Institut Curie

This early-phase study tested adding the immunotherapy drug nivolumab to standard chemoradiation for people with locally advanced cervical cancer. The main goal was to check safety and find the right dose, while also looking at how well the combination worked. 21 adults took part…

This study tested whether adding a special PET scan (FAZA PET/CT) to standard imaging can improve local control of chordoma, a rare bone tumor, after surgery. The scan identifies oxygen-starved (hypoxic) cells that are resistant to radiation, allowing doctors to target them more …

This study tested a more intense chemotherapy plan for people aged 2 to 50 with Ewing sarcoma that has spread to bones or bone marrow. The goal was to see if the stronger treatment could improve how long patients live without the cancer getting worse. 45 patients took part, and t…

This study tested two different ways of giving radiation to children and teens (ages 4 to 21) with a standard-risk brain tumor called medulloblastoma. One method used smaller, more frequent doses (hyperfractionated), while the other used standard daily doses. The goal was to see …

This study tested whether adding a targeted drug called cetuximab to standard radiation and chemotherapy (cisplatin) could help control cervical cancer better than standard treatment alone. It involved 76 patients with stage IB2 to IIIB cervical cancer that was not immediately op…

This study tested the drug trastuzumab, given directly into the spinal fluid, for people with HER2-positive breast cancer that spread to the lining of the brain (carcinomatous meningitis). The goal was to find a safe dose and see if it could slow the cancer's growth in the nervou…

This early-phase study tested the drug olaparib together with radiation in 24 women with advanced triple-negative breast cancer that did not respond to chemotherapy. The main goal was to find the safest dose of olaparib when used with radiation. The study is complete, and results…

This study tested a combination of three drugs (pomalidomide, cyclophosphamide, and dexamethasone) in 100 adults with multiple myeloma whose cancer returned after initial treatment. Participants had previously received standard therapies including bortezomib and lenalidomide. The…

This study looked at 155 women with metastatic breast cancer whose original tumors were HER2-negative. Researchers checked their blood for HER2-amplified circulating tumor cells. If found, participants received the drug T-DM1. The goal was to see if these blood-based markers coul…

This study tested a new, rapid PSA test that uses a small drop of blood to quickly screen for prostate cancer. Researchers compared its accuracy to the standard lab test in 94 patients with prostate issues. The goal was to see if the faster test could reliably detect high PSA lev…

This study tested whether injecting a local anesthetic (ropivacaine) during breast cancer surgery could prevent chronic pain that often follows. 260 women having breast-conserving surgery or mastectomy received either the anesthetic or a placebo. The main goal was to see if fewer…

This study looked at whether adding supportive care early on helps with the emotional and practical needs of people with metastatic uveal melanoma, a rare eye cancer that has spread. 162 adults took part, filling out surveys about their care needs after 6 months. The goal was to …

This study looked at whether a day hospital focused on integrated palliative care can improve quality of life for adults with advanced cancer. 144 patients took part. The goal was to see if this approach helps patients feel better and supports their caregivers.

This study compared two types of nerve blocks (ESP and PVB) given before breast cancer surgery to see which one better controls pain right after the operation. About 292 women having breast surgery took part. The main goal was to see how many patients needed morphine in the first…

This study tested whether a special dressing (Hydrosorb) is better than a water-based spray at managing skin irritation from radiation therapy in 278 women with breast cancer. The goal was to prevent skin damage from getting worse and avoid interruptions in radiation treatment. P…

This study tested whether a numbing injection (ropivacaine) given near the chest muscles before breast cancer surgery could reduce pain right after the operation. 182 women having a lumpectomy with lymph node removal took part. The goal was to see if fewer patients needed strong …

This study looked at whether a morphine gel applied to the skin can reduce pain from severe radiation burns (radiodermatitis) in the perineal area. Seventeen patients who were not getting enough relief from standard pain pills were included. The main goal was to see if pain decre…

This study tested whether temporarily stopping blood flow to a skin cancer (basal cell carcinoma) and then releasing it could increase blood flow to the tumor. 12 adults with this skin cancer had their tumor's blood supply briefly clamped during surgery. Researchers used a specia…

This study tested whether giving a booklet with suggested questions helps cancer patients or their families ask more during palliative care visits. 121 adults with metastatic cancer and limited life expectancy took part. The goal was to see if the booklet encourages people to ask…

This study aimed to develop and validate a blood test that can detect circulating tumor DNA in patients with metastatic choroidal melanoma, a rare eye cancer that has spread. Researchers collected blood samples from 40 adult patients and compared different detection techniques (P…

This study tested whether choosing cancer drugs based on the genetic profile of a patient's tumor could help people with advanced solid tumors live longer without their cancer growing. Over 700 adults whose cancer had stopped responding to standard treatments were randomly assign…

This study looked at how healthy women with a family history of breast cancer feel after getting a personalized risk estimate using a special computer model. About 405 women took part, and researchers measured their emotional responses and understanding of their risk. The goal wa…

This study looked at whether checking for cancer cells in the blood (circulating tumor cells) can help doctors decide when to switch chemotherapy in women with metastatic breast cancer. 265 women who had already tried two chemotherapies took part. The goal was to see if this appr…

This study tested whether breast cancer has a unique smell that can be detected by a special sensor. Researchers collected odor samples from the hands of 35 women with breast cancer before and after their tumor was removed. The goal was to see if the sensor could identify cancer-…

This study tested whether a 3D ultrasound technique called shear wave elastography can accurately predict how breast tumors respond to chemotherapy before surgery. Researchers measured tumor stiffness at several points during treatment in 140 women with locally advanced breast ca…

This study looked at how long antibodies against the COVID-19 virus last in healthy hospital and non-hospital workers. About 1,971 volunteers from Institut Curie and Institut Pasteur gave blood samples at several time points over a year. The goal was to understand the body's immu…

This study looked at 130 patients with chronic wounds to find out if biofilm (a slimy layer of bacteria) is present and how it affects healing. Researchers used special microscopes and checked medical records. The goal was to learn more, not to test a new treatment.

This study collected urine and blood samples from 80 men, including those with prostate cancer, those with suspected cancer, and healthy volunteers. The goal was to find genetic markers (long non-coding RNA) that could help diagnose prostate cancer and predict its progression wit…

This study aimed to create a communication tool to help doctors and patients talk about cancer that stops responding to treatment. Researchers interviewed 128 people, including patients with certain breast cancers, metastatic uveal melanoma, and parents of children with cancer, a…

This study tested a method to identify immune cells (T cells) that recognize unique mutations in tumors from patients with breast cancer or melanoma. Researchers looked at lymph nodes invaded by cancer to see if these cells were present. The goal was to see if the method works, n…

This study looked at 60 people with uveal melanoma that spread to the liver and who were eligible for surgery to remove it. Researchers measured circulating tumor DNA in the blood before and after surgery to see if it could predict whether all cancer was removed. The goal was to …