New artificial disc could replace fusion for neck pain sufferers

NCT ID NCT03123549

Completed Disease control Sponsor: NuVasive Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new artificial disc called the Simplify Disc for people with two-level cervical disc disease causing arm pain, neck pain, or nerve problems. The trial involved 182 participants and compared the disc to standard fusion surgery. The goal was to see if the disc is at least as safe and effective at reducing disability and improving neurological function over 24 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Simplify Cervical Artificial Disc (device)
What this could lead to: If successful, this artificial disc could offer a motion-preserving alternative to fusion surgery for people with two-level cervical disc disease, potentially reducing pain and disability while maintaining neck movement.
What could go wrong: This is a completed study comparing a device to standard surgery, but results may not apply to all patients. There are risks of implant failure, additional surgery, or serious adverse events.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL DEGENERATIVE DISC DISORDER

Contacts and locations

Locations

Buffalo Spine Surgery

Lockport, New York, 14094, United States
Carolina Neurosurgery and Spine Associates

Charlotte, North Carolina, 28204, United States
Connecticut Orthopaedic Specialists

Hamden, Connecticut, 06518, United States
Indiana Spine Group

Carmel, Indiana, 46032, United States
Kennedy-White orthopedic Center

Sarasota, Florida, 34232, United States
NorthShore University Health System

Evanston, Illinois, 60201, United States
Oregon Neurosurgery

Springfield, Oregon, 97477, United States
Orthopaedic Education and Research Institute of Southern California

Orange, California, 92868, United States
Orthopaedic Institute of Western Kentucky

Paducah, Kentucky, 42003, United States
Parkview Research Center

Fort Wayne, Indiana, 46845, United States
Spine Education and Research Foundation

Thornton, Colorado, 80229, United States
Spine institute of Louisiana

Shreveport, Louisiana, 71101, United States
Texas Back Institute

Plano, Texas, 75093, United States
Texas Spine Consultants

Addison, Texas, 75001, United States
The Disc Replacement Center

West Jordan, Utah, 84088, United States
The Spine Institute for Spine Restoration

Santa Monica, California, 90403, United States
Virginia Spine Institute

Reston, Virginia, 20191, United States
William Beaumont Hospital

Royal Oak, Michigan, 48073, United States

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