eight participants received either the low-oxygen treatment or a sham (normal air) over …

This study tested a 'Digital Strolling' program where people with severe mobility impairment use a virtual reality headset to walk in a digital world. 24 participants either used the VR walking or watched walking videos for 10 days. The goal was to see if this approach could impr…

This study tested whether a continuous drip of numbing medicine into the surgical wound for two days after back fusion surgery could reduce pain and speed recovery better than a placebo. Fifty adults having lumbar fusion for degenerative spine disease took part. The goal was to i…

This small study tested whether training with a robotic exoskeleton (a wearable robot suit) can help improve bowel function in people with spinal cord injury. Ten adults with long-term spinal cord injury used the exoskeleton in a supervised program. Researchers measured changes i…

This study tested whether adding dexamethasone or dexmedetomidine to a standard nerve block (erector spinae plane block) could extend pain relief after spine surgery. 90 adults undergoing lumbar spine surgery received one of the two additives or a placebo. The main goal was to se…

This study tested a 6-week program that combines specific exercises with education to see if it improves walking ability in people with lumbar spinal stenosis and nerve-related leg pain. Fifty-one adults aged 50 and older took part. The intervention group received both exercises …

This study tested whether adding a special nerve stimulation treatment to standard exercise could improve neck disability in people with whiplash from a car accident. 44 adults with recent whiplash were split into two groups: one did only exercises, the other did exercises plus t…

This study tested a home-based program for people with spinal cord injury that combines leg cycling with electrical stimulation, arm exercise, and a hormone treatment. The goal was to see if this combination improves aerobic fitness, daily function, and overall health better than…

This study looked at whether injecting a dextrose (sugar) solution into the ligaments around the tailbone can reduce pain and improve daily function in people with long-lasting coccydynia (tailbone pain). Researchers reviewed records of 50 adults who received 3-6 injections over …

This study compared a newer, less invasive endoscopic surgery to standard open surgery for people with lumbar spinal stenosis, a condition that causes back and leg pain. 36 adults who needed surgery were randomly assigned to one of the two procedures. Researchers measured pain, w…

This study tested whether giving acetaminophen (Tylenol) through an IV works better than pills for pain after lumbar spine surgery. 166 adults having a specific type of back fusion surgery were randomly assigned to receive either IV or oral acetaminophen. The goal was to see if t…

This study tested a low-cost elastic band device designed to help therapists assist people with spinal cord injury while walking on a treadmill. The device uses rubber bands to help move the legs forward during walking. Nineteen participants with spinal cord injury tried the devi…

This study looked at different rehabilitation programs for 90 adults who had back surgery for degenerative lumbar disease. The goal was to see which rehab approach best reduces nerve pain, helps patients regain function, and improves quality of life. Participants were randomly as…

This completed study tested a 7-week, peer-led program for adults with spinal cord injury and chronic pain. The program combined education about pain neuroscience with body-based tools like red light therapy, massage, and guided movement. Twelve participants attended group sessio…

This study tested a five-day neck education program for 62 parents of children with disabilities who had chronic neck pain. The program taught neck anatomy, proper posture, ergonomics, and exercises. After 12 weeks, parents who took the program reported less neck-related disabili…

This study tested whether people with spinal cord injuries can reach a high-intensity heart rate while walking in a robotic exoskeleton. Eleven participants completed five training sessions using the Ekso device. Researchers measured heart rate, walking speed, and endurance befor…

This study tested whether adding virtual reality (VR) games to standard physical therapy helps people with lumbar disc herniation. 93 participants received either conventional therapy or conventional therapy plus VR for six weeks. Researchers measured changes in balance, pain, fe…

This study tested whether a mild electrical stimulation (40 kHz) applied through the skin can safely reduce nerve pain in people with spinal cord injury. Thirty adults with paraplegia and chronic nerve pain received either real or placebo stimulation alongside their usual treatme…

This study tested a special wheelchair that lets people with spinal cord injuries stand up and move around at the same time. The goal was to see if using this chair at home and in the community helps them stand more often and feel more satisfied with their daily activities. Twent…

This study tested a minimally invasive procedure called CT-guided trans-facet screw fixation for 24 patients whose spine became unstable after a prior back surgery (laminectomy). Instead of open surgery under general anesthesia, the procedure uses a CT scan to guide small screws …

This study tested two types of magnetic brain stimulation (TMS) to see if they can reduce nerve pain in people with spinal cord injury. 26 adults with long-term nerve pain that didn't respond to medication took part. The goal was to measure changes in pain severity, daily functio…

This study tested whether a web-based telerehabilitation exercise program is more effective than a traditional brochure-based home exercise program for people with lumbar disc herniation (a slipped disc). 46 adults with bulging or protruding discs were randomly assigned to either…

This pilot study tested whether a non-invasive treatment called extracorporeal shockwave therapy (ESWT) can safely reduce spasticity—muscle stiffness and spasms—in people with chronic spinal cord injury. Five participants received ESWT or a sham treatment, and researchers measure…

This study compared two pain relief methods for people undergoing lower back decompression surgery. One group received a nerve block (erector spinae plane block), while the other received ketamine through an IV. Researchers measured how well patients recovered using a quality-of-…

This completed Phase 3 trial tested whether brivaracetam, a drug used for seizures, can reduce chronic nerve pain in people with spinal cord injury. 44 adults with persistent pain took part. The study compared brivaracetam to a placebo and measured changes in pain intensity and d…

This study tested a device that combines mild electrical muscle stimulation with a balance-board video game to help people with spinal cord injury or stroke improve their balance and reduce fall risk. 18 adults who were at least one year past their injury took part. The goal was …

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This study tested two methods of giving a nerve block to control pain after a type of back surgery called unilateral biportal endoscopic discectomy. One method used ultrasound to guide the injection, and the other was done by the surgeon during the operation without ultrasound. T…

This study compared two surgical approaches for people with a single level of lumbar spinal stenosis (a narrowed spine canal causing leg pain and trouble walking). 96 adults aged 40-75 were randomly assigned to receive either minimally invasive decompression and fusion or traditi…

This study compared two procedures for relieving pain from lumbar spinal stenosis, a common cause of back and leg pain in older adults. One group received a newer technique called erector spinae plane block, while the other got a standard caudal epidural steroid injection. Resear…

This study looked at whether a type of physical therapy called Maitland mobilization, combined with exercises, can help people with tailbone pain after a colonoscopy. 42 adults with this condition were split into two groups: one received standard care (heat and stretches), and th…

This study tested whether Opalmon tablets can improve symptoms and physical function in 107 adults with acquired lumbar spinal stenosis, a condition where the spinal canal narrows and causes leg pain when walking. Participants took the medication for 8 weeks, and researchers meas…

This study tested a gentle hands-on technique called Primal Reflex Release for people with tailbone pain after a colonoscopy. 46 adults received either the reflex technique or standard physiotherapy. Researchers measured pain, movement, and quality of life to see if the new appro…

This study tested two types of magnetic brain stimulation (iTBS and rTMS) combined with robotic walking therapy in 30 people with chronic spinal cord injury. The goal was to see if these treatments could improve leg strength, walking ability, and daily independence. All participa…

This study tested a less invasive spine surgery in one person with neuromuscular scoliosis, a severe spine curve caused by nerve or muscle problems. The goal was to see if the mini-invasive approach could reduce pain, blood loss, and complications compared to standard surgery. Th…

This study tested whether adding the steroid dexamethasone to a standard nerve block could reduce pain and inflammation after lumbar laminectomy (back surgery). Thirty-six adults undergoing surgery received either the nerve block with dexamethasone or without. The dexamethasone g…

This study tested whether wet cupping therapy, an ancient practice where small cuts are made on the skin and cups are used to draw out a small amount of blood, can help people with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Half of the 100 particip…

This study tested two different ways to treat long-lasting tailbone pain using heat from a needle (radiofrequency ablation). Fifty adults who had not gotten better with standard treatments were randomly assigned to one of two procedures. The goal was to see which method provided …

This study looked at whether adding local anesthetics to standard steroid injections in the neck helps people with long-term neck pain. Sixty patients who were already scheduled for the injection took part. Researchers measured pain levels and neck function to see if the combinat…

This study compared two methods of pain control for people having back fusion surgery: a nerve block given before surgery versus numbing medicine injected at the end. Researchers measured pain, inflammation, confusion after surgery, and overall recovery in 29 adults. The goal is …

This study tested whether giving a steroid (dexamethasone) during minimally invasive back surgery reduces pain and disability afterward. 90 adults with a herniated disc in the lower back took part. Half received the steroid during surgery, half got a saltwater placebo. Researcher…

This study looked at two types of surgery for people over 50 with a slipped vertebra (spondylolisthesis) and a narrowed spine canal (stenosis). One group had a smaller surgery to take pressure off the nerves (decompression alone), while the other had that plus a fusion with metal…

This study tested two 8-week home exercise programs for 96 adults with spinal cord injury. One program used movement to music, the other standard exercises. Researchers measured physical activity levels and pain to see which approach worked better.

This study looked at whether adding therapeutic exercises to a hands-on technique called positional release helps people with chronic low back pain more than the technique alone. Sixty adults aged 20-65 with ongoing back pain took part. Researchers measured pain, disability, and …

This study tested a lightweight robotic suit called the Myosuit in 34 people with incomplete spinal cord injury. Participants used the suit during walking exercises and then took it home for six weeks to see if it improved their daily walking. The goal was to measure changes in w…

This study tested a new device called Ceragem Master V6 that gently stretches the spine in people with herniated discs or spinal stenosis. 60 adults were randomly assigned to use the new device or standard physical therapy. The goal was to see if the device could improve spine st…

This small study tested whether a spinal cord stimulator can reduce back and leg pain in people with lumbar spinal stenosis caused by epidural lipomatosis (fatty tissue buildup). Three adults with chronic pain received the device and were followed for 6 weeks. The main goal was t…

This small study tested whether functional electrical stimulation (FES) arm cycling could improve arm strength and function in people with recent spinal cord injury. Six participants with cervical-level injuries cycled with electrical stimulation 3 times a week for 6 weeks. The s…

This study tested whether a nerve block called an erector spinae plane block, given before cervical spine surgery, can reduce pain and the need for opioids afterward. Sixty adults undergoing neck fusion surgery were randomly assigned to receive either the anesthetic ropivacaine o…

This study tested a mobile app called SurgeryPal that teaches teens coping skills before and after major spine surgery. 433 teens aged 12-18 were randomly assigned to use the app or receive standard education. The goal was to see if the app could reduce pain and prevent pain from…

This study looked at whether a type of talk therapy called prolonged exposure therapy can help reduce PTSD symptoms in people with spinal cord injuries. Thirty adults with both conditions were randomly assigned to receive the therapy or continue their usual care. The main goal wa…

This study tested a new online program to help people with spinal cord injury cope better and improve their mental health. Twelve adults with spinal cord injury and mild anxiety or depression took part in eight weekly online group sessions led by a nurse. The main goal was to see…

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This study tested whether kinesiology tape, applied to the back and shoulders, can reduce pain and improve posture, balance, and breathing in people with ankylosing spondylitis. 63 adults with the condition took part. The tape was compared with routine home exercises to see if it…

This study looked at whether high-intensity walking training is better than lower-intensity walking exercise for people with chronic, motor incomplete spinal cord injury. Researchers measured walking speed and distance in 53 participants. The goal was to find a more effective way…

This study tested a new approach to help people with spinal cord injury walk better. Participants received brief sessions of mild low-oxygen air (acute intermittent hypoxia) combined with gentle electrical stimulation on the back, plus walking practice. The goal was to see if thi…

This study tested an intensive motor rehabilitation program that uses advanced technology to help adults with chronic stroke or spinal cord injury improve their daily functioning. 102 participants were randomly assigned to either the tech-enhanced rehab or a control group. The go…

This study tested a computer game-based exercise program to help people with stroke or spinal cord injury improve hand and arm function. Thirty-five adults who were at least six months post-injury used a special mouse-like device to play games designed to practice hand movements.…

This completed study looked at 90 people with lower back pain from conditions like herniated discs or spinal stenosis. Researchers compared two different target areas for injecting numbing medicine during a lumbar spine block to see which provides better pain relief and blood flo…

This pilot study tested whether starting physical therapy immediately after diagnosis helps adolescent athletes with spondylolysis (a stress fracture in the lower back) recover better than waiting until pain goes away. Sixty-four athletes aged 10-19 were randomly assigned to eith…

This study tested whether adding supervised motor control exercises to standard physical therapy helps people who had lumbar decompression surgery. Fifty-one volunteers were split into two groups: one got usual care (stretching, strengthening, and education), and the other got th…

This study looked at whether giving patients menthol ice or frozen saline after lumbar disc surgery could reduce thirst and sore throat. 102 adults who had surgery under general anesthesia took part. The researchers measured thirst discomfort and throat pain to see if these simpl…

This early-stage study tested whether an injection called STA363 is safe for people with sciatica from a herniated (slipped) disc. Twenty-five adults received either the study drug or a placebo injection into the disc. Researchers checked for side effects and measured changes in …

This study tested a new approach to help people with cervical spinal cord injury improve arm and hand function. Participants received non-invasive brain stimulation combined with upper limb training over several weeks. The goal was to see if this combination could strengthen musc…

This study tested a procedure called 'PRP Spinoplasty' for people with long-term lower back pain from disc disease, facet joint arthritis, and muscle spasms. 35 adults who had not improved with standard care received injections of platelet-rich plasma (PRP) into multiple areas of…

This study tested whether combining two drugs—dextromethorphan (taken by mouth) and lidocaine (given through a vein)—can reduce central neuropathic pain in people with spinal cord injury. 26 adults with moderate or worse pain for at least 3 months took part. Each person received …

This study tested three doses of dextromethorphan (a common cough medicine) against a placebo to see if it could reduce nerve pain in people with spinal cord injuries. 26 adults with chronic central neuropathic pain took part. The goal was to measure pain relief and satisfaction …

This completed Phase 1 trial tested whether three FDA-approved drugs (cyproheptadine, carbidopa-levodopa, and atomoxetine) could improve hand function when combined with hand training exercises in 25 people with chronic spinal cord injury. Participants took a single dose of one d…

This study tested whether a 9-week personalized physical training program using an exercise bike could help people with ankylosing spondylitis, a type of arthritis that affects the spine. Fifty-six patients participated, and researchers measured how many achieved a meaningful imp…

This study tested a special talking therapy (values-based cognitive behavioral therapy) for 6 adults with spinal cord injury from road accidents. The goal was to see if it helps reduce daily pain and improve living according to personal values. Participants attended 10 therapy se…

This early-phase study tested whether short bursts of low-oxygen breathing (acute intermittent hypoxia) combined with high-intensity arm training could improve hand and arm function in 58 people with chronic spinal cord injury. Participants had injuries between neck levels C1 and…

This completed study tested a nerve block called the erector spinae plane block in 40 adults with chronic low back pain from degenerative disc disease. The procedure aims to reduce pain and improve daily function. Researchers measured pain levels and disability scores to see if t…

This study tested whether a specific nerve block, called an erector spinae plane block, can lower the amount of morphine patients need after lumbar spine surgery. 100 adults having surgery for herniated discs or spinal stenosis were included. The block is given under ultrasound g…

This study looked at ways to manage pain after elective lower back surgery without relying on opioids. The goal was to see if using a combination of non-opioid pain medicines could reduce pain and avoid side effects like nausea or breathing problems. 75 adults having lumbar disc …

This study tested whether starting gentle leg cycling in bed within 48 hours after spinal surgery is safe and doable for people with severe spinal cord injuries. Forty-five adults took part, cycling for 30 minutes daily for two weeks. Researchers checked for safety, how many sess…

This study looked at whether wearing a back brace after spinal fusion surgery improves pain and quality of life. 43 adults with degenerative spine conditions were randomly assigned to wear a brace or not. Researchers measured disability, pain, and general health at 6 weeks and 3 …

This study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…

This study tested whether daily electrical stimulation of the buttock muscles can help people with chronic spinal cord injury. Thirty participants used a device for 35 minutes each day over six months. Researchers measured muscle volume and sitting pressure to see if the stimulat…

This study tested whether therapy sessions delivered via iPad FaceTime could help people with spinal cord injury who feel depressed. 75 adults with recent spinal cord injury and mild to moderate depression received cognitive behavior therapy from a psychologist. The goal was to r…

This study tested whether using a device that electrically stimulates the abdominal muscles can help people with spinal cord injury manage their bowel movements more quickly and comfortably. 36 adults with injuries at or above T12 were randomly assigned to receive real or low-dos…

This small study tested whether combining virtual walking (watching a first-person walk video) with mild brain stimulation (tDCS) could help ease chronic nerve pain in people with spinal cord injury. Four participants tried the 2-week program, keeping pain diaries and reporting h…

This study compared two ultrasound-guided pain blocks—caudal block and quadratus lumborum plane block—in 111 adults undergoing lumbar spine surgery. The goal was to see which provides better pain relief and reduces the need for opioid painkillers. Researchers measured how long it…

This study tested a new, non-invasive treatment for people with cervical spinal cord injury who have difficulty using their hands and arms. Fifteen participants received either electrical stimulation of the spinal cord combined with physical therapy, or physical therapy alone. Th…

This study tested whether a high-intensity exercise program, run by physical therapy students, can help people with neurologic disabilities move better in everyday life. Fifteen participants with conditions like cerebral palsy, stroke, or spinal cord injury completed the program.…

This pilot study tested whether brivaracetam, a drug used for seizures, can reduce severe nerve pain in people with chronic spinal cord injury. 24 participants received either brivaracetam or a placebo for 3 months. The study aimed to see if a larger trial is possible and measure…

This study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…

This study tested whether adding gentle nerve gliding exercises (called neurodynamic mobilization) to standard physical therapy could help people with a herniated disc in their lower back. Forty adults with confirmed disc herniation and at least 6 weeks of low back pain took part…

This pilot study tested whether using ultrasound to guide pharmacopuncture (herbal injections) is safe and effective for neck and back pain. Fifty adults with spinal disorders received the treatment, and researchers tracked side effects, pain levels, disability, and quality of li…

This study looked at whether adding Dynamic Neuromuscular Stabilization (DNS) exercises to standard physical therapy helps women with chronic low back pain caused by a herniated disc. 44 women took part, with one group doing only standard exercises and the other adding DNS moves.…

This study tested prefabricated carbon fiber ankle-foot orthoses (AFOs) in 65 children and teenagers with conditions like cerebral palsy, spina bifida, or spinal cord injuries that affect walking. Researchers measured stride length, walking speed, and user satisfaction by compari…

This study tested whether an injection of amniotic fluid, a natural anti-inflammatory, works better than a standard steroid injection for chronic back and leg pain caused by spinal stenosis. Sixty-one adults who had not improved with other treatments were randomly assigned to rec…

This study tested whether virtual reality (VR) games could help people with tetraplegia (paralysis of all four limbs) improve arm and hand function during hospital rehabilitation. Twelve participants either received standard therapy or added VR games to their routine for 12 weeks…

This study tested whether applying mild electrical stimulation to the skin over the spinal cord could help regulate blood pressure in veterans with spinal cord injury who have chronically low blood pressure. Ten participants with injuries at or above T6 received stimulation at di…

This study looked at whether lumbar traction therapy (a device that gently pulls on the spine) can reduce pain and improve function in people with obesity and chronic low back pain. 49 participants received 30 minutes of traction daily for 4 weeks. Researchers measured pain, disa…

This completed study tested whether a new type of electrical stimulation, called spatially distributed sequential stimulation, works better than standard stimulation for people with upper motor neuron disease. Ten adults with stable symptoms used both methods while cycling. Resea…

This completed trial tested whether adding battlefield acupuncture (a quick ear-needle technique) to standard electroacupuncture and pain medication can better relieve chronic low back pain caused by spine degeneration. Sixty adults in Vietnam with moderate to severe pain for at …

This study tested whether adding chiropractic manipulation to standard physiotherapy helps people with a herniated disc in the lower back. Forty-five adults were split into three groups: one got only physiotherapy, another got physiotherapy plus lumbar manipulation, and the third…

This phase 2 trial tested whether buspirone, a drug usually used for anxiety, can improve breathing capacity in people with chronic high-level spinal cord injuries. Thirteen participants took either buspirone or a placebo for 14 days. Researchers measured lung function, breathing…

This Phase 2 trial tested whether KAI-1678, given as a single injection under the skin, can reduce pain in people with spinal cord injury. Only 5 adults with long-term spinal cord injury and chronic pain took part. The study compared KAI-1678 to a placebo to see if it improved pa…

This study tested whether walking training overground with body weight support helps people with chronic spinal cord injury walk better. Fourteen participants were randomly assigned to either overground or treadmill training for four weeks. The goal was to see if the overground a…

This study tested two different robotic exoskeletons—one that balances itself and one that requires the user to balance—in 6 people with spinal cord injury. Researchers measured how fast and far participants could walk with each device, along with muscle activity and user feedbac…

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This study tested whether using a screening questionnaire called the STarT Back Tool helps doctors tailor low back pain treatment for military members. 290 adults aged 18-50 with low back pain were randomly assigned to either risk-stratified care or usual care. The goal was to se…

This study gathered information from 193 adults who had surgery or orthopedic treatment for spine problems. Researchers collected clinical, functional, and social data to create a detailed database. The goal was to better understand patient outcomes and standardize how data is co…

This completed study from France reviewed the long-term results of a surgery called continent cutaneous urinary diversion in 70 spinal cord injury patients. The surgery creates a new way to drain urine through the belly when patients cannot use a catheter normally. Researchers co…

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This study looked at 120 adults with neck or lower back spine issues to compare two types of scans: contrast-enhanced MRI and FDG-PET/CT. Researchers checked how clear the images were and whether the scans caused any short-term changes in kidney function or blood counts. The goal…

This study tested whether wearable motion sensors can accurately measure spinal movement in people with ankylosing spondylitis (AS), a condition that causes back pain and stiffness. Forty participants (20 with AS and 20 healthy volunteers) wore sensors while performing everyday m…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This completed trial tested how quickly paramedics can stabilize a patient's spine using a scoop stretcher versus a vacuum mattress. Fifteen emergency medical workers participated in a simulated emergency. The goal was to see which device is faster and whether the quality of stab…

This study looked at whether using a special 3D scan during surgery, combined with a navigation system, helps place screws more accurately in the lower back compared to the usual X-ray method. It involved 126 adults having lumbar spine surgery. The main goal was to see if the new…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study looked at how the interaction between a physical therapist and a patient affects recovery during robot-assisted walking training for people with spinal cord injury. 55 participants were split into two groups: one with high therapist interaction and one with minimal int…

This study looked at whether slow, yogic-style breathing can affect heart rate and blood pressure in people with spinal cord injuries. Seventeen wheelchair users completed breathing exercises while their heart and blood pressure were measured. The goal was to learn more about how…

This completed study looked at how the skeleton is aligned with gravity in adults with postural problems. Researchers used a low-dose X-ray device called EOS to create 3D images of the spine and pelvis. The goal was to better understand the body's geometry in people with balance …

This study aimed to find blood markers that can predict whether the drug adalimumab will successfully treat ankylosing spondylitis after 6 months. Researchers analyzed blood samples from 50 adults starting adalimumab for the first time. The goal was to create an algorithm to help…

This completed study investigated whether air pollution affects flare-ups in people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis. Researchers followed 86 patients for 6 months, asking them to complete weekly questionnaires about their symptoms. They a…

This pilot study tested whether a single dose of an oral ketone supplement could increase blood flow and improve brain connectivity in 15 older adults with subjective or mild cognitive decline. Participants had one 2-hour session including MRI scans and cognitive tests. The goal …

This study checks whether a simple six-minute pegboard and ring test is a valid and reliable way to measure upper body exercise capacity in people with spinal cord injury. Researchers will compare the pegboard results with standard strength and function tests in 34 adults who use…

This completed study looked at nearly 7,000 adults with inflammatory joint diseases like rheumatoid arthritis and psoriatic arthritis. Researchers compared two versions of a standard health survey (EQ-5D-3L and EQ-5D-5L) to see which one better measures health and quality of life…

This study looked at 20 people with lumbar spinal stenosis (a narrowing in the spine that can cause leg pain when walking) who were waiting for surgery. Researchers measured their walking patterns and asked about pain, function, and quality of life before and after the operation.…

This pilot study tested whether a larger trial is possible comparing two standard surgeries for lumbar spinal stenosis with a related condition called spondylolisthesis. The two procedures are decompression alone and decompression with fusion. The study enrolled 70 surgical candi…

This study tested a new robotic device called REACTION that combines an exoskeleton and a gait trainer to help people with stroke or spinal cord injury improve walking and balance. Seven participants completed two sessions of walking and balance tasks, followed by an interview. T…

This study looked at blood samples from 24 people with axial spondyloarthritis (a type of inflammatory arthritis) and 12 healthy volunteers to understand how a receptor called KIR3DL2 contributes to inflammation. Researchers also tested whether a drug called IPH4102 could reduce …

This study looked at whether robotic gait training helps people with spinal cord injury walk better compared to standard walking therapy. 115 patients in inpatient rehab took part. The goal was to measure improvements in walking ability and speed.

This study looked at 128 adults with back pain from a herniated disc. Researchers measured certain inflammation-related substances in the blood before and after physical therapy or a steroid injection. The goal was to see if these substances change with treatment and if they rela…

This study followed 50 people with chronic low back pain for 10 years after they had a procedure that punctured a spinal disc. Researchers used MRI scans to check if the punctured disc wore out faster than expected. The main goal was to see if the puncture itself caused extra dam…

This study looked at how spinal cord epidural stimulation affects bladder, bowel, and blood pressure control in 61 adults with spinal cord injury. Researchers monitored participants in a lab and at home to understand autonomic dysreflexia and test stimulation as a therapy. The go…

This study tested whether a special ultrasound with a contrast agent (DEFINITY®) can measure blood flow in the spinal cord during surgery for acute spinal cord injury. 27 patients received the contrast agent while surgeons performed routine decompression. The goal was to see if t…

This study looked at 22 adults with spinal cord injury to understand whether anxiety or physical discomfort causes changes in heart rate and blood pressure during bladder catheterization. Participants either did the procedure themselves or had a nurse do it, with some not knowing…

This study explored how frailty affects people with lumbar spinal stenosis, a common age-related back condition. Researchers measured pain, balance, disability, fear of falling, and quality of life in 91 participants aged 45-80. The goal was to better understand frailty in this g…

This completed study from Turkey examined 81 adults aged 45–80 with lumbar spinal stenosis—a condition that causes back and leg pain when walking. Researchers measured pain, disability, sleep quality, depression, and a condition called central sensitization (where the nervous sys…

This study tested a new lightweight device called PYTHEAS ODYSSEE that helps surgeons place screws in the spine more accurately. Fourteen adults having spine surgery used the device to guide screw placement. The goal was to see if the device reduces screw misplacement and is safe…

This study tested whether an internet-based app could improve how well people follow their home rehabilitation exercises after lumbar disc surgery. One hundred adults aged 18 to 59 used the app, which sent reminders, exercise videos, and daily tips, and answered online surveys fo…

This study looked back at 170 adults with chronic neck pain from whiplash injuries to compare two treatments: radiofrequency (a nerve-blocking procedure) and neck fusion surgery. Researchers reviewed medical records from a 20-year period to see which treatment provided better pai…

This study reviewed records of 107 adults who received steroid injections in the neck for arm and neck pain caused by a pinched nerve. The goal was to find out which patient traits or injection details were linked to better pain relief at 6 months. By identifying these predictors…

This study looked at three different ways to close surgical wounds after spine surgery. Researchers measured blood flow around the wound to see if one method was better. The study involved 50 adults with spinal stenosis who had back surgery at Mayo Clinic.

This study looks at whether CT scans are better than regular X-rays for measuring how the spine stiffens and fuses in people with ankylosing spondylitis. Researchers will follow 63 adults over 4 years, using scans, blood tests, and flexibility measurements. The goal is to find a …

This study tested whether a gentle electrical stimulation on the ear (taVNS) can improve how the heart and nervous system respond during exercise in people with chronic spinal cord injury. 35 adults completed two exercise sessions—one with real stimulation and one with a sham (fa…

This study looked at 65 adults with ankylosing spondylitis, a type of arthritis that affects the spine. Researchers wanted to see if a blood test called the CALLY index could measure inflammation better than patient-reported symptoms. They reviewed medical records and compared th…

This study looked at whether manual therapy, exercise, and acupuncture can reduce pain and improve walking in older adults with lumbar spinal stenosis, a common cause of back and leg pain. Researchers enrolled 60 participants to see if a larger trial is possible. The goal is to f…

This study looked at chest expansion, lung function, and a new measure of breathing muscle strength called the S-index in 52 people with radiographic axial spondyloarthritis and healthy controls. The goal was to see if these measures differ between the two groups and if the S-ind…

This completed study looked at 57 people with CURRARINO syndrome, a rare condition that can include a tumor near the tailbone. Researchers used yearly MRI scans and blood tests to track tumor growth and understand genetic links. The goal was to find out who is most at risk and wh…

This completed study surveyed 70 women with spinal cord injury to learn about their experiences with fertility, contraception, and pregnancy. Researchers asked closed- and open-ended questions to understand how the injury affects decisions about having children and choosing birth…

This study looked back at 25 years of medical records from 246 patients aged 50+ with lumbar spinal stenosis (a narrowing in the spine that can cause leg pain and trouble walking). Researchers compared patients who had a less invasive surgery (tubular decompression, with or witho…

This study looked at what resilience means for people living with a spinal cord injury. Researchers interviewed 28 adults who had their injury at least one year ago, asking about their experiences and having them fill out surveys. The goal was to find common themes among people a…

This study tested whether a special type of MRI (called DBSI) can predict how well people recover after surgery for a compressed spinal cord. 71 patients with cervical spondylotic myelopathy had this MRI before surgery and again 2 years later. Researchers looked for imaging marke…

This study tested a new training device called an eccentric arm-crank in 12 athletes with spinal cord injury. Over 20 training sessions, participants used the device to build upper body strength and endurance. The goal was to see if the device is practical and effective for impro…

This study looked at 44 people aged 12-25 having scoliosis surgery to see if a nerve block (ESP block) is more cost-effective than standard IV anesthesia. Researchers measured quality of life and healthcare costs shortly after surgery. The goal is to find out if the nerve block p…

This small study tested whether it is safe and practical to use two devices together in people with recent spinal cord injury. Eight participants received both a mild electrical stimulator placed on the back and leg, and a low-level laser. The main goal was to see if the equipmen…

This study looks back at 84 cases of sacrococcygeal teratoma, a rare tumor in fetuses and infants. Researchers want to find factors that predict how the tumor will behave, whether it will come back, and what long-term effects it may have. The goal is to give parents clearer infor…

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This study looked at how the calf muscle and Achilles tendon work together during walking in people who have had a stroke or spinal cord injury, compared to healthy individuals. Researchers used ultrasound and motion analysis to measure muscle and tendon lengths in 64 adults. The…

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and their mood to understand why weight gain happens. The goal is to use this information to design better programs that help people wi…

This completed study examined the link between erectile dysfunction, nerve pain, disease activity, and daily function in 90 men with axial spondyloarthritis (a type of arthritis affecting the spine). Participants were either on anti-TNF drugs, NSAIDs, or were healthy volunteers. …

This completed study looked at how the brain controls muscles after a spinal cord injury. Researchers tested 120 people with chronic neck-level injuries to measure nerve signals and motor function. The goal was to better understand how to improve hand and arm movement for daily t…

This study looked at how walking with a robot (Lokomat) helps people with spinal cord injuries recover movement. Ten patients were assessed before, during, and after training, plus one month later. The goal was to understand how gait improves over time, not to test a new drug or …

This study looked at 75 adults having lower back surgery to see if body weight affects how well a nerve block controls pain. Researchers measured pain levels at rest and while coughing in the first hours after surgery. The goal is to understand if heavier patients need different …

This study looked at using 3D navigation to help guide spine fusion surgery in 11 adults with worn-out discs. The goal was to see if the technology helps place screws more accurately and reduces complications. Researchers measured things like surgery time, blood loss, and pain re…

This study followed 18 adults with active ankylosing spondylitis who were starting anti-TNF therapy for the first time. Researchers measured their sleep quality using overnight sleep tests and a questionnaire, and tracked their daily step counts with a wearable device. The goal w…

This study used MRI to examine neck muscles in 158 people with ankylosing spondylitis (AS), a type of arthritis that affects the spine. Researchers measured muscle size, fat buildup, and spine alignment, comparing them to healthy controls. The goal was to better understand how AS…

This study tested a new way to control a robotic arm mounted on a power wheelchair. The arm uses a camera to help guide movements, making tasks like grabbing a drink easier. 21 adults who use power wheelchairs and have trouble with everyday tasks took part. They compared the new …

This study looked at whether ultrasound can measure bladder wall thickness in people with spinal cord injury and how it relates to standard bladder function tests. Researchers studied 116 adults to see if this non-invasive method could help assess bladder health. The goal is to f…

This study looked at 50 people with lumbar spinal stenosis to see if simple decompression surgery or a more complex fusion surgery leads to better outcomes. Researchers measured pain, disability, quality of life, and movement using questionnaires and wearable sensors. The goal wa…

This completed study surveyed 56 adults with spinal cord injury in Türkiye to find out which everyday activities—like eating, bathing, or using a wheelchair—they value most and how independent they hope to become. Participants rated each activity on a 0–10 scale and stated their …

This study looked at 72 people with lumbar stenosis who had decompression surgery to relieve leg and back pain. Researchers wanted to see if the surgery also improved their posture, specifically a forward-leaning stance. They used special X-ray imaging to measure changes in spine…

This study looked at 39 people having lower back surgery for a herniated disc or spinal stenosis. Researchers checked for nerve pain before surgery and again 1, 3, 6, and 12 months after using a simple questionnaire. The goal was to see how common nerve pain is after surgery and …

This study looked at 40 adults with lumbar spinal stenosis (a narrowing in the spine that causes pain and trouble walking) who were scheduled for surgery. Researchers measured how fast they could walk before and after the operation using a 6-minute walk test. The goal was to see …

This study analyzed blood and other samples from 106 adults with recent spinal cord injuries to find molecules linked to better recovery. Researchers measured changes in these molecules before and after rehabilitation and one year after injury. The goal is to identify biological …

This study tested whether injecting a contrast dye into the disc space during TLIF spine surgery helps surgeons assess how well they have removed the disc. 56 patients having spinal fusion for degenerative spine disease were randomly assigned to either have the dye used as a chec…

This pilot study tested a wearable robotic exoskeleton called EksoNR in 5 people with stroke, spinal cord injury, cerebellar ataxia, or spastic paraplegia. The goal was to see if using the device for gait training in an outpatient setting is safe, tolerable, and feasible. Researc…

This study looked at 94 adults with a recent spinal cord injury to see if keeping their blood pressure at a higher or lower target helped them heal better. Participants were split into two groups: one with a standard blood pressure goal and one with a higher goal, maintained for …

This study used MRI scans to measure the volume of spinal fluid in 40 adults before they received spinal anesthesia for surgery. Researchers wanted to see if the amount of fluid affected how high and how long the anesthesia worked. The goal is to help doctors tailor anesthesia do…

This study looked at how the spine moves in 10 people with spinal tumors before and after vertebrectomy surgery. Researchers used motion analysis to measure walking, standing, and trunk movements. The goal was to better understand spine function and possibly improve future treatm…

This study tested whether a non-invasive ultrasound device can reduce inflammation in people with inflammatory arthritis (psoriatic arthritis, rheumatoid arthritis, or ankylosing spondylitis). Sixteen participants received four sessions of focused ultrasound or a sham (placebo) t…

This study looked at whether people who inject opioids can safely finish a course of IV antibiotics at home instead of staying in the hospital. Ten participants received home antibiotic therapy along with addiction medication and support from a health coach and case manager. The …

This completed study surveyed 229 people with chronic inflammatory rheumatism (like rheumatoid arthritis) and their doctors to find out what makes it hard to follow care recommendations after a hospital visit. The goal was to identify barriers to good outpatient management. No tr…

This study looked at 70 people with spondyloarthritis, a type of inflammatory arthritis affecting the spine and joints. Researchers measured immune markers in the blood to see if they could predict how the disease would progress or how well patients would respond to treatment. Th…

This study looked at how well nerve monitoring works during a type of spine surgery called XLIF. It involved 323 adults with worn-out discs in their lower back. The goal was to see if the monitoring could accurately detect nerve problems during the operation.

This study collected information from over 8,000 people who had spine surgery for conditions like degeneration, deformity, or trauma. Researchers gathered X-ray and health data to learn which treatments work best for different patients. The goal was to build a database to answer …

This completed study of 292 women looked at tailbone pain (coccydynia) after childbirth. Researchers used the Paris Questionnaire to measure pain and compared it with quality-of-life and functional scores. The goal was to see if this simple questionnaire could help doctors better…

This study tested a method to monitor nerve health during a specific type of spine surgery called XLIF. Researchers used mild electrical stimulation on the lower back nerves during surgery and checked if changes in nerve signals could predict nerve problems after surgery. 324 adu…

This study tested a new method to monitor nerves during spine surgery for degenerative lumbar disc disease. Researchers used surface electrodes on the skin to stimulate nerves in the lower back and record muscle responses in the legs. The goal was to see if this approach is relia…

This study tested whether having spine surgery patients wear an Apple Watch could help doctors track their recovery. 255 adults wore the watch before and after surgery to measure steps and distance. The goal was to see if this data matched how patients felt and if it could improv…

This completed study looked at data from 1,000 lupus patients and gathered expert opinions to find where diagnosis and treatment fall short. Researchers reviewed existing information, discussed with doctors, and built consensus on unmet needs. The goal is to publish findings that…

This study tested whether a brain-spinal cord-muscle training program can strengthen connections that control movement in people with spinal cord injury. Twenty-one participants completed four months of training using brain stimulation and muscle monitoring. The goal was to see i…

This completed study looked at 80 people with spinal cord injuries to understand how arm, shoulder, and wrist problems relate to their daily lives. Researchers used ultrasound to examine these areas and compared the findings with pain levels and physical exams. The goal was to id…

This study looks at how genes might influence the severity of ankylosing spondylitis, a type of arthritis that can fuse spine bones. Researchers will follow 299 adults with the condition for up to 5 years, tracking symptoms, spine flexibility, and X-rays. The goal is to identify …

This study tested whether personalized walking training based on detailed 3D movement analysis works better than standard walking therapy. 63 people with spinal cord damage from injury or multiple sclerosis took part. The goal was to see if customizing exercises to each person's …

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study involved 32 adults with arm weakness from stroke, multiple sclerosis, or spinal cord injury. Researchers measured how much force patients could voluntarily produce in their arms and used that data to build mathematical models. The goal is to use these models to improve…

This completed study followed 127 adults with moderate to severe plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, or non-radiographic axial spondyloarthritis who were already taking or starting secukinumab. Researchers observed them for two years to see how long the…

This completed study followed 100 patients who had outpatient neck surgery for cervical stenosis, a condition where the spinal canal narrows. Researchers tracked neurologic function, pain, and complications over about 2.5 years. The goal was to see if performing this complex surg…

This completed study used MRI scans to see how thinking difficulties appear in the brains of people with spinal cord injury. Fifty-four participants completed cognitive tasks while their brain activity was measured. The goal was to better understand non-motor challenges that ofte…

This study looked at 120 people aged 50 and older with low back pain to see how well MRI-based grading of lumbar spinal stenosis matches what patients report on disability and pain questionnaires. Researchers compared three common questionnaires (Oswestry Disability Index, Istanb…

This small study tested whether mild nerve stimulation could increase vaginal blood flow in women with sexual problems, spinal cord injury, or no issues at all. Nine women had a small sensor placed in the vagina to measure blood flow changes during stimulation. The goal was to un…

This study tested a mobile app called SCI-Lynx designed to help people with spinal cord injury connect with others who have similar exercise goals. Over one month, 33 participants used the app to find exercise buddies, set goals, and track progress. The goal was to see if the app…

This small study tested whether briefly restricting blood flow to one arm (called remote ischemic conditioning, or RIC) could improve hand function in people with spinal cord injury or ALS. Participants did hand exercises while receiving either active RIC or a sham version. The g…

This study looked back at 465 patients who had lumbar spine fusion surgery for degenerative disc disease. Researchers compared two types of implants (expandable cages and static cages) to see which ones were less likely to sink into the bone after surgery. The goal is to help sur…

This completed study with 92 people tested whether a measure called perfusion index (a way to check blood flow) can predict how well a nerve block (erector spinae plane block) relieves chronic neck pain from conditions like herniated discs or spinal narrowing. Researchers tracked…

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This study reviewed the records of 978 adults who had spinal fusion surgery to see how often routine follow-up X-rays led to additional tests or changes in treatment. The goal is to find out whether these X-rays are truly helpful or if they can be skipped. The results could help …

This study looked at 43 adults with incomplete spinal cord injury to see how their own views on safe walking matched their therapists' views and actual walking ability. Researchers measured walking independence, leg strength, balance, and fall risk. The goal is to improve dischar…

This study from the University of Zurich looked at how people with different neurological conditions walk. Researchers measured walking patterns in 208 adults, including those with stroke, Parkinson's, multiple sclerosis, and spinal cord injury, as well as healthy volunteers. The…

This early-phase trial in 13 healthy volunteers measures how two drugs, neostigmine and glycopyrrolate, enter the bloodstream when given through a skin patch using a mild electric current (iontophoresis) compared to an IV. The goal is to see if this needle-free method could one d…

This study followed 35 men with spinal cord injuries over 18 months to see how their sperm quality changes and what factors might cause problems. Researchers measured sperm health, inflammation, and infections from ejaculates collected every 6 months. The goal is to find ways to …

This study looked at two community-based wellness programs for adults with disabilities like spina bifida, cerebral palsy, spinal cord injury, and traumatic brain injury. Researchers measured changes in health, mood, quality of life, and healthcare costs over up to 24 months. The…

This study looked at how sleep apnea and low oxygen levels affect muscle strength and breathing in people with chronic spinal cord injury. Thirty adults with neck-level spinal cord injuries were tested using hand grip strength and muscle activity measurements. The goal was to und…

This study tested whether robotic training that adjusts errors based on each person's abilities can improve motor learning in healthy adults and people with neurological conditions like stroke. Over 250 participants performed arm tasks with robotic devices while researchers measu…

This completed study looked at the safety of pharmacopuncture—herbal extracts injected into acupuncture points—in 1,000 hospitalized adults with spine or joint problems. Researchers tracked infections and other side effects to see how often problems occur. The goal was to gather …

This study looks at how a robotic body-weight support system called FLOAT affects the way people with incomplete spinal cord injury perform everyday tasks like walking, standing up, and climbing stairs. Researchers measure movement and muscle activity with and without the robot's…

This study tested whether a single session of high-intensity interval training (three 20-second all-out efforts on an arm bike) could improve heart and brain function in 30 people with spinal cord injury compared to uninjured controls. The goal was to see if this type of exercise…