Artificial disc shows promise in 5-Year neck pain study

NCT ID NCT04980378

Completed Disease control Sponsor: NuVasive Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study followed 291 patients for 5 years after receiving the Simplify Disc, an artificial disc for the neck. The goal was to see if the disc remains safe and effective over time. Researchers measured pain, nerve function, and whether any further surgeries were needed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Simplify Disc (artificial cervical disc)
What this could lead to: If successful, this could confirm that the Simplify Disc is a safe and effective long-term option for treating cervical disc disease, potentially reducing pain and improving function.
What could go wrong: This is a post-approval study confirming earlier results, not a new breakthrough. Risks include implant failure, need for additional surgery, or no long-term benefit for some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL DEGENERATIVE DISC DISORDER

Contacts and locations

Locations

Buffalo Spine Surgery

Lockport, New York, 14094, United States
Carolina Neurosurgery and Spine Associates

Charlotte, North Carolina, 28204, United States
Connecticut Orthopaedic Specialists

Hamden, Connecticut, 06518, United States
Indiana Spine Group

Carmel, Indiana, 46032, United States
Kennedy-White Orthopedic Center

Sarasota, Florida, 34232, United States
NorthShore University Health System

Evanston, Illinois, 60201, United States
Oregon Neurosurgery

Springfield, Oregon, 97477, United States
Orthopaedic Education and Research Institute of Southern California

Orange, California, 92868, United States
Orthopaedic Institute of Western Kentucky

Paducah, Kentucky, 42003, United States
Parkview Research Center

Fort Wayne, Indiana, 46845, United States
Spine Education and Research Foundation

Thornton, Colorado, 80229, United States
Spine Institute of Louisiana

Shreveport, Louisiana, 71101, United States
Texas Back Institute

Plano, Texas, 75093, United States
Texas Spine Consultants

Addison, Texas, 75001, United States
The Disc Replacement Center

West Jordan, Utah, 84088, United States
The Spine Institute for Spine Restoration

Santa Monica, California, 90403, United States
Virginia Spine Institute

Reston, Virginia, 20191, United States
William Beaumont Hospital Research Institute

Royal Oak, Michigan, 48073, United States

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