Gene-Guided cancer therapy put to the test in 742 patients

NCT ID NCT01771458

First seen Jan 10, 2026 · Last updated Jun 06, 2026 · Updated 18 times

Summary

This study tested whether choosing cancer drugs based on the genetic makeup of a patient's tumor works better than standard treatment. It included 742 adults with advanced solid tumors that had stopped responding to usual therapies. Patients were randomly assigned to receive either a targeted therapy matched to their tumor's molecular profile or conventional treatment chosen by their doctor.

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Contacts and locations

Locations

  • Centre Alexis Vautrin

    Vandœuvre-lès-Nancy, 54500, France

  • Centre Leon Berard

    Lyon, 69373, France

  • Centre régional de lutte contre le cancer de Bourgogne Georges François Leclerc

    Dijon, 21079, France

  • Insitut Curie

    Paris, 75248, France

  • Institut Claudius Régaud

    Toulouse, 31052, France

  • Institut Curie Hopital Rene Huguenin

    Saint-Cloud, 92210, France

  • Institut Paoli Calmettes

    Marseille, 13009, France

  • Institut de cancérologie de l'Ouest Centre René Gauducheau

    Saint-Herblain, 44000, France

Conditions

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