Institut Curie

This study aims to find out if giving radiation therapy after successful surgery for stage II or III thymoma helps prevent the cancer from coming back better than just regular monitoring. It will enroll about 314 adults who have had their thymoma completely removed. Participants …

This study is testing a personalized approach to choose the first chemotherapy for people with advanced pancreatic cancer that has spread. Doctors will analyze the genetic makeup of a patient's tumor biopsy to predict which of two standard chemotherapy combinations might work bet…

This study is testing two different approaches to treat retinoblastoma, a rare eye cancer in children, while trying to save the affected eye and preserve vision. One part compares two chemotherapy methods delivered directly to the eye, while another part evaluates vision outcomes…

This trial aims to help doctors choose the most effective second treatment for people with advanced breast cancer that has stopped responding to initial hormone therapy. It uses special scans and blood tests to guide whether patients should receive more hormone-based treatments o…

This study is testing whether a combination of two existing drugs, tucatinib and trastuzumab, can help control advanced breast cancer that has a specific genetic mutation (called HER3) but is not the usual HER2-positive type. It's for people whose cancer has grown despite trying …

This study is testing a personalized method to help choose the next chemotherapy for patients with advanced breast cancer. Doctors take a small sample of a patient's tumor and grow it in the lab to create a 'tumor avatar.' They test different chemotherapy drugs on this avatar to …

This study is testing whether a new monitoring approach can find returning triple negative breast cancer earlier. It will track 450 women at high risk of their cancer coming back using regular blood tests that look for tiny pieces of tumor DNA. If the blood test turns positive, h…

This study is testing a new type of PET scan called FAPI PET to see if it can detect the return or spread of pancreatic cancer earlier than current standard scans like CT or MRI. It involves 35 patients who have already been diagnosed with non-metastatic pancreatic cancer and are…

This study is testing if a special solution called taurolidine can prevent infections in the catheters used by children and young adults with cancer. Researchers will compare it to a standard saline solution to see which one better stops germs from growing inside the catheter. Th…

This study is testing whether using anesthesia without opioids during breast reconstruction surgery leads to less need for morphine pain medication afterward. Researchers will compare two groups of patients: one receiving traditional opioid-based anesthesia and one receiving opio…

This study aims to find better ways to monitor patients with high-risk uveal melanoma (a type of eye cancer) for signs that the cancer has spread to the liver. Researchers will follow 700 patients for up to 10 years, collecting regular MRI scans and blood samples to look for biol…

This study aims to see if simple blood tests can predict how well immunotherapy will work for people with advanced lung cancer. Researchers will track 300 patients receiving first-line immunotherapy, taking regular blood samples to look for cancer DNA and immune cell changes. The…

This study aims to learn more about thymic epithelial tumors (TETs), a rare type of cancer. Researchers will collect tumor and blood samples from 50 patients undergoing surgery to analyze the immune cells and genetic features of these tumors. The goal is to build a detailed pictu…

This study aims to learn if cancer markers found in blood samples can provide the same information as a traditional tissue biopsy. It will enroll 2,050 people already being treated for cancer to collect blood samples over time. The research is observational and will not change an…

This study aims to understand how often and why skin reactions like redness and itching occur under the dressings that cover implanted chest ports used for chemotherapy. It will follow 500 new chemotherapy patients to measure the problem and look for links to factors like the typ…

This study aims to collect and store tumor tissue and blood samples from patients with certain cancers. The goal is to better understand the relationship between a tumor's genetic makeup, its surrounding environment, and the body's immune response. Patients will receive standard …

This study is testing if a new type of PET scan can predict how well a patient's triple-negative breast cancer will respond to a standard combination of chemotherapy and immunotherapy before they even start treatment. Researchers will scan 60 patients with early-stage, high-risk …

This study aims to understand how common and severe the fear of cancer returning is for people treated for breast or lung cancer. Researchers will survey 200 patients and conduct in-depth interviews to learn about their experiences and needs. The goal is to develop better tools t…