Institut Curie

This study compares two approaches after complete removal of stage II/III thymoma: giving radiation therapy versus simply monitoring. The goal is to see if radiation reduces the chance of the tumor returning. About 314 adults aged 18-75 who had their thymoma fully removed are eli…

This study tests two new chemotherapy strategies to treat retinoblastoma, a rare eye cancer in children, while trying to save the eye and preserve vision. One part compares a two-drug injection directly into the eye's artery versus a single drug. The other part looks at standard …

This study tests a combination of two targeted drugs, tucatinib and trastuzumab, in people with a specific type of advanced breast cancer (HER3-mutant, HER2-negative) that has not responded to at least two prior chemotherapies. The goal is to see if this treatment can shrink tumo…

This study is testing a new type of PET scan called FAPI PET to see if it can find pancreatic cancer progression or return earlier than current tests like CT or MRI. About 35 adults with pancreatic cancer that hasn't spread will get FAPI scans at several points during their treat…

This study tests whether a taurolidine lock solution, placed inside the catheter after each use, can prevent infections better than a standard saline lock. The trial involves 148 children and young adults with cancer who need a central catheter. Participants are randomly assigned…

This study tests whether avoiding opioids during breast reconstruction surgery can reduce the need for morphine afterward. About 158 women having free flap breast reconstruction will be randomly assigned to receive either opioid-free or standard opioid anesthesia. The goal is to …

This study looks at the immune cells and genetic makeup of thymic epithelial tumors (a rare type of chest cancer). Researchers will analyze tumor samples from 50 patients who have not yet been treated. The goal is to better understand the disease and identify potential new target…

This study will track 500 adults starting chemotherapy with a chest port to see how often skin reactions like itching and redness happen at the dressing site. Researchers want to find out what increases the risk of these reactions, such as the type of dressing or the drugs used. …

This study looks at whether training for patients and healthcare workers can increase the use of enteral nutrition (feeding through a tube) in cancer patients who are malnourished. About 80 adults with cancer who need this type of nutrition will take part. The goal is to see if t…

This study looks at whether regular blood tests (ctDNA monitoring) and special PET scans can find triple negative breast cancer returning earlier in women at high risk. About 450 women who finished treatment for early-stage cancer will be monitored. If the blood test detects sign…

This study aims to see if using genetic signatures from a liver biopsy can help doctors choose the most effective first chemotherapy for people with advanced pancreatic cancer. About 85 participants will have their treatment selected based on these genetic tests, and researchers …

This study tests a new way to choose the next treatment for people with a common type of advanced breast cancer (ER-positive, HER2-negative). Doctors will use a special PET scan and blood tests to decide whether hormone therapy or chemotherapy is the better option. The goal is to…

This study is testing whether a simple blood test (liquid biopsy) can predict how well immunotherapy works in people with advanced lung cancer. Researchers will follow 300 patients who have not yet been treated and are starting immunotherapy, with or without chemotherapy. The goa…

This study looks at how many breast and lung cancer patients have a strong, ongoing fear that their cancer will return. Researchers will survey 200 patients and interview 40 of them to understand their feelings, thoughts, and whether they feel they get enough support. The goal is…

This study follows 700 people with uveal melanoma (a rare eye cancer) who have a high chance of the cancer spreading to the liver. Researchers collect blood samples to look for biomarkers that might signal early spread. The goal is to see if personalized follow-up schedules can c…

This study is testing whether a personalized lab test, called a tumorogram, can help choose the best treatment for people with metastatic breast cancer. Researchers take a small sample of the tumor and grow it in the lab to create a 'tumor avatar.' They then test different drugs …

This study is gathering tumor, blood, and plasma samples from over 1,000 people with certain cancers (ovarian, triple-negative breast, head and neck, cervical, vulva, and sarcoma). The goal is to find new biomarkers that link a tumor's genetic changes and the body's immune respon…