New pain block could replace standard for breast surgery

NCT ID NCT04827030

Completed Symptom relief Sponsor: Institut Curie Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a newer nerve block called ESP works as well as the standard PVB block for pain after breast cancer surgery. 292 women received one of the two blocks before surgery. The main goal was to see how many needed morphine in the first two hours after surgery. The results could help doctors choose a simpler pain control method.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ropivacaine (a numbing medicine)
What this could lead to: If ESP works as well as PVB, it could offer a simpler, safer option for controlling pain after breast surgery.
What could go wrong: This is a completed Phase 4 trial, so results are known. The main risk is that ESP may not be as effective as PVB, leading to more pain or morphine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast adenocarcinoma breast cancer breast carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST SURGERY

Contacts and locations

Locations

AP-HP Hôpital Tenon

Paris, 75970, France
Centre Jean Perrin

Clermont-Ferrand, 63000, France
Institut Claudius Régaud UICT

Toulouse, 31059, France
Institut Curie

Saint-Cloud, 92210, France
Institut de Cancérologie de Lorraine

Vandœuvre-lès-Nancy, 54500, France

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