Institut Curie

This is a first-in-human study to test the safety and find the right dose of a new drug called PEP-010. It is being given alone and in combination with standard chemotherapy drugs to patients with advanced solid tumors that have spread. The main goals are to see how safe it is an…

This study is testing a new combination of two immunotherapy drugs (tiragolumab and atezolizumab) with standard chemotherapy for triple-negative breast cancer. It aims to see if this three-part treatment is safe and more effective at shrinking tumors before surgery for early-stag…

This study is testing different combinations of chemotherapy drugs and local treatments for children under 6 with retinoblastoma, a rare eye cancer. The main goal is to control the cancer and save the child's eye, avoiding surgical removal or external beam radiation whenever poss…

This study tests a decision-making tool designed to help doctors and patients with advanced lung cancer decide when to continue or stop aggressive treatments near the end of life. It compares usual care to using a structured checklist that guides conversations about treatment goa…

This study tests different chemotherapy and radiation treatments for children with advanced retinoblastoma (eye cancer) who have had an eye surgically removed. Doctors tailor treatment based on how far the cancer had spread in the removed eye, aiming to prevent the cancer from re…

This study is testing whether adding either lenalidomide or ibrutinib to standard chemotherapy works better for adults with newly diagnosed primary brain lymphoma. The first part determines safe drug doses, while the second part compares how well patients respond to each combinat…

This study is testing whether a combination of two existing cancer drugs, pembrolizumab and lenvatinib, can help control metastatic uveal melanoma, a rare and aggressive cancer that starts in the eye. It will enroll about 51 patients into two groups based on whether they have had…

This study is testing a blood test that looks for tiny pieces of cancer DNA to see if it can detect the return of HPV-related pelvic cancers earlier than current methods. It involves 172 patients who have been treated for these cancers and are now in follow-up care. Researchers w…

This study is testing whether regular MRI scans can help detect second cancers early in people who had hereditary retinoblastoma as children and were treated with radiation therapy. The research involves 88 participants who are at least 7 years old and had radiation treatment at …

This study compares two types of wound dressings to see which one causes less bleeding when bandages are changed for patients with large, cancerous skin wounds. Researchers are testing a special 'hemostatic' dressing designed to stop bleeding against a standard, non-hemostatic dr…