New Scan-Guided proton therapy aims to stop rare bone tumors
NCT ID NCT02802969
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether using a special PET scan (FAZA) to find oxygen-starved (hypoxic) tumor cells can help guide proton therapy for chordomas of the skull base, spine, or sacrum. 64 adults who had surgery or were getting radiation received a higher radiation dose to the hypoxic areas. The goal was to improve local tumor control at 3 years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- proton therapy
- What this could lead to
- If successful, this approach could improve local control of chordomas by better targeting resistant tumor cells.
- What could go wrong
- This is a small Phase 2 trial with 64 participants, so results may not apply broadly. The technique is complex and may not significantly improve outcomes over standard therapy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Institut Curie - Hôpital René Huguenin
Saint-Cloud, Île-de-France Region, 92210, France
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