Institut Curie

This study looks at whether giving radiation therapy after surgery can stop thymoma (a rare chest tumor) from returning in patients with stage II or III disease. About 314 adults aged 18-75 who had the tumor completely removed will be randomly assigned to receive radiation or jus…

This study tests a combination of two drugs, tucatinib and trastuzumab, in people with a specific type of advanced breast cancer that has a mutation in the HER3 gene. The cancer must be HER2-negative and has already been treated with at least two prior chemotherapies. The goal is…

This study tests a new approach for metastatic breast cancer patients. Doctors take a biopsy of a tumor and grow it in the lab to create a 'tumorogram'—a map showing which drugs might work best. Then, patients receive a treatment chosen based on this map. The goal is to see if th…

This study tests two ways to treat retinoblastoma, a childhood eye cancer, while trying to save the eye and vision. One part compares two types of artery-directed chemotherapy (one with two drugs, one with one) to see which better preserves the eye. The other part looks at how we…

This study tests a new type of PET scan that uses a tracer called FAPI to see if it can find pancreatic cancer progression or relapse earlier than standard CT or MRI scans. 35 adults with non-spread pancreatic cancer will receive the FAPI-PET scan at several points during their t…

This study is testing whether a new type of PET scan (68Ga-FAPI-46) can predict if triple-negative breast cancer will completely respond to chemotherapy plus immunotherapy before treatment begins. About 60 women with early-stage, high-risk breast cancer will get the scan before s…

This study tests whether a special solution (taurolidine) placed inside the catheter can prevent infections better than the standard saltwater solution. About 148 children with cancer who need a central catheter will take part. The goal is to see if the taurolidine lock reduces t…

This study compares opioid-free anesthesia using dexmedetomidine and lidocaine to standard opioid-based anesthesia in 158 women undergoing breast reconstruction after cancer. The goal is to see if the opioid-free approach reduces morphine use and side effects in the first 48 hour…

This study looks at whether a structured program can help more high-risk smokers get a first lung cancer screening with a CT scan. About 500 people aged 50 to 74 who smoke or recently quit will join. The goal is to see if a dedicated network makes screening easier and more effect…

This study looks at genetic changes in families to figure out which ones truly increase cancer risk. Researchers will analyze DNA from 11,000 people, including those with certain gene variants and their relatives. The goal is to improve genetic counseling and help doctors decide …

This study looks at whether training for doctors and educational workshops for patients can increase the use of enteral nutrition (feeding through a tube) in cancer patients who are malnourished. About 80 adults with cancer who need this type of nutrition will take part. The goal…

This study is collecting blood samples from 300 cancer patients to look for immune cells that target tumors. Researchers want to understand how the immune system responds to cancer and treatments. The study does not test a new drug or therapy, but aims to gather knowledge that co…

This pilot study aims to see if using five gene signatures from a patient's tumor can help doctors choose the best first chemotherapy for advanced pancreatic cancer. About 85 people with metastatic pancreatic cancer will have their tumor genes analyzed to pick between two standar…

This study tests whether a special PET scan (EstroTEP) and blood tests can help doctors pick the best second-line treatment for people with ER-positive, HER2-negative metastatic breast cancer. About 300 participants will be assigned to either endocrine therapy or chemotherapy bas…

This study is collecting blood samples from up to 2050 cancer patients to look for tiny pieces of tumors, called biomarkers, in the blood. The goal is to see how often these markers can be detected. Participation does not change standard cancer care or treatments.

This study collects tumor and blood samples from over 1,000 people with certain cancers (ovarian, breast, head and neck, cervical, vulva, and sarcoma). Researchers will analyze the samples to find links between genetic changes, the immune system, and how the cancer behaves. Parti…

This study looks at how common severe fear of cancer recurrence is among people treated for breast or lung cancer. Researchers will survey 200 patients and interview 40 of them to understand their experiences and what kind of support they need. The goal is to find better ways to …

This study looks at whether regular blood tests (ctDNA monitoring) combined with a special type of PET scan can detect the return of triple negative breast cancer earlier than standard methods. About 450 women who finished treatment for early-stage triple negative breast cancer w…

This study is testing whether a liquid biopsy (a blood test that looks for tumor DNA) can predict how well immunotherapy works in people with advanced lung cancer. Researchers will track changes in ctDNA levels from before treatment to six weeks after, and see if those changes ma…

This study looks at thymic epithelial tumors, a rare type of cancer in the chest. Researchers will collect tumor and blood samples from 50 patients during surgery to analyze the immune cells and genetic changes in the tumors. The goal is to better understand the disease and ident…

This study will follow 500 adults starting chemotherapy with a chest port (a small device under the skin to deliver drugs). The goal is to measure how often skin reactions like itching or redness happen from the dressing that covers the port. Researchers will also look for factor…

This study follows 700 people with uveal melanoma, a rare eye cancer, who are at high risk of the cancer spreading to the liver. Participants get regular liver MRIs and blood tests to look for early signs of metastasis. The goal is to see if personalized monitoring can detect rel…