Institut Curie

This study tests whether chemotherapy followed by local treatments can control retinoblastoma (an eye cancer in children) and avoid removing the eye or using radiation. About 133 children with different stages of the disease will receive tailored drug regimens. The main goal is t…

This study looks at whether giving chemotherapy and, if needed, radiation after removing the eye can stop retinoblastoma from coming back in children. About 195 children with advanced retinoblastoma in one eye will receive this extra treatment based on how risky their tumor looks…

This early-phase study tests a new drug called PEP-010, given alone or with chemotherapy (paclitaxel or gemcitabine), in people with metastatic solid tumors that have not responded to standard treatments. The main goals are to check safety and find the right dose, and to see if t…

This study tests two drugs, pembrolizumab and lenvatinib, in people with a rare eye cancer that has spread (metastatic uveal melanoma). The goal is to see if the combination can slow or stop tumor growth. About 51 adults are taking part, and they will be monitored with scans ever…

This study tests adding either lenalidomide or ibrutinib to standard chemotherapy for adults aged 18-65 with newly diagnosed primary central nervous system lymphoma (a rare brain cancer). The goal is to improve treatment response before a stem cell transplant. The trial first fin…

This study tests whether adding the drug tiragolumab to standard chemotherapy and atezolizumab can help people with triple negative breast cancer. It includes two groups: those with early-stage cancer and those with advanced cancer that has spread. The goal is to see if the combi…

This study looks at whether a simple blood test can find early signs of HPV-positive pelvic cancer coming back after treatment. About 172 people who finished curative therapy for cancers like cervical or anal cancer will give blood samples. The test measures tiny bits of tumor DN…

This study looks at whether a special decision-making tool can help doctors and patients with advanced non-small cell lung cancer choose wisely about continuing or stopping cancer treatments. The goal is to reduce the use of chemotherapy and other treatments in the last month of …

This study looks at whether regular MRI scans can detect new head, neck, or brain cancers early in people with hereditary retinoblastoma who were treated with radiation therapy. The goal is to see if early detection leads to better surgery outcomes. About 88 participants aged 7 a…