Dye test helps spine surgeons see if They've cleaned enough

NCT ID NCT07363759

Completed Knowledge-focused Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether injecting a contrast dye into the disc space during TLIF spine surgery helps surgeons assess how well they have removed the disc. 56 patients having spinal fusion for degenerative spine disease were randomly assigned to either have the dye used as a check or as a guide to do more cleaning. The goal was to see if the dye improves the quality of disc space preparation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ISOVUE-300 contrast dye
What this could lead to: If successful, this technique could give surgeons real-time feedback to improve disc preparation during spinal fusion surgery.
What could go wrong: This is a small, completed trial with 56 patients. The dye is only used during surgery to guide the procedure, not to treat the underlying spine condition.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder lumbar disk degenerative disorder spondylolisthesis spondylosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE SPINE LUMBAR DEGENERATIVE DISC DISEASE LUMBAR DEGENERATIVE DISEASE

Contacts and locations

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Locations

Rush University Medical Center

Chicago, Illinois, 60612, United States

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