Stem cell bone graft shows promise for back pain relief

NCT ID NCT00947583

Completed Disease control Sponsor: NuVasive Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested Osteocel Plus, a special bone graft that contains stem cells, in 19 people with degenerative disc disease who needed spinal fusion surgery. The goal was to see if the graft helps bones fuse together as well as the standard method using the patient's own bone. The results could offer a less painful option for patients with chronic back pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Osteocel Plus (a stem-cell enriched bone graft from donated bone tissue)
What this could lead to: If successful, this could provide a safer alternative to using the patient's own bone for spinal fusion, potentially reducing pain and improving fusion rates.
What could go wrong: This is a small, early study with only 19 participants, so results may not apply to everyone. There is also a risk of complications like infection or non-union (failed fusion).

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder lumbar disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE DISC DISEASE

Contacts and locations

Locations

University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States

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