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New spine implants tested for safety in patients with back problems

NCT ID NCT04420143

Completed Disease control Sponsor: NuVasive Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at the safety and performance of two types of expandable spine implants (MLX and XLX ACR) in 109 adults with degenerative disc disease, spondylolisthesis, or scoliosis. Researchers tracked complications, bone fusion, and improvement in nerve symptoms after surgery. The goal was to understand how well these implants work over the medium to long term.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
expandable lumbar interbody implants (MLX and XLX ACR)
What this could lead to
If successful, this could confirm that these implants are safe and effective for treating degenerative spine conditions, offering a surgical option to reduce pain and improve function.
What could go wrong
This is a completed study with only 109 participants and no comparison group, so results may not apply to all patients. Risks include complications from surgery and implant failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder lumbar disk degenerative disorder scoliosis spondylolisthesis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE DISC DISEASE DEGENERATIVE SCOLIOSIS SPONDYLOLISTHESIS

Contacts and locations

Locations

  • Carolina NeuroSurgery & Spine Associates

    Charlotte, North Carolina, 28204, United States

  • Lyerly Neurosurgery

    Jacksonville, Florida, 32207, United States

  • OrthoCarolina Research Institute

    Charlotte, North Carolina, 28207, United States

  • Orthopaedic Specialty Institute

    Orange, California, 92868, United States

More trials for these conditions

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