Neurological pain disorder

This trial investigates how a new experimental drug called KL0011034 interacts with alfentanil, a strong opioid painkiller, in adults with moderate-to-severe chronic pain. The study measures how the drugs affect each other's levels in the body and monitors safety. Participants re…

This study tested whether the drug rimegepant can help prevent migraines in Chinese adults. 787 participants took either rimegepant or a placebo every other day for 12 weeks. The main goal was to see if rimegepant reduced the number of migraine days per month compared to placebo.…

Researchers are testing whether medical cannabis can reduce pain and opioid use in people with chronic pain. Participants who already take prescription opioids will either opt to use medical cannabis or not for three months. Those in the cannabis group will try different THC and …

This trial compares two behavioral programs for people with chronic pain who take prescription opioids. One is cognitive behavioral therapy led by a psychologist, and the other is a peer-led self-management course. Researchers want to see if either approach helps people lower the…

This trial tests whether adding structured telemonitoring—weekly text messages and video calls—to standard conservative care helps people with temporomandibular disorder (TMD)-related jaw pain. Participants receive behavioral counseling, habit reversal training, and home exercise…

This study follows over 500 adults with migraine who have not responded well to other preventive treatments. Participants take atogepant as prescribed by their doctor and are monitored for a year to see how well it reduces headache and migraine days, and how long they stay on the…

This Phase 1 trial evaluates the safety, tolerability, and how the body processes a single dose of JS010 injection in healthy adults aged 18 to 45. Participants receive one of six dose levels or a placebo to assess side effects and drug levels in the blood. The goal is to gather …

This study compares atogepant and topiramate, two daily pills used to prevent migraines, to see which one people tolerate better. About 545 adults with frequent migraines (at least 4 per month) will take one of the two drugs for 24 weeks, then all eligible participants will recei…

This study tested a wearable device called Nerivio that delivers mild electrical pulses to the arm to help prevent migraines. 150 people with chronic migraine used the device for 3 months. Researchers tracked changes in monthly migraine days, attack duration, and patient-reported…

This study tests whether fremanezumab, a monthly injection, can prevent episodic migraine in children aged 6 to 17. Participants receive either the drug or a placebo for 12 weeks, and researchers track changes in monthly migraine days. The goal is to see if fremanezumab is safe a…

This study looks at people who received a total lumbar disc prosthesis (Baguera®L) for lower back pain or sciatica caused by disc degeneration or herniation. The goal is to see how many return to their original job five years after surgery. Unlike spinal fusion, which often limit…

This phase 3 trial tested whether adding the oral drug atogepant (QULIPTA) to standard Botox injections can safely and effectively prevent chronic migraine in adults. 75 participants took atogepant daily for 24 weeks alongside their regular Botox. Researchers monitored side effec…

This study looked at how well eptinezumab works and is tolerated for preventing migraines. It included 130 adults with episodic or chronic migraine. Researchers tracked changes in monthly migraine days over 3 to 12 months of treatment.

This study tested whether a daily oral medication called atogepant (brand name Qulipta) can prevent migraines in Japanese adults who have 4 to 14 migraine days per month. Over 500 participants were randomly assigned to receive one of three doses of atogepant or a placebo for 12 w…

This completed phase 4 study tested whether rimegepant, a dissolvable tablet taken every other day, can prevent migraines in adults who did not get enough relief from other oral preventive medications. Over 960 participants were enrolled. The main goal was to see if rimegepant re…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) works better than standard medications (Cymbalta or Lyrica) for fibromyalgia triggered by emotional trauma. 48 adults completed the trial, and researchers measured symptom improve…

This study tested two tools to help older adults (65+) on long-term opioid therapy use painkillers more safely. The PainTracker tool helps doctors focus on improving daily function and mental health, while the Opioid Misuse Measure screens for risky opioid use. Researchers studie…

This study tested two ways to help primary care doctors prescribe opioids more safely for patients with chronic pain, depression, or anxiety. One approach used an electronic tool that reminded doctors about risk checks and guidelines. The other added a team of a pharmacist, a soc…

This study tested a 12-month telephone-based nurse care program for 805 adults with depression and signs of opioid use disorder. Participants were randomly assigned to receive nurse support or usual care. The goal was to see if the program could improve treatment for opioid use a…

This study tested whether giving adults with chronic pain discounted vouchers for medical cannabis soft-gel capsules could help them reduce their opioid painkiller use. 270 participants were randomly assigned to receive vouchers for placebo or cannabis capsules with different THC…

This study tested whether adding eptinezumab to a brief educational program helps adults with both migraine and medication overuse headache. Over 600 participants received either eptinezumab or a placebo. The goal was to see if the drug could reduce the number of migraine days an…

This study looked at the long-term safety of eptinezumab, a drug given by IV infusion to prevent migraines. It included 160 Japanese patients who had already completed a previous study. The main goal was to see if the drug is safe and tolerable over 60 weeks of treatment.

This completed study tested whether reducing loneliness through group therapy could lower opioid misuse in 102 adults on long-term opioids for chronic pain. Participants received either cognitive behavior therapy or social navigation in weekly sessions. Researchers measured chang…

This phase 3 trial tested whether a monthly injection of erenumab could reduce the number of migraine days in adults with chronic migraine (15 or more headache days per month). Over 550 Asian participants received either the drug or a placebo for 12 weeks. The main goal was to se…

This study tested whether videonystagmography (VNG) with caloric testing, a standard balance exam, can distinguish people with vestibular migraine from those with other migraines and healthy individuals. Researchers compared eye movement patterns in 173 participants across three …

This trial tests a wearable device called CAVA that records eye and head movements for 30 days in people with dizziness conditions like Meniere's disease and BPPV. The goal is to see if the device can accurately detect episodes of nystagmus, an eye movement linked to dizziness, a…

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study tested 776 people with chronic pain of unknown cause to see if they had Fabry disease, a rare inherited disorder that can cause pain, kidney, heart, and nerve problems. Researchers used enzyme tests in men and genetic tests in women to find cases. The goal was to see h…

This study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…

This study tested whether a special infrared (FLIR) camera can help measure pain and disease severity in people newly diagnosed with Complex Regional Pain Syndrome (CRPS). Thirty adults with CRPS in one limb had a thermal picture taken of their foot and answered pain questionnair…

Researchers are testing whether 24 weeks of Tai Chi training can prevent episodic migraines in Chinese women as effectively as standard preventive medication. The trial enrolls 220 women aged 18 to 65 who have two to six migraines a month. Participants in the Tai Chi group attend…

This trial tests whether memantine, a drug used for Alzheimer's disease, can prevent the chronic nerve pain that sometimes develops after breast cancer surgery. Half of the participants receive memantine for four weeks, starting two weeks before their operation, while the other h…

This study tested whether taking vitamin C before and after planned upper limb surgery could prevent complex regional pain syndrome (CRPS), a chronic pain condition. Nearly 1,000 adults participated, receiving either vitamin C or a placebo. The goal was to see if vitamin C reduce…

This clinical trial tested a new drug called Lu AG09222 to prevent migraines in 874 adults who had already tried 1 to 4 other preventive medications without success. The study compared different doses of the drug against a placebo to find the best dose. The main goal was to see i…

This study looked at whether taking vitamin C can prevent Complex Regional Pain Syndrome (CRPS), a painful condition that can develop after a wrist fracture. Researchers enrolled 220 adults with specific types of wrist fractures and gave them vitamin C to see if it reduced their …

This study tested a drug called eptinezumab to see if it can prevent migraines in people with chronic migraine (15 or more headache days per month). About 981 adults took part, receiving either the drug or a placebo. The main goal was to see if the drug reduced the number of mont…

This study tested the long-term safety of a daily pill called atogepant for preventing migraines in adults with chronic or episodic migraine. Over 156 weeks, 596 participants took 60 mg of atogepant each day. Researchers tracked side effects and lab results to see if the drug rem…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if it is practical and acceptable for adults who are in treatment for opioid use disorder and also have chronic pain. Ten participants will use the app for 8 we…

This trial examines whether pelvic floor muscle exercises can improve vaginal and sexual health in postmenopausal women. Twenty women who are sexually active and have gone through menopause join the study. One group receives training from a physiotherapist and does home exercises…

Researchers are testing whether certain ingredients in toothpaste can trigger migraines. Adults with migraine who do not take preventive medicines join one of two groups: one swaps toothpaste for saline solution when brushing, the other keeps using toothpaste. Both groups follow …

Pregnancy can worsen fibromyalgia symptoms like pain, fatigue, and poor sleep, affecting both mother and baby. This trial tests a community-based nursing program that combines weekly education sessions with twice-weekly exercise, including prenatal yoga and stretching, for pregna…

Pudendal neuralgia is a painful condition caused by a trapped nerve in the pelvis. Researchers at Nantes University Hospital are comparing three injection mixtures placed near the pudendal nerve: lidocaine alone, lidocaine plus a steroid, and lidocaine plus steroid plus a large v…

Researchers are testing whether soticlestat, an experimental tablet, can reduce pain in adults with chronic complex regional pain syndrome (CRPS) that has lasted at least six months. About 24 participants will take either soticlestat or a placebo alongside their usual pain treatm…

This study tests whether atogepant, a drug already used to prevent migraines, can also treat migraine attacks quickly. About 1300 adults with a history of migraines will take either atogepant or a placebo when they have a migraine, and then report pain levels and symptoms after 2…

This study tests whether osteopathic manipulative treatment (OMT) — a gentle, hands-on therapy — can reduce muscle stiffness, improve jaw motion, and ease pain in people with chronic neck pain and headaches. Thirty adults aged 19 to 65 will receive OMT and undergo various measure…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This completed trial tested whether electroacupuncture (acupuncture with a mild electric current) can reduce pain in people with postherpetic neuralgia, a lingering nerve pain after shingles. 448 adults aged 45-75 with moderate-to-severe pain were randomly assigned to real or sha…

Researchers are testing whether a stretching exercise program supervised over video call can improve pain, depression, sleep, and daily function in women with fibromyalgia. The trial enrolls 28 women aged 30 to 60 in southern Brazil. Half join live stretching sessions twice a wee…

This study tests whether adding a specific leg-rotation technique to standard physical therapy can better relieve sciatica caused by disc problems in the lower back. Researchers will measure pain, flexibility, and daily function in 70 adults aged 18 to 50. The goal is to see if t…

Researchers are testing a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) in adults with chronic neuropathic pain. The trial compares three approaches: stimulating two brain targets alternately, stimulating one target, or a sham (pla…

This study tests whether eptinezumab can reduce migraine days and improve quality of life in 164 adults who previously did not get enough relief from other CGRP-targeting migraine drugs. Participants receive the drug and report changes in migraine frequency and severity over time…

This small pilot study tested a mindfulness-based therapy designed for older Black adults (age 50+) who have both chronic pain and early memory decline. The goal was to see if the program could improve quality of life and reduce how much pain interferes with daily activities. Nin…

This pilot study tested whether a non-invasive vagus nerve stimulator can help people with post-COVID syndrome who suffer from fatigue and headaches. Eighteen participants used the device, and researchers measured changes in their functional status and fatigue levels. The goal is…

This study tested a nerve block called a stellate ganglion block for people with chronic migraine that didn't get better with other treatments. 42 patients received the injection under ultrasound guidance. Researchers tracked changes in monthly headache days and pain scores over …

Researchers are testing whether propranolol, a common blood pressure drug, can help people with fibromyalgia who also have post-traumatic stress disorder. Participants take propranolol and then read their own traumatic story about 75 minutes later, once a week for six weeks. The …

This study tests whether physical therapy, combined with motivational support and planning, can help older adults with chronic hip, knee, or back pain become more physically active. Participants work with physical therapists to set personal goals and adapt activities to their con…

This study compares a 6-month physiotherapy program focused on pelvic floor relaxation to no structured exercise in women with pudendal neuralgia, a chronic pelvic pain condition. Researchers will measure muscle stiffness using ultrasound and track symptoms like pain and sexual d…

This trial tests whether real acupuncture can reduce the numbness, tingling, and pain that chemotherapy often leaves behind. Cancer survivors with persistent nerve symptoms will receive either genuine acupuncture or a sham version with superficial needling at non-acupoints. The g…

This early-stage study tested a new drug called 4ET1103 in 40 healthy volunteers to see if it is safe and how the body processes it. Each person received a single dose of either the drug or a placebo. The goal was to check for side effects and measure drug levels, not to treat pa…

This trial tests whether a sensory rehabilitation program, guided by physiotherapists, can reduce nerve pain and improve balance in people with chemotherapy-induced peripheral neuropathy (CIPN). Participants are adults who finished chemotherapy more than three months ago and repo…

This trial tests whether combining mindfulness-based stress reduction with physiotherapy can help older adults manage chronic musculoskeletal pain. Participants aged 65 and older will attend 8 weekly mindfulness sessions alongside 20 physiotherapy sessions, with a 3-month follow-…

This study is testing whether a group music therapy program, called POPSINGER, is practical and well-liked by people with chronic pain. The program includes both in-person and online sessions. Researchers will track how many people stay in the study and attend sessions to see if …

This trial tests whether injecting lidocaine under the skin at the shingles rash site can reduce pain and help prevent post-herpetic neuralgia, a long-lasting nerve pain that can follow shingles. Adults with acute shingles pain or established post-herpetic neuralgia will receive …

This trial tests whether two types of talking therapy can help people with chronic migraine. One is standard cognitive behavioral therapy, and the other is a traditional Islamic psychotherapy that blends psychological methods with Islamic principles. Adults aged 18 to 40 with a n…

This study looked at whether prayer can help people with migraines feel less pain and improve anxiety and depression. About 100 adults, half with migraines and half without, took part. They compared the effects of prayer versus reading a neutral text on pain sensitivity and emoti…

This study tested a device that sends mild electrical pulses to a nerve in the ear (trigeminal nerve) to see if it helps people with migraine. 102 adults with episodic migraine received either real or sham stimulation three times a week for 12 weeks. Researchers measured headache…

This trial tests whether brief mindfulness-based audio recordings can ease pain and improve jaw function in university students with painful temporomandibular disorders (TMD), a common cause of chronic jaw pain. Participants listen to the recordings three times a week for three m…

This study looks at whether fremanezumab, a migraine prevention drug, can reduce the emotional burden on caregivers of people with migraine and depressive symptoms. Researchers will measure caregiver stress and the quality of the couple's relationship before and after six months …

This study looked at whether teaching patients about pain before a planned hysterectomy (removal of the uterus) could help lower their anxiety, stress, and pain after surgery. 62 adults took part and received either standard care or extra education about pain. The goal was to see…

This pilot study tests whether a mindfulness program delivered through a web app can help hospitalized neurological patients and their caregivers cope with stress and anxiety. Participants learn mindfulness techniques in an initial face-to-face session, then practice via weekly o…

This study tested whether a type of compassion meditation could help Veterans with chronic pain who also have depression or PTSD. 142 Veterans were randomly assigned to either compassion meditation training or a health education group. The goal was to see if meditation could redu…

This study investigates whether foot massage using a roller can reduce nerve pain caused by chemotherapy in cancer patients. About 80 adults receiving certain chemotherapy drugs will either receive foot massage twice daily for three weeks or continue with routine care. The goal i…

This study tested a non-invasive treatment called radial pressure wave therapy for people with mild to moderate carpal tunnel syndrome. 60 adults received three weekly sessions of either a constant or modulated dose of the therapy. Researchers measured pain, hand function, and ne…

This study looked at whether an antidepressant, physical therapy, or a combination of both can help people with chronic low back pain who also struggle with negative feelings. About 308 adults aged 18-75 with pain lasting over 6 months took part. The goal was to see if these trea…

This study tests whether a brief behavioral class called Empowered Relief can reduce disability and symptoms in adults with chronic migraine. 300 participants will be randomly assigned to the class, a health education session, or usual care, all done remotely. The goal is to see …

This study tested whether adding Kinesio Taping (a special elastic tape) to posture correction exercises helps university students with tension-type headaches. Fifty-two students aged 18-25 were split into two groups: one did posture exercises alone, the other added Kinesio Tapin…

This trial tests whether pulsed radiofrequency, a technique that applies short bursts of electrical energy to a nerve, can reduce chronic lumbar radicular pain, a type of back and leg pain. Adults with pain lasting at least 4 months and matching MRI or CT findings receive either …

This completed Phase IIb trial tested an oral drug called elismetrep (K-304) in 431 adults with moderate or severe migraine. Participants received one of four doses of elismetrep or a placebo. The main goal was to see if the drug could make pain disappear within a set time. Secon…

This study tests whether a virtual program called Lin Health can improve daily life for people with fibromyalgia. Researchers at Mayo Clinic will follow 300 adults with fibromyalgia to see if online behavioral health support reduces symptoms and improves function. The goal is to …

This trial compares two non-drug treatments for myofascial pelvic pain syndrome in women: precise AI-controlled radiofrequency therapy versus biofeedback combined with electrical stimulation. Researchers will randomly assign 70 women to one of the two treatments and measure chang…

This study tests whether a smartphone-based mindfulness program is practical and liked by teens and young adults (ages 15-39) with sickle cell disease who have chronic pain or sleep problems. Participants use a guided meditation app for about 8 weeks. The goal is to see if people…

This study tests whether a medicine called fremanezumab can reduce migraines that happen around a woman's period. Women aged 18 to 45 with menstrual migraines will get either the medicine or a placebo injection every three months for six months. Researchers will track migraine da…

This trial tests whether different versions of yoga nidra, a guided relaxation practice, can help people with chronic pain. Participants will be randomly assigned to one of three groups: basic yoga nidra, yoga nidra with a pain acceptance intention, or yoga nidra with pain accept…

This study explores whether interactive music and guided imagery, delivered via telehealth, can help ease migraines. Researchers will check if the approach is practical and acceptable for Veterans, and whether it leads to meaningful changes in headache frequency and related outco…

This pilot study tested whether a mindfulness program could help veterans with chronic pain and thoughts of suicide. 76 veterans took part to see if the program was acceptable and could reduce pain, depression, and suicide risk. The goal was to improve quality of life and daily f…

This trial tests a two-month interdisciplinary program for adults with fibromyalgia, combining adapted aerobic exercise, online education about pain, cognitive-behavioral and mindfulness counseling, and personalized nutritional advice. The goal is to see if this holistic approach…

This study tested whether a painless brain stimulation technique called tDCS could help veterans suffering from chronic pain, PTSD, and depression. 38 veterans received tDCS sessions during an intensive outpatient program. Researchers measured changes in pain levels and mental he…

This trial tests whether a steroid injection or a dextrose (sugar water) injection, both guided by ultrasound, better reduces knee pain in people with osteoarthritis and a common meniscus problem called medial meniscal extrusion. Adults aged 40-79 with chronic medial knee pain an…

This study asks whether adding acupuncture to a multidisciplinary treatment plan can reduce pain and improve quality of life for women with vulvodynia or chronic pelvic pain lasting at least six months. Half of the participants will receive acupuncture sessions, while the other h…

This study tests an 8-week hybrid physiotherapy program for adults aged 45-75 who live with both chronic pain and depression. The program combines weekly face-to-face sessions on pain science with guided exercises and online videos. Researchers will measure changes in pain intens…

This study tests a 12-week home program that combines AI-guided exercises with pain education for adults with fibromyalgia. Half of the 50 participants will use the digital program, while the other half receives usual care. The goal is to see if this approach reduces pain and imp…

This trial tests whether a 15-minute mixed reality session, featuring underwater scenes and guided relaxation, can reduce pain intensity in adults with chronic musculoskeletal pain. Participants are randomly assigned to either the active therapy or a sham control, both delivered …

This study tested a personalized psychological intervention for 5 adolescents aged 12-18 with recurrent headaches. Researchers used smartphone surveys to track each teen's unique headache triggers and coping patterns, then delivered 4-5 weekly online therapy sessions based on tha…

This trial tests whether TECAR therapy, a non-invasive device that delivers energy to painful areas, can reduce pain in people with fibromyalgia. About 46 adults with fibromyalgia will receive either real or sham TECAR sessions twice a week for three weeks. Researchers will measu…

This small early-phase trial tests whether a single oral dose of a hemp-derived CBD/CBD-A extract can reduce neuropathic pain and change brain activity in people with spinal cord injury. Six participants with moderate to severe nerve pain for at least three months will receive ei…

This trial tests whether sensory discrimination training—a technique that sharpens the brain's ability to sense touch—can reduce pain and improve function in people with chronic low back pain linked to central sensitization. Participants will be randomly assigned to receive eithe…

This trial asks whether connective tissue massage, which uses pulling strokes to trigger reflex effects, can reduce migraine pain, attack frequency, and disability better than classical massage. About 30 adults with migraines who only use painkillers will receive one of the two m…

This study compared cognitive functional therapy (CFT) to conventional therapy for adults with chronic neck pain lasting over 3 months. Sixty participants were randomly assigned to one of the two treatments. CFT combines physical exercises with psychological strategies to help pa…

This trial investigates whether injecting Botox near a nerve bundle in the face, called the sphenopalatine ganglion, can reduce the number of severe headache days in people with chronic migraine that hasn't improved with other treatments. Participants receive either Botox or a pl…

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This trial tests whether injecting a mix of ketamine and lidocaine into the skin, a technique called mesotherapy, can reduce neuropathic pain in people with complex regional pain syndrome type 1 (CRPS1). Participants receive four sessions of either the drug mixture or lidocaine a…

This study tests whether a noninvasive device that stimulates the vagus nerve can reduce pain and other symptoms in women with fibromyalgia. Participants will receive either the nerve stimulation, standard medical treatment, or both, to see which approach works best. The goal is …

This trial tests whether adding neural mobilization—a gentle, controlled leg movement technique—to standard manual therapy can improve pain, function, and quality of life in people with lumbar disc herniation and sciatica. About 72 adults aged 18–65 with unilateral leg symptoms w…

This trial tests whether taking magnesium can reduce stress in people with fibromyalgia, a condition marked by widespread pain and fatigue. Participants will be randomly assigned to receive magnesium or a placebo, and researchers will measure stress levels along with pain, sleep,…

This study compares mirror therapy, brain stimulation (rTMS), and robotic hand training added to standard rehab for stroke patients. 120 adults who had a stroke at least 3 months ago will receive 20 sessions over 4 weeks. The goal is to see which approach best improves arm functi…

This pilot study is testing whether injecting Botox directly into the painful area inside the mouth can reduce continuous nerve pain in the teeth or jaw. Eight adults with long-lasting dentoalveolar pain that hasn't responded to standard treatments will receive two rounds of inje…

This trial tests whether high-intensity or preferred-intensity resistance training better improves quality of life in women with fibromyalgia. Participants will complete 16 supervised sessions of each type, with a washout period in between. Researchers will measure disease impact…

This pilot study tests whether manual lymphatic drainage, a gentle massage technique, can help people with migraine. Twenty adults aged 20-55 who have at least 4 migraines per month will receive either the massage or standard care. Researchers will measure pain, disability, and q…

This study tests whether online cognitive-behavioral therapy (CBT) for insomnia, combined with CBT for pain, can reduce headaches and improve sleep in adolescents aged 11-17 who have both migraine and insomnia. Participants receive internet-delivered programs focusing on sleep hy…

This trial tests whether daily creatine supplements can reduce pain, fatigue, and muscle weakness in people with fibromyalgia. Eighty adults diagnosed with fibromyalgia will receive either creatine or a placebo for a set period. Researchers will measure changes in pain levels, mu…

This study compares two treatments for chronic tailbone pain (coccydynia): osteopathic manual therapy (a hands-on approach) and a nerve block injection. Researchers will enroll 100 adults who have had tailbone pain for at least 3 months and have not gotten relief from other treat…

This study tests an 8-week program called PhYoMind, which blends physiotherapy, yoga postures, breathing exercises, and mindfulness, against home exercise alone in 40 adults with fibromyalgia. The goal is to see if the combined approach reduces disability, pain, fatigue, and stre…

This trial tests whether adding brain-focused therapies — pain education, breathing exercises, and guided relaxation — to standard physiotherapy can better relieve chronic nonspecific neck pain. Researchers will measure changes in pain, movement, fear of pain, and quality of life…

This trial tests whether a non-invasive device that delivers pulsed radiofrequency energy behind the knee can reduce pain and improve function in people with diabetic neuropathy whose pain persists despite medication. About 92 participants will receive either the active device or…

This trial investigates whether open-label placebos—pills that patients know contain no active drug—can reduce pain and opioid use in adults with chronic low-back pain. Participants take the placebo twice daily for 21 days and receive different types of explanations (such as a st…

This trial is testing a digital program called iGET Living for adolescents aged 10–18 with chronic musculoskeletal pain. The program uses graded exposure therapy, a behavioral approach that helps patients gradually face feared and avoided activities. The study will first test the…

This study tests whether applying pregabalin gel through ultrasound (phonophoresis) combined with nerve flossing exercises can reduce pain and improve sensation in people with diabetic peripheral neuropathy. The trial includes 24 adults aged 40–75 who have chronic nerve pain in t…

This study compared telemedicine follow-ups to standard in-person clinic visits for cancer patients with chronic pain. Researchers measured how much pain interfered with daily activities using a standard questionnaire. The goal was to see if remote care could be as effective and …

This study looks at whether joining a private social media group with others who have fibromyalgia can improve feelings of loneliness, hopelessness, and overall well-being. Researchers analyzed data from over 1,000 adults with fibromyalgia who participated in an online support co…

This study tests an online program called VACT-CP that uses a virtual therapist to help veterans with chronic pain. The program is based on Acceptance and Commitment Therapy, which focuses on accepting pain and committing to value-driven actions. Researchers aim to see if the pro…

This study investigates whether Tongluo Kaibi Tablets, a traditional Chinese herbal medicine, can reduce pain and improve quality of life in people with fibromyalgia syndrome. The trial enrolls 150 adults aged 18 to 75 who meet fibromyalgia criteria and have significant pain. Par…

This study compares two common treatments—shockwave therapy and therapeutic ultrasound—each given alongside standard physiotherapy, for people with chronic sciatica. The goal is to see which approach better reduces pain, improves hamstring flexibility, enhances sleep quality, and…

This study tests whether combining a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) with a type of talk therapy called acceptance and commitment therapy (ACT) can help veterans who have both chronic pain and depression. The goa…

This study tests whether graded motor imagery—a brain-based therapy involving left/right judgment, imagined movements, and mirror exercises—can relieve nerve pain and improve leg function in cancer patients with chemotherapy-induced peripheral neuropathy. Half the participants wi…

This study tested whether doing exercise in a virtual reality headset can improve quality of life, thinking, and mood in people with fibromyalgia. Thirty adults with fibromyalgia took part in a crossover trial where everyone tried both virtual reality exercise and regular exercis…

This study tested a 90-minute pain management class for 110 youth aged 10-18 with chronic pain. The class teaches pain science and self-regulation skills like relaxation and cognitive techniques. Researchers checked if the class was acceptable and helpful by surveying participant…

This study tests whether acupuncture can reduce the nerve pain, numbness, and tingling that often lingers after chemotherapy. Cancer survivors who completed chemo at least three months ago will receive either real acupuncture, a sham (fake) version, or no extra treatment. The goa…

This study tests whether chairs with special foam materials and shapes can reduce tailbone pain and improve comfort for people with coccydynia. About 42 adults who sit at desks 5-6 hours daily will use the chairs for one week. Researchers will measure pressure distribution, pain …

This study compares a smartphone app that tracks migraine attacks, sends pill reminders, and includes a community blog against a traditional paper diary. About 400 adults with migraine will use both methods in a crossover design. The goal is to see if the app reduces headache imp…

This study investigates whether combining spinal cord stimulation with a specific exercise program can reduce pain and improve quality of life in people with persistent back pain after surgery (failed back surgery syndrome). Participants will be randomly assigned to receive eithe…

This study tested whether sound therapy using weighted tuning forks, combined with relaxation, could reduce pain in women with fibromyalgia. Forty women aged 30 to 60 took part, attending three weekly sessions. Researchers compared pain levels before and after sessions between th…

This study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can reduce pain, fatigue, and mood problems while improving walking in adults with fibromyalgia. Participants receive either real rTMS or a sham version to se…

This trial investigates whether a multidisciplinary day hospital program can improve quality of life for adults with chronic regional pain syndrome (CRPS), a painful condition that affects movement and daily function. Participants receive coordinated care from a team of specialis…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Participants will learn strategies to manage pain and related symptoms. The goal is to see if this coaching improves pain relief and satisfaction.

This study investigates whether adding focal muscle vibration to shoulder exercises can improve how the brain processes sensory and movement signals in people with chronic subacromial impingement syndrome. Participants will receive 12 sessions of either vibration-assisted exercis…

This study tested whether adding a steroid called dexamethasone to a standard occipital nerve block (using numbing medicines) provides extra headache relief. 120 adults with various headache types received injections at the back of the head. Researchers tracked changes in headach…

This study tested a 16-session web-based resistance training program for people with fibromyalgia. Researchers measured balance, muscle performance, and symptoms in 13 adults. The goal was to see if a home-based exercise program could improve physical function and ease fibromyalg…

This study tested two different methods for placing a spinal cord stimulator (SCS) lead in people with chronic back pain. One method uses the patient's sensation of tingling (paresthesia) to guide placement, while the other uses the spine's natural midline as a guide. Sixty adult…

This study tested a 24-session program for 100 adults with fibromyalgia. The program brings together nurses, doctors, physiotherapists, nutritionists, and mental health experts to teach self-management skills. Researchers measured quality of life, pain impact, and mood over 12 mo…

This study tests whether high-intensity laser therapy (HILT) can reduce pain during intercourse for women with provoked vestibulodynia, a condition causing severe pain at the vaginal opening. About 145 women with moderate to severe pain will receive either real or sham laser trea…

This study tested a web-based tool called MigraineManager for teens with migraines. The tool helps teens, their parents, and doctors track headaches and manage symptoms. The goal was to see if it could reduce how often headaches happen. 40 teens with frequent migraines took part.

This study looked at whether adding immersive virtual reality (VR) to standard rehab helps people with long-term arm pain (Complex Regional Pain Syndrome) use their arm better. 13 adults took part, using VR during occupational therapy sessions. The goal was to see if VR could imp…

This study tested whether a 12-week lifestyle-based physical activity program before intensive rehabilitation helps people with chronic low back pain. Twenty-four adults were split into two groups: one did the preparatory program followed by intensive rehab, the other did only th…

This study tested a new pain self-management program called COPES against standard cognitive behavioral therapy for chronic pain in 764 veterans. The goal was to see if COPES could better reduce how much pain interferes with daily life. Participants had chronic musculoskeletal pa…

This pilot study tested whether a TENS device, placed on the forehead, is safe and practical for treating chronic eye pain in 39 veterans. Participants used the device at home for 6 months. The goal was to see if it reduces pain and to prepare for a larger trial.

This study tested two treatments for chronic tailbone pain (coccygodynia) in 100 adults. One group received osteopathic manual therapy—gentle hands-on techniques to mobilize the tailbone and relax muscles—over 6 weeks. The other group got a nerve block injection guided by X-ray. …

This study looked at whether adding a gentle electrical nerve stimulation (TENS) to cognitive behavior therapy (CBT) and standard medicines could reduce pain and improve quality of life in 60 postmenopausal women with fibromyalgia. Participants were split into three groups: one r…

This study looked at how satisfied people with migraines were using Sumavel DosePro, a needle-free injector for migraine medication. 246 adults who already used triptan drugs took part. The goal was to see if they liked this new method better than their usual treatment.

This study looked at whether adding TENS (a device that sends mild electrical pulses through the skin) and exercise to usual migraine medication can reduce pain and disability in women with migraine. Thirty-eight women participated, all continuing their prescribed meds. The goal …

This study tested whether taking gabapentin along with oxcarbazepine works better than oxcarbazepine alone for trigeminal neuralgia, a condition causing severe facial pain. 44 adults were split into two groups and had their pain measured over 2 months. The goal was to see which a…

This study looked at how the brain processes pain in people with fibromyalgia compared to healthy individuals. Researchers tested whether a non-invasive procedure called transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate the brain, could reduce pain …

This completed study tested a laser device (BTL-043) on 31 adults with temporomandibular joint (TMJ) pain. Participants received four 20-minute laser sessions over a few weeks. Researchers measured pain levels, jaw movement, and daily function at 1 and 3 months after treatment to…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This completed trial tested whether a Whole Health Team (WHT) approach helps veterans with chronic pain improve their daily functioning and quality of life compared to group education or usual care. Over 790 veterans from six VA sites participated, with follow-up lasting 12 month…

This completed study looked at whether giving a continuous nerve block along with intensive physical and occupational therapy can improve recovery in people with Complex Regional Pain Syndrome type 1 (CRPS 1). The study enrolled 30 patients and followed them for up to a year. The…

This study tested whether tailoring magnetic brain stimulation to each person's brain signals can better relieve chronic pain. Researchers measured brain activity before treatment to customize the stimulation. 90 adults with chronic pain took part. The goal was to see if this per…

This study tested how well two approved migraine medications, ubrogepant (for acute attacks) and atogepant (for prevention), work together in real-world settings. 391 adults with migraine used both drugs as prescribed by their doctor for 30 days. The goal was to see if the combin…

This study tested whether draining some fluid from the spine (a lumbar puncture) can help relieve severe headaches that often follow a brain aneurysm rupture. The trial involved 74 patients with mild to moderate brain bleeds. Half received a real lumbar puncture, and half receive…

This study tested a telehealth program (CBT-TS) to help 300 veterans on long-term opioids for chronic pain feel more willing to try non-drug treatments like therapy or exercise. The goal was to reduce pain and reliance on opioids. Results will show if changing beliefs about these…

This study looked at whether a single educational phone call from a nurse, before a doctor's appointment, could help people with medication overuse headaches. 88 adults with frequent migraines took part. The goal was to see if the call reduced the number of headache days in the m…

This study looked at whether hypnosis or a placebo pill (given honestly, without deception) can reduce chronic nerve pain and improve how the brain handles pain. Seventy-two adults with long-term nerve pain were randomly assigned to hypnosis, open-label placebo, or usual care. Th…

This completed trial tested a program called REDOCVR for 174 adults with chronic pain. The program combines group education, emotional support, and virtual reality experiences to help people reduce their pain medications. Researchers measured changes in medication use, mental wel…

This study tested whether adding virtual reality to motor imagery exercises (mentally practicing movements) can better reduce pain and disability in people with post-stroke shoulder hand syndrome. Forty adults aged 40-70 who had a stroke at least 3 months ago took part. The main …

This study tested whether a spinal cord stimulation device can reduce chronic leg pain caused by diabetic neuropathy. Twenty-eight people with diabetes received the implant and reported their pain relief and overall improvement over 12 months. The goal was to see if this device c…

This pilot study tested whether adding virtual reality (VR) to a standard educational program helps people with chronic pain and central sensitization. 128 participants completed eight weekly sessions that combined pain education, mindfulness, and VR activities. The study measure…

This study tested two drugs, zonisamide and topiramate, to see which works better for preventing migraines. About 600 people with migraines took one of the medicines for three months. Researchers measured how much their monthly migraine days dropped and how many people had at lea…

This study tested whether a nasal spray called zavegepant can safely and effectively treat migraine attacks in Asian adults. Over 1,400 participants took either the drug or a placebo when they had a moderate or severe migraine. The main goals were to see if the spray could stop p…

This study tested a 7-week program to help older adults with both chronic pain and mild memory problems manage their pain better. Participants received weekly phone coaching and watched educational videos. The goal was to see if the program was practical and could reduce how much…

This study tested whether a wearable device that delivers gentle vibrations through the skull can improve balance and reduce motion sickness in people with vestibular migraine. Fifty-one participants wore the device while sitting in a rotating chair and answered questions about t…

This study looked at whether aerobic dance exercises can improve symptoms and quality of life in women with fibromyalgia. Forty-four women were split into two groups: one did aerobic dance sessions led by a physiotherapist, and the other did standard postural exercises. Researche…

This study tested whether an ultrasound-guided injection of sugar water around the sciatic nerve could safely reduce sciatica pain in the emergency department. Researchers enrolled 69 adults with acute sciatica and followed up 72 hours later. The goal was to see if the procedure …

This study looked at whether adding progressive muscle relaxation to aerobic exercise helps people with migraine more than exercise alone. 44 adults with migraine were split into two groups: one did both exercise and relaxation, the other did only exercise. Researchers measured p…

This study tested whether a device that delivers pulsed electromagnetic fields (I-ONE) could help people with complex regional pain syndrome (CRPS) of the foot or ankle. Twenty-eight participants received the device therapy plus standard rehabilitation. Researchers measured pain,…

This study tested whether a daily probiotic supplement could reduce pain, fatigue, and cognitive issues in women with fibromyalgia. 97 participants took either a multi-strain probiotic or a placebo for 12 weeks. Researchers measured changes in pain, sleep, mood, and quality of li…

This pilot study tested a simple procedure called a sphenopalatine ganglion block (SPGB) — applying numbing medicine (lidocaine) inside the nose — against standard care (bed rest and extra fluids) for people who developed a severe headache after an accidental spinal needle punctu…

This pilot study tested whether acupuncture can help headaches in women going through IVF egg stimulation. 37 women received a 30-minute acupuncture session. Researchers measured headache intensity, stress, and emotional distress before and after treatment. The study is small and…

This study tested whether applying antibiotics directly into the tooth socket after wisdom tooth removal works as well as taking antibiotic pills. 90 adults having their lower wisdom teeth taken out were split into two groups: one got antibiotic gel at the surgery site, the other…

This study tested whether stimulating a nerve in the ear (taVNS) can help people with fibromyalgia feel better and exercise more. 90 adults with fibromyalgia were split into three groups: one-sided stimulation, both ears, or just a home exercise program. Over two weeks, researche…

This study tested whether a digital sleep therapy program called Sleepio can improve quality of life, sleep, and thinking in people with fibromyalgia. 80 participants were randomly assigned to use Sleepio or receive standard sleep advice. Researchers measured changes in symptoms …

This study tested whether treating the greater occipital nerve on one side or both sides of the head with pulsed radiofrequency provides better migraine relief. 217 adults with episodic or chronic migraine who did not respond well to preventive medications received the procedure …

This study tested whether remote monitoring through the Neurosphere app could improve pain relief and lower healthcare costs for people with chronic pain using spinal cord stimulators. Thirty-two adults were split into two groups: one had in-person clinic visits, the other used r…

This study tested whether injecting a local anesthetic (bupivacaine) into nerves at the back of the head could reduce menstrual migraine pain. Forty-eight women with menstrual migraines received either the active drug or a placebo (salt water) twice a month for three months. The …

This study tested whether a single 2-hour infusion of ketamine combined with magnesium sulfate can reduce the number of daily attacks in people with refractory chronic cluster headache—a rare and severe headache disorder. 93 adults who had at least 2 attacks per day and did not r…

This study compared two methods of pain relief after hip replacement surgery: a newer technique called erector spinae plane block (ESPB) and the standard epidural. 60 adults having hip replacement took part. Researchers measured pain levels, opioid use, muscle strength, and walki…

This study tested whether adding functional electrical stimulation (FES)-assisted cycling to standard rehab helps stroke survivors with Complex Regional Pain Syndrome (CRPS). Forty participants either received FES cycling plus conventional therapy or conventional therapy alone fo…

This study tested two non-drug treatments for piriformis syndrome, a condition where a muscle in the buttock presses on a nerve, causing pain. Seventy adults received either low-level laser therapy or radial shockwave therapy, both combined with exercise, over four weeks. Researc…

This study looked at whether injecting a dextrose (sugar) solution into the ligaments around the tailbone can reduce pain and improve daily function in people with long-lasting coccydynia (tailbone pain). Researchers reviewed records of 50 adults who received 3-6 injections over …

This study tested a one-day educational workshop for people with chronic non-cancer pain who take high doses of opioids. The workshop, led by a team of doctors, psychologists, and pharmacists, provided information on opioid risks and taught coping strategies. Researchers wanted t…

This study looked at whether adding dexmedetomidine to standard spinal anesthesia could lower the chance of acute neuropathic pain after a leg amputation. Thirty adults having elective lower limb amputation were split into two groups: one got the standard anesthetic plus a placeb…

This study tested whether NT 201 injections can reduce pain in adults with long-term nerve pain caused by shingles or a nerve injury. 123 people received either NT 201 or a placebo shot, and researchers tracked their pain levels over 20 weeks. The goal was to see if the treatment…

This study tested a web-based program that combines cognitive behavioral therapy and pain self-management for people being treated for opioid use disorder who also have chronic pain. The program includes online lessons and daily text surveys to track pain and activity. Researcher…

This pilot study tested a 6-week group program for adults with chronic non-cancer pain. The program combined pain education, personalized exercises, and healthy lifestyle tips. Researchers measured quality of life, pain levels, and other factors in 12 participants before, after, …

This study tested whether a short motivational interview combined with self-management techniques could help Hungarian teens aged 12-18 who have had chronic pain for at least 3 months. The program included a 30-minute in-person session plus two follow-up phone calls. Researchers …

This completed study tested two versions of a cooled radiofrequency procedure to relieve chronic knee pain from osteoarthritis. Ten adults with moderate to severe pain received either the standard or a revised nerve-targeting technique. Researchers measured pain, knee function, q…

This study looked at different rehabilitation programs for 90 adults who had back surgery for degenerative lumbar disease. The goal was to see which rehab approach best reduces nerve pain, helps patients regain function, and improves quality of life. Participants were randomly as…

This study tested whether rimegepant, a dissolvable tablet, can relieve migraine pain in adults who cannot take triptans due to side effects, lack of effectiveness, or heart problems. Over 800 participants took either rimegepant or a placebo during a migraine attack. The main goa…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could reduce pain and improve quality of life in people with fibromyalgia, compared to standard medications like Cymbalta or Lyrica. Seventy-six adults with fibromyalgia and a his…

This study from Harvard University tested whether mindfully noticing changes in pain throughout the day can help people with chronic pain feel more in control and reduce pain intensity. 300 adults with chronic pain for at least six months were split into groups that either paid c…

This study looked at whether two common drugs, memantine and dextromethorphan, can help maintain or improve pain relief after a ketamine treatment in people with long-term nerve pain. Seven adults with chronic neuropathic pain who had already responded to ketamine took part. The …

This study tested the DOZE app, a digital self-management program designed to improve sleep in young adults aged 18-25 with chronic pain and insomnia. Forty participants used the app and a sleep diary for 10 weeks. The goal was to see if the app is easy to use and helps with pain…

This completed study tested whether hyperbaric oxygen therapy (HBOT) combined with creative art psychotherapy can help women with fibromyalgia who have a history of psychological trauma. Thirty women received 60 sessions of HBOT plus psychotherapy. Researchers measured pain sensi…

This study tested whether ethosuximide, a drug already used for epilepsy, can reduce pain in people with nerve damage. 114 adults with peripheral neuropathic pain took either the drug or a placebo for 42 days. Researchers measured pain levels and quality of life to see if the dru…

This completed Phase 2 trial tested whether blood thinners (rivaroxaban) or antiplatelet drugs (aspirin, clopidogrel) work better than standard migraine medication (metoprolol) for people with both migraine and a small heart hole called PFO. 1,000 participants took one of the fou…

This study compared two hands-on treatments—post-facilitation stretch and active release technique—for piriformis syndrome in 40 women aged 25 to 45. Researchers measured pain, disability, quality of life, and hip movement over six weeks. The goal was to see which approach offers…

This completed study compared two treatments for piriformis syndrome, a condition causing buttock and leg pain. Forty adults whose pain lasted at least three months were randomly assigned to receive either five sessions of focused sound wave therapy or a single steroid injection.…

This study tested a smartphone app and website called iCanCope with Pain, designed to help teens and young adults (ages 15-25) manage chronic pain. The app lets users track pain, sleep, mood, and activity, set goals, and learn coping strategies. The goal was to see if the program…

This study tested whether slowly reducing prescribed opioids (tapering) can help people with long-term chronic pain use fewer painkillers without worsening their pain or quality of life. 140 adults on daily opioids for chronic non-cancer pain were randomly assigned to start taper…

This study tested a new online program that teaches mindfulness and coping skills to people recovering from surgery. The goal was to see if patients find it helpful and easy to use compared to a workshop led by a psychologist. 68 adults who had surgery and were referred to a pain…

This study tested whether mirror therapy can reduce pain and improve movement in stroke patients who also have complex regional pain syndrome (CRPS). Forty adults who had a stroke within the past year and were diagnosed with CRPS took part. They received either real mirror therap…

This study compared a capsaicin patch (Qutenza) to a standard nerve pain medication (amitriptyline) in 13 head and neck cancer survivors with long-term nerve pain. The goal was to see if the patch could reduce pain and improve quality of life. Participants received either the pat…

This study tested whether two combinations of migraine medications can reduce the impact of moderate-to-severe tinnitus. 78 adults were randomly assigned to receive either nortriptyline plus topiramate, verapamil plus paroxetine, or a placebo. The main goal was to see if these dr…

This completed study looked at how well radiofrequency ablation (a procedure that uses heat to calm pain nerves) works for people with chronic pain. 298 participants were treated with a Boston Scientific device and then rated their improvement. The goal was to see real-world resu…

This study tested whether foot reflexology massage could reduce pain, improve sleep, and boost quality of life in women with migraines. Twenty-two women were split into two groups: one received 10 sessions of foot reflexology over 5 weeks, and the other served as a control. Resea…

This study tested whether attending weekly group mindfulness sessions could improve function and reduce pain for people with chronic low back pain. Over 450 adults took part, comparing group mindfulness with usual one-on-one care. The goal was to see if this approach helps people…

This study tested two physical therapy techniques—nerve gliding exercises and manual muscle release—to see which better relieves sciatica pain. 48 adults with long-term sciatica took part. Researchers measured pain, leg movement, and daily function to find the most effective appr…

This study compared using 3 points versus 1 point to fix a lightweight mesh during laparoscopic hernia repair (TAPP) in 351 adults with a first-time inguinal hernia. The goal was to see which method leads to less pain, fewer complications like seroma or infection, and lower recur…

This study tested a group breathwork program for people with chronic musculoskeletal pain. 35 adults participated to see if the program was feasible, acceptable, and could help reduce pain. The goal was to develop a simple, group-based breathing technique that might ease symptoms…

This pilot study tested whether adding cognitive behavioral therapy and mindfulness meditation to ketamine infusions could make pain relief last longer for people with chronic nerve pain. Thirty adults with moderate-to-severe neuropathic pain were randomly assigned to receive ket…

This study followed 226 adults in Israel who were prescribed ubrogepant or atogepant for their migraines. Researchers wanted to see how satisfied people were with these drugs in real-world settings, not just in a lab. Participants used an app to track their experience over 90 day…

This study tested whether a slow, gentle back massage can help women with fibromyalgia feel less pain and fatigue. 48 women took part, receiving 30-minute massages three times a week. The goal was to see if this simple, drug-free approach could improve daily comfort.

This study tested the drug erenumab in 512 adults who have frequent migraines (7 to 14 headache days per month) and had already tried at least one other preventive treatment that didn't work. The main goal was to see if erenumab could reduce the number of hours they spent with mo…

This study tested two types of magnetic brain stimulation (TMS) to see if they can reduce nerve pain in people with spinal cord injury. 26 adults with long-term nerve pain that didn't respond to medication took part. The goal was to measure changes in pain severity, daily functio…

This study tested whether prazosin, a drug used for high blood pressure and PTSD nightmares, can reduce headaches in veterans and service members who had a mild traumatic brain injury. 89 participants received either prazosin or a placebo for 12 weeks. Researchers tracked headach…

This study tested a mobile app designed to help people with chronic pain better manage their symptoms and reduce how much pain interferes with daily life. The app uses proven therapy techniques like Acceptance and Commitment Therapy and Cognitive Behavioral Therapy, plus tools to…

This study tested whether adding virtual reality (VR) exercises to standard home balance training helps people with vestibular migraine, a condition causing dizziness and balance problems. Forty adults with the condition were split into two groups: one did only home exercises, th…

This study tested whether combining two manual therapy techniques—fascial manipulation and perineal massage—can improve quality of life for women with dyspareunia (pain during vaginal penetration). Fifty Portuguese women with pelvic floor muscle spasms were split into two groups:…

This completed study tested two multimodal programs in 70 adults with non-specific chronic low back pain. Both programs combined exercise, behaviour change, education, and mindfulness; one also added functional resistance training. The goal was to see if these approaches improve …

This study tested whether repeated injections of a numbing drug (bupivacaine) into the back of the head could help people with chronic migraine or chronic tension-type headache. 290 adults received either the drug or a placebo (salt water) injection over three months. The main go…

This study tested whether a type of mindfulness training called Acceptance and Commitment Therapy (ACT) could help women with frequent migraines. 75 women aged 18-65 with 4-14 migraine days per month took part. The main goal was to see if a larger study was possible, but research…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical and helpful. 63 adults with opioid use disorder and pain took part. The goal was to see if they would stick with the program and if it could reduce pain, cravings, …

This study looked at whether indoor physical activity can improve symptoms in people with both fibromyalgia and irritable bowel syndrome (IBS). Researchers measured changes in gut and pain symptoms, intestinal health, and psychological well-being in 165 participants. The goal was…

This study looked at whether doing hip abductor strengthening exercises could help people with piriformis syndrome feel less pain and move better. 48 adults with the condition took part. The exercises focused on strengthening muscles that move the leg away from the body. The goal…

This study tested two procedures—cryoablation (freezing nerves) and endoscopic denervation (cutting nerves)—to treat chronic sacroiliac joint pain. 51 adults with confirmed pain from the joint were included. The goal was to see which method better reduces pain and improves daily …

This completed Phase 3 trial tested whether brivaracetam, a drug used for seizures, can reduce chronic nerve pain in people with spinal cord injury. 44 adults with persistent pain took part. The study compared brivaracetam to a placebo and measured changes in pain intensity and d…

This study tested whether adding augmented reality mirror therapy (ARMT) to standard physical and occupational therapy helps people with complex regional pain syndrome (CRPS) of the upper limb. Seven participants received both conventional therapy and ARMT sessions over a month. …

This study tested a minimally invasive procedure called pulsed radiofrequency on a nerve bundle in the face (the sphenopalatine ganglion) to see if it could reduce pain in 55 people with chronic headaches or facial pain who hadn't gotten relief from medication. The procedure uses…

This study tested two treatments for vestibulodynia, a chronic pain condition affecting the vulvar area. 209 women received either a lidocaine/estradiol cream, the antidepressant nortriptyline, both, or a placebo. The goal was to see which approach best reduces pain and improves …

This study looked at whether Tai Chi, a gentle mind-body exercise, can help adults over 45 living with both HIV and chronic pain. Researchers tested the program with 36 participants to see if it was practical and liked by patients. The goal was to find a non-drug way to reduce pa…

This study tested two different doses of lidocaine given through an IV to women who had nerve pain after mastectomy for breast cancer. Thirty women took part, and researchers measured how the pain felt (like burning or stinging) using a special scale. The goal was to see if lidoc…

This study tested whether a non-invasive magnetic brain stimulation technique called rTMS can reduce chronic low back pain. Thirty adults with long-lasting pain received multiple sessions of rTMS over the brain's motor cortex. Researchers measured pain changes using a standard pa…

This study tested a 12-week telehealth program for people with migraines, combining online modules, phone sessions, and a headache diary app. Twenty adults from a headache center in New York participated. The goal was to see if the program was feasible and acceptable, not yet to …

This study tested whether the drug acetazolamide can improve sleep-disordered breathing in 39 adults with chronic pain who use opioids. Participants took either the drug or a placebo for one week each. The goal was to see if the pill could reduce sleep apnea events as an alternat…

This study tested whether a nerve block placed near the breastbone after heart surgery can reduce the need for opioid painkillers. 340 adults having heart surgery through a standard chest incision were randomly assigned to receive either the numbing drug ropivacaine or a saltwate…

This study compared two physical therapy techniques—neurodynamic mobilization and Mulligan SNAGs—for people with chronic sciatica caused by a disc problem. 66 participants completed the trial at Cairo University. Researchers measured pain intensity, pressure pain threshold, and l…

This study tested whether foot reflexology—a type of focused foot massage—could help people with migraines feel less pain and fatigue and have a better quality of life. 78 adults with migraines took part; half received 10 reflexology sessions over 5 weeks, while the other half co…

This study tested different treatment sequences for chronic low back pain in 749 adults. Participants first received either physical therapy or cognitive behavioral therapy. Those who didn't improve were switched to the other therapy or added mindfulness. The goal was to find whi…

This study tested a procedure called pulsed radiofrequency treatment on the greater occipital nerve at the C2 level in 25 people with cervicogenic headache who had not responded to other treatments. The goal was to see if it could reduce headache severity and frequency. The treat…

This study tested a new program called Mindful Action for Pain (MAP) in 126 veterans with chronic pain. MAP combines mindfulness meditation with techniques from acceptance and commitment therapy to help people better manage pain and improve daily function. The goal was to see if …

This study tested an experimental drug called LX9211 in 79 adults with postherpetic neuralgia, a type of nerve pain that can last for months after a shingles rash heals. The goal was to see if the drug reduces pain and helps with sleep compared to a placebo over 11 weeks. Partici…

This study tested whether adding acceptance and commitment therapy (ACT) to standard migraine treatment could reduce monthly headache days in people with high-frequency episodic migraine (9-14 headache days per month). Sixty-four adults were randomly assigned to either standard c…

This study tested a device called Mi-Helper that cools the inside of the nose to treat migraine headaches at home. 156 adults with migraines used either the real device or a fake one. The goal was to see if the device could safely relieve pain and other bothersome symptoms within…

This study tested whether different types of sounds (natural, city, broadband, or silence) can help improve mood, stress, and anxiety in people with fibromyalgia. 72 adults with fibromyalgia listened to each sound for 20 minutes during four weekly visits. Researchers measured cha…

This study looked at how intravenous lidocaine affects sleep and quality of life in 51 people with fibromyalgia who still had pain and sleep problems despite other treatments. Researchers measured pain, sleep quality, and overall impact of the condition. The goal was to see if th…

This study looked at whether giving children with migraine an IV of salt water (a common fluid) in the emergency room can help reduce their headache pain. 46 children took part. The goal was to see if the fluid alone, without any other medicine, could make them feel better.

This study looked at whether an 8-week foot exercise program could help people with fibromyalgia who have foot pain. 27 adults with fibromyalgia took part. The program focused on strengthening the small muscles in the feet. Researchers measured changes in foot pain, function, and…

This study tested a 12-week virtual program called RAMP that teaches mind-body skills to help rural veterans manage chronic pain. Forty veterans participated in weekly group sessions and coaching via video. The goal was to see if the program is feasible and acceptable, not yet to…

This study tested a device that uses muscle sensors and a phone app to teach people how to relax tense muscles. It included 330 adults with chronic low back pain, recent breast surgery pain, or migraines. Half used the device plus usual care; the other half had only usual care. T…

This study looked at whether working with a care manager (patient navigator) and using an online pain coping program can help people with chronic pain improve how they manage their pain and daily activities. The study included 32 adults who had daily pain for at least 3 months an…

This Phase 3 trial tested a single dose of AXS-07, a combination of meloxicam and rizatriptan, for treating migraines in adults. 302 participants took either the drug or a placebo at the first sign of migraine pain. The study measured how many were pain-free and free of their mos…

This completed pilot study tested whether a smartphone app teaching mindfulness could help people with fibromyalgia. Fifty-four adults used the app daily for pain tracking and weekly for mindfulness lessons, while a control group only tracked symptoms. The goal was to see if the …

This study tested whether low-level laser therapy, combined with a self-care program, could help people with jaw joint pain (TMJ disorders). 66 adults with recent jaw muscle pain received the treatment. Researchers measured pain levels, jaw movement, and tender spots to see if th…

This study tested a device called the Human Regenerator Jet, which emits cold atmospheric plasma, to see if it can improve quality of life in adults with chronic stress, fatigue, pain, or Long COVID. Forty participants received 10 sessions of either the plasma or plain air, and r…

This study tested a new program to help older adults manage chronic pain using educational podcasts and support from a community health worker. 40 people aged 50 and older with long-lasting pain took part. The program aimed to teach pain self-management skills and help participan…

This study tested two types of telehealth programs for people with chronic pain: an online self-guided program and live sessions led by a health coach via phone or video. Over 2,300 adults from four healthcare systems took part. The goal was to see if these programs could help re…

This study looked at how well and how safely lasmiditan works for treating migraine attacks. One hundred adults with migraine took lasmiditan tablets (50, 100, or 200 mg) when they had an attack. Researchers measured how many people were pain-free after 2 hours and tracked any si…

This study tested whether the drug erenumab can help prevent migraines in children (ages 6 to 12) and teenagers (ages 12 to 18) who have chronic migraines. About 284 participants received either the drug or a placebo. The main goal was to see if the drug reduced the number of mig…

This study tested whether a non-invasive brain stimulation method called tDCS can help relieve chronic pelvic pain in women with endometriosis. Thirty women who were already on hormone therapy and had daily pain scores above 4 out of 10 took part. They received multiple tDCS sess…

This study tested a non-drug approach to help people with phantom limb pain—pain felt in a missing limb. Twenty adults with arm or leg amputations learned to change their brain responses using real-time feedback. The goal was to retrain the brain to reduce pain and improve qualit…

This study tested whether mirror therapy—a technique using visual feedback from a mirror to trick the brain—works better than routine physical therapy for people with Complex Regional Pain Syndrome (CRPS), a chronic pain condition often after injury. Fifty-two adults aged 40-65 w…

This completed study tested whether a non-invasive brain stimulation technique called tDCS can reduce pain and improve daily function in 100 women with fibromyalgia. Researchers also looked at how a person's tendency to respond to placebo might affect results. Participants receiv…

This study tested a non-invasive brain stimulation method called tDCS to see if it can reduce chronic nerve pain. Researchers compared real stimulation to a placebo in 24 healthy volunteers and patients with long-term nerve pain. The goal was to measure changes in pain levels and…

This study tested whether a toolkit called Pain at Work (PAW) can help employees with chronic pain manage their symptoms and stay productive. Around 380 workers from different workplaces in England took part, with some using the toolkit plus support calls and others receiving usu…

This study tested three types of non-invasive brain or spinal stimulation (tDCS, rTMS, and tsDCS) to see which best reduces pain in people with algoneurodystrophy, a chronic pain condition. 36 adults who had pain for over a year and didn't respond to drugs took part. The goal was…

This study tested whether adding a gentle brain stimulation technique called rTMS to standard exercise therapy could reduce pain in people with fibromyalgia. Forty-two adults with long-term pain took part, receiving either real or fake rTMS alongside exercise for 14 weeks. Resear…

This study tested surgery to treat Complex Regional Pain Syndrome (CRPS) in the upper limb. 74 adults with CRPS who had not improved with other treatments received either nerve decompression or correction of a specific structural problem. Pain levels were measured before surgery,…

This study looked at whether a targeted ultrasound-guided nerve block (SPSIPB) can reduce pain in people with postherpetic neuralgia, a chronic pain condition that can linger after shingles. Researchers reviewed records of 34 adults who received this injection and measured pain l…

This study tested a T-shirt printed with ceramic particles that claim to use body heat to emit far infrared radiation, potentially reducing inflammation and muscle pain. Fifty adults with chronic neck or lower back pain wore the shirt for 8 hours. Researchers measured changes in …

This study looked at whether very low-level electrical stimulation of nerves near the spine can reduce chronic pain more than a sham (inactive) device. Twenty adults who already have a nerve stimulator implant took part. Each person received both the real low-level stimulation an…

This study tested whether Erickson hypnosis can reduce chronic pain in people with Parkinson's disease. 33 participants were split into two groups: one received weekly hypnosis sessions for 2 months, the other got usual care. The main goal was to see if pain intensity changed fro…

This study tested whether a mindfulness-based group therapy program, originally developed in Canada, could work for French teenagers aged 12-17 with chronic pain. The main goal was to see if teens would attend at least 6 out of 8 sessions. Researchers also looked at effects on pa…

This pilot study tested a new behavioral treatment called Emotional Awareness and Expression Therapy (EAET) for people with migraines. Thirty adults with frequent migraines were randomly assigned to either EAET or a control group. The therapy involved 8 weekly online sessions whe…

This study tested two stretching techniques—Post-Isometric Relaxation and Post-Facilitation Stretching—in 36 adults with piriformis syndrome, a condition that causes buttock pain and limits hip movement. Participants did the exercises three times a week for four weeks. Researcher…

This study tested different ways to help people on medication for opioid use disorder do more yoga to manage their chronic pain. 192 adults who had been in treatment for at least 3 months took part. The goal was to see which combination of support methods helped them practice yog…

This study tested a virtual reality device to see if it could reduce pain in adults with chronic low back pain that didn't respond to medication. 122 participants used the VR system, which creates a 3D environment with changing colors. The main goal was to measure pain levels aft…

This small pilot study tested whether injecting a gel-like substance (hyaluronic acid) into the vaginal area could help menopausal women with pain during sex and vaginal dryness. Twenty women received the injections and were followed for 8 weeks. The main goal was to see if the v…

This study tested two methods to prevent chronic pain after thyroid removal: a nerve block (superficial cervical plexus block) and the drug ketamine. 69 adults having thyroid surgery were randomly assigned to one of the two approaches. The main goal was to see which method better…

This study tested whether relaxation therapy can reduce chronic pain and improve daily life in people with fibromyalgia. Eighty adults with fibromyalgia were randomly assigned to either active relaxation sessions with a therapist or to relax alone in a quiet room (placebo) for 12…

This study tested whether different types of sounds—like birdsong, traffic noise, or white noise—can reduce pain in people with fibromyalgia, a condition causing widespread pain. 88 adults with fibromyalgia listened to four different sound environments for 20 minutes each, one we…

This study tested whether adding virtual reality to standard physiotherapy could help teenagers with chronic musculoskeletal pain. 34 teens aged 10-17 took part in up to 8 sessions over 6-12 weeks. The goal was to see if VR was practical and enjoyable, and whether it could improv…

This study looked at whether medical cannabis can reduce nerve pain and inflammation in people with HIV. Thirty-five adults with HIV and neuropathic pain used different ratios of THC and CBD over 14 weeks. Researchers measured changes in pain severity and blood markers of inflamm…

This study looked at whether self-monitoring physical activity and using a massage gun can reduce chronic pain in women aged 65 and older. 108 participants tracked their steps and massage use to see which habits best improved pain. The goal was to find simple, effective ways for …

This early-phase study tested whether injecting lidocaine and steroids into two brain arteries could safely treat chronic migraines that don't respond to standard treatments. Ten adults with hard-to-treat migraines received one injection and were followed for 12 weeks. The main g…

This study looked at whether a non-invasive brain training method called neurofeedback can help veterans who have had a mild traumatic brain injury and still suffer from chronic headaches, trouble sleeping, and attention problems. 87 veterans were randomly assigned to receive neu…

This study tested whether adding a stellate ganglion block (a numbing injection in the neck) to cognitive processing therapy (a type of talk therapy) helps reduce PTSD and chronic pain more than therapy alone. Sixty adults with PTSD took part. The goal was to see if the combinati…

This study tested whether combining a non-opioid pain medication (duloxetine) with an online pain-coping skills program helps people with long-term muscle and joint pain. 280 adults with daily pain for at least 3 months took part. The goal was to see if this approach reduces pain…

This study looked at whether offering telehealth sessions of massage, yoga, chiropractic, or physical therapy could help adults with chronic pain reduce their opioid use and feel better. Twenty-one people participated, and researchers tracked changes in pain intensity, pain inter…

This study tested a 12-week home exercise program for women with fibromyalgia. Sixty participants were randomly assigned to exercise or a control group. Researchers measured changes in pain, fatigue, quality of life, and mood. The goal was to see if a structured, at-home routine …

This study tested whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in women with fibromyalgia. 131 women with both conditions received either CBT-I or sleep hygiene education. Researchers measured sleep quality, pain sensitivity, and bra…

This study looked at whether cognitive behavioral therapy (CBT) can help veterans with serious mental illnesses like schizophrenia or bipolar disorder manage chronic pain. 47 veterans took part in a 12-session CBT program designed for chronic pain. The goal was to see if the ther…

This study tested whether phone calls from a nurse could help people with fibromyalgia feel less pain and be more active. 44 adults were split into two groups: one got standard care, the other also received an educational booklet and three phone calls over 4 weeks covering exerci…

This study tested a home-based biofeedback app called Cerebri in 279 adults with episodic migraine. Participants used the app daily for 10 minutes, along with sensors to track muscle tension, heart rate, and finger temperature. The goal was to see if this approach could reduce th…

This study tested whether giving nitrous oxide (laughing gas) during a spine procedure called vertebroplasty could reduce pain and the need for morphine afterward. It included 39 adults who were already taking opioids for more than a month. The goal was to see if nitrous oxide, w…

This study tested two treatments for people with ongoing back pain after spinal surgery: pulsed radiofrequency (a procedure using mild electrical pulses) and a standard steroid injection. About 130 patients were followed for several months to see which approach reduced pain and i…

This study tested whether cognitive behavioral therapy (CBT) can reduce persistent pain after fracture surgery. Over 1,000 adults with broken arm or leg bones received either CBT or usual care. The goal was to see if CBT lowers the number of people who still have moderate to seve…

This study looked at whether 6 weeks of osteopathic treatment (gentle hands-on manipulation) could reduce pain in people with fibromyalgia. 101 adults with long-term fibromyalgia took part, comparing real osteopathy sessions to fake ones. The main goal was to track pain levels we…

This clinical trial is testing a medical device that has not been approved or cleared by the U.S. FDA. The trial's status is currently withheld, meaning key details about its progress and results are not publicly available. The purpose appears to be gathering information about th…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study looks at how motivation to exercise relates to quality of life in people with fibromyalgia. Researchers will survey 105 adults with fibromyalgia to understand what encourages or discourages physical activity. The goal is to identify factors that could help improve exer…

This study looks at whether muscle twitching in the neck during a standard pain treatment (radiofrequency ablation) can help predict who will get good pain relief. Researchers will grade twitching in 60 adults with chronic neck pain and then check if those with more twitching had…

This study tested a brief, computer-based personalized feedback program for adults with chronic pain who drink heavily and take prescription opioids. The program was designed to educate participants about the risks of mixing alcohol and opioids and to motivate them to reduce drin…

This study aims to find out which patient factors influence how well a nerve block works for medication-overuse headache. Researchers will give 70 adults an ultrasound-guided injection and track their pain and medication use for one month. The goal is to better predict who will b…

This study looks at how common nerve pain is in people aged 80 and older. Researchers will check pain levels and overall health in 450 volunteers. The goal is to better understand the link between nerve pain and aging, not to test a new treatment.

This study examines people with trigeminal neuralgia and persistent idiopathic facial pain, two conditions that cause chronic facial pain. Researchers will use sensory tests and MRI scans to look for signs of nerve damage and see how they relate to each other. The goal is to bett…

This study checks if a new melt-in-the-mouth version of a migraine drug works the same as the approved tablet. It involves 36 healthy adults who will take both forms at different times. The goal is to see if the body absorbs the drug similarly, not to treat migraines.

Researchers are testing an oral drug called Ketamir-2, a chemical cousin of ketamine, in healthy adults aged 18 to 65. The trial gives single or repeated doses to small groups and compares them against a placebo to see how the body handles the drug and what side effects occur. Th…

This study follows patients with cutaneous T-cell lymphoma or chronic cluster headache who are receiving corticosteroid treatment as part of their regular care. Participants fill out a short daily questionnaire on their phone for about 40 days, starting a few days before treatmen…

This study looks at whether women with fibromyalgia are more likely to have orthorexia nervosa—an unhealthy obsession with eating only healthy foods—compared to women without the condition. Researchers will also examine how body image, anxiety, depression, and pain levels relate …

This study looks at how often sleep disorders—like poor sleep quality, sleep apnea, and restless legs syndrome—occur in people with fibromyalgia. Researchers will use questionnaires to screen patients in specialized pain clinics across France. They will also ask doctors how they …

This Phase 1 trial evaluates the safety, tolerability, and how the body processes an experimental oral drug called AJH-2947. It involves healthy Korean or Caucasian men aged 19 to 55, who receive either the drug or a placebo. The study aims to determine safe dosing and preliminar…

This trial tests whether a smartphone app called e-DOL can help doctors and patients track chronic pain over time. The app lets patients record pain levels, anxiety, and sleep quality, while doctors view the data on a web platform. The study includes adults with chronic pain who …

This study looks at whether chronic neuropathic pain and the medications used to treat it—like antidepressants, antiepileptics, or opioids—are linked to changes in hormone levels. Researchers will compare hormone levels in 120 adults with chronic pain to healthy volunteers matche…

This study looked at how having fibromyalgia changes body measurements and sleep patterns in people with obstructive sleep apnea. Researchers measured neck, waist, and hip sizes, and used sleep tests and ultrasound to compare 77 participants. The goal was to better understand the…

This study aims to find out how many employees at a French furniture shop experience chronic pain, defined as pain rated above 3 out of 10. Researchers will use questionnaires to assess pain, anxiety, depression, quality of life, and how pain affects work. The goal is to better u…

This study looks at whether certain tests—like brain imaging, pain sensitivity measurements, and psychological questionnaires—can help predict which women will develop long-term pelvic pain after a hysterectomy. Researchers will follow women undergoing hysterectomy for benign con…

This study investigates whether genetic differences and altered pain processing contribute to fibromyalgia, a condition marked by widespread pain and increased sensitivity to painful stimuli. Researchers will compare 260 adults with fibromyalgia to a matched control group, measur…

This study tested a school program called SocLaLola that uses a comic book to teach children aged 8-11 about pain. The goal was to see if it improves kids' understanding of pain and reduces their fear of moving. Eighty-two students from two primary schools took part. The program …

This study aimed to develop and test two new questionnaires for people with recurrent urinary tract infections (UTIs). The Recurrent UTI Symptom Scale measures symptom severity, while the Recurrent UTI Impact Questionnaire looks at how the condition affects daily life, work, and …

This study investigates factors that may influence the development of chronic pain after mastectomy surgery. Researchers will follow 200 women undergoing elective mastectomy, tracking their pain levels and quality of life at 3 and 6 months after surgery. The goal is to identify r…

This trial tests whether a communication training program for primary care doctors can improve how they discuss pain with patients and manage opioid prescriptions. Doctors are randomly assigned to receive the training or standard guidelines. Researchers then record patient visits…

This study gathered information from 73 adults with chronic pain who were already using or planning to use an approved medical device (like a spinal cord stimulator) for their pain. Researchers asked participants to report their pain levels on a 0-10 scale and other outcomes duri…

This study investigates whether changes in a brain network called the default mode network (DMN) are linked to the nocebo effect — experiencing side effects from negative expectations rather than from a treatment itself. Researchers will use functional MRI to scan the brains of 4…

This study investigates whether systemic ozone therapy, used for conditions like chronic pain and osteoarthritis, damages the corneal endothelium—the eye's inner layer that keeps the cornea clear. Researchers will compare 48 patients receiving ozone therapy with 48 healthy matche…

This completed study looked at how often hospitalized patients with cirrhosis experience pain. Researchers asked 30 patients about their pain, its location, intensity, and whether it was chronic. The goal was to highlight an often-overlooked issue and encourage better pain care f…

This study used a special ultrasound technique to measure stiffness in pelvic floor muscles of 94 women — some healthy and some with pudendal neuralgia, a chronic nerve pain condition. Researchers compared the muscle stiffness between the two groups to see if differences exist. T…

This study looks at whether measuring the optic nerve sheath diameter—the lining around the nerve that connects the eye to the brain—using ultrasound can help doctors know if a treatment for spontaneous intracranial hypotension (a condition where low spinal fluid causes severe he…

This study follows adults with migraine who have been prescribed rimegepant (a dissolving tablet) for acute attacks. Researchers want to see how consistently the drug provides meaningful pain relief across multiple attacks and how satisfied people are with it. The study also look…

This study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid mis…

This study tracked 582 children aged 6 to 18 who had surgery to see how many still had pain 3 months later. Researchers used a pain questionnaire to measure pain levels and identify risk factors. The goal was to better understand chronic post-operative pain in kids, not to test a…

This study looked at how acupuncture affects the brain in people with migraine without aura. Forty adults received either real acupuncture or a sham (fake) version, and their brains were scanned with MRI before and after treatment. The goal was to see if real acupuncture causes d…

This study looked at 20 people with hard-to-treat chronic cluster headache who were already receiving occipital nerve stimulation. Researchers used brain scans to see how the stimulation changes brain activity. The goal was to understand how the treatment works, not to test if it…

This study compared 80 women with and without fibromyalgia to measure muscle strength, muscle thickness, vitamin D levels, and sleep quality. Researchers used advanced tools like isokinetic dynamometers and ultrasound to find differences between the groups. The goal was to better…

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This completed study aimed to find biological markers that could predict which migraine patients respond best to a new class of drugs called CGRP monoclonal antibodies. Researchers studied 243 adults with severe migraine, using genetic, brain imaging, and other tests. The goal is…

This study tested whether wearable devices can be used to monitor activity in older adults with chronic low back pain. 30 participants wore ankle sensors to track movement and reported on their pain and mobility. The goal was to see if this approach is practical and acceptable fo…

This study looked at 98 women who had a blood patch to treat severe headaches caused by an accidental spinal fluid leak during labor. Researchers wanted to see if certain factors during the blood patch procedure were linked to headaches that last 1 to 6 months. The goal is to bet…

This study follows 87 women who had chronic low back pain 13 years ago to see how their pain, daily activities, and ability to work have changed. Researchers are looking for patterns that might predict who will improve or worsen over time. The goal is to better understand the lon…

This study talked to 50 adults with long-term (non-cancer) pain and their healthcare providers to learn about their experiences managing pain in primary care. The goal was to use this information to create a decision aid tool that helps patients and doctors make informed choices …

This completed registry study followed 120 migraine patients in the Guangdong-Hong Kong-Macao Greater Bay Area who were prescribed rimegepant by their doctors. The goal was to see how the drug affects their quality of life, daily functioning, work productivity, and overall satisf…

This study tested a Portuguese version of the DIVA questionnaire to see if it reliably measures how vaginal aging symptoms (like dryness, itching, or pain) affect daily activities, sex life, emotions, and body image. 300 women with at least one symptom of vulvovaginal atrophy too…

This study looked at 202 Polish adults with chronic low back pain to find out how severe their anxiety symptoms are. Participants filled out a questionnaire called GAD-7, which scores anxiety from none to severe. The goal was simply to measure the problem, not to test any treatme…

This study looked at symptoms children experience after a migraine attack (called the postdrome phase). Researchers asked 45 children with migraine about their symptoms and how they differ by age and gender. The goal was to better understand this often-overlooked phase of migrain…

This completed study looked at 393 adults aged 65 and older with chronic pain to see how frailty relates to the type and location of pain, as well as nutritional risk. Researchers measured frailty using standard criteria and assessed pain intensity and type. The goal is to help d…

This study tested whether adding an AI-generated summary to brain MRI reports helps people understand the results. Over 2700 adults read six fictional reports and answered questions about what they found. The goal was to see if the simple summary improved understanding compared t…

This study looked at whether the weekly performance of a favorite NFL team affects chronic pain in avid football fans. Thirty-two adults with chronic pain completed weekly surveys during the football season, rating their pain, mood, and pain-related thoughts. The goal was to see …

This pilot study tested a program called STEPPT to see if it could reduce ethnic disparities in physical therapy referrals and attendance for spine pain. The program included educating clinic staff, updating electronic health records to automate referrals, and providing patient n…

This study tested whether wearable devices like the Apple Watch and Oura Ring, along with digital surveys, can predict outcomes for chronic pain patients receiving spinal cord stimulation. Twenty-eight adults with long-term pain were implanted with Abbott's spinal cord stimulator…

This study looked at 24 people with Complex Regional Pain Syndrome (CRPS) type I in their legs who already use a device that stimulates nerves near the spine (dorsal root ganglion stimulation) to control pain. Researchers used special wearable sensors to track things like heart r…

This completed pilot study looked at how lifestyle factors like diet, physical activity, sleep, stress, smoking, and alcohol use relate to pain sensitivity in 20 women with fibromyalgia. Participants wore a Fitbit, logged food, completed questionnaires, and had pain sensitivity t…

This early-stage study tested a single inhaled dose of prochlorperazine in 54 healthy adults to see if it is safe and how the body processes it. The goal was to gather information for future migraine treatments. No treatment benefit was measured, as participants were healthy volu…

This study used ultrasound to measure the thickness of certain hip muscles in 60 adults with hip pain on one side (Greater Trochanteric Pain Syndrome) and compared them to healthy people. The goal was to see if muscle thickness differs between the groups and to check for related …

This study looked at 56 women with endometriosis to see if severe pain during sex is linked to a condition called central sensitization, where the nervous system becomes overly sensitive to pain. Researchers used pain-pressure tests and daily surveys over 6 weeks to measure pain …

This study looked at how migraine patients and healthcare providers in Thailand experience eptinezumab, a preventive migraine infusion given every 3 months. Researchers interviewed 30 participants to find out what makes it easier or harder to use this treatment in a real-world ho…

This study looked at whether levels of certain minerals (like selenium, magnesium, and zinc) in the blood are different in women with fibromyalgia compared to healthy women. It also checked if those mineral levels are linked to how severe the disease is, or to anxiety and depress…

This study looked at 264 people with chronic lower back and leg pain caused by a pinched nerve. Researchers wanted to see if routine blood test results could predict who would get good pain relief from a combination of two treatments: a nerve block and a short electrical pulse to…

This study looked at 65 people with fibromyalgia to figure out what kind of pain they have—nerve pain, tissue pain, or a mixed type. Researchers used a special checklist and simple tests like brushing the skin or pressing with a tool. The goal is to help doctors choose better tre…

This study looked at how spinal cord stimulation (SCS) affects pain processing in 34 people with chronic pain. Participants already had an SCS device as part of their care. Researchers tested different stimulation patterns (burst, kHz, tonic, and sham) to see how they changed the…

This study looked at whether people with fibromyalgia have early, hidden changes in heart function. Researchers used a special ultrasound technique called Global Longitudinal Strain (GLS) to measure heart muscle movement in 59 fibromyalgia patients and 59 healthy volunteers. The …

This completed study looked at 204 patients who had a kidney removed (nephrectomy) to find out what factors might lead to chronic pain lasting months or years after surgery. Researchers measured pain levels at 1 hour, 3 months, and 1 year after the operation using a simple 0-to-1…

This study looked at whether genetic testing can help doctors choose better medicines for depression, acute pain, and chronic pain. Over 4,000 people were screened to join one of three trials. The goal was to see if matching drugs to a person's genes improves outcomes compared to…

This study looked at 420 people aged 80 and older to find out how many have fibromyalgia, a condition that causes widespread pain and fatigue. Researchers used standard medical criteria to diagnose fibromyalgia and also checked participants' memory, thinking, and overall health. …

This study tested an online tool designed to help doctors decide which patients with chronic pain are good candidates for spinal cord stimulation. About 80 adults with conditions like failed back surgery syndrome or complex regional pain syndrome took part. The tool's recommendat…

This study tested a French version of a questionnaire that measures how people with chronic pain think about their condition. Researchers compared it to another questionnaire about pain self-confidence. The goal was to see if the new scale adds useful information beyond existing …

This study looked at 77 adults with long-term nerve pain after shingles (postherpetic neuralgia) to see if a spinal nerve stimulation device works better for certain types of pain. Researchers grouped patients by their pain features and measured pain levels, quality of life, and …

This study looked at 158 adults to find out if certain traits or risk factors can predict who will develop chronic pain after lower back surgery. Researchers measured pain severity, disability, and other health factors using questionnaires. The goal was to better understand why s…

This study created a questionnaire to measure health beliefs in people with vestibular migraine, a condition causing dizziness and imbalance. 213 patients completed the scale and received a single educational session about their condition. The goal was to see if the scale is reli…

This study looked at 84 adults with chronic neck pain to see how central sensitization (a condition where the nervous system becomes overly sensitive) relates to pain intensity, thinking patterns, sleep quality, and jaw function. Researchers used questionnaires to measure these f…

This study used ultrasound to measure the thickness of the piriformis muscle and sciatic nerve in 19 people with piriformis syndrome, comparing the painful side to the pain-free side. The goal was to see if ultrasound can help tell whether the pain comes more from muscle or nerve…

This study looks at people who still have chronic back or leg pain after back surgery, a condition called Failed Back Surgery Syndrome (FBSS). Researchers want to better understand what causes this pain and how to diagnose it faster. They will collect detailed information from 20…

This study surveyed 803 people diagnosed with New Daily Persistent Headache (NDPH) to learn about their headache patterns and what treatments they have tried. The goal was to gather information on this poorly understood condition. The survey is now complete, and the results may h…

This study used special brain scans to look for signs of inflammation in the brains and spinal cords of 60 people with chronic low back pain. Researchers also tested whether a short course of the antibiotic minocycline could reduce both inflammation and pain. The goal was to bett…

This study looked at 39 people having lower back surgery for a herniated disc or spinal stenosis. Researchers checked for nerve pain before surgery and again 1, 3, 6, and 12 months after using a simple questionnaire. The goal was to see how common nerve pain is after surgery and …

This study tested whether a small device that collects blood from the arm (instead of a needle in the vein) works as well for measuring levels of the drug zavegepant. Fourteen healthy adults took the nasal spray and gave blood samples using both methods. The goal was to see if th…

This study reviewed medical records of 60 adults who had radiofrequency treatment for intercostal neuralgia, a type of nerve pain in the chest wall. The goal was to find out which patient or clinical factors are linked to better pain relief after the procedure. Researchers measur…

This study tested a seven-session pain school program for 82 adults with chronic non-cancer pain. The program included teaching, group discussions, and exercises led by a team of pain specialists. The goal was to see if patients found the program helpful and relevant to their nee…

This study explored whether adding mindfulness training to physical therapy is practical for people with long-term muscle and joint pain who also take opioid painkillers. Researchers developed a training manual for physical therapists and tested different ways to teach them mindf…

This completed study looked at 164 women with and without fibromyalgia to see if certain autoantibodies are linked to more severe symptoms. Researchers compared patients with high and low antibody levels, and healthy controls, using questionnaires, blood tests, skin biopsies, and…

This study looked at whether ivabradine, a medicine used for heart conditions, could stop migraines triggered by another drug called levcromakalim. 37 adults with migraine without aura took part. The goal was to see if ivabradine could reduce the number of migraines caused by the…

This study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…

This study looked at 65 women with deep infiltrating endometriosis to see if the number of nerve fibers in their lesions is linked to how much pain they feel. Researchers measured nerve density in surgically removed tissue and compared it to pain scores reported by patients. The …

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study looked at whether measuring a protein called S100B in the blood can help emergency doctors tell the difference between primary headaches (like migraines) and secondary headaches (caused by something serious like a bleed or infection). Researchers enrolled 81 adults wit…

This study looked at 80 people with muscle pain to see if genetics can predict which treatment works best. Participants received laser, ultrasound, or sugar-water injections. Researchers analyzed blood and urine to find markers that could guide personalized pain care in the futur…

This study followed 392 adults who had planned surgeries to map their pain levels over the first 7 days after the operation. Researchers wanted to see if certain pain patterns could predict who would still have pain 3 months later. The goal is to better understand and possibly pr…

This study tested a computer tool that helps doctors and patients with chronic pain make treatment decisions together. The tool was used in primary care clinics for patients with long-term muscle or bone pain who had recently taken opioids. The goal was to see if clinics would ad…

This study looked at how different types of touch, like those used in massage, affect pain in people with fibromyalgia compared to healthy volunteers. Researchers measured pain levels, touch pleasantness, and other factors like mood and trauma history. The goal was to better unde…

This study tested two ways of teaching older adults with knee osteoarthritis about their pain. One group learned about the biology of pain and how to manage it, while the other received standard information about joint damage. Researchers measured whether the type of education af…

This study looked at how focusing on negative thoughts (rumination) versus distracting yourself affects your mood after physical activity in people with fibromyalgia. 47 adults with fibromyalgia took part. Researchers gave them instructions to either ruminate on their muscle tens…

This study looked at how repetitive negative thinking (rumination) affects the emotional and mental symptoms of fibromyalgia. Researchers studied 107 adults with fibromyalgia using questionnaires. The goal was to understand if rumination plays a role in depression and anxiety oft…

This study looked at how stress changes gene activity in women with chronic widespread pain (fibromyalgia). Researchers compared 84 women with and without the condition, using mental stress tests and relaxation breathing. They measured changes in DNA methylation, a process that c…

This study looked at how common migraines are in infertile women and how they change during IVF treatment. Researchers gave 137 women a simple questionnaire to track headaches and medical history. The goal was to understand if the hormone changes from IVF can trigger or worsen mi…