Institut Curie

This study tested a new way to plan radiation therapy for chordomas, rare tumors of the skull base and spine. Researchers used a special PET scan to find low-oxygen areas in the tumor that are resistant to standard radiation. They then aimed to deliver a higher dose of radiation …

This completed international trial compared two different schedules of radiation therapy for children and young adults (ages 4-21) with standard-risk medulloblastoma, a type of brain tumor. All participants received the same chemotherapy, but were randomly assigned to receive rad…

This early-stage trial tested the safety of combining a pill called olaparib with standard radiation therapy. It involved 24 women with advanced or hard-to-treat triple-negative breast cancer that had not fully responded to prior chemotherapy. The main goal was to find the highes…

This study tested an intensive chemotherapy treatment for Ewing sarcoma, a rare bone cancer, in patients aged 2 to 50 whose cancer had already spread to bones or bone marrow at diagnosis. The goal was to see if a strong initial chemotherapy regimen could help more patients become…

This study tested whether delivering the breast cancer drug trastuzumab (Herceptin) directly into the spinal fluid could help patients whose cancer had spread to the membranes around the brain and spinal cord. The trial involved 34 people with advanced HER2-positive breast cancer…

This study tested whether using a blood test to track cancer cells could help doctors choose more effective chemotherapy for women with advanced breast cancer that has spread. It involved 265 women whose cancer had worsened after two prior rounds of chemotherapy. Researchers comp…

This study tested a combination of three drugs (pomalidomide, cyclophosphamide, and dexamethasone) in 100 adults with multiple myeloma whose cancer had returned after their first treatment. The goal was to see if this new drug combination could effectively control the disease in …

This study tested if adding a targeted drug called cetuximab to the standard treatment of radiation and chemotherapy (cisplatin) was better for controlling cervical cancer. It involved 76 women with stage IB2, II, or IIIB cervical cancer who were not eligible for immediate surger…

This study tested the safety of adding a new immunotherapy drug called nivolumab to the standard treatment of radiation and chemotherapy for women with locally advanced cervical cancer. It involved 21 patients and aimed to see if this combination was safe and might be more effect…

This study tested a personalized approach to treating advanced cancer that had stopped responding to standard treatments. Researchers analyzed the genetic makeup of each patient's tumor to find specific abnormalities. Patients were then randomly assigned to receive either a drug …

This study tested whether a blood test could identify metastatic breast cancer patients who might benefit from a targeted drug, even when their original tumor test suggested they wouldn't. Researchers screened 155 patients with HER2-negative breast cancer using a blood test that …

This study aimed to find new markers in blood and urine that could help doctors better detect, predict the course of, and monitor prostate cancer. It involved 80 men, including those with prostate cancer, those suspected of having it, and healthy volunteers. Researchers collected…

This study tested a new, faster way to check PSA levels, a marker for prostate health. Researchers compared a simple test strip that uses a few drops of blood to the standard, more complex lab test. They wanted to see if the quick test was as accurate for monitoring patients with…

This study tested whether a special 3D ultrasound scan, called Shear Wave Elastography, could accurately predict how well chemotherapy was shrinking tumors in patients with locally advanced breast cancer before their surgery. Researchers followed 140 patients, measuring changes i…

This study tested whether adding supportive care services early alongside standard cancer treatment helps meet patients' psychological needs better than waiting until problems arise. Researchers compared two groups of adults with metastatic uveal melanoma (eye cancer that has spr…

This study tested if injecting a numbing medicine (ropivacaine) near nerves in the chest before breast cancer surgery could better control pain right after the operation. It compared the numbing shot to a placebo (saltwater) shot in 182 women having a lumpectomy. The main goal wa…

This study compared two different nerve block techniques for pain relief after breast cancer surgery. Researchers tested whether a newer method (erector spinae block) works as well as the standard method (paravertebral block) at reducing pain and the need for morphine after surge…

This study tested whether a medical spray called Hydrosorb works better than a simple water spray to prevent and treat skin damage from radiation therapy in women with breast cancer. Researchers enrolled 278 women who developed mild to moderate skin redness or irritation during t…

This study tested whether giving a booklet with example questions helps patients with advanced cancer or their families get the information they need during palliative care visits. Researchers enrolled 121 French-speaking adults with metastatic cancer to see if using the booklet …

This study tested whether injecting a local anesthetic (ropivacaine) during breast cancer surgery could prevent long-term pain in the breast area. It involved 260 women who had surgery for breast cancer. Researchers compared the anesthetic injection to a placebo to see which grou…

This study looked at how specialized day hospital care affects the quality of life for people with advanced cancer. Researchers followed 144 patients to see if integrated palliative care helped reduce fatigue, improve emotional state, and maintain overall well-being. The goal was…

This study looked back at medical records to see if a morphine gel applied directly to the skin helped relieve severe pain from radiation burns (radiodermatitis) in the pelvic area. It involved 17 adult cancer patients whose pain wasn't controlled by regular pain pills. The main …

This study aimed to understand how blood flows through basal cell carcinoma skin tumors. Researchers temporarily blocked and then restored blood flow to tumors during surgical removal while measuring blood circulation changes with a special laser camera. The goal was to learn abo…

This study looked at how giving women personalized estimates of their breast cancer risk affects them psychologically. Researchers followed 405 healthy women with family histories of breast cancer who underwent genetic testing in France and Germany. The goal was to understand how…

This study explored whether breast cancer has a unique smell that could be used for detection. Researchers collected odor samples from the hands, breasts, and tumors of 35 women undergoing breast cancer surgery using a special polymer. They also tested if trained dogs could ident…

This study followed nearly 2,000 employees from two French research institutes to understand how COVID-19 antibodies develop and change over time. Participants gave blood samples at four points over a year to measure antibody levels, and some also provided nasal swabs. The goal w…

This study aimed to create a communication tool to help doctors and patients have better conversations when cancer treatments stop working. Researchers interviewed 128 people, including cancer patients, parents of children with cancer, and healthcare professionals, to understand …

This study aimed to understand why some wounds take a very long time to heal. Researchers looked at wound samples from 130 patients to check for a sticky layer of bacteria called a biofilm. They did not test a treatment; instead, they observed and linked what they saw under a mic…

This study tested whether a blood test that looks for tiny pieces of cancer DNA could help doctors monitor patients after surgery. It involved 60 people with eye melanoma that had spread to the liver, who were having surgery to remove all visible tumors. Researchers took blood sa…

This study tested a new method to understand how the body's immune system recognizes cancer cells in lymph nodes. Researchers worked with 25 patients who had breast cancer or melanoma and were scheduled for lymph node surgery. They measured specific immune cells that target cance…

This study aimed to develop and compare different blood test methods to detect tiny amounts of tumor DNA from eye melanoma that has spread. Researchers worked with 40 patients whose cancer had spread to find the most sensitive and cost-effective technique. The goal was to improve…